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diseases and health conditions. The companys Triage rapid diagnostics are currently used in approximately 50% of U.S. hospitals and in more than 50 international markets. 5. Horiba ABX Kyoto, Japan $139 million The acquisition of French manufacturer ABX in 1996 took the Horiba Group into the diagnostic equipment industry, in particular by expanding its share of the small-size hematology analyz-er market. Renamed Horiba ABX, the company plans to expand its operations in this segment by targeting the market for large-size hematology analyzers that are used in major hospitals and medical institutions. The company also plans to expand its presence through new product introductions in clinical chemistry analyzers. 6. Ventana Medical Systems Inc. Tucson, AZ $132 million Ventana develops and manufactures instruments and reagent systems that automate slide preparation and staining in clinical histology and drug discovery laboratories. The companys clinical systems are used in the diagnosis and treatment of cancer and infectious diseases. The company also develops drug discovery systems for accelerating the discovery of new drug targets. The company was founded in 1985 by Thomas M. Grogan, MD, a pathologist at the University of Arizona, who was interested in improving the practice of medicine through automation. 7. Trinity Biotech plc Bray, Ireland $66 million Trinity Biotech develops and manufactures more than 500 diagnostic products for the point-of-care and clinical laboratory segments of the diagnostic market. The companys test kits are used to detect infectious diseases, sexually transmitted diseases, blood coagulation disorders, and autoimmune diseases. The company sells worldwide in more than 80 countries through its own sales force and a network of international distributors and strategic partners. Formed in 1992, Trinity is a public company with manufacturing facilities in Ireland, New York, California, Germany, and Sweden. 8. Digene Corp. Gaithersburg, MD $63 million Digene develops and manufactures proprietary gene-based testing systems for the screening, monitoring, and diagnosis of human diseases. The companys primary focus is in womens cancers and infectious diseases. The company has applied its proprietary Hybrid Capture technology to develop a diagnostic test for human papillomavirus (HPV). In addition to its HPV-test marketing efforts, the company is focusing its commercialization strategy in two areas: diagnostic testing and genomics research. 9. TriPath Imaging Inc. Burlington, NC $54 million TriPath Imaging develops and manufactures solutions for the clinical management of cancer. In September 1999, the company was formed through the merger of AutoCyte Inc. and NeoPath Inc., and the acquisition of Neuromedical Systems technology and intellectual property. The company was created to leverage the complementary nature of the products, technologies, and intellectual property developed by the predecessor companies. These companies were early pioneers in the application of computerized image processing and analysis to detect cellular abnormalities associated with cancer and its precursors. 10. Qiagen NV Venlo, The Netherlands $41 million Qiagen is a provider of enabling technologies and products for the separation, purification, and handling of nucleic acids and proteins. The company has developed a portfolio of more than 320 consumable products for numerous applications, such as
nucleic acid amplification, as well as automated instrumentation and synthetic nucleic acid products. The company is also positioning its products for sale in developing commercial markets, including applied-testing markets, clinical research, nucleic acidbased molecular diagnostics, genetic vaccination, and gene therapy.
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