PMIDOWN STATDA DCOMIS IS VI IP DP TI PG AB nges

24665327 NLM PubMed-not-MEDLINE 20140325 20140325 1735-4668 (Print) 1735-4668 (Linking) 8 1 2014 Winter Screening for depression in hospitalized pediatric patients. 47-51 OBJECTIVE: In chronically ill children who are hospitalized, many mood cha

occur. For example, in children with cancer or renal failure, prolonged hospitalization and chemotherapy can lead to depression. With the improved survival of childhood malignancies, the effect of treatment on child's psychosocial well-being becomes increasingly relevant. In this study, we e xamined the prevalence of depression in hospitalized children with chronic and acu te conditions in Dr Sheikh Pediatrics Hospital in Mashhad. MATERIALS & METHOD S: After receiving the approval from the Ethics Committee of Mashhad Universi ty of Medical Sciences, we did this cross-sectional descriptive study, from Apri l to June 2012 in Dr Sheikh Pediatric Hospital in Mashhad. Ninety children, bet ween 8 to 16 years, were screened for depression. The sampling method was census. Children with a history of depressive or other mental disorders were exclu ded. Three groups of children (children with chronic renal disease, malignancy, and acute disease) were evaluated for depression using standard Children Depre ssion Inventory Questionnaire (CDI). Two specifically trained nurses filled out the questionnaires at patients' bedside under the supervision of a psychiatris t. Depression scores were then analyzed by SPSS software. RESULTS: Of 90 chil dren, 43(47.7%) were male and 47(52.2%) were female. The Children's mean age was 11+/-2.3 years, and the mean length of hospitalization was 8+/-5.3 days. Depression was detected in various degrees in 63% of patients (N=57), and 36.6% of children (N=32) had no symptoms of depression. Severe depression was no t seen in any of the patients with acute illness. More than half of patients with cancer and chronic kidney disease had moderate to severe depression. There was a significant statistical relationship between the duration of illness and s everity of depression. There was also a significant correlation between severity o f depression and frequency of hospitalization. Children who had been hospita lized more than 3 times in the previous year, experienced more severe levels of depression. We also found a significant correlation between pubertal age a

nd severity of depression in patients with cancers and chronic renal failure. CONCLUSION: Children who are hospitalized due to chronic conditions are at a higher risk for mood disorders in comparison with the ones with acute cond itions. It is therefore advisable to consider more practical plans to improve the care for hospitalized children's mental health. FAU - Esmaeeli, Mohammad-Reza AU - Esmaeeli MR AD - Pediatric Nephrology Department, Mashhad University of Medical Sciences, M ashhad, Iran. FAU - Erfani Sayar, Reza AU - Erfani Sayar R AD - Anesthesiology Department, Pain Clinic, Mashhad University of Medical Scie nces, Mashhad, Iran. FAU - Saghebi, Ali AU - Saghebi A AD - Psychiatry Department, Shiraz University of Medical Sciences, Shiraz, Iran . FAU - Elmi, Saghi AU - Elmi S AD - Pediatric Department, Mashhad University of Medical Sciences, Mashhad, Ira n. FAU - Rahmani, Shagheyegh AU - Rahmani S AD - Research Center for Patient Safety and Health Quality, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Elmi, Sam AU - Elmi S AD - Research Center for Patient Safety and Health Quality, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Rabbani Javadi, Akram AU - Rabbani Javadi A AD - MSc of Mental Health Nursing, Mashhad University of Medical Sciences, Mash had, Iran. LA - eng PT - Journal Article PL - Iran TA - Iran J Child Neurol JT - Iranian journal of child neurology JID - 101463836 OTO - NOTNLM OT - Depression OT - Hospitalization OT - Pediatric patients EDAT- 2014/03/26 06:00 MHDA- 2014/03/26 06:01 CRDT- 2014/03/26 06:00 PHST- 2013/03/27 [received] PHST- 2013/06/26 [revised] PHST- 2013/07/11 [accepted] PST - ppublish SO - Iran J Child Neurol. 2014 Winter;8(1):47-51.

PMID- 24665323 OWN - NLM STAT- PubMed-not-MEDLINE DA - 20140325 DCOM- 20140325 IS - 1735-4668 (Print) IS - 1735-4668 (Linking) VI - 8 IP - 1 DP - 2014 Winter TI - The best time for EEG recording in febrile seizure. PG - 20-5 AB - OBJECTIVE: Some studies suggest that detection of epileptic discharge is u nusual during the first postictal week of febrile seizure and others believe that EEGs carried out on the day of the seizure are abnormal in as many as 88% of th e patients. In this study, we intend to compare early and late EEG abnormali ties in febrile seizure. MATERIALS & METHODS: EEG was recorded during daytime slee p, 24-48 hours (early EEG) and 2 weeks (late EEG) after the seizure in 36 chi ldren with febrile seizure (FS), aged between 3 months and 6 years. EEGs that sh owed generalized or focal spikes, sharp, spike wave complex, and slowing were considered as abnormal EEG. Abnormalities of the first EEG were compared w ith those of second EEG. RESULTS: The most common abnormal epileptiform discha rges recorded in the early EEG were slow waves (27.6%) and sharp waves in late EEG (36%). Distribution of abnormalities in early and late EEG showed no signi ficant statistical difference. CONCLUSION: The early and late EEG recording had t he same results in patient with febrile seizure. FAU - Karimzadeh, Parvaneh AU - Karimzadeh P AD - Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran ; Pediatric Neurology Excellence Center, Ped iatric Neurology Department, Mofid Children Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran. FAU - Rezayi, Alireza AU - Rezayi A AD - Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran. FAU - Togha, Mansoureh AU - Togha M AD - Neurology Department, Sina Hospital, Tehran University of Medical Science, Tehran, Iran. FAU - Ahmadabadi, Farzad AU - Ahmadabadi F AD - Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran. FAU - Derakhshanfar, Hojjat AU - Derakhshanfar H

AD - Pediatric Emergency Department, Mofid Children's Hospital, Faculty of Medi cine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Azargashb, Eznollah AU - Azargashb E AD - Social Medicine Department, Faculty of Medicine, Shahid Beheshti Universit y of Medical Sciences, Tehran, Iran. FAU - Khodaei, Fatemeh AU - Khodaei F AD - Department of Midwifery, School of Nursing & Midwifery, Isfahan University of Medical Sciences, Esfahan, Iran. LA - eng PT - Journal Article PL - Iran TA - Iran J Child Neurol JT - Iranian journal of child neurology JID - 101463836 OTO - NOTNLM OT - Complex OT - Electroencephalography OT - Epileptiform discharges OT - Febrile seizures OT - Simple EDAT- 2014/03/26 06:00 MHDA- 2014/03/26 06:01 CRDT- 2014/03/26 06:00 PHST- 2013/01/02 [received] PHST- 2013/06/01 [revised] PHST- 2013/06/07 [accepted] PST - ppublish SO - Iran J Child Neurol. 2014 Winter;8(1):20-5. PMIDOWN STATDA DCOMIS IS VI IP DP TI 24665293 NLM PubMed-not-MEDLINE 20140325 20140325 1735-4668 (Print) 1735-4668 (Linking) 7 2 2013 Spring A Novel Deletion Mutation in ASPM Gene in an Iranian Family with Autosomal Recessive Primary Microcephaly. PG - 23-30 AB - OBJECTIVE: Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental and genetically heterogeneous disorder with decreased h ead circumference due to the abnormality in fetal brain growth. To date, nine loci and nine genes responsible for the situation have been identified. Mutatio ns in the ASPM gene (MCPH5) is the most common cause of MCPH. The ASPM gene with 28 exons is essential for normal mitotic spindle function in embryonic neurob lasts. MATERIALS & METHODS: We have ascertained twenty-two consanguineous familie s with

intellectual disability and different ethnic backgrounds from Iran. Ten ou t of twenty-two families showed primary microcephaly in clinical examination. W e investigated MCPH5 locus using homozygosity mapping by microsatellite mark er. RESULT: Sequence analysis of exon 8 revealed a deletion of nucleotide (T) in donor site of splicing site of ASPM in one family. The remaining nine fami lies were not linked to any of the known loci .More investigation will be neede d to detect the causative defect in these families. CONLUSION: We detected a no vel mutation in the donor splicing site of exon 8 of the ASPM gene. This delet ion mutation can alter the ASPM transcript leading to functional impairment of the gene product. FAU - Akbariazar, Elinaz AU - Akbariazar E AD - Msc of human genetics, University of Social Welfare & Rehabilitation Scien ces, Tehran, Iran. FAU - Ebrahimpour, Mohammad AU - Ebrahimpour M AD - Msc of human genetics, University of Social Welfare & Rehabilitation Scien ces, Tehran, Iran. FAU - Akbari, Saeedeh AU - Akbari S AD - Msc of human genetics, University of Social Welfare & Rehabilitation Scien ces, Tehran, Iran. FAU - Arzhanghi, Sanaz AU - Arzhanghi S AD - Bsc in Nursing, Genetics Research Center, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran. FAU - Abedini, Seydeh Sedigheh AU - Abedini SS AD - Msc of human genetics, University of Social Welfare & Rehabilitation Scien ces, Tehran, Iran. FAU - Najmabadi, Hossein AU - Najmabadi H AD - Professor of Molecular Biology, University of Social Welfare & Rehabilitat ion Sciences, Tehran, Iran. FAU - Kahrizi, Kimia AU - Kahrizi K AD - Professor of Medical Genetics, Genetics Research Center, University of Soc ial Welfare & Rehabilitation Sciences, Tehran, Iran. LA - eng PT - Journal Article PL - Iran TA - Iran J Child Neurol JT - Iranian journal of child neurology JID - 101463836 OTO - NOTNLM

OT OT OT OT EDATMHDACRDTPHSTPHSTPHSTPST SO -

ASPM Autosomal Recessive Primary Microcephaly Homozygosity Mapping MCPH5 2014/03/26 06:00 2014/03/26 06:01 2014/03/26 06:00 2012/12/10 [received] 2013/01/23 [revised] 2013/02/05 [accepted] ppublish Iran J Child Neurol. 2013 Spring;7(2):23-30.

PMID- 24664805 OWN - NLM STAT- Publisher DA - 20140325 IS - 1099-1557 (Electronic) IS - 1053-8569 (Linking) DP - 2014 Mar 24 TI - Instrumental variable applications using nursing home prescribing preferen ces in comparative effectiveness research. LID - 10.1002/pds.3611 [doi] AB - PURPOSE: Nursing home residents are of particular interest for comparative effectiveness research given their susceptibility to adverse treatment eff ects and systematic exclusion from trials. However, the risk of residual confou nding because of unmeasured markers of declining health using conventional analy tic methods is high. We evaluated the validity of instrumental variable (IV) m ethods based on nursing home prescribing preference to mitigate such confounding, using psychotropic medications to manage behavioral problems in dementia as a ca se study. METHODS: A cohort using linked data from Medicaid, Medicare, Minimu m Data Set, and Online Survey, Certification and Reporting for 2001-2004 was established. Dual-eligible patients >/=65 years who initiated psychotropic medication use after admission were selected. Nursing home prescribing pre ference was characterized using mixed-effects logistic regression models. The plausibility of IV assumptions was explored, and the association between psychotropic medication class and 180-day mortality was estimated. RESULTS : High-prescribing and low-prescribing nursing homes differed by a factor of 2. Each preference-based IV measure described a substantial proportion of var iation in psychotropic medication choice (beta(IV --> treatment): 0.22-0.36). Mea sured patient characteristics were well balanced across patient groups based on instrument status (52% average reduction in Mahalanobis distance). There w as no evidence that instrument status was associated with markers of nursing hom e quality of care. CONCLUSION: Findings indicate that IV analyses using nurs ing

home prescribing preference may be a useful approach in comparative effect iveness studies, and should extend naturally to analyses including untreated compa rison groups, which are of great scientific interest but subject to even stronge r confounding. Copyright (c) 2014 John Wiley & Sons, Ltd. CI - Copyright (c) 2014 John Wiley & Sons, Ltd. FAU - Huybrechts, Krista F AU - Huybrechts KF AD - Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medi cine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Gerhard, Tobias AU - Gerhard T FAU - Franklin, Jessica M AU - Franklin JM FAU - Levin, Raisa AU - Levin R FAU - Crystal, Stephen AU - Crystal S FAU - Schneeweiss, Sebastian AU - Schneeweiss S LA - ENG PT - JOURNAL ARTICLE DEP - 20140324 TA - Pharmacoepidemiol Drug Saf JT - Pharmacoepidemiology and drug safety JID - 9208369 OTO - NOTNLM OT - comparative effectiveness OT - confounding OT - epidemiologic methods OT - instrumental variable OT - nursing home OT - pharmacoepidemiology OT - prescribing preference EDAT- 2014/03/26 06:00 MHDA- 2014/03/26 06:00 CRDT- 2014/03/26 06:00 PHST- 2013/10/10 [received] PHST- 2014/02/02 [revised] PHST- 2014/02/17 [accepted] AID - 10.1002/pds.3611 [doi] PST - aheadofprint SO - Pharmacoepidemiol Drug Saf. 2014 Mar 24. doi: 10.1002/pds.3611. PMID- 24664461 OWN - NLM STAT- Publisher DA - 20140325 IS - 1178-1653 (Print) IS - 1178-1653 (Linking) DP - 2014 Mar 25 TI - New Insight into the Role of Patients During Medical Appointments: A Synth esis of Three Qualitative Studies. AB - BACKGROUND: The complexity of the doctor-patient relationship requires indepth research to enable a better understanding of the nature of the doctor's

appointment. OBJECTIVE: To explore how patients can facilitate their medic al appointments, and how they can be responsible for their relationship with their doctors. METHODS: A synthesis of our previous three qualitative studies of doctor-patient relationships focussed on the consultations. The analysis i nvolved three qualitative studies based on in-depth interviews with 94 patients of family doctors in Poland. RESULTS: A detailed analysis of these data allowed us t o distinguish several different ways in which patients participate in medica l consultation, namely: 1. facilitating the visit; 2. having an impact on bo th patient and doctor perception of satisfaction with the visit; and 3. showi ng concern for the doctor, understanding the doctor's situation and having em pathy. CONCLUSION: This study concerning patient-doctor interactions shows that e ach participant can explicitly provide emotional support for the other, despit e the evident asymmetry in the roles of doctor and patient. Patients can substan tially contribute to the personalisation of their relationship with the doctor, w hich is often facilitated by the repetition and regularity of the interaction. FAU - Marcinowicz, Ludmila AU - Marcinowicz L AD - Department of Family Medicine and Community Nursing, Medical University of Bialystok, Mieszka I 4 B, 15 054, Bialystok, Poland, ludmila.marcinowicz@umb.edu.pl. FAU - Pawlikowska, Teresa AU - Pawlikowska T FAU - Konstantynowicz, Jerzy AU - Konstantynowicz J FAU - Chlabicz, Slawomir AU - Chlabicz S LA - ENG PT - JOURNAL ARTICLE DEP - 20140325 TA - Patient JT - The patient JID - 101309314 EDAT- 2014/03/26 06:00 MHDA- 2014/03/26 06:00 CRDT- 2014/03/26 06:00 AID - 10.1007/s40271-014-0056-1 [doi] PST - aheadofprint SO - Patient. 2014 Mar 25.