Ensemb: European bioinformatics institute NCBI: national center for biotechnology OMIM: online Mendelian inheritance in man HGMD:

human genome mutation database

PDB: protein Data Bank Swissprot: protein data Bioinformatics tools NDJINN: perform a search for sequence (nucleotides) or protein structure. BLAST: find a sequence or protein that matches a smaple sequence/ protein CLUSTAL: align a sequence/protein to one or more sequences/ proteins AASTATS:show the amino acid percentages for a protein DRAWTREE: create a rooted phylogenetic tree for a alignment Book eg cook Title of the book the joy of cooking Chapters Recipe Genome every organism has a genom

Chromsomes 23 in human other 22 Gene is recipe for specific proein Gene give instruction of how to make heamoglobine Instructions Exons instruction that expressed or not expressed /introm Words Amino acids Litters Nucloteds ACGT How can I take information from inside the human genome and translate that into the creation of drugs 1. Simply knowledge of the genom leads to the knowledge of protein 2. Knowledge of proteins leads to knowledge of potential receptors put drug and have the drug with the wright receptor, hopfully results have some useful therapeutic effect Demo case study Angiotensin a series of small proteins 1,2,3,4,5,6 and 7. Responsible for control of blood vessels Medical importance: control of blood pressure. Angiotensin control expantion and inpantion of the blood, causeing your body that has a right effect the blood pressure for thatat drugs intract angiotensin proteins

Ensemble OMIM HGMD Biology workbench PDB

What is bioinformatics f Deals with the computational maagmeen and analysis of biologuical information : genes, genome proteins, cells, ecological system, medical information, robots, artificial intelligence.. Bio= informatics One idea for a definition? Bioinformatics is conceptualizing biology in terms of molecules ( in the sense of physical chemistry) and then applying informatics techinques derived from disciplines such as applied math, CS and statstics) to under stand and orgnzie the information associated wth these molecules, one a large scale Bioninfromatics is MIS for molecular biology infromtion Ex You have discovered a new protein sequence you dont know this sequence we can use unknown sequenced we can match it with similar known sequeance using data base There many many applications for genome Structural biology is the most part get benifite form bioinformatics How bioinformatics work Relationships between Sequence (sequence and predicte sequence of proeins-3D structure(construct 3d structure of protein allow us understanding it very well ) protein function ( we need the functionality of the protein) Properties and evolution of gemomic (genes, genomes) , proteimic proteins, metabolic pathway in cell Use of this knowledge for prediction , modelling and design.

Data types Primary data AATGCGTATAGGC DMPVERILEALAVE Secondary data motifs/ regular expressions, blocks, profiles, fingerprints Some you need to predict from primary data Tertiary data Sometime you need to predicte fprm primary data Atomic co-ordinates Sequence DNA Aminoacid Secondary protein structure e.g alpha-helices, beta-strands Primary database Pimrary data Second

Tertiary protein structure

Seconday database

Domains, folding units

Tertiary database

Proteins have sencodary and ertiary data