INDUSTRY CONSULTING AGREEMENT This Agreement is made this 60 day of march 11st, 2014, by and between Bina Marga

(the Com any!", a cor oration organi#ed and e$isting %nder the &aws of the indonesia state, and '()A (the Cons%&tant!", an em &oyee and fac%&ty member of *ar+ard Medica& ,choo&, an ed%cationa& instit%tion and charitab&e cor oration &ocated in Boston, Massach%setts (*M,!"'*./.A,, the Cons%&tant, as a member of the fac%&ty at *ar+ard Medica& ,choo& (*M,!", is ermitted to erform &imited cons%&ting ser+ices for com anies, s%b0ect to the terms of Cons%&tant1s em &oyment re&ationshi with *M,2*,3M and the a &icab&e o&icies and roced%res of *ar+ard 4ni+ersity and *M,2*,3M5 '*./.A,, the Com any desires that the Cons%&tant ro+ide ad+ice and assistance to the Com any in his or her area of e$ ertise5 and '*./.A,, the Cons%&tant desires to ro+ide s%ch ad+ice and assistance to the Com any %nder the terms and conditions of this Agreement5 67', T*./.87/., the Com any and the Cons%&tant hereby agree as fo&&ows9 1- Cons%&ting ,er+ices (a" ,%b0ect to the terms and conditions of this Agreement, the Com any hereby retains Cons%&tant as a cons%&tant and technica& ad+isor to erform the cons%&ting ser+ices s ecifica&&y set o%t in .$hibit A attached to this Agreement and made a art hereof (hereafter referred to as the ,er+ices!", as said .$hibit may be amended in writing from time to time, and Cons%&tant agrees, s%b0ect to the terms and conditions of this Agreement, render s%ch ,er+ices d%ring the term of this Agreement- ,%ch ser+ices sha&& be &imited to the area of e$ ertise described in .$hibit A (the 8ie&d!", as amended in writing from time to time- Cons%&tant sha&& render ser+ices here%nder at s%ch times and &aces as sha&& be m%t%a&&y agreed by Com any and Cons%&tant- Cons%&tant1s commitment here%nder sha&& not e$ceed 60 days er month(b" (t is %nderstood that the %r ose of the Cons%&ting is to ro+ide eriodic re+iew and ad+ice re&e+ant to certain Com any matters, and that neither Cons%&tant nor Com any wi&& benefit if Cons%&tant ro+ides inacc%rate ad+ice or commentary based on ins%fficient information- To that end, Com any sha&& ro+ide Cons%&tant, in ad+ance of meetings, with acc%rate, %nbiased and s%fficient information for him to re+iew the s%b0ect matter thereof, and sha&& rom t&y ro+ide f%rther information that Cons%&tant reasonab&y deems re&e+ant to forming any ertinent conc&%sions re&e+ant to the matter for disc%ssion- (t is e$ ress&y %nderstood that Cons%&tant has no fid%ciary ob&igation to Com any, b%t instead a contract%a& one described by the terms of this Agreement5 that Cons%&tant1s ro&e is to ro+ide inde endent ad+ice %ninf&%enced by commercia& concerns5 and that ser+ice as a Cons%&tant does not re:%ire him to be an ad+ocate for Com any or its rod%cts in any for%m, %b&ic or ri+ate- Com any e$ ress&y agrees that %nder no circ%mstances wi&& this ro&e be com romised or inacc%rate&y re resented-

2- Com ensation and reimb%rsement(n consideration of the ser+ices to be ro+ided by Cons%&tant to the Com any here%nder, the Com any sha&& ay to Cons%&tant ; 2<,000-00- (n addition, the Com any sha&& reimb%rse Cons%&tant for reasonab&e tra+e& and other e$ enses Cons%&tant inc%rs in connection with erforming the ,er+ices- To obtain reimb%rsement, Cons%&tant sha&& s%bmit to the =resident of the Com any, or his or her designee, an in+oice describing ser+ices rendered and e$ enses inc%rred %nder this Agreement- Com any sha&& ro+ide any doc%mentation re:%irements and any tra+e& o&icy restrictions to cons%&tant in writing in ad+ance, or be forec&osed from re&ying on s%ch re:%irements and restrictions to deny reimb%rsement- The Com any sha&& ay to Cons%&tant in+oiced amo%nts within thirty (>0" days after the date of in+oice- Com any wi&& accommodate Cons%&tant1s re:%est to arrange, at Com any1s e$ ense, for a&& of Cons%&tant1s tra+e& and accommodations in connection with s%ch meetings if they occ%r o%tside the Boston metro o&itan area>- (nde endent contractor stat%sThe arties agree that this Agreement creates an inde endent contractor re&ationshi , not an em &oyment re&ationshi - The Cons%&tant ac?now&edges and agrees that the Com any wi&& not ro+ide the Cons%&tant with any em &oyee benefits, inc&%ding witho%t &imitation any em &oyee stoc? %rchase &an, socia& sec%rity, %nem &oyment, medica&, or ension ayments, and that income ta$ withho&ding is Cons%&tant1s res onsibi&ity- (n addition, the arties ac?now&edge that neither arty has, or sha&& be deemed to ha+e, the a%thority to bind the other arty4- (ndemnification 6otwithstanding any other term of this Agreement, Com any sha&& indemnify, defend and ho&d harm&ess Cons%&tant, and *M,, its cor orate affi&iates, c%rrent or f%t%re directors, tr%stees, officers, fac%&ty, medica& and rofessiona& staff, em &oyees, st%dents and agents and their res ecti+e s%ccessors, heirs and assigns (the (ndemnitees!", against any c&aim, &iabi&ity, cost, damage, deficiency, &oss, e$ ense or ob&igation of any ?ind or nat%re (inc&%ding witho%t &imitation reasonab&e attorneys1 fees and other costs and e$ enses of &itigation" inc%rred by or im osed % on the (ndemnitees or any one of them in connection with any c&aims, s%its, actions, demands or 0%dgments arising o%t of this Agreement (inc&%ding, b%t not &imited to, actions in the form of tort, warranty, or strict &iabi&ity"<- (nte&&ect%a& =ro erty (a" Cons%&tant and *M, %nderstand and ac?now&edge that Com any wi&& be ro+iding access to ro rietary and +a&%ab&e information that Cons%&tant might otherwise not recei+e- (n addition, those arties a&so %nderstand that sho%&d Cons%&tant, in the co%rse of ro+iding ,er+ices, in+ent or artici ate in in+enting modifications or im ro+ements to Com any techno&ogy, Com any reasonab&y see?s to sec%re s%ch im ro+ements for its own %se and ractice- At the same time, Com any %nderstands and ac?now&edges that Cons%&tant has re@e$isting and on@going ob&igations to *M, and the s onsors of research at *M, (inc&%ding ob&igations %nder grants, contracts, co&&aborati+e agreements, and a artici ation agreement! assigning to *M, a&& in+entions within the sco e of certain o&icies"- These ob&igations inc&%de a d%ty on the art of Cons%&tant to disc&ose and assign to *M, any in+entions or other ro rietary rights arising d%ring 2

the co%rse of s%ch em &oyment and any o+er&a ing cons%&ting arrangements (inc&%ding this Agreement", and an ob&igation to ens%re that any cons%&ting agreement he enters into is not in conf&ict with the *M, =o&icy on (n+entions and (nte&&ect%a& =ro erty or in conf&ict with other *M, commitments, s%ch as Cons%&tant1s ob&igation to %b&ish research res%&ts(b" (n order to enter into this Agreement with Cons%&tant, Com any therefore f%rther ac?now&edges and agrees that in the e+ent that any conf&ict sho%&d arise between the d%ties set forth in this Agreement and Cons%&tant1s ob&igations to *M, or s onsors of research at *M,, Cons%&tant sha&& necessari&y notify *M, immediate&y, and that Cons%&tant1s ob&igations to *M, and s onsors of research at *M, sha&& ta?e recedence o+er the terms of this Agreement(c" *owe+ e r, the artie s agre e that it is m%t % a&&y ben eficia& that Cons%&t a n t be ab&e to artici a t e f%&&y in ro+iding ,er+ices , as stat e d her ein, witho% t being ob&igat e d to cons tr ain her or his com m e n t s or contrib%tion s bas e d % on the com &e $ities of a &ying thes e conf&icting ob&igation s to inte&&ect % a& ro e r t y owners hi - Therefore, in order to reconci&e these ob&igations, and romote Cons%&tant1s artici ation, d%ring the term of this Agreement Cons%&tant sha&& rom t&y re ort and sim%&taneo%s&y disc&ose to *M, and to the =resident of Com any, or his or her designee, a&& in+entions, im ro+ements, modifications, disco+eries, methods and de+e&o ments, whether atentab&e or not, made or concei+ed by Cons%&tant, or by em &oyees or agents of Com any %nder Cons%&tant1s direction, d%ring the erformance of this Agreement that res%&t direct&y from Confidentia& (nformation ro+ided by Com any %rs%ant to this Agreement and either embody Com any techno&ogy or are red%ced to ractice as a modification or im ro+ement to Com any techno&ogy (hereby designated (n+entions!"- 7wnershi of s%ch (n+entions, and any atent rights re&ated thereto, sha&& reside with *M,, if co+ered by a &icab&e *M, o&icies, or otherwise with Com any b%t s%b0ect to a mandatory, cost@free &icense bac? to Cons%&tant to %se the (n+ention for academic research %r oses- (f ownershi &ies with *M,, then, ro+ided s%ch (n+entions are not s%b0ect to rior conf&icting ob&igations to s onsors of research at *M,, Com any sha&& ha+e an e$c&%si+e o tion, for 120 days fo&&owing notice of Cons%&tant1s disc&os%re, to negotiate an e$c&%si+e wor&d@wide &icense, on reasonab&e terms c%stomary for *M,, to %se, ractice, &icense and s%b&icense rights %nder atents c&aiming s%ch (n+entions within a m%t%a&&y agreed fie&d of %se- ('hi&e the arties be&ie+e that conf&icting ob&igations to research s onsors are %n&i?e&y, it is concei+ab&e that in the co%rse of s%ch s onsored research (n+entions %sef%& to Com any may emerge5 rather than forego disc&osing s%ch fort%ito%s in+entions to Com any, to the e$tent ermitted by s%ch s onsorshi and re&ated agreements Cons%&tant and *M, wi&& endea+or to disc&ose and &icense s%ch (n+entions %rs%ant to this Agreement-" (d" The Cons%&tant ac?now&edges that the Com any does not desire to ac:%ire any trade secrets, ?now@how, confidentia& information, or other inte&&ect%a& ro erty that the Cons%&tant may ha+e ac:%ired from or de+e&o ed for any third arty, inc&%ding the (nstit%tion (Third@=arty (=!"- The Com any agrees that in the co%rse of ro+iding the ,er+ices, the Cons%&tant sha&& not be re:%ired to %se or disc&ose any Third@=arty (=, inc&%ding witho%t &imitation any inte&&ect%a& ro erty of (i" any former or c%rrent em &oyer, (ii" any erson for whom the Cons%&tant has erformed or c%rrent&y erforms cons%&ting ser+ices, or (iii" any other erson to whom the Cons%&tant has a &ega& ob&igation regarding the %se or disc&os%re of s%ch inte&&ect%a& ro erty6- Confidentia& (nformation

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(a" The arties ac?now&edge that in connection with Cons%&tant1s ,er+ices, the Com any may disc&ose to Cons%&tant confidentia& and ro rietary information and trade secrets of the Com any, and that Cons%&tant may a&so create s%ch information within the sco e and in the co%rse of erforming the ,er+ices (hereinafter, s%b0ect to the e$ce tions be&ow, Com any Confidentia& (nformation!"- ,%ch information may ta?e the form of, for e$am &e9 data concerning scientific disco+eries made by the Com any5 the Com any1s ?now@how5 the Com any1s man%fact%ring strategies and rocesses5 the Com any1s mar?eting &ans5 data from the Com any1s e+a&%ations in anima&s and h%mans5 the Com any1s ast, resent and f%t%re b%siness &ans5 the Com any1s strategy for or stat%s of reg%&atory a ro+a&5 or the Com any1s forecasts of sa&es and sa&es data6otwithstanding the abo+e, the Com any ac?now&edges and agrees that none of the information described in this =aragra h 6 (e$ce t Confidentia& (nformation created by Cons%&tant" wi&& be considered Com any Confidentia& (nformation for %r oses of this Agreement, %n&ess the information is disc&osed to Cons%&tant by the Com any in writing and is c&ear&y mar?ed as confidentia&, or, where +erba&&y disc&osed to Cons%&tant by the Com any, is fo&&owed within thirty (>0" days of s%ch +erba& disc&os%re by a writing from the Com any confirming s%ch disc&os%re and indicating that s%ch disc&os%re is confidentia&(b" ,%b0ect to the terms and conditions of this Agreement, Cons%&tant hereby agrees that d%ring the term of this Agreement and for a eriod of three (>" years thereafter9 (i" Cons%&tant sha&& not %b&ic&y di+%&ge, disseminate, %b&ish or otherwise disc&ose any Com any Confidentia& (nformation witho%t the Com any1s rior written consent, which consent sha&& not be %nreasonab&y withhe&d5 and (ii" Cons%&tant sha&& not %se any s%ch Com any Confidentia& (nformation for any %r oses other than cons%&tation with the Com any, e$ce t that Cons%&tant1s %se of s%ch information for %re&y interna& academic research, witho%t disc&os%re o%tside *M,, sha&& not be a breach of this Agreement ro+ided that Cons%&tant is not in breach of the (nte&&ect%a& =ro erty ro+isions of =aragra h < abo+e- 6otwithstanding the abo+e, the Com any and Cons%&tant ac?now&edge and agree that the ob&igations set o%t in this =aragra h 6 sha&& not a &y to any ortion of Com any Confidentia& (nformation which9 (i" was at the time of disc&os%re to Cons%&tant art of the %b&ic domain by %b&ication or otherwise5 or (ii" became art of the %b&ic domain after disc&os%re to Cons%&tant by %b&ication or otherwise, e$ce t by breach of this Agreement5 or (iii" was a&ready ro er&y and &awf%&&y in Cons%&tant1s ossession at the time it was recei+ed from the Com any5 or (i+" was or is &awf%&&y recei+ed by Cons%&tant from a third arty who was %nder no ob&igation of confidentia&ity with res ect thereto5 or (+" was or is inde endent&y de+e&o ed by Cons%&tant witho%t reference to Com any Confidentia& (nformation5 (+i" is re:%ired to be disc&osed by &aw, reg%&ation or 0%dicia& or administrati+e rocess5 or

(+ii" in the case of information re ared by Cons%&tant, is encom assed within and deri+ed from Cons%&tant1s academic and rofessiona& commitments to *M,, and2or any other cons%&ting or research engagement, ro+ided that Confidentia& (nformation described in this c&a%se (+ii" which constit%tes (n+entions sha&& be s%b0ect to the inte&&ect%a& ro erty ro+isions of ,ection < of this Agreement (c" 6otwithstanding any other term of this Agreement, the Com any agrees that it sha&& not disc&ose to Cons%&tant any information which is Com any Confidentia& (nformation9 (i" e$ce t to the e$tent necessary for Cons%&tant to f%&fi&& Cons%&tant1s ob&igations to the Com any %nder this Agreement5 or (ii" %n&ess Cons%&tant has agreed in writing to acce t s%ch disc&os%re- A&& other information and comm%nications between the Com any and Cons%&tant sha&& be deemed to be ro+ided to Cons%&tant by the Com any on a non@confidentia& basis- The Com any a&so agrees that Cons%&tant may share the terms of this agreement on a confidentia& basis with its em &oyers, &ega& and financia& ad+isors, ins%rers and other third arties who ha+e a &egitimate need to ?now abo%t them, and that Cons%&tant may disc&ose the e$istence and genera& nat%re of his cons%&ting arrangement with the Com any with the 4ni+ersity, his co&&eag%es and co@wor?ers, and his co&&aborators, as we&& as %b&ishers and a%dience members at scientific conferences and for%ms at which Cons%&tant is s ea?ing or resenting, whene+er s%ch disc&os%res are &ega&&y or ethica&&y re:%ired or a ro riate- The Com any f%rther agrees that Cons%&tant sha&& not be &iab&e to the Com any or to any third arty c&aiming by or thro%gh the Com any for any %na%thori#ed disc&os%re or %se of Com any Confidentia& (nformation which occ%rs des ite Cons%&tant1s com &iance with Cons%&tant1s ob&igations %nder this Agreement(d" 4 on termination of the Agreement, or any other termination of Cons%&tant1s ser+ices for the Com any, a&& records, drawings, noteboo?s and other doc%ments ertaining to any Confidentia& (nformation of the Com any, whether re ared by Cons%&tant or others, and any materia&, s ecimens, e:%i ment, too&s or other de+ices owned by the Com any then in Cons%&tant1s ossession, and a&& co ies of any doc%ments, sha&& be ret%rned to the Com any, e$ce t Cons%&tant may ?ee one co y of a&& doc%ments for his or her fi&es (which co y sha&& be s%b0ect to the confidentia&ity and non@%se re:%irements set o%t in this Agreement"A- =%b&ication 6otwithstanding any other ro+ision of this Agreement, Com any %nderstands that Cons%&tant has rimary rofessiona&, academic and ethica& ob&igations arising in connection with Cons%&tant1s ositions at *M, and that Cons%&tant is s%b0ect to o&icies of those instit%tions which rotect academic freedom and reser+e ownershi of inte&&ect%a& ro erty rights- Com any agrees that Cons%&tant sha&& be free to %b&ish within the sco e of his or her rofessiona& and academic d%ties with res ect to Cons%&tant1s artici ation as a Cons%&tant, ro+ided that Cons%&tant does not re+ea& Confidentia& (nformation- Com any therefore agrees that in the co%rse of her or his rofessiona& and academic d%ties, Cons%&tant may disc%ss s%ch artici ation at conferences, with co&&eag%es, and with st%dents, residents and fe&&ows as Cons%&tant deems a ro riate, witho%t re+ea&ing s%ch Confidentia& (nformation- (n either conte$t, as we&& as in the sco e of his or her d%ties %nder this Agreement, Cons%&tant sha&& be free to cond%ct her@ or himse&f witho%t restraint or im ro er inf&%ence, in accordance with *M, and (nstit%tiona& academic, ethica& and %b&ication standards- ,o&e&y in order to ermit Com any an o ort%nity to determine if Confidentia& (nformation or (n+entions are therein im ro er&y disc&osed, Cons%&tant agrees to %se reasonab&e efforts to (i" ro+ide to Com any at &east thirty days in ad+ance of s%bmission to a <

0o%rna& any s%bstantia&&y com &ete man%scri t that inc&%des s%ch Confidentia& (nformation5 (ii" ro+ide notice to Com any no &ater than fi+e wor?ing days before s%bmission for %b&ication or to a conference of any s%bstantia&&y fina& abstract referring to s%ch Confidentia& (nformation5 and (iii" notify Com any thirty days in ad+ance of any conference at which s%ch Confidentia& (nformation can foreseeab&y be re+ea&ed- (f within that thirty@day eriod Com any re:%ests a de&ay in %b&ication so that a atent may be fi&ed on (n+entions disc&osed in the man%scri t, Cons%&tant wi&& de&ay %b&ication for % to an additiona& si$ty days (not to e$ceed a tota& of ninety days from the initia& s%bmission of a man%scri t to Com any"- Com any agrees to ho&d a&& s%ch s%bmissions and information in confidence ending %b&ication- Com any agrees to notify Cons%&tant rom t&y if any action is necessary to de&ete Confidentia& (nformation- Com any has no other right to re:%est a&teration or de&etion of any ortion of the man%scri t or abstractB- Term (a" This Agreement sha&& remain in effect for a term of one (1" year commencing on the date first written abo+e, %n&ess sooner terminated as hereinafter ro+ided, or %n&ess e$tended by agreement of the arties and the assent of *M,(b" This Agreement may be terminated by either arty, with or witho%t ca%se, % on thirty (>0" days rior written notice to the other5 ro+ided that if Cons%&tant terminates this Agreement, Cons%&tant sha&&, in accordance with the terms and conditions hereof, ne+erthe&ess wind % in an order&y fashion assignments for the Com any which Cons%&tant began rior to the date of notice of termination here%nder(c" 4 on termination of this Agreement for any reason, Cons%&tant sha&& be entit&ed to recei+e s%ch com ensation and reimb%rsement, if any, accr%ed %nder the terms of this Agreement, b%t %n aid, as of the date Cons%&tant ceases wor? %nder this Agreement- (n addition, Cons%&tant sha&& be reimb%rsed for any noncance&&ab&e ob&igations, any cance&&ation ena&ties, and, %n&ess Cons%&tant terminates the agreement witho%t ca%se, any e$ endit%res reasonab&y made in order to erform the ,er+ices that were to occ%r had cance&&ation not occ%rredC- 7ther Agreements (a" The Cons%&tant sha&& %se reasonab&e efforts not to %se any faci&ities, f%nds, or e:%i ment owned or administered by the (nstit%tion in the erformance of the ,er+ices, e$ce t with the rior written consent of the Com any and in accordance with a&& a &icab&e o&icies of the (nstit%tion(b" Com any sha&& not %se Cons%&tant1s name or de iction, or the name, &ogos, trademar?s, or de ictions of *M,, or any officer, director, em &oyee, a ointee, medica& staff member of em &oyee of either, or any ada tation thereof, in any romotiona&, ad+ertising or mar?eting &iterat%re, or in any other way witho%t the rior written consent of *M,, the indi+id%a&, or *M,, as a ro riate, ro+ided howe+er that in ne%tra& circ%mstances that do not im &y endorsement or ad+ocacy, or otherwise misre resent the terms of this Agreement or Cons%&tant1s ro&e, Com any may acc%rate&y state that Cons%&tant is a cons%&tant to Com any, and &ist his or her rofessiona& degrees and tit&es(c" 6o a&teration or modification of this Agreement, inc&%ding .$hibit A hereto, sha&& be +a&id %n&ess made in writing and e$ec%ted by Cons%&tant and the Com any and assented to by *M,6

(d" The Cons%&tant and Com any m%t%a&&y re resent that to the best of their ?now&edge neither c%rrent&y has any agreement with, or any other ob&igation to, any third arty that conf&icts with the terms of this Agreement- The arties agree that they sha&& not intentiona&&y and ?nowing&y enter into any s%ch agreement(e" The &aws of the Commonwea&th of Massach%setts sha&& go+ern this Agreement(f" Any notice or other comm%nication by one arty to the other here%nder sha&& be in writing and sha&& be gi+en, and be deemed to ha+e been gi+en, if either hand de&i+ered or mai&ed, ostage re aid, certified mai& (ret%rn recei t re:%ested", or transmitted by facsimi&e, addressed as fo&&ows9 (f to Cons%&tant9 violate the terms specified there will be cancellation of the contract that has been written previously (f to the Com any9 violate the terms specified there will be more as closing tax losses that have been previously agreed (g" The arties ac?now&edge that the ,er+ices are ersona& in nat%re, and that from Cons%&tant1s ers ecti+e the s ecific identity of the Com any, inc&%ding its &eadershi , cor orate c%&t%re, scientific staff and re %tation, is materia& to Cons%&tant1s choice to enter into this Agreement-

Therefore the arties e$ ress&y agree that no arty may assign this Agreement witho%t the written consent of the other-

(6 '(T6.,, '*./.78, the arties ha+e e$ec%ted this Agreement on the dates indicated be&owDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD ECons%&tant1s ,ignat%reF [COMPANY] By9 DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD ECom any /e resentati+e ,ignat%reF Tit&e9 DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD 3ate9 DDDDDDDDDDDDDDD DDDDDDDDDDDDDDDDDDDDDDDDDD E3ateF

.$hibit A@ 3escri tion of Cons%&ting Acti+ities

6at%re of ,er+ices9

8ie&d of e$ ertise or in:%iry (define precisely"9