PMIDOWN STATDA IS IS VI IP DP TI irin:

24520278 NLM Publisher 20140212 1792-0981 (Print) 1792-0981 (Linking) 7 3 2014 Mar Effectiveness of cilostazol in transient ischemic attack refractory to asp A report of two cases. PG - 739-741 AB - Transient ischemic attack (TIA) is a warning of impending ischemic stroke. It provides an important therapeutic time window in which appropriate interve ntion may prevent permanent neurological injury. The anti-platelet agent, aspiri n, is an option for reducing the risk of stroke following TIA. However, for pati ents who are not responsive to aspirin, cilostazol may be an effective treatmen t. The current study presents two cases of TIA that were refractory to aspirin bu t were successfully treated with cilostazol. In case 1, an 83-year-old female pat ient suffered from episodes of weakness and numbness of the left extremities. A spirin alone or aspirin in combination with clopidogrel were not effective. Anticoagulation therapy with low molecular heparin decreased the frequency of ischemic episodes with complete remission following antiplatelet therapy w ith cilostazol. In case 2, a 51-year-old male presentedwith episodes of paroxy smal weakness of the left extremities with dysarthria. Antiplatelet therapy wit h aspirin was initiated. Eight episodes of ischemic attack recurred on the s eventh day following admission. After the change of the antiplatelet agent to cilostazol, no ischemic episodes recurred, with the exception of three on the first day. This study suggested that cilostazol may be efficacious in the prevention of ischemic stoke following TIA of a non-cardiac origin that wa s not responsive to aspirin. FAU - Lin, Gaoping AU - Lin G AD - Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China. FAU - Ren, Dongdong AU - Ren D AD - Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China. FAU - Guo, Shunyuan AU - Guo S AD - Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China. FAU - Geng, Yu

AU - Geng Y AD - Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China. LA - ENG PT - JOURNAL ARTICLE DEP - 20131231 TA - Exp Ther Med JT - Experimental and therapeutic medicine JID - 101531947 PMC - PMC3919941 OTO - NOTNLM OT - aspirin OT - cilostazol OT - transient ischemic attack EDAT- 2014/02/13 06:00 MHDA- 2014/02/13 06:00 CRDT- 2014/02/13 06:00 PHST- 2013/08/07 [received] PHST- 2013/12/23 [accepted] PHST- 2013/12/31 [epublish] AID - 10.3892/etm.2013.1468 [doi] AID - etm-07-03-0739 [pii] PST - ppublish SO - Exp Ther Med. 2014 Mar;7(3):739-741. Epub 2013 Dec 31. PMIDOWN STATDA IS IS VI IP DP TI 24518409 NLM In-Data-Review 20140212 1537-4505 (Electronic) 1531-7129 (Linking) 35 3 2014 Mar Side-to-End Hypoglossal to Facial Anastomosis With Transposition of the Intratemporal Facial Nerve. PG - 509-13 LID - 10.1097/MAO.0b013e3182936bcf [doi] AB - OBJECTIVE: To describe results in a large series of patients using a recen t variation of hypoglossal-facial nerve anastomosis (HFA) in which the intratemporal facial nerve segment is used, obviating the need for a senso ry nerve "jump graft." STUDY DESIGN: Retrospective chart review. SETTING: Ter tiary neurotologic referral center. PATIENTS: Nineteen patients (12 female/7 mal e subjects) with facial paralysis because of posterior fossa surgery for tum or (n = 15), Bell's palsy (n = 1), facial neuroma (n = 1), hemangioma (n = 1), and trauma (n = 1) who underwent HFA from 1997 to 2011, with at least 1-year follow-u p. Mean age at surgery is 47.4 years (range, 11.2-83 yr). Mean follow-up is 4.0 ye ars. INTERVENTION: Side-to-end hypoglossal to facial anastomosis with transposi tion of the intratemporal facial nerve (swingdown HFA). MAIN OUTCOME MEASURE: House-Brackmann (H-B) facial nerve grade. RESULTS: Seven patients (36.8%) achieved an H-B Grade III, 9 patients (47.4%) a grade IV, and 3 patients (

15.8%) a grade V at last follow-up. No patients complained of dysphagia, dysarthr ia, or had evidence of oral incompetence. One patient complained of mild tongue weakness. Age at time of HFA (p </= 0.049, III younger than V) and time fr om facial nerve injury to HFA (p </= 0.02, III<IV and V) were significant fac tors for ultimate facial nerve outcome. All patients with an H-B III result had HFA within 6 months of injury. Other factors were not significant. CONCLUSION: The HFA swingdown technique is a safe and effective method to restore facial n erve function in patients with facial paralysis and obviates the need for an interposition jump graft. FAU - Slattery, William H 3rd AU - Slattery WH 3rd AD - *House Clinic and House Research Institute; daggerMassachusetts Eye and Ea r Infirmary, Boston, MA; previously, Clinical Fellow, House Clinic and House Research Institute, Los Angeles; and double daggerHouse Research Institute , Marina del Rey, California, U.S.A. FAU - Cassis, Adam M AU - Cassis AM FAU - Wilkinson, Eric P AU - Wilkinson EP FAU - Santos, Felipe AU - Santos F FAU - Berliner, Karen AU - Berliner K LA - eng PT - Journal Article PL - United States TA - Otol Neurotol JT - Otology & neurotology : official publication of the American Otological So ciety, American Neurotology Society [and] European Academy of Otology and Neuroto logy JID - 100961504 SB - IM EDAT- 2014/02/13 06:00 MHDA- 2014/02/13 06:00 CRDT- 2014/02/13 06:00 AID - 10.1097/MAO.0b013e3182936bcf [doi] AID - 00129492-201403000-00019 [pii] PST - ppublish SO - Otol Neurotol. 2014 Mar;35(3):509-13. doi: 10.1097/MAO.0b013e3182936bcf. PMIDOWN STATDA IS IS VI IP DP TI 24503934 NLM Publisher 20140207 1421-9972 (Electronic) 1021-7762 (Linking) 65 4 2014 Feb 1 Changes in Voice Quality after Speech-Language Therapy Intervention in Old

er Children with Cerebral Palsy. PG - 200-207 AB - Objective: We examined whether perceived voice quality is altered in a gro up of children with cerebral palsy (CP) following an intervention focusing on respiration and phonation, and whether possible improvements might be asso ciated with increased intelligibility levels. Methods: Sixteen individuals with C P and dysarthria (9 girls, mean age 14 years, SD = 2; 9 with spastic type CP, 2 dyskinetic, 4 mixed, 1 Worster-Drought syndrome) completed intelligibility assessments on separate days twice before intervention, at termination of treatment and at 6-week follow-up using 50 words from the Children's Speec h Intelligibility Measure lists, and describing cartoon strips. Experienced speech-language pathologists rated voice quality employing GRBAS scales. R esults: There was no clear evidence that change in voice quality pre-post interven tion was large compared with change in the pre-intervention or post-interventio n periods. Asthenia demonstrated largest improvement (effect size of 0.4). Intelligibility correlated weakly with Grade, Breathiness and Asthenia, bu t not with Roughness or Strain. A deterioration of 1 unit on the Grade and Asthe nia scales was associated with an approximately 11% decrease in intelligibilit y. Conclusion: Perceived changes in voice quality were small compared to chan ges in intelligibility. Further investigations must examine other variables poten tially associated with intelligibility gain to better understand the links betwee n the respiratory-phonatory intervention and improved intelligibility. (c) 2014 S. Karger AG, Basel. FAU - Miller, Nick AU - Miller N AD - Institute of Health and Society University of Newcastle, Newcastle upon Ty ne, Great Britain. FAU - Pennington, Lindsay AU - Pennington L FAU - Robson, Sheila AU - Robson S FAU - Roelant, Ella AU - Roelant E FAU - Steen, Nick AU - Steen N FAU - Lombardo, Eftychia AU - Lombardo E LA - ENG PT - JOURNAL ARTICLE DEP - 20140201 TA - Folia Phoniatr Logop JT - Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) JID - 9422792

EDATMHDACRDTPHSTAID AID PST SO PMIDOWN STATDA IS IS VI IP DP TI PG LID LID AB nant

2014/02/08 06:00 2014/02/08 06:00 2014/02/08 06:00 2014/02/01 [aheadofprint] 000355864 [pii] 10.1159/000355864 [doi] aheadofprint Folia Phoniatr Logop. 2014 Feb 1;65(4):200-207. 24182841 NLM In-Process 20131125 1090-2155 (Electronic) 0093-934X (Linking) 127 3 2013 Dec Speech in spinocerebellar ataxia. 317-22 10.1016/j.bandl.2013.10.002 [doi] S0093-934X(13)00174-0 [pii] Spinocerebellar ataxias (SCAs) are a heterogeneous group of autosomal domi

cerebellar ataxias clinically characterized by progressive ataxia, dysarth ria and a range of other concomitant neurological symptoms. Only a few studies inc lude detailed characterization of speech symptoms in SCA. Speech symptoms in SC A resemble ataxic dysarthria but symptoms related to phonation may be more prominent. One study to date has shown an association between differences in speech and voice symptoms related to genotype. More studies of speech and voice phenotypes are motivated, to possibly aid in clinical diagnosis. In additi on, instrumental speech analysis has been demonstrated to be a reliable measur e that may be used to monitor disease progression or therapy outcomes in possible future pharmacological treatments. Intervention by speech and language pathologis ts should go beyond assessment. Clinical guidelines for management of speech, communication and swallowing need to be developed for individuals with progressive cerebellar ataxia. CI - Copyright (c) 2013 Elsevier Inc. All rights reserved. FAU - Schalling, Ellika AU - Schalling E AD - Department of Clinical Science, Intervention and Technology, Division of S peech and Language Pathology, Karolinska Institutet, 141 86 Stockholm, Sweden; Department of Speech and Language Pathology, Karolinska University Hospita l, 171 76 Stockholm, Sweden. Electronic address: ellika.schalling@ki.se. FAU - Hartelius, Lena AU - Hartelius L LA - eng PT - Journal Article DEP - 20131030

PL TA JT JID SB OTO OT OT OT OT OT OT EDATMHDACRDTPHSTPHSTPHSTPHSTAID AID PST SO 2013 PMIDOWN STATDA IS IS VI IP DP TI ue PG LID LID AB on ter -

United States Brain Lang Brain and language 7506220 IM NOTNLM Ataxic dysarthria Instrumental acoustic analysis Perceptual analysis Progression of dysarthria Speech and language pathology intervention Spinocerebellar ataxia 2013/11/05 06:00 2013/11/05 06:00 2013/11/05 06:00 2013/04/08 [received] 2013/09/13 [revised] 2013/10/06 [accepted] 2013/10/30 [aheadofprint] S0093-934X(13)00174-0 [pii] 10.1016/j.bandl.2013.10.002 [doi] ppublish Brain Lang. 2013 Dec;127(3):317-22. doi: 10.1016/j.bandl.2013.10.002. Epub Oct 30. 23994051 NLM In-Data-Review 20140224 1532-821X (Electronic) 0003-9993 (Linking) 95 3 2014 Mar Tongue-controlled computer game: a new approach for rehabilitation of tong motor function. 524-30 10.1016/j.apmr.2013.08.008 [doi] S0003-9993(13)00620-5 [pii] OBJECTIVE: To investigate the influence of tongue disability, age, and sex motor performance for a tongue-training paradigm involving playing a compu game using the Tongue Drive System (TDS). DESIGN: Two controlled observati

onal studies. SETTING: A neurorehabilitation center and a dental school. PARTIC IPANTS: In study 1, tongue-disabled patients with symptoms of dysphagia and dysart hria (n=11) and age- and sex-matched controls (n=11) participated in tongue tra ining. In study 2, healthy elderly persons (n=16) and healthy young persons (n=16 ) volunteered. INTERVENTION: In study 1 and study 2, the tongue training las ted 30 and 40 minutes, respectively. Participants were instructed to play a compu ter game with the tongue using TDS. MAIN OUTCOME MEASURES: Motor performance w

as compared between groups in both studies. Correlation analyses were perform ed between age and relative improvement in performance. Subject-based reports of motivation, fun, pain, and fatigue evaluated on 0-to-10 numeric rating sca les were compared between groups. RESULTS: In study 1, tongue-disabled patient s performed poorer than healthy controls (P=.005) and with a trend of a sex difference (P=.046). In study 2, healthy young participants performed bett er than healthy elderly participants (P<.001), but there was no effect of sex (P=. 140). There was a significant negative correlation between age and relative impr ovement in performance (delta=-.450; P=.009). There were no significant difference s in subject-based reports of motivation, fun, pain, and fatigue between groups in any of the studies (P>.094). CONCLUSIONS: The present study provides evidence that tongue disability and age can influence behavioral measures of tongue moto r performance. TDS may be a new adjunctive neurorehabilitation regimen in tr eating tongue-disabled patients. CI - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved. FAU - Kothari, Mohit AU - Kothari M AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus Unive rsity, Aarhus C, Denmark. Electronic address: mohit.kothari@odontologi.au.dk. FAU - Svensson, Peter AU - Svensson P AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus Unive rsity, Aarhus C, Denmark; MINDLab, Center for Functionally Integrative Neuroscien ce, Aarhus University Hospital, Aarhus C, Denmark. FAU - Jensen, Jim AU - Jensen J AD - Hammel Neurorehabilitation and Research Centre, Hammel, Denmark. FAU - Holm, Trine Davidsen AU - Holm TD AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus Unive rsity, Aarhus C, Denmark. FAU - Nielsen, Mathilde Skorstengaard AU - Nielsen MS AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus Unive rsity, Aarhus C, Denmark. FAU - Mosegaard, Trine AU - Mosegaard T AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus Unive rsity, Aarhus C, Denmark.

FAU - Nielsen, Jorgen Feldbaek AU - Nielsen JF AD - Hammel Neurorehabilitation and Research Centre, Hammel, Denmark. FAU - Ghovanloo, Maysam AU - Ghovanloo M AD - GT-Bionics Lab, School of Electrical and Computer Engineering, Georgia Ins titute of Technology, Atlanta, GA. FAU - Baad-Hansen, Lene AU - Baad-Hansen L AD - Section of Clinical Oral Physiology, Department of Dentistry, Aarhus Unive rsity, Aarhus C, Denmark. LA - eng PT - Journal Article DEP - 20130827 PL - United States TA - Arch Phys Med Rehabil JT - Archives of physical medicine and rehabilitation JID - 2985158R SB - AIM SB - IM OTO - NOTNLM OT - Aging OT - Performance OT - Rehabilitation OT - Tongue Drive System OT - Tongue disability OT - Tongue training EDAT- 2013/09/03 06:00 MHDA- 2013/09/03 06:00 CRDT- 2013/09/03 06:00 PHST- 2013/04/18 [received] PHST- 2013/06/28 [revised] PHST- 2013/08/06 [accepted] PHST- 2013/08/27 [aheadofprint] AID - S0003-9993(13)00620-5 [pii] AID - 10.1016/j.apmr.2013.08.008 [doi] PST - ppublish SO - Arch Phys Med Rehabil. 2014 Mar;95(3):524-30. doi: 10.1016/j.apmr.2013.08. 008. Epub 2013 Aug 27. PMID- 23929996 OWN - NLM STAT- PubMed-not-MEDLINE DA - 20130809 DCOM- 20130809 LR - 20130812 IS - 0257-7941 (Print) IS - 0257-7941 (Linking) VI - 32 IP - 1 DP - 2012 Jul TI - Efficacy of Ayurvedic treatment using Pancakarma combined with balance exe rcises for disability and balance in progressive supranuclear palsy. PG - 54-8 LID - 10.4103/0257-7941.113793 [doi] AB - A 55-year-old female presented at Department of Pancakarma with diagnosis

of progressive supranuclear palsy (PSP). For assessing disability, progressiv e supranuclear palsy rating scale (PSPRS) was used and balance was assessed by using Tetrax Interactive Balance System (IBS) posturography. Ayurvedic tre atment was given along with Pancakarma and balance exercises for 3 months. As par t of Ayurvedic treatment, first Virecana karma was done with classical method a nd then Matra basti, Sirobasti, and other palliative treatment was given for 3 mon ths. Amanatidine was not continued during Virecana karma but started thereafter . On comparison with pre-intervention scores, there was a significant improveme nt in the patient post-treatment. The features which mainly showed improvement w ere: Eye movements, spontaneous episodes of laughing, dysphagia, dysarthria, do uble vision, and neck rigidity. Balance showed significant improvement and ther e was a remarkable decrease in the postural sway. This case study may present new possibilities for treatment of neurodegenerative diseases by Ayurveda. FAU - Jindal, Nitin AU - Jindal N AD - Department of Panchakarma, Ayurvedic and Unani Tibbia College and Hospital , New Delhi, India. FAU - Shamkuwar, Manoj K AU - Shamkuwar MK FAU - Kaur, Jaskirat AU - Kaur J FAU - Berry, Sadhan AU - Berry S LA - eng PT - Journal Article PL - India TA - Anc Sci Life JT - Ancient science of life JID - 8307589 PMC - PMC3733209 OID - NLM: PMC3733209 OTO - NOTNLM OT - Basti OT - Pacakarma OT - Virecana OT - progressive supranuclear palsy OT - yurveda OT - irobasti EDAT- 2013/08/10 06:00 MHDA- 2013/08/10 06:01 CRDT- 2013/08/10 06:00 AID - 10.4103/0257-7941.113793 [doi] AID - ASL-32-54 [pii] PST - ppublish SO - Anc Sci Life. 2012 Jul;32(1):54-8. doi: 10.4103/0257-7941.113793. PMID- 23889836

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NLM MEDLINE 20130729 20140311 1460-6984 (Electronic) 1368-2822 (Linking) 48 4 2013 Jul-Aug The Living with Dysarthria group for post-stroke dysarthria: the participa

voice. PG - 402-20 LID - 10.1111/1460-6984.12017 [doi] AB - BACKGROUND: The Living with Dysarthria group programme, devised for people with post-stroke dysarthia and family members, was piloted twice. Feedback from those who experience an intervention contributes to the evaluation of speech and language therapy programmes, giving the participant view of the interventi on's value and guiding further developments. RESEARCH QUESTION: What feedback d o participants in the Living with Dysarthria programme provide, informing on its perceived usefulness and guiding its future development? METHODS & PROCEDU RES: Nine people with chronic dysarthria following stroke and four family membe rs who completed the Living with Dysarthria programme all contributed to Focus Gr oup (FG) discussion, transcribed and thematically analysed, and completed an Anonymous Questionnaire Evaluation (AQE), comprising closed statements and open questions. An anonymous descriptive adjective selection task (ADAST) was a lso used. OUTCOMES & RESULTS: The varied forms of feedback provided complement ary information. Thematic analysis of FG data and AQE open question responses were configured around programme benefits, programme structure and content, and programme practicalities. Benefits associated with participation included learning and insight, being supported by peers and professionals, and impr oved speech and confidence. These are consistent with the main programme elemen ts of education, support and speech practice. All activities were seen as releva nt and positively received. Flexibility, recognition of and catering to individua l needs were valued characteristics. The community location was approved by all. M ost participants thought the format of eight weekly sessions of 2 h was approp riate. Responses to AQE closed statements provided almost unanimous confirmation of the very positive feedback conveyed in FG discussions. The main response to su ggested improvements in AQEs was that the number of sessions should be increased. Feedback indicated that for a few individuals there was negative reaction

to some facts about stroke, home practice tasks were difficult to complete, the pe rson with dysarthria/family member pair may not be the optimum combination for paired practice activities and pre-programme information should be extended. The ADAST showed that the programme was enjoyable, interesting, stimulating and usef ul. CONCLUSIONS & IMPLICATIONS: Participant feedback indicates that group ther apy, with family member participation, is a valid form of management for chroni c post-stroke dysarthria. Education, peer and professional support, and spee ch practice are confirmed as relevant programme components. Consistent majori ty opinions were communicated in different situations and via varied mediums. Some individuals expressed views relevant to their own needs, and these respons es also inform future implementation of the Living with Dysarthria programme. CI - (c) 2013 Royal College of Speech and Language Therapists. FAU - Mackenzie, C AU - Mackenzie C AD - School of Psychological Sciences and Health, University of Strathclyde, Gl asgow, UK. c.mackenzie@strath.ac.uk FAU - Kelly, S AU - Kelly S FAU - Paton, G AU - Paton G FAU - Brady, M AU - Brady M FAU - Muir, M AU - Muir M LA - eng PT - Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Studies DEP - 20130417 PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders / Royal Colleg e of Speech & Language Therapists JID - 9803709 SB - IM MH - Aged MH - Aged, 80 and over MH - Attitude MH - Chronic Disease MH - Dysarthria/*psychology/*rehabilitation MH - Family/psychology MH - Feedback, Psychological MH - Female MH - Focus Groups MH - Humans MH - Male

MH MH MH MH MH MH MH OTO OT OT OT OT EDATMHDACRDTPHSTAID PST SO -

Middle Aged *Patient Satisfaction Program Evaluation Psychotherapy, Group/methods/*organization & administration/standards Questionnaires Stroke/*psychology/*rehabilitation Treatment Outcome NOTNLM dysarthria feedback group therapy stroke 2013/07/31 06:00 2014/03/13 06:00 2013/07/30 06:00 2013/04/17 [aheadofprint] 10.1111/1460-6984.12017 [doi] ppublish Int J Lang Commun Disord. 2013 Jul-Aug;48(4):402-20. doi: 10.1111/1460-6984.12017. Epub 2013 Apr 17.

PMID- 23672922 OWN - NLM STAT- MEDLINE DA - 20130515 DCOM- 20140113 IS - 1938-2367 (Electronic) IS - 0147-7447 (Linking) VI - 36 IP - 5 DP - 2013 May TI - Reversal of acute ischemic stroke after THA using tissue plasminogen activ ator. PG - e676-8 LID - 10.3928/01477447-20130426-35 [doi] AB - Acute ischemic stroke is a potentially catastrophic medical emergency. Rec ently, successful reversal of the neurologic deficits associated with major ische mic strokes has been accomplished in selected patients through the use of intr avenous tissue plasminogen activator (tPA), an agent that can accomplish thromboly sis of arterial clots if given within the first few hours after the onset of stro ke. Because tPA works by thrombolysis of fresh clots, a potential exists for catastrophic hemorrhage if given to acute postoperative patients. Therefor e, the use of tPA has never been studied in postoperative patients, and the safet y of the drug in postoperative patients is unknown.The author describes a patie nt who had an acute ischemic stroke 2 days after total hip arthroplasty who was successfully treated with tPA without major complications. The patient was 51 years old and developed progressive facial droop, right arm paralysis, and dysarthria 2 days after elective hip arthroplasty. Imaging confirmed occlu sion of the left middle cerebral artery. Neurologic recovery was believed to be un likely

without tPA. After tPA administration, the patient had full neurologic rec overy within minutes but did develop a large (nondraining) hematoma and severe ecchymosis at the surgical site; a drop in hematocrit required 3 units of packed red blood cell transfusion. The wound did not develop skin necrosis, infec tion, or compartment syndrome, and the hematoma resolved within several weeks wi thout the need for surgical intervention.The author describes the patient's spec ific circumstances, the decision-making process behind the use of tPA, and the need for contingency plans in the event that severe uncontrolled hemorrhage occ urs. This information may be useful if other surgeons are faced with the dilemm a of a CI FAU AU AD 7 , major stroke in acute postoperative patients. Copyright 2013, SLACK Incorporated. Ezzet, Kace A Ezzet KA Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California 9203 USA. ezzet.kace@scrippshealth.org eng Case Reports Journal Article United States Orthopedics Orthopedics 7806107 EC 3.4.21.68 (Tissue Plasminogen Activator) IM Arthroplasty, Replacement, Hip/*adverse effects Brain Ischemia/*drug therapy/*etiology Humans Male Middle Aged Osteoarthritis, Hip/*complications/*surgery Stroke/*drug therapy/*etiology Tissue Plasminogen Activator/*therapeutic use Treatment Outcome 2013/05/16 06:00 2014/01/15 06:00 2013/05/16 06:00 10.3928/01477447-20130426-35 [doi] ppublish Orthopedics. 2013 May;36(5):e676-8. doi: 10.3928/01477447-20130426-35. 23441834 NLM MEDLINE 20130411 20130530 20140319 1469-8749 (Electronic) 0012-1622 (Linking) 55 5 2013 May

LA PT PT PL TA JT JID RN SB MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID PST SO PMIDOWN STATDA DCOMLR IS IS VI IP DP -

TI PG LID AB eath

Intensive dysarthria therapy for younger children with cerebral palsy. 464-71 10.1111/dmcn.12098 [doi] AIM: The aim of this study was to investigate if intervention targeting br support, phonation, and speech rate increases speech intelligibility and participation in the conversational interactions of younger children with dysarthria and cerebral palsy (CP). METHOD: Fifteen children with dysarthr

ia and CP (nine males, six females; age range 5-11 y, mean age 8 y, SD 2 y; CP ty pe: eight spastic, four dyskinetic, one ataxia, two Worster Drought syndrome; Gross Motor Function Classification System levels II-IV, median level II) partic ipated in this study. Children received three sessions of individual therapy per week for 6 weeks. Intelligibility of single words and connected speech was comp ared across five points: 1 and 6 weeks before therapy and 1, 6, and 12 weeks af ter therapy. Three familiar listeners and three unfamiliar listeners scored ea ch recording. Participation in communicative interactions was measured using the Focus on the Outcomes of Communication Under Six (FOCUS) tool. Analyses of variance and paired t-tests were used to investigate change. RESULTS: Mean speech intelligibility increased after therapy to familiar listeners (single word s 10.8%, 95% confidence interval [CI] 7.2-14.4; connected speech 9.4%, 95% C I 4.8-14.1) and unfamiliar listeners (single words 9.3%, 95% CI 6.8-11.8; co nnected speech 10.5%, 95% CI 7.3-13.8). FOCUS scores increased following therapy f or parents (mean increase 30.3, 95% CI 10.2-50.4) and for teachers (28.25, 95 % CI 14.4-42.1), but changes did not correlate with intelligibility. A wide var iation was seen in individual responses to therapy. INTERPRETATION: Brief intensi ve therapy is associated with gains in intelligibility and communicative interactions for some younger children with dysarthria. CI - (c) The Authors. Developmental Medicine & Child Neurology (c) 2013 Mac Kei th Press. FAU - Pennington, Lindsay AU - Pennington L AD - Institute of Health and Society, Newcastle University, Newcastle upon Tyne , UK. lindsay.pennington@ncl.ac.uk FAU - Roelant, Ella AU - Roelant E FAU - Thompson, Vicki AU - Thompson V FAU - Robson, Sheila AU - Robson S FAU - Steen, Nick AU - Steen N

FAU AU LA GR PT PT DEP PL TA JT JID SB CIN MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTPHSTPHSTAID PST SO 2013 PMIDOWN STATDA DCOMIS IS VI IP DP TI tices

Miller, Nick Miller N eng CDF/01/021/Department of Health/United Kingdom Journal Article Research Support, Non-U.S. Gov't 20130226 England Dev Med Child Neurol Developmental medicine and child neurology 0006761 IM Dev Med Child Neurol. 2013 May;55(5):403-4. PMID: 23441870 Analysis of Variance Cerebral Palsy/*complications Child Child, Preschool Communication Dysarthria/*etiology/*rehabilitation Female Follow-Up Studies Humans Male Parents/psychology Severity of Illness Index Speech/*physiology Speech Therapy/*methods Treatment Outcome 2013/02/28 06:00 2013/06/01 06:00 2013/02/28 06:00 2012/11/16 [accepted] 2013/02/26 [aheadofprint] 10.1111/dmcn.12098 [doi] ppublish Dev Med Child Neurol. 2013 May;55(5):464-71. doi: 10.1111/dmcn.12098. Epub Feb 26. 23121530 NLM MEDLINE 20121105 20130423 1460-6984 (Electronic) 1368-2822 (Linking) 47 6 2012 Nov-Dec Survey of UK speech and language therapists' assessment and treatment prac

for people with progressive dysarthria. PG - 725-37 LID - 10.1111/j.1460-6984.2012.00183.x [doi] AB - BACKGROUND: Dysarthria knowledge is predominantly impairment-based. As a r esult, speech and language therapists (SLTs) have traditionally adopted impairment-focused management practices. However, guidance for best practi ce suggests that SLTs should consider the client holistically, including the

impact of dysarthria beyond the impairment. AIMS: To investigate the current asse ssment and treatment practices used by UK SLTs with clients with progressive dysa rthria and to identify whether these satisfy the needs of SLTs in their everyday practice. To investigate the extent to which they consider oromotor abilit ies, intelligibility, functional communication, participation and interaction t o be important regarding assessment and treatment decisions. To explore whether management decisions are affected by level of clinical experience or setti ngs in which SLTs work. METHODS & PROCEDURES: An online survey of UK SLTs working with adults with progressive dysarthria. OUTCOMES & RESULTS: A total of 119 SLT s completed the survey. Respondents considered that targeting the levels of impairment, activity and participation are important in the management of clients with progressive dysarthria, as recommended by clinical guidelines and rec ent research. However a particularly high proportion of respondents reported t he use of impairment-based assessments. Respondents reported lacking the necessar y tools to target interaction in assessment and intervention. The intervention tha t respondents use with clients varies according to the progressive disorder and dysarthria severity. There is evidence for a trend that less experienced S LTs and those working predominantly in hospital-based settings focus on the impair ment, whereas more SLTs with more experience and those based in predominantly community-based settings look beyond the impairment. CONCLUSIONS & IMPLICA TIONS: The values held by SLTs match guideline recommendations for best practice, however the clinical reality is that the assessment of progressive dysarth ria remains predominantly impairment-focused. New tools need to be developed a nd integrated into practice to target interaction in assessment and intervent ion, to reduce the gap between best practice recommendations and clinical reality. Ongoing research into the effectiveness of SLT intervention with clients w ith progressive dysarthria is required to guide clinical management decisions. CI - (c) 2012 Royal College of Speech and Language Therapists. FAU - Collis, Jessica AU - Collis J AD - Division of Psychology and Language Sciences, University College London, L ondon, UK. jesscollis@hotmail.com FAU - Bloch, Steven AU - Bloch S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120927

PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders / Royal Colleg e of Speech & Language Therapists JID - 9803709 SB - IM MH - Adult MH - *Attitude of Health Personnel MH - Disease Progression MH - Dysarthria/etiology/*therapy MH - Female MH - Great Britain MH - Guideline Adherence MH - *Health Care Surveys MH - *Health Knowledge, Attitudes, Practice MH - Humans MH - Huntington Disease/complications MH - Language Therapy/*methods MH - Male MH - Motor Neuron Disease/complications MH - Multiple Sclerosis/complications MH - Parkinson Disease/complications MH - Speech Therapy/*methods EDAT- 2012/11/06 06:00 MHDA- 2013/04/24 06:00 CRDT- 2012/11/06 06:00 PHST- 2012/09/27 [aheadofprint] AID - 10.1111/j.1460-6984.2012.00183.x [doi] PST - ppublish SO - Int J Lang Commun Disord. 2012 Nov-Dec;47(6):725-37. doi: 10.1111/j.1460-6984.2012.00183.x. Epub 2012 Sep 27. PMIDOWN STATDA DCOMIS IS VI IP DP TI p 23121529 NLM MEDLINE 20121105 20130423 1460-6984 (Electronic) 1368-2822 (Linking) 47 6 2012 Nov-Dec The living with dysarthria group: implementation and feasibility of a grou

intervention for people with dysarthria following stroke and family member s. PG - 709-24 LID - 10.1111/j.1460-6984.2012.00180.x [doi] AB - BACKGROUND: The broad life implications of acquired dysarthria are recogni zed, but they have received little attention in stroke management. Reports of g roup therapy, which may be a suitable approach to intervention, are not availab le for stroke-related dysarthria. AIMS: To examine the operational feasibility of and response to a new eight-session weekly group intervention programme, Livin g with Dysarthria, designed for people with chronic dysarthria following stroke a

nd their main communication partners. METHODS & PROCEDURES: The target partic ipation was for programme completion by two groups of eight people with dysarthria (PWD) and available family members (FMs) or carers. An active recruitment strate gy was undertaken from the speech and language therapy case records for the previ ous 6 years in two hospitals with combined annual stroke admissions of over 500 people. Twelve PWD and seven FMs were recruited (group 1: seven PWD and four FMs; group 2: five PWD and three FMs). Speech intelligibility, communication effectiv eness, general well-being, quality of communication life, and knowledge of stroke and dysarthria were assessed pre- and post-programme. Each PWD and FM also set an individual goal and rated their achievement of this on a 0-10 scale. OUTCO MES & RESULTS: Recruitment to the programme was lower than anticipated and below target. The 12 PWD were recruited from 62 initial contacts, which was the total number who according to available information met the criteria. The progra mme was viable: it ran to plan, with only minor content alterations, in community accommodation, and with good participant engagement. Group median score ch anges were in a positive direction for all measures and effect sizes ranged from 0.17 (quality of communication life) to 0.46 (intelligibility). Significant post-programme changes were present for intelligibility and knowledge of s troke and dysarthria (p= 0.05). Participants' ratings of goal achievements range d from 6 (some change) to 10 (a lot of change). CONCLUSIONS & IMPLICATIONS: The recruitment experience revealed a take-up rate of around 20% from PWD foll owing stroke, informing future planning. The participant engagement and performa nce results from the piloting of the programme indicate that the Living with Dysarthria programme is viable and has potential for effecting positive ch ange. Further testing is justified. CI - (c) 2012 Royal College of Speech and Language Therapists. FAU - Mackenzie, Catherine AU - Mackenzie C AD - University of Strathclyde, Glasgow, UK. c.mackenzie@strath.ac.uk FAU - Paton, Gillian AU - Paton G FAU - Kelly, Shona AU - Kelly S FAU - Brady, Marian AU - Brady M FAU - Muir, Margaret AU - Muir M LA - eng PT - Clinical Trial PT - Journal Article

PT DEP PL TA JT e of JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTPHSTAID PST SO PMIDOWN STATDA DCOMIS IS VI IP DP TI nt

Research Support, Non-U.S. Gov't 20120809 United States Int J Lang Commun Disord International journal of language & communication disorders / Royal Colleg Speech & Language Therapists 9803709 IM Adult Aged Aged, 80 and over Caregivers/psychology Chronic Disease Dysarthria/*psychology/*rehabilitation Family/psychology Feasibility Studies Feedback, Psychological Female Humans Interpersonal Relations Male Middle Aged Outcome Assessment (Health Care) Pilot Projects Program Evaluation Psychotherapy, Group/*methods/organization & administration Speech Intelligibility Speech Therapy/*methods/organization & administration Stroke/*psychology/*rehabilitation 2012/11/06 06:00 2013/04/24 06:00 2012/11/06 06:00 2012/08/09 [aheadofprint] 10.1111/j.1460-6984.2012.00180.x [doi] ppublish Int J Lang Commun Disord. 2012 Nov-Dec;47(6):709-24. doi: 10.1111/j.1460-6984.2012.00180.x. Epub 2012 Aug 9. 23071195 NLM MEDLINE 20121113 20130430 1558-9110 (Electronic) 1058-0360 (Linking) 21 4 2012 Nov Innovative technology for the assisted delivery of intensive voice treatme

(LSVT(R)LOUD) for Parkinson disease. PG - 354-67 LID - 10.1044/1058-0360(2012/11-0125) [doi] AB - PURPOSE: To assess the feasibility and effectiveness of a newly developed assistive technology system, Lee Silverman Voice Treatment Companion (LSVT ((R)) Companion, hereafter referred to as "Companion"), to support the delivery of LSVT((R))LOUD, an efficacious speech intervention for individuals with Par

kinson disease (PD). METHOD: Sixteen individuals with PD were randomized to an im mediate (n = 8) or a delayed (n = 8) treatment group. They participated in 9 LSVT LOUD sessions and 7 Companion sessions, independently administered at home. Aco ustic, listener perception, and voice and speech rating data were obtained immedi ately before (pre), immediately after (post), and at 6 months post treatment (follow-up). System usability ratings were collected immediately post trea tment. Changes in vocal sound pressure level were compared to data from a histori cal treatment group of individuals with PD treated with standard, in-person LS VT LOUD. RESULTS: All 16 participants were able to independently use the Comp anion. These individuals had therapeutic gains in sound pressure level, pre to po st and pre to follow-up, similar to those of the historical treatment group. CONCLUSIONS: This study supports the use of the Companion as an aid in tre atment of hypokinetic dysarthria in individuals with PD. Advantages and disadvant ages of the Companion, as well as limitations of the present study and directions for future studies, are discussed. FAU - Halpern, Angela E AU - Halpern AE AD - University of Colorado at Boulder, USA. angela.halpern@lsvtglobal.com FAU - Ramig, Lorraine O AU - Ramig LO FAU - Matos, Carlos E C AU - Matos CE FAU - Petska-Cable, Jill A AU - Petska-Cable JA FAU - Spielman, Jennifer L AU - Spielman JL FAU - Pogoda, Janice M AU - Pogoda JM FAU - Gilley, Phillip M AU - Gilley PM FAU - Sapir, Shimon AU - Sapir S FAU - Bennett, John K AU - Bennett JK FAU - McFarland, David H AU - McFarland DH LA - eng GR - R21-DC05583/DC/NIDCD NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20121015 PL - United States TA - Am J Speech Lang Pathol JT - American journal of speech-language pathology / American Speech-Language-H earing

JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTPHSTAID AID PST SO -

Association 9114726 IM Aged Aged, 80 and over Dysarthria/etiology/*rehabilitation Feasibility Studies Female Humans Male Middle Aged Parkinson Disease/*complications Phonetics Speech Speech Production Measurement Speech Therapy/instrumentation/*methods Therapy, Computer-Assisted/instrumentation/methods Treatment Outcome Voice Disorders/etiology/*rehabilitation *Voice Training 2012/10/17 06:00 2013/05/01 06:00 2012/10/17 06:00 2012/10/15 [aheadofprint] 1058-0360_2012_11-0125 [pii] 10.1044/1058-0360(2012/11-0125) [doi] ppublish Am J Speech Lang Pathol. 2012 Nov;21(4):354-67. doi: 10.1044/1058-0360(2012/11-0125). Epub 2012 Oct 15.

PMID- 22895930 OWN - NLM STAT- MEDLINE DA - 20120816 DCOM- 20120926 LR - 20130628 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 8 DP - 2012 TI - Speech and language therapy versus placebo or no intervention for speech p roblems in Parkinson's disease. PG - CD002812 LID - 10.1002/14651858.CD002812.pub2 [doi] AB - BACKGROUND: Parkinson's disease patients commonly suffer from speech and v ocal problems including dysarthric speech, reduced loudness and loss of articul ation. These symptoms increase in frequency and intensity with progression of the disease). Speech and language therapy (SLT) aims to improve the intelligib ility of speech with behavioural treatment techniques or instrumental aids. OBJE CTIVES: To compare the efficacy of speech and language therapy versus placebo or n o intervention for speech and voice problems in patients with Parkinson's di sease. SEARCH METHODS: Relevant trials were identified by electronic searches of numerous literature databases including MEDLINE, EMBASE, and CINAHL, as we

ll as handsearching of relevant conference abstracts and examination of referenc e lists in identified studies and other reviews. The literature search included tr ials published prior to 11(th) April 2011. SELECTION CRITERIA: Only randomised controlled trials (RCT) of speech and language therapy versus placebo or n o intervention were included. DATA COLLECTION AND ANALYSIS: Data were abstra cted independently by CH and CT and differences settled by discussion. MAIN RES ULTS: Three randomised controlled trials with a total of 63 participants were fo und comparing SLT with placebo for speech disorders in Parkinson's disease. Da ta were available from 41 participants in two trials. Vocal loudness for reading a passage increased by 6.3 dB (P = 0.0007) in one trial, and 11.0 dB (P = 0. 0002) in another trial. An increase was also seen in both of these trials for mo nologue speaking of 5.4 dB (P = 0.002) and 11.0 dB (P = 0.0002), respectively. It is likely that these are clinically significant improvements. After six month s, patients from the first trial were still showing a statistically significa nt increase of 4.5 dB (P = 0.0007) for reading and 3.5 dB for monologue speak ing. Some measures of speech monotoni city and articulation were investigated; however, all these results were non-significant. AUTHORS' CONCLUSIONS: Alt hough improvements in speech impairments were noted in these studies, due to the small number of patients examined, methodological flaws, and the possibility of publication bias, there is insufficient evidence to conclusively support o r refute the efficacy of SLT for speech problems in Parkinson's disease. A l arge well designed placebo-controlled RCT is needed to demonstrate SLT's effect iveness in Parkinson's disease. The trial should conform to CONSORT guidelines. Ou tcome measures with particular relevance to patients with Parkinson's disease sh ould be chosen and patients followed for at least six months to determine the dura tion of any improvement. FAU - Herd, Clare P AU - Herd CP AD - School of Clinical and Experimental Medicine, College of Medical and Denta l Sciences, Birmingham, UK. c.e.clarke@bham.ac.uk. FAU - Tomlinson, Claire L AU - Tomlinson CL FAU - Deane, Katherine H O AU - Deane KH FAU - Brady, Marian C AU - Brady MC FAU - Smith, Christina H

AU FAU AU FAU AU LA GR PT PT PT PT DEP PL TA JT JID SB UOF MH MH MH MH MH MH MH MH EDATMHDACRDTAID PST SO PMIDOWN STATDA DCOMLR IS IS VI IP DP TI apy ested

Smith CH Sackley, Catherine M Sackley CM Clarke, Carl E Clarke CE eng Chief Scientist Office/United Kingdom Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Review 20120815 England Cochrane Database Syst Rev The Cochrane database of systematic reviews 100909747 IM Cochrane Database Syst Rev. 2001;(2):CD002812. PMID: 11406044 Dysarthria/etiology/*therapy Humans *Language Therapy Parkinson Disease/*complications Randomized Controlled Trials as Topic Speech Intelligibility *Speech Therapy Watchful Waiting 2012/08/17 06:00 2012/09/27 06:00 2012/08/17 06:00 10.1002/14651858.CD002812.pub2 [doi] epublish Cochrane Database Syst Rev. 2012 Aug 15;8:CD002812. doi: 10.1002/14651858.CD002812.pub2. 22837542 NLM MEDLINE 20130122 20130821 20131115 1477-0873 (Electronic) 0269-2155 (Linking) 27 2 2013 Feb Trial participants' experiences of early enhanced speech and language ther after stroke compared with employed visitor support: a qualitative study n

within a randomized controlled trial. PG - 174-82 LID - 10.1177/0269215512450042 [doi] AB - OBJECTIVES: To explore trial participants' experiences of the process and outcomes of early, enhanced speech and language therapy after stroke with support from an employed visitor. DESIGN: Qualitative study nested within a random ized controlled trial. PARTICIPANTS: Twney-two people who, after stroke, had a diagnosis of aphasia (12), dysarthria (5) or both (5) and who participated in the

ACT NoW study. SETTING: Eight English NHS usual care settings. METHOD: Ind ividual interviews. Thematic content analysis assisted by a bespoke data transform ation protocol for incorporating non-verbal and semantically ambiguous data. RES ULTS: Participants highly regarded regular and sustained contact with someone ou tside of immediate family/friends who engaged them in deliberate activities/communication in the early months after stroke. Participants identified differences in the process of intervention between speech and l anguage therapists and employed visitors. But no major discriminations were made b etween the impact or value of this contact according to whether provided by a spe ech and language therapist or employed visitor. Participant-defined criteria for effectiveness of contact included: impact on mood and confidence, self-recognition of progress and the meeting of individual needs. CONCLUSI ONS: As in the randomized controlled trial, participants reported no evidence of a dded benefit of early communication therapy beyond that from attention control. The findings do not imply that regular contact with any non-professional can h ave beneficial effects for someone with aphasia or dysarthria in the early wee ks following a stroke. The study points to specific conditions that would hav e to be met for contact to have a positive effect. FAU - Young, Alys AU - Young A AD - School of Nursing Midwifery and Social Work, University of Manchester, Man chester Academic Health Sciences Centre, UK. alys.young@manchester.ac.uk FAU - Gomersall, Timothy AU - Gomersall T FAU - Bowen, Audrey AU - Bowen A CN - ACT NoW investigators LA - eng GR - Department of Health/United Kingdom PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20120726 PL - England TA - Clin Rehabil JT - Clinical rehabilitation JID - 8802181 SB - IM MH - Aged MH - Aged, 80 and over MH - Aphasia/etiology/psychology/*rehabilitation MH - Cohort Studies MH - Dysarthria/etiology/psychology/*rehabilitation MH - Female MH - Humans MH - *Language Therapy

MH - Male MH - Middle Aged MH - Outcome and Process Assessment (Health Care) MH - *Patient Satisfaction MH - Qualitative Research MH - *Speech Therapy MH - Stroke/*complications/rehabilitation PMC - PMC3757994 OID - NLM: PMC3757994 EDAT- 2012/07/28 06:00 MHDA- 2013/08/22 06:00 CRDT- 2012/07/28 06:00 PHST- 2012/07/26 [aheadofprint] AID - 0269215512450042 [pii] AID - 10.1177/0269215512450042 [doi] PST - ppublish SO - Clin Rehabil. 2013 Feb;27(2):174-82. doi: 10.1177/0269215512450042. Epub 2 012 Jul 26. PMIDOWN STATDA DCOMLR IS IS VI DP TI fter PG LID LID AB n the tured social contact). DESIGN: Externally randomised, pragmatic, parallel, super iority trial with blinded outcome assessment. SETTING: Twelve UK hospital and com munity stroke services. PARTICIPANTS: 170 adults (mean age 70 years) randomised w ithin two weeks of admission to hospital with stroke (December 2006 to January 2 010) whom speech and language therapists deemed eligible, and 135 carers. INTERVENTIONS: Enhanced, agreed best practice, communication therapy speci fic to aphasia or dysarthria, offered by speech and language therapists according to participants' needs for up to four months, with continuity from hospital t o community. Comparison was with similarly resourced social contact (without communication therapy) from employed visitors. OUTCOME MEASURES: Primary o utcome was blinded, functional communicative ability at six months on the Therapy Outcome Measure (TOM) activity subscale. Secondary outcomes (unblinded, si 22797843 NLM MEDLINE 20120716 20120927 20131115 1756-1833 (Electronic) 0959-535X (Linking) 345 2012 Effectiveness of enhanced communication therapy in the first four months a stroke for aphasia and dysarthria: a randomised controlled trial. e4407 10.1136/bmj.e4407 [doi] bmj.e4407 [pii] OBJECTIVE: To assess the effectiveness of enhanced communication therapy i first four months after stroke compared with an attention control (unstruc

x months): participants' perceptions on the Communication Outcomes After Str oke scale (COAST); carers' perceptions of participants from part of the Carer COAST; carers' wellbeing on Carers of Older People in Europe Index and quality of life items from Carer COAST; and serious adverse events. RESULTS: Therapist and visitor contact both had good uptake from service users. An average 22 con tacts (intervention or control) over 13 weeks were accepted by users. Impairment focused therapy was the approach most often used by the speech and languag e therapists. Visitors most often provided general conversation. In total, 8 1/85 of the intervention group and 72/85 of the control group completed the primar y outcome measure. Both groups improved on the TOM activity subscale. The es timated six months group difference was not statistically significant, with 0.25 ( 95% CI -0.19 to 0.69) points in favour of therapy. Sensitivity analyses that adju sted for chance baseline imbalance further reduced this difference. Per protoco l analyses rejected a possible dilution of treatment effect from controls de clining their allocation and receiving usual care. There was no added benefit of t herapy on secondary outcome measures, subgroup analyses (such as aphasia), or ser ious adverse events, although the latter were less common after intervention (o dds ratio 0.42 (95% CI 0.16 to 1.1)). CONCLUSIONS: Communication therapy had n o added benefit beyond that from everyday communication in the first four months a fter stroke. Future research should evaluate reorganised services that support functional communication practice early in the stroke pathway. This projec t was funded by the NIHR Health Technology Assessment programme (project No 02/1 1/04) and is published in full in Health Technology Assessment 2012;16(26):1-160 . TRIAL REGISTRATION: ISRCTN78617680. FAU - Bowen, Audrey AU - Bowen A AD - HCD, Ellen Wilkinson Building, University of Manchester MAHSC, Manchester Academic Health Science Centre, Manchester M13 9PL, UK. audrey.bowen@manchester.ac.uk FAU - Hesketh, Anne AU - Hesketh A FAU - Patchick, Emma AU - Patchick E FAU - Young, Alys AU - Young A FAU - Davies, Linda AU - Davies L FAU - Vail, Andy AU - Vail A

FAU AU FAU AU FAU AU FAU AU FAU AU FAU AU LA SI GR PT PT PT PT DEP PL TA JT JID SB SB CIN CIN CIN CIN CIN MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH PMC OID EDATMHDACRDT-

Long, Andrew F Long AF Watkins, Caroline Watkins C Wilkinson, Mo Wilkinson M Pearl, Gill Pearl G Ralph, Matthew A Lambon Ralph MA Tyrrell, Pippa Tyrrell P eng ISRCTN/ISRCTN78617680 Department of Health/United Kingdom Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't 20120713 England BMJ BMJ (Clinical research ed.) 8900488 AIM IM BMJ. 2012;345:e6014; author reply e6023. PMID: 22963945 BMJ. 2012;345:e4870. PMID: 22807163 BMJ. 2012;345:e6020; author reply e6023. PMID: 22963946 BMJ. 2012;345:e6022; author reply e6023. PMID: 22963947 J Neurol. 2012 Nov;259(11):2510-2. PMID: 23086178 Adult Aged Aged, 80 and over Aphasia/etiology/*rehabilitation Caregivers Communication Dysarthria/etiology/*rehabilitation Female Great Britain Humans Interpersonal Relations Language Therapy Male Middle Aged Outcome Assessment (Health Care)/*statistics & numerical data Patient Selection Practice Guidelines as Topic *Quality of Life Regression Analysis Severity of Illness Index *Speech Therapy Stroke/complications/*rehabilitation Treatment Outcome Visitors to Patients PMC3396461 NLM: PMC3396461 2012/07/17 06:00 2012/09/28 06:00 2012/07/17 06:00

PST - epublish SO - BMJ. 2012 Jul 13;345:e4407. doi: 10.1136/bmj.e4407. PMIDOWN STATDA IS IS VI IP DP TI nd 22754604 NLM Publisher 20120703 1940-7742 (Print) 1940-7742 (Linking) 18 3 2011 Oct 1 Children with 7q11.23 Duplication Syndrome: Speech, Language, Cognitive, a

Behavioral Characteristics and their Implications for Intervention. PG - 108-116 AB - 7q11.23 duplication syndrome is a recently-documented genetic disorder ass ociated with severe speech delay, language delay, a characteristic facies, hypoton ia, developmental delay, and social anxiety. Developmentally appropriate nonve rbal pragmatic abilities are demonstrated in socially comfortable situations. M otor speech disorder (Childhood Apraxia of Speech and/or dysarthria), oral apra xia, and/or phonological disorder or symptoms of these disorders are common as are characteristics consistent with expressive language disorder. Intensive speech/language therapy is critical for maximizing long-term outcomes. FAU - Velleman, Shelley L AU - Velleman SL AD - Department of Communication Sciences and Disorders, 402 Pomeroy, 489 Main Street, University of Vermont, Burlington VT 05405, shelley.velleman@uvm.edu , 802-656-3868. FAU - Mervis, Carolyn B AU - Mervis CB LA - ENG GR - R01 NS035102-15/NS/NINDS NIH HHS/United States GR - R37 HD029957/HD/NICHD NIH HHS/United States GR - R37 HD029957-20/HD/NICHD NIH HHS/United States PT - JOURNAL ARTICLE TA - Perspect Lang Learn Educ JT - Perspectives on language learning and education JID - 101514255 PMC - PMC3383616 MID - NIHMS356374 EDAT- 2012/07/04 06:00 MHDA- 2012/07/04 06:00 CRDT- 2012/07/04 06:00 AID - 10.1044/lle18.3.108 [doi] PST - ppublish SO - Perspect Lang Learn Educ. 2011 Oct 1;18(3):108-116. PMIDOWN STATDA DCOM22613690 NLM MEDLINE 20120522 20121018

IS IS VI IP DP TI of ed

2046-4924 (Electronic) 1366-5278 (Linking) 16 26 2012 May Clinical effectiveness, cost-effectiveness and service users' perceptions early, well-resourced communication therapy following a stroke: a randomis

controlled trial (the ACT NoW Study). PG - 1-160 LID - 10.3310/hta16260 [doi] AB - OBJECTIVE: To determine the clinical effectiveness, cost-effectiveness and service users' views of enhanced early communication therapy by speech and language (SL) therapists compared with attention control (AC). DESIGN: Suc cessful feasibility study followed by a randomised trial with economic evaluation, and nested qualitative study using 32 individual interviews. SETTING: Twelve E nglish NHS hospital and community stroke services. PARTICIPANTS: One hundred and seventy adults with aphasia or dysarthria admitted to hospital with stroke, Decemb er 2006 to January 2010. Eligibility determined by NHS SL therapists. Seventeen pe ople declined follow-up. INTERVENTIONS: A best-practice, flexible intervention by NHS SL therapists, up to three contacts per week for up to 16 weeks compared w ith a similar number of AC contacts by employed visitors. MAIN OUTCOME MEASURES: Primary outcome was blinded, functional communicative ability 6 months pos t randomisation on the Therapy Outcome Measure activity subscale (TOM). Seco ndary outcomes were participants' perceptions on the Communication Outcomes Afte r Stroke scale (COAST); carers' perceptions of participants from part of the Carer COAST; carer well-being on Carers of Older People in Europe Index and quality-of-life items from Carer COAST. Serious adverse events (SAEs) were recorded. Economic evaluation: participants' utility (European Quality of Life-5 Dimensions), service use and cost data from medical records and carers, an d a discrete choice experiment. RESULTS: Intervention typically started after 2 weeks, providing 22 contacts. Both groups improved on the TOM. The estimat ed 6 months' group difference [95% confidence interval (CI)] was 0.25 (-0.19 to 0.69) points in favour of SL therapy. Sensitivity analyses adjusting for baselin e chance imbalance or not imputing values for decedents further reduced this difference. Per-protocol analyses rejected a possible dilution of therapy from controls refusing allocation and receiving NHS SL therapy. There was no ev idence of added benefit of therapy on any secondary outcome measure or SAEs, alth ough

the latter were less frequent in the therapy group [odds ratio 0.42 (95% C I 0.16 to 1.1)]. Regardless of group allocation, interviewed participants reporte d positive impacts on their confidence and mood, identified drivers for chan ge and valued early and sustained contact. Health economic analysis indicated a h igh level of uncertainty. Early enhanced SL therapy for communication is likel y to be cost-effective only if decision-makers are prepared to pay >/= pound25,000 to gain one unit of utility. CONCLUSIONS: These findings exclude the possibil ity of a clinically significant difference of 0.5 points on the TOM. There was no evidence, on any measure, of added benefit of early communication therapy beyond that from AC. It is unclear whether therapy is more or less cost-effective than AC. Early, frequent contact was highly valued by users and had good uptake . Functional communication improved for both groups, plausibly due to natura l recovery and early and regular opportunity to practise everyday communicat ion with a professional (therapist/visitor). There is no evidence to recommend enhancing the provision of early communication therapy by a qualified SL therapist over and above usual care. SL therapy service reorganisation sho uld consider skill mix and timing within a stepped care model and should take place within the context of a trial. FAU - Bowen, A AU - Bowen A AD - University of Manchester MAHSC (Manchester Academic Health Science Centre) , Manchester, UK. audrey.bowen@manchester.ac.uk FAU - Hesketh, A AU - Hesketh A FAU - Patchick, E AU - Patchick E FAU - Young, A AU - Young A FAU - Davies, L AU - Davies L FAU - Vail, A AU - Vail A FAU - Long, A AU - Long A FAU - Watkins, C AU - Watkins C FAU - Wilkinson, M AU - Wilkinson M FAU - Pearl, G AU - Pearl G FAU - Lambon Ralph, M AU - Lambon Ralph M FAU - Tyrrell, P AU - Tyrrell P CN - ACT NoW investigators

LA SI PT PT PT PL TA JT JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID PST SO -

eng ISRCTN/ISRCTN78617680 Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't England Health Technol Assess Health technology assessment (Winchester, England) 9706284 IM Adult Aged Aged, 80 and over Aphasia/therapy Dysarthria/therapy Feasibility Studies Female Great Britain Humans Interviews as Topic Male Middle Aged Outcome Assessment (Health Care)/*methods *Patient Satisfaction Speech Therapy/*economics State Medicine Stroke/physiopathology/*rehabilitation 2012/05/23 06:00 2012/10/19 06:00 2012/05/23 06:00 10.3310/hta16260 [doi] ppublish Health Technol Assess. 2012 May;16(26):1-160. doi: 10.3310/hta16260.

PMID- 22463811 OWN - NLM STAT- MEDLINE DA - 20120910 DCOM- 20130118 IS - 1360-046X (Electronic) IS - 0268-8697 (Linking) VI - 26 IP - 5 DP - 2012 Oct TI - Urgent superficial temporal artery to middle cerebral artery bypass shortl y after intravenous rt-PA. PG - 773-5 LID - 10.3109/02688697.2012.665517 [doi] AB - Whether to provide surgical intervention within 24 hours of intravenous recombinant tissue plasminogen activator (rt-PA) treatment is a subject of controversy. In this study, we report a case in which neurological deterio ration was prevented by urgent bypass surgery performed shortly after rt-PA treat ment. FAU - Ishishita, Yohei AU - Ishishita Y AD - Department of Neurosurgery and Stroke Unit, NTT Medical Center Tokyo, Shin agawa, Tokyo, Japan. yi44ta@yahoo.co.jp

FAU AU FAU AU LA PT PT DEP PL TA JT JID RN RN SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTPHSTAID PST SO pub

Kimura, Toshikazu Kimura T Morita, Akio Morita A eng Case Reports Journal Article 20120331 England Br J Neurosurg British journal of neurosurgery 8800054 0 (Fibrinolytic Agents) EC 3.4.21.68 (Tissue Plasminogen Activator) IM Aged Blood Vessel Prosthesis Blood Vessel Prosthesis Implantation/*methods *Carotid Artery, Internal Carotid Stenosis/*therapy Cerebral Infarction/*therapy Dysarthria/etiology Emergency Treatment Facial Paralysis/etiology Fibrinolytic Agents/*administration & dosage Humans Infusions, Intravenous Male Middle Cerebral Artery/surgery Paresis/etiology Temporal Arteries/surgery Tissue Plasminogen Activator/*administration & dosage 2012/04/03 06:00 2013/01/19 06:00 2012/04/03 06:00 2012/03/31 [aheadofprint] 10.3109/02688697.2012.665517 [doi] ppublish Br J Neurosurg. 2012 Oct;26(5):773-5. doi: 10.3109/02688697.2012.665517. E 2012 Mar 31.

PMID- 22348261 OWN - NLM STAT- MEDLINE DA - 20120705 DCOM- 20121120 IS - 1754-9515 (Electronic) IS - 1754-9507 (Linking) VI - 14 IP - 4 DP - 2012 Aug TI - Improved status following behavioural intervention in a case of severe dys arthria with stroke aetiology. PG - 318-28 LID - 10.3109/17549507.2011.652672 [doi] AB - There is little published intervention outcome literature concerning dysar thria acquired from stroke. Single case studies have potential for more detailed

specification and interpretation than is generally possible in larger stud ies so are informative for clinicians dealing with similar cases. Such research a lso contributes to planning of larger scale investigations. Behavioural interv ention is described which was carried out between 7-9 months after stroke with a 69-year-old man with severe dysarthria. Pre-intervention stability between 5-7 months contrasted with post-intervention gains. Significant improvement wa s demonstrated using randomized, blinded assessment by 10 judges on measures of word and reading intelligibility and communication effectiveness in conver sation. A range of speech analyses were undertaken (rate, pause, and intonation characteristics in connected speech and single word phonetic transcription ), with the aim of identifying speech components which might explain the listeners ' perceptions of improvement. Changes were detected mainly in parameters rel ated to utterance segmentation and intonation. The basis of post-intervention impr ovement in dysarthria is complex, both in terms of the active therapeutic dimensio ns and also the specific speech alterations which account for changes to intellig ibility and effectiveness. FAU - Mackenzie, Catherine AU - Mackenzie C AD - University of Strathclyde, Glasgow, UK. c.mackenzie@strath.ac.uk FAU - Lowit, Anja AU - Lowit A LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120221 PL - England TA - Int J Speech Lang Pathol JT - International journal of speech-language pathology JID - 101320232 SB - IM MH - Aged MH - Dysarthria/*etiology/physiopathology/*therapy MH - Humans MH - Male MH - Outcome Assessment (Health Care) MH - Phonetics MH - *Severity of Illness Index MH - Speech Intelligibility/physiology MH - Speech Therapy/*methods MH - Speech-Language Pathology/methods MH - Stroke/*complications MH - Treatment Outcome EDAT- 2012/02/22 06:00 MHDA- 2012/12/10 06:00 CRDT- 2012/02/22 06:00 PHST- 2012/02/21 [aheadofprint]

AID - 10.3109/17549507.2011.652672 [doi] PST - ppublish SO - Int J Speech Lang Pathol. 2012 Aug;14(4):318-28. doi: 10.3109/17549507.2011.652672. Epub 2012 Feb 21. PMIDOWN STATDA DCOMLR IS IS VI IP DP TI ial 22268906 NLM MEDLINE 20120124 20120522 20140224 1460-6984 (Electronic) 1368-2822 (Linking) 47 1 2012 Jan-Feb Prevalence and severity of voice and swallowing difficulties in mitochondr

disease. PG - 106-11 LID - 10.1111/j.1460-6984.2011.00072.x [doi] AB - BACKGROUND: Mutations of mitochondrial DNA (mtDNA) cause a broad spectrum of clinical phenotypes. Anecdotal evidence suggests that voice and swallow pr oblems are a common feature of these diseases. AIMS: To characterize accurately t he prevalence and severity of voice and swallow problems in a large cohort of patients with mitochondrial disease. METHODS & PROCEDURES: Patients with p roven mitochondrial disease were sent validated questionnaires to assess both vo ice and swallow function. The presence of voice and swallow symptoms was correlate d with other clinical features of mitochondrial disease in affected patients. OUT COMES & RESULTS: From the original 177 patients contacted, 98 swallowing status questionnaires and 96 Voice Handicap Index questionnaires were returned, r esponse rates of 55% and 54%, respectively. Swallow: 48% of patients reported more difficulties with swallowing than control participants. Patients with sing le mtDNA deletions were most likely to report problems (65.2%), with patients with an m.8344A>G point mutation least likely (33.3%). All genotypes had a mean severity score in excess of the normal range, the highest mean score being found in the single large-scale mtDNA deletion group (10.12), the lowest in the m.3243A>G group (5.56) Voice; 48% of patients reported some difficulty wit h voice. Patients with single large-scale deletions showed the highest preva lence (65.2%), patients with the m.3243A>G mutation the lowest (33%). The most s evere voice difficulties were reported by patients with an m.8344A>G point mutat ion. Patients with an m.3243A>G point mutation had the mildest and lowest incid ence of voice problems. All genotypes scored outside of the normal range expected on the

VHI overall (>/=11.5 in control trials). Patients with an m.8344A>G point mutation reported a significantly higher degree of physical voice handicap than m.3243A>G patients (13.13 versus 4.40, p = 0.02). In patients with either single or multiple mtDNA deletions the likely pathophysiological mechanism is of proximal muscle weakness, whereas in patients with the m.8344A>G mutation cerebellar ataxia is the likely cause. CONCLUSIONS & IMPLICATIONS: Dysphag ia and dysarthria have been identified as symptoms in previous research, however the prevalence and pathophysiology of these symptoms have not been explored. T his paper indicates that voice and swallow problems are a common, though predominantly mild feature of mitochondrial disease and that there is a co re group of pathophysiological symptoms linked to the presence of voice and swallowing problems. This paper recommends early referral to speech and la nguage therapists to identify emerging dysphonia and dysphagia and to provide appropriate intervention. CI - (c) 2011 Royal College of Speech and Language Therapists. FAU - Read, Jennifer L AU - Read JL AD - Department of Health Professions, Manchester Metropolitan University, Manc hester, UK. j.read@mmu.ac.uk FAU - Whittaker, Roger G AU - Whittaker RG FAU - Miller, Nick AU - Miller N FAU - Clark, Sue AU - Clark S FAU - Taylor, Robert AU - Taylor R FAU - McFarland, Robert AU - McFarland R FAU - Turnbull, Douglass AU - Turnbull D LA - eng GR - 096919/Wellcome Trust/United Kingdom GR - G0700718/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110620 PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders / Royal Colleg e of Speech & Language Therapists JID - 9803709 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Deglutition Disorders/*epidemiology/physiopathology MH - Dysarthria/*epidemiology/physiopathology MH - Female MH - Health Surveys/statistics & numerical data

MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTPHSTAID PST SO -

Humans Male Middle Aged Mitochondrial Diseases/*epidemiology/physiopathology Prevalence Prospective Studies Questionnaires Retrospective Studies *Severity of Illness Index Voice Disorders/*epidemiology/physiopathology Young Adult 2012/01/25 06:00 2012/05/23 06:00 2012/01/25 06:00 2011/06/20 [aheadofprint] 10.1111/j.1460-6984.2011.00072.x [doi] ppublish Int J Lang Commun Disord. 2012 Jan-Feb;47(1):106-11. doi: 10.1111/j.1460-6984.2011.00072.x. Epub 2011 Jun 20.

PMID- 22232403 OWN - NLM STAT- MEDLINE DA - 20120813 DCOM- 20130107 LR - 20131015 IS - 1558-9102 (Electronic) IS - 1092-4388 (Linking) VI - 55 IP - 4 DP - 2012 Aug TI - Intelligibility of 4-year-old children with and without cerebral palsy. PG - 1177-89 LID - 10.1044/1092-4388(2011/11-0083) [doi] AB - PURPOSE: The authors examined speech intelligibility in typically developi ng (TD) children and 3 groups of children with cerebral palsy (CP) who were classi fied into speech/language profile groups following Hustad, Gorton, and Lee (201 0). Questions addressed differences in transcription intelligibility scores am ong groups, the effects of utterance length on intelligibility, the relationsh ip between ordinal ratings of intelligibility and orthographic transcription intelligibility scores, and the difference between parent and naive listen er ordinal ratings. METHOD: Speech samples varying in length from 1 to 7 word s were elicited from 23 children with CP ( M (age) = 54.3 months) and 20 TD child ren ( M (age) = 55.1 months). Two hundred fifteen naive listeners made orthographi c transcriptions and ordinal ratings of intelligibility. Parent ordinal rati ngs of intelligibility were obtained from a previous study (Hustad et al., 2010). RESULTS: Intelligibility varied with speech/language profile group and utt erance length, with different patterns observed by profile group. Ratings of intelligibility by parents and naive listeners did not differ, and both we

re highly correlated with transcription intelligibility scores. CONCLUSION: Intelligibility was reduced for all groups of children with CP relative to TD children, suggesting the importance of speech-language intervention and th e need for research investigating variables associated with changes in intelligib ility FAU AU AD FAU AU FAU AU FAU AU LA GR GR GR GR PT PT PT DEP PL TA JT JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH PMC MID OID OID EDATMHDACRDTPHSTAID AID PST SO in children. Hustad, Katherine C Hustad KC University of Wisconsin-Madison, Wisconsin, USA. kchustad@wisc.edu Schueler, Brynn Schueler B Schultz, Laurel Schultz L DuHadway, Caitlin DuHadway C eng P30 HD003352-46/HD/NICHD NIH HHS/United States P30HD03352/HD/NICHD NIH HHS/United States R01 DC009411-04/DC/NIDCD NIH HHS/United States R01DC009411/DC/NIDCD NIH HHS/United States Comparative Study Journal Article Research Support, N.I.H., Extramural 20120109 United States J Speech Lang Hear Res Journal of speech, language, and hearing research : JSLHR 9705610 IM Cerebral Palsy/complications/*psychology Child Development Child, Preschool Communication Dysarthria/etiology/*psychology Female Humans Language Development Linguistics Male Motor Skills Speech Disorders/etiology/*psychology *Speech Intelligibility Speech Production Measurement PMC3349823 NIHMS347444 NLM: NIHMS347444 NLM: PMC3349823 2012/01/11 06:00 2013/01/08 06:00 2012/01/11 06:00 2012/01/09 [aheadofprint] 1092-4388_2011_11-0083 [pii] 10.1044/1092-4388(2011/11-0083) [doi] ppublish J Speech Lang Hear Res. 2012 Aug;55(4):1177-89. doi: 10.1044/1092-4388(2011/11-0083). Epub 2012 Jan 9.

PMIDOWN STATDA DCOMIS IS VI IP DP TI rt,

22215460 NLM MEDLINE 20120116 20120514 1537-4505 (Electronic) 1531-7129 (Linking) 33 2 2012 Feb Mucosal melanoma of the middle ear cavity and Eustachian tube: a case repo

literature review, and focus on surgical technique. PG - 239-43 LID - 10.1097/MAO.0b013e3182423191 [doi] AB - OBJECTIVE: To present a case of mucosal melanoma of the Eustachian tube wi th a focus on surgical technique and to review the literature on treatment of m ucosal melanoma of the head and neck, and review cases involving the middle ear a nd/or Eustachian tube. PATIENT: A 67-year-old man was diagnosed with mucosal mel anoma of the middle ear and Eustachian tube. INTERVENTION: The patient underwent primary surgical resection including transtemporal/transpetrosal approach, endoscopic nasopharyngectomy, infratemporal fossa dissection, temporomandi bular joint resection, ipsilateral neck dissection (levels II-IV), and superfici al parotidectomy. RESULTS: The patient was discharged on postoperative Day 7 with a very good functional status. He did have early dysphagia and dysarthria as a result of the VII to XII anastomosis for facial nerve reconstruction, whic h did require PEG tube placement. However, at 4 months after surgery, the patien t was eating solid foods and returning to normal activities. He received radiati on therapy postoperatively. There has been no evidence of tumor recurrence at 8 months after treatment. CONCLUSION: The standard treatment of head and nec k mucosal melanoma is primarily surgical. Surgical removal of mucosal melano ma in the Eustachian tube/middle ear can present challenges in achieving microscopically negative margins. However, gross tumor resection with postoperative radiotherapy has been shown to improve locoregional control. FAU - Peters, Geoffrey AU - Peters G AD - Department of Otolaryngology-Head and Neck Surgery, LSU Health Sciences Ce nter, New Orleans, Louisiana 70112, USA. FAU - Arriaga, Moises A AU - Arriaga MA FAU - Nuss, Daniel W AU - Nuss DW FAU - Pou, Anna M AU - Pou AM FAU - DiLeo, Michael

AU - DiLeo M FAU - Scrantz, Kelly AU - Scrantz K LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Otol Neurotol JT - Otology & neurotology : official publication of the American Otological So ciety, American Neurotology Society [and] European Academy of Otology and Neuroto logy JID - 100961504 SB - IM MH - Aged MH - Combined Modality Therapy MH - Ear Neoplasms/pathology/*surgery MH - Ear, Middle/pathology/*surgery MH - Endoscopy MH - Eustachian Tube/pathology/*surgery MH - Facial Nerve/surgery MH - Head and Neck Neoplasms/pathology/*surgery MH - Hearing Loss, Conductive/etiology MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Mastoid/surgery MH - Microsurgery MH - Neck Dissection MH - Otologic Surgical Procedures/*methods MH - Patient Care Team MH - Sarcoma, Clear Cell/pathology/*surgery MH - Temporomandibular Joint/surgery MH - Treatment Outcome MH - Tympanoplasty EDAT- 2012/01/05 06:00 MHDA- 2012/05/15 06:00 CRDT- 2012/01/05 06:00 AID - 10.1097/MAO.0b013e3182423191 [doi] PST - ppublish SO - Otol Neurotol. 2012 Feb;33(2):239-43. doi: 10.1097/MAO.0b013e3182423191. PMIDOWN STATDA DCOMLR IS IS VI DP TI 21918728 NLM PubMed-not-MEDLINE 20110915 20111110 20130513 2042-0080 (Electronic) 2042-0080 (Linking) 2011 2011 A cognitive-perceptual approach to conceptualizing speech intelligibility deficits and remediation practice in hypokinetic dysarthria. PG - 150962 LID - 10.4061/2011/150962 [doi] AB - Hypokinetic dysarthria is a common manifestation of Parkinson's disease, w hich negatively influences quality of life. Behavioral techniques that aim to i mprove

speech intelligibility constitute the bulk of intervention strategies for this population, as the dysarthria does not often respond vigorously to medical interventions. Although several case and group studies generally support t he efficacy of behavioral treatment, much work remains to establish a rigorou s evidence base. This absence of definitive research leaves both the speech-language pathologist and referring physician with the task of deter mining the feasibility and nature of therapy for intelligibility remediation in P D. The purpose of this paper is to introduce a novel framework for medical practi tioners in which to conceptualize and justify potential targets for speech remedia tion. The most commonly targeted deficits (e.g., speaking rate and vocal loudnes s) can be supported by this approach, as well as underutilized and novel treatmen t targets that aim at the listener's perceptual skills. FAU - Lansford, Kaitlin L AU - Lansford KL AD - Motor Speech Disorders Laboratory, Department of Speech and Hearing Scienc e, Arizona State University, P.O. Box 870102, Tempe, AZ 85287-0102, USA. FAU - Liss, Julie M AU - Liss JM FAU - Caviness, John N AU - Caviness JN FAU - Utianski, Rene L AU - Utianski RL LA - eng GR - R01 DC006859/DC/NIDCD NIH HHS/United States GR - R01 DC006859-08/DC/NIDCD NIH HHS/United States PT - Journal Article DEP - 20110912 PL - United States TA - Parkinsons Dis JT - Parkinson's disease JID - 101539877 PMC - PMC3171761 OID - NLM: PMC3171761 EDAT- 2011/09/16 06:00 MHDA- 2011/09/16 06:01 CRDT- 2011/09/16 06:00 PHST- 2011/04/09 [received] PHST- 2011/06/14 [revised] PHST- 2011/07/13 [accepted] PHST- 2011/09/12 [epublish] AID - 10.4061/2011/150962 [doi] PST - ppublish SO - Parkinsons Dis. 2011;2011:150962. doi: 10.4061/2011/150962. Epub 2011 Sep 12. PMIDOWN STATDA DCOM21899669 NLM MEDLINE 20110908 20120529

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1460-6984 (Electronic) 1368-2822 (Linking) 46 5 2011 Sep-Oct Acquired dysarthria in conversation: methods of resolving understandabilit

problems. PG - 510-23 LID - 10.1111/j.1460-6984.2011.00076.x [doi] AB - BACKGROUND: People with acquired progressive dysarthria typically experien ce increased problems with intelligibility in everyday conversation as their disease progresses. Such problems are likely to impact on both the person with dys arthria and those with whom they interact. If this is the case then we may ask que stions not just about the nature of these problems but how it is that such proble ms are dealt with by participants when they occur. AIMS: To investigate ways thro ugh which problems resulting from dysarthria in everyday conversation are reso lved by participants. Further, to examine some of the features of repair resolutio n, particularly where understanding of self-repair attempts themselves prove difficult. METHODS & PROCEDURES: Video data of natural conversation from t wo dyads were selected for this paper. One dyad features a 58 year-old man wi th multiple sclerosis and moderate intelligibility problems, the other a 79 y ear-old woman with motor neurone disease with mild to moderate intelligibility pro blems. Both elected to be recorded in conversation with their spouses. The dyads were video-recorded at home with no researcher present. Using the methods of Conversation Analysis (CA) a collection of sequences was identified and transcribed. The sequences were analysed with reference to how the partici pants resolve problems in the understanding of dysarthric speech. OUTCOMES & RES ULTS: It is shown how some problems resulting from dysarthria in conversation ca n be resolved relatively quickly, particularly where a specific element of a pr ior turn is highlighted by the recipient as problematic. In other instances, t he recipient's understanding problem may be more global. These result in long er repair sequences in which problematic elements are addressed individually. Such a resolution method is ultimately successful but may also be characterised b y additional understanding problems. These findings draw attention to an imp ortant distinction between intelligibility and understandability. CONCLUSIONS & IMPLICATIONS: It is concluded that problems resulting from dysarthria in conversation can require extensive repair work involving both parties. Thi

s has implications for the assessment of dysarthria in everyday conversation and also the promotion of intervention strategies that encompass the activities of both participants when dealing with dysarthria in interaction. These findings m ay be usefully employed in informing both direct clinical work and through train ing CI FAU AU AD those who work with this client group and their significant others. (c) 2011 Royal College of Speech & Language Therapists. Bloch, Steven Bloch S Language and Communication Research, University College London, UK. s.bloch@ucl.ac.uk Wilkinson, Ray Wilkinson R eng Journal Article Research Support, N.I.H., Extramural 20110809 United States Int J Lang Commun Disord International journal of language & communication disorders / Royal Colleg Speech & Language Therapists 9803709 IM Adaptation, Psychological Aged *Communication Dysarthria/etiology/*psychology/*rehabilitation Female Humans Male Middle Aged Motor Neuron Disease/complications/*psychology Multiple Sclerosis/complications/*psychology Phonation *Social Behavior Speech Intelligibility 2011/09/09 06:00 2012/05/30 06:00 2011/09/09 06:00 2011/08/09 [aheadofprint] 10.1111/j.1460-6984.2011.00076.x [doi] ppublish Int J Lang Commun Disord. 2011 Sep-Oct;46(5):510-23. doi: 10.1111/j.1460-6984.2011.00076.x. Epub 2011 Aug 9. 21899668 NLM MEDLINE 20110908 20120529 1460-6984 (Electronic) 1368-2822 (Linking) 46 5 2011 Sep-Oct

FAU AU LA PT PT DEP PL TA JT e of JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTPHSTAID PST SO PMIDOWN STATDA DCOMIS IS VI IP DP -

TI - Investigating interactional competencies in Parkinson's disease: the poten tial benefits of a conversation analytic approach. PG - 497-509 LID - 10.1111/j.1460-6984.2011.00012.x [doi] AB - BACKGROUND: Around 70% of people who develop Parkinson's disease (PD) expe rience speech and voice changes. Clinicians often find that when asked about thei r primary communication concerns, PD clients will talk about the difficultie s they have 'getting into' conversations. This is an important area for clients a nd it has implications for quality of life and clinical management. AIMS: To rev iew the extant literature on PD and communication impairments in order to reveal k ey topic areas, the range of methodologies applied, and any gaps in knowledge relating to PD and social interaction and how these might be usefully addr essed. METHODS & PROCEDURES: A systematic search of a number of key databases and available grey literatures regarding PD and communication impairment was conducted (including motor speech changes, intelligibility, cognitive/lang uage changes) to obtain a sense of key areas and methodologies applied. Researc h applying conversation analysis in the field of communication disability wa s also reviewed to illustrate the value of this methodology in uncovering common interactional difficulties, and in revealing the use of strategic collabor ative competencies in naturally occurring conversation. In addition, available s peech and language therapy assessment and intervention approaches to PD were exa mined with a view to their effectiveness in promoting individualized interventio n planning and advice-giving for everyday interaction. MAIN CONTRIBUTION: A great deal has been written about the deficits underpinning communication change s in PD and the impact of communication disability on the self and others as measu red in a clinical setting. Less is known about what happens for this client group in everyday conversations outside of the clinic. Current speech and language therapy assessments and interventions focus on the individual and are largely impa irment based or focused on compensatory speaker-oriented techniques. A conversati on analysis approach would complement basic research on what actually happens in everyday conversation for people with PD and their co-participants. CONCLU SIONS & IMPLICATIONS: The potential benefits of a conversation analysis approach t o communication disability in PD include enabling a shift in clinical focus from individual impairment onto strategic collaborative competencies. This woul

d have implications for client-centred intervention planning and the development of new and complementary clinical resources addressing participation. The impact would be new and improved support for those living with the condition as well as their families and carers. CI - (c) 2011 Royal College of Speech & Language Therapists. FAU - Griffiths, Sarah AU - Griffiths S AD - Institute of Health Services Research, Peninsula College of Medicine & Den tistry, University of Plymouth, UK. sgriffiths@marjon.ac.uk FAU - Barnes, Rebecca AU - Barnes R FAU - Britten, Nicky AU - Britten N FAU - Wilkinson, Ray AU - Wilkinson R LA - eng PT - Journal Article PT - Review DEP - 20110418 PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders / Royal Colleg e of Speech & Language Therapists JID - 9803709 SB - IM MH - Dysarthria/*etiology/*psychology MH - Humans MH - Parkinson Disease/*complications/*psychology MH - *Quality of Life MH - *Speech Intelligibility EDAT- 2011/09/09 06:00 MHDA- 2012/05/30 06:00 CRDT- 2011/09/09 06:00 PHST- 2011/04/18 [aheadofprint] AID - 10.1111/j.1460-6984.2011.00012.x [doi] PST - ppublish SO - Int J Lang Commun Disord. 2011 Sep-Oct;46(5):497-509. doi: 10.1111/j.1460-6984.2011.00012.x. Epub 2011 Apr 18. PMIDOWN STATDA DCOMLR IS IS VI DP TI PG LID AB tor 21603029 NLM PubMed-not-MEDLINE 20110523 20110714 20110728 2090-1860 (Electronic) 2090-1860 (Linking) 2011 2011 Communication Support for People with ALS. 714693 10.1155/2011/714693 [doi] Almost all people with amyotrophic lateral sclerosis (ALS) experience a mo

speech disorder, such as dysarthria, as the disease progresses. At some po int, 80 to 95% of people with ALS are unable to meet their daily communication nee ds using natural speech. Unfortunately, once intelligibility begins to decrea se, speech performance often deteriorates so rapidly that there is little time to implement an appropriate augmentative and alternative communication (AAC) intervention; therefore, appropriate timing of referral for AAC assessment and intervention continues to be a most important clinical decision-making iss ue. AAC acceptance and use have increased considerably during the past decade. Man y people use AAC until within a few weeks of their deaths. FAU - Beukelman, David AU - Beukelman D AD - Institute for Rehabilitation Science and Engineering Madonna Rehabilitatio n Hospital and University of Nebraska, 202 Barkley Memorial Center, P.O. Box 830732, Lincoln, NE 68583-0732, USA. FAU - Fager, Susan AU - Fager S FAU - Nordness, Amy AU - Nordness A LA - eng PT - Journal Article DEP - 20110414 PL - United States TA - Neurol Res Int JT - Neurology research international JID - 101543314 PMC - PMC3096454 OID - NLM: PMC3096454 EDAT- 2011/05/24 06:00 MHDA- 2011/05/24 06:01 CRDT- 2011/05/24 06:00 PHST- 2010/11/15 [received] PHST- 2011/02/02 [accepted] PHST- 2011/04/14 [epublish] AID - 10.1155/2011/714693 [doi] PST - ppublish SO - Neurol Res Int. 2011;2011:714693. doi: 10.1155/2011/714693. Epub 2011 Apr 14. PMIDOWN STATDA DCOMLR IS IS IP DP TI 21563158 NLM MEDLINE 20110512 20110623 20131125 1469-493X (Electronic) 1361-6137 (Linking) 5 2011 Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis. PG - CD006981 LID - 10.1002/14651858.CD006981.pub2 [doi]

AB - BACKGROUND: Motor neuron disease (MND), also known as amyotrophic lateral sclerosis, is a progressive, neurodegenerative condition which may cause dysphagia, as well as limb weakness, dysarthria, emotional lability and respiratory failure. Since normal salivary production is 0.5 to 1.5 litres daily, loss of salivary clearance due to dysphagia leads to salivary pooling and sialorrhea, often resulting in distress and inconvenience to patients. OBJECTIVES: To systematically review evidence on treatment of sialorrhea i n MND, including medications, radiotherapy and surgery. SEARCH STRATEGY: We searc hed the Cochrane Neuromuscular Disease Group Specialized Register (1 October 2010) , the Cochrane Central Register of Controlled Trials )(CENTRAL) (The Cochrane Li brary issue 3, 2010), MEDLINE (January 1966 to September 2010), EMBASE (January 1980 to September 2010), AMED (1985 to September 2010) and CINAHL Plus (January 19 37 September 2010). All bibliographies of the identified randomized trials we re reviewed and authors contacted as needed. Known experts in the field were contacted to identify further published and unpublished papers. SELECTION CRITERIA: We included randomized and quasi-randomised controlled studies o n any intervention for sialorrhea and related symptoms, in people with MND. DATA COLLECTION AND ANALYSIS: Review authors summarised data independently in a customised data collection form and confirmed data presented in Cochrane R eview Manager software. MAIN RESULTS: Only one randomized controlled trial was identified. This was a well designed study of botulinum toxin B injected i nto parotid and submandibular glands of 20 patients, which showed positive res ults for four weeks (Jackson 2009). There was low risk of bias in the study and no significant adverse events reported. AUTHORS' CONCLUSIONS: There is some e vidence for use of botulinum toxin injections to salivary glands for the treatment of sialorrhea in MND. Further research is required on this important symptom. Data are needed on the problem of sialorrhea in MND and its measurement, both b y patient self report measures and objective tests. These will allow the development of better randomized controlled trials. FAU - Young, Carolyn A AU - Young CA AD - The Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK, L9 7LJ. FAU - Ellis, Cathy AU - Ellis C FAU - Johnson, Julia AU - Johnson J FAU - Sathasivam, Sivakumar AU - Sathasivam S FAU - Pih, Nicky AU - Pih N LA - eng PT - Journal Article

PT DEP PL TA JT JID RN RN RN SB MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID PST SO PMIDOWN STATDA DCOMIS IS VI IP DP TI e of

Review 20110511 England Cochrane Database Syst Rev The Cochrane database of systematic reviews 100909747 0 (Neuromuscular Agents) 0Y70779M1F (rimabotulinumtoxinB) EC 3.4.24.69 (Botulinum Toxins) IM Amyotrophic Lateral Sclerosis/*complications Botulinum Toxins/*administration & dosage Humans Motor Neuron Disease/complications Neuromuscular Agents/*administration & dosage Parotid Gland Randomized Controlled Trials as Topic Salivation/drug effects Sialorrhea/*drug therapy/etiology Submandibular Gland 2011/05/13 06:00 2011/06/24 06:00 2011/05/13 06:00 10.1002/14651858.CD006981.pub2 [doi] epublish Cochrane Database Syst Rev. 2011 May 11;(5):CD006981. doi: 10.1002/14651858.CD006981.pub2. 21480809 NLM MEDLINE 20110412 20110720 1754-9515 (Electronic) 1754-9507 (Linking) 13 2 2011 Apr Dysarthria in stroke: a narrative review of its description and the outcom

intervention. PG - 125-36 LID - 10.3109/17549507.2011.524940 [doi] AB - Dysarthria is a frequent and persisting sequel to stroke and arises from v aried lesion locations. Although the presence of dysarthria is well documented, for stroke there are scant data on presentation and intervention outcome. A literature search was undertaken to evaluate (a) the features of dysarthri a in adult stroke populations relative to the conventional Mayo system for classification, which was developed from diverse pathological groups, and (b) the current status of evidence for the effectiveness of intervention in dysart hria caused by stroke. A narrative review of results is presented. The limited data available indicate that, regardless of stroke location, imprecise articula tion and slow speaking rate are consistent features, and voice disturbances,

especially harshness, and reduced prosodic variation are also common. Dysa rthria is more prevalent in left than in right hemisphere lesions. There is a nee d for comprehensive, thorough analysis of dysarthria features, involving larger populations, with stroke and other variables controlled and with appropria te age-referenced control data. There is low level evidence for benefits aris ing from intervention in stroke-related dysarthria. Because studies involve fe w participants, without external control, and sometimes include stroke with other aetiologies, their results lack the required weight for confident evidence -based practice. FAU - Mackenzie, Catherine AU - Mackenzie C AD - School of Psychological Sciences and Health, University of Strathclyde, So uthbrae Drive, Glasgow G13 1PP, UK. c.mackenzie@strath.ac.uk LA - eng PT - Journal Article PT - Review PL - England TA - Int J Speech Lang Pathol JT - International journal of speech-language pathology JID - 101320232 SB - IM MH - Dysarthria/*etiology/*therapy MH - Humans MH - Stroke/*complications MH - Treatment Outcome EDAT- 2011/04/13 06:00 MHDA- 2011/07/21 06:00 CRDT- 2011/04/13 06:00 AID - 10.3109/17549507.2011.524940 [doi] PST - ppublish SO - Int J Speech Lang Pathol. 2011 Apr;13(2):125-36. doi: 10.3109/17549507.2011.524940. PMIDOWN STATDA DCOMIS IS VI IP DP TI 21330650 NLM MEDLINE 20110503 20110907 1558-9110 (Electronic) 1058-0360 (Linking) 20 2 2011 May The importance of production frequency in therapy for childhood apraxia of speech. PG - 95-110 LID - 10.1044/1058-0360(2011/09-0005) [doi] AB - PURPOSE: This study explores the importance of production frequency during speech therapy to determine whether more practice of speech targets leads to incr eased performance within a treatment session, as well as to motor learning, in t

he form of generalization to untrained words. METHOD: Two children with childhood apraxia of speech were treated with an alternating treatment AB design, with produ ction frequency differing in the 2 treatments. The higher production frequency treatment required 100+ productions in 15 min, while the moderate-frequenc y treatment required 30-40 productions in the same time period. One child wa s treated 3 times weekly for 11 weeks; the other child was treated twice wee kly for 5 weeks. At the conclusion of each treatment phase, 5 min of probes were administered to determine whether generalization had occurred. Maintenance data to measure performance and learning were collected after a break from trea tment. RESULTS: Both children showed improvement on all targets; however, the tar gets with the higher production frequency treatment were acquired faster, evide nced by better in-session performance and greater generalization to untrained prob es. CONCLUSIONS: Both treatment designs were effective, though frequent and in tense practice of speech resulted in more rapid response to treatment in 2 child ren whose primary communication difficulty was childhood apraxia of speech. FAU - Edeal, Denice Michelle AU - Edeal DM AD - Portland State University, OR, USA. FAU - Gildersleeve-Neumann, Christina Elke AU - Gildersleeve-Neumann CE LA - eng PT - Journal Article DEP - 20110217 PL - United States TA - Am J Speech Lang Pathol JT - American journal of speech-language pathology / American Speech-Language-H earing Association JID - 9114726 SB - IM MH - Adoption MH - Apraxias/diagnosis/*therapy MH - Articulation Disorders/diagnosis/*therapy MH - Asian Americans/psychology MH - Child MH - Child, Preschool MH - Cleft Lip/therapy MH - Cleft Palate/therapy MH - Combined Modality Therapy MH - Communication Aids for Disabled MH - Dysarthria/diagnosis/*therapy MH - Early Intervention (Education) MH - Emigrants and Immigrants MH - Follow-Up Studies MH - Generalization (Psychology) MH - Humans MH - Language Development Disorders/diagnosis/*therapy

MH MH MH MH MH MH MH MH MH EDATMHDACRDTPHSTAID AID PST SO PMIDOWN STATDA DCOMIS IS VI IP DP TI PG AB f

Language Therapy/*methods Male Outcome and Process Assessment (Health Care) Phonetics *Practice (Psychology) Speech Articulation Tests Speech Intelligibility Speech Production Measurement Speech Therapy/*methods 2011/02/19 06:00 2011/09/08 06:00 2011/02/19 06:00 2011/02/17 [aheadofprint] 1058-0360_2011_09-0005 [pii] 10.1044/1058-0360(2011/09-0005) [doi] ppublish Am J Speech Lang Pathol. 2011 May;20(2):95-110. doi: 10.1044/1058-0360(2011/09-0005). Epub 2011 Feb 17. 21249589 NLM MEDLINE 20110511 20111227 1028-768X (Print) 1028-768X (Linking) 20 1 2011 Mar Cerebellar bacterial brain abscess: report of eight cases. 47-52 PURPOSE: To analyze the clinical characteristics and therapeutic outcome o

patients with solely cerebellar bacterial brain abscess (BBA). CASE REPORT : Eight patients with solely cerebellar BBA, collected during a period of 23 years from 210 BBA patients, were included in this study. The eight patients were fiv e men and three women, aged 5-54 years (mean, 36.6 years). Six of them were adul ts, one was a child, and one was an adolescent. Six patients had underlying medical/surgical problems. Of the clinical presentations, dizziness was th e most common (87.5%, 7/8), followed by headache (62.5%, 5/8), altered consciousn ess (62.5%, 5/8), fever (50%, 4/8), ataxia (25%, 2/8), hearing impairment (12. 5%, 1/8), dysarthria (12.5%, 1/8), and hemiparesis (12.5%, 1/8). The Image Sev erity Index (ISI) scores of these eight patients ranged from 6 to 12 points. All eight patients received both medical and surgical treatment. One patient died ow ing to a complication in the neurosurgical procedure and the remaining patients survived. The therapeutic outcome was quantified one month after discharge by modified Rankin scale (mRS) and the result showed six of the seven survivo rs had good outcomes, while the other one had a poor outcome (ataxic gait). CONCL

USION: Cerebellar BBA accounted for 3.8% (8/210) of the overall BBA. In cerebella r BBA, dizziness is a frequent symptom. Early diagnosis and a combination of antimicrobial and neurosurgical intervention is important for its treatmen t. The small case number is a limitation of this study; therefore, further largescale FAU AU AD FAU AU FAU AU FAU AU FAU AU FAU AU FAU AU FAU AU FAU AU LA PT PT PL TA JT JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID PST SO study of cerebellar BBA is needed for better delineation of the clinical characteristics, therapeutic outcome, and prognostic factors. Hsu, Che-Wei Hsu CW Department of Neurology, Chang Gung University College of Medicine, Kaohsiung,Taiwan. Lu, Chen-Hsien Lu CH Chuang, Ming-Jung Chuang MJ Huang, Chi-Ren Huang CR Chuang, Yao-Chung Chuang YC Tsai, Nai-Wen Tsai NW Chen, Shu-Fang Chen SF Chang, Chung-Chih Chang CC Chang, Wen-Neng Chang WN eng Case Reports Journal Article China (Republic : 1949- ) Acta Neurol Taiwan Acta neurologica Taiwanica 9815355 IM Adolescent Adult Ataxia/etiology Brain Abscess/complications/*pathology Cerebellum/*microbiology/*pathology Child Female Glasgow Coma Scale Headache/etiology Hearing Loss/etiology Humans Magnetic Resonance Imaging Male Middle Aged 2011/01/21 06:00 2011/12/28 06:00 2011/01/21 06:00 10196099/20006 [pii] ppublish Acta Neurol Taiwan. 2011 Mar;20(1):47-52.

PMID- 21227642

OWN - NLM STAT- MEDLINE DA - 20111114 DCOM- 20120315 LR - 20130502 IS - 1873-4588 (Electronic) IS - 0892-1997 (Linking) VI - 25 IP - 6 DP - 2011 Nov TI - Changes in speech characters of patients with Parkinson's disease after bi lateral subthalamic nucleus stimulation. PG - 751-8 LID - 10.1016/j.jvoice.2010.08.002 [doi] AB - OBJECTIVE: To investigate the effects of bilateral subthalamic nucleus dee p brain stimulation (STN-DBS) on acoustic characteristics of speech in Chinese pat ients with Parkinson's disease (PD). METHODS: Eleven patients (five men and six women) diagnosed with PD participated in this study. Motor disabilities and speec h samples were evaluated and recorded under six different conditions accordi ng to the states of medication and stimulation. Motor disabilities were evaluate d with the Unified Parkinson's Disease Rating Scale (UPDRS). Acoustic signals wer e recorded from the subjects during production of sustained vowels /a/, /i/, and/u/; repetitions of /pataka/; and sentence production tasks. Acoustic a nalysis was performed with the Multidimensional Voice Program (MDVP), the Motor Sp eech Profile (MSP), and Computerized Speech Lab (CSL) (Kay Elemetrics, Lincoln Park, NJ). RESULTS: Based on the UPDRS III scores, the motor ability of the pati ents improved. There was almost no change in the speech score, which was also supported by the instrumental analysis of PD speech. This indicated that bilateral STN-DBS was associated with a significant improvement in the pat ients' motor disabilities but did not have much influence on speech performance d uring the short time after the stimulation switch was turned on. Furthermore, gender-related differences for speech performance were demonstrated, with the vowel /i/ being more sensitive. CONCLUSION: These results are consistent w ith previous studies that have reported disparity between limb and speech improvements after neurosurgical intervention for PD, such as STN-DBS. The long-term effects of STN-DBS on Parkinsonian speech of Chinese patients sh ould be studied further. CI - Copyright (c) 2011 The Voice Foundation. Published by Mosby, Inc. All righ ts reserved. FAU - Xie, Yan AU - Xie Y AD - Department of Physiology, Key Laboratory for Neurodegenerative Disorders o

f the FAU AU FAU AU FAU AU FAU AU FAU AU FAU AU FAU AU LA PT PT PT DEP PL TA JT JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTPHSTPHSTPHSTAID AID PST SO 1 Jan PMIDOWN STATDA DCOMIS IS Ministry of Education, Capital Medical University, Beijing, PR China. Zhang, Yuqing Zhang Y Zheng, Zhe Zheng Z Liu, Aihua Liu A Wang, Xuan Wang X Zhuang, Ping Zhuang P Li, Yongjie Li Y Wang, Xiaomin Wang X eng Clinical Trial Journal Article Research Support, Non-U.S. Gov't 20110112 United States J Voice Journal of voice : official journal of the Voice Foundation 8712262 IM Adult Aged Asian Continental Ancestry Group *Deep Brain Stimulation Dysarthria/etiology/*therapy Female Humans Male Middle Aged Motor Activity Parkinson Disease/complications/*therapy Severity of Illness Index Sex Factors Speech Acoustics 2011/01/14 06:00 2012/03/16 06:00 2011/01/14 06:00 2010/06/01 [received] 2010/08/18 [accepted] 2011/01/12 [aheadofprint] S0892-1997(10)00156-6 [pii] 10.1016/j.jvoice.2010.08.002 [doi] ppublish J Voice. 2011 Nov;25(6):751-8. doi: 10.1016/j.jvoice.2010.08.002. Epub 201 12. 23362598 NLM MEDLINE 20130131 20130312 0735-0120 (Print) 0735-0120 (Linking)

VI - 36 DP - 2010 Nov TI - Submental muscle tissue compliance during relaxation, contraction, and aft er tone-modification interventions. PG - 6-15 AB - Deviations in muscle tone are presumed to accompany speech motor control d eficits in select forms of dysarthria, although there is little confirmation of th ese associations. For patients experiencing neuromuscular impairments, therape utic interventions and/or principles have been devised to alleviate tone deviat ions where they occur and to prevent the development or exacerbation of tone deviations. Potentially therapeutic effects of these interventions on musc le tone in the speech musculature have not been studied empirically. One reason fo r the paucity of research is that tools for assessing muscle tone in the speech musculature are not generally available. This pilot study explored the feasibility of a commercially available, handheld instrument for measuring submental muscle compliance during relaxed and active conditions in 16 wom en with normal speech and swallowing. Additionally, the study examined changes in muscle compliance when interventions presumed to impact muscle tone were applied to the submental region. The Myotonometer was sensitive to changes in tissue comp liance related to active contraction of the submental musculature. Applying ice o r vibration to the submental region resulted in no systematic changes in sub mental tissue compliance in the relaxed or contracted state. Additional research is needed to validate the use of this instrument to reliably assess muscle to ne and other contributors to tissue compliance. If successful, studies should exa mine the sensitivity of the Myotonometer to assess intervention-induced tissue compliance changes in patient groups with suspected muscle tone impairment s. Further study of intervention effects across muscle groups and dosage leve ls can help inform clinical decisions about the potential usefulness of tone-alte ring interventions for the orofacial musculature. FAU - Clark, Heather M AU - Clark HM AD - Dept of Communication Sciences and Disorders, Appalachian State University , Boone, NC 28608, USA. clarkhm@appstate.edu FAU - Solomon, Nancy Pearl AU - Solomon NP LA - eng PT - Journal Article PL - United States TA - Int J Orofacial Myology JT - The International journal of orofacial myology : official publication of t

he JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTPST SO International Association of Orofacial Myology 8207532 D Cryotherapy Deglutition/physiology Feasibility Studies Female Humans Muscle Contraction/*physiology Muscle Relaxation/*physiology Muscle Tonus/*physiology Myofunctional Therapy/instrumentation Neck Muscles/*physiopathology Pilot Projects Speech/physiology Tongue/physiology Vibration/therapeutic use Young Adult 2010/11/01 00:00 2013/03/13 06:00 2013/02/01 06:00 ppublish Int J Orofacial Myology. 2010 Nov;36:6-15.

PMID- 20831375 OWN - NLM STAT- MEDLINE DA - 20101222 DCOM- 20110506 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) VI - 33 IP - 3 DP - 2011 TI - The impact of stroke-related dysarthria on social participation and implic ations for rehabilitation. PG - 178-86 LID - 10.3109/09638288.2010.517897 [doi] AB - INTRODUCTION: Each year an estimated 30,000-45,000 UK individuals experien ce stroke-related dysarthria (impairment of movements required to produce spe ech). Many will experience persistent dysarthria long after discharge from strok e services. Although we have some insight into the impact of other communica tion impairments, we have very limited information on the impact of dysarthria on social participation. PURPOSE: To explore the impact of dysarthria on soci al participation following stroke. METHODS: We report data from in-depth semi-structured interviews with 24 individuals with stroke-related dysarth ria. RESULTS: Our findings suggest a complex association between the severity o f an individual's dysarthria and the impact on their social participation. Participants' descriptions highlighted their experiences of social partici pation

and isolation. We further suggest that, in some cases, the coping strategi es adopted by the participants could be seen to further exacerbate this isola tion. These results have important implications for the prioritisation, planning and delivery of therapeutic interventions for people with dysarthria. CONCLUSI ONS: The impact of stroke-related dysarthria transcends the physiological impai rment to impact upon individuals' social participation, which is key to the proc ess of rehabilitation. The development and evaluation of the effectiveness of an intervention that addresses these impacts is the next challenge for therap ists and researchers working in this area. FAU - Brady, Marian C AU - Brady MC AD - Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UK. m.brady@gcal.ac.uk FAU - Clark, Alexander M AU - Clark AM FAU - Dickson, Sylvia AU - Dickson S FAU - Paton, Gillian AU - Paton G FAU - Barbour, Rosaline S AU - Barbour RS LA - eng GR - Canadian Institutes of Health Research/Canada PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20100910 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM MH - Adaptation, Psychological MH - Adult MH - Aged MH - Aged, 80 and over MH - Dysarthria/etiology/*psychology/*rehabilitation MH - Female MH - Humans MH - *Interpersonal Relations MH - Interviews as Topic MH - Male MH - Middle Aged MH - Quality of Life MH - Severity of Illness Index MH - Social Adjustment MH - Speech Therapy/methods MH - Stroke/*complications/psychology/rehabilitation EDAT- 2010/09/14 06:00 MHDA- 2011/05/07 06:00 CRDT- 2010/09/14 06:00 PHST- 2010/09/10 [aheadofprint] AID - 10.3109/09638288.2010.517897 [doi] PST - ppublish

SO - Disabil Rehabil. 2011;33(3):178-86. doi: 10.3109/09638288.2010.517897. Epu b 2010 Sep 10. PMIDOWN STATDA DCOMIS IS VI IP DP TI PG LID AB ic l illness and one person with dysarthria following stroke were interviewed i n depth about their experience of living with dysarthria. They covered a range of ages, time post-onset and dysarthria severity levels. Interviews were transcribe d and analysed using Framework Method of Analysis. RESULTS: Acquired dysarthria can negatively impact on speakers' lives. Findings here suggest that the exper ience of living with dysarthria is highly individual. There were some common perspectives. Six key themes emerged from interviews: 'dysarthria as only part of the picture', 'communication has changed', 'people treat me differently', 'dysarthria resulting in negative emotions', 'barriers to communication' a nd 'life is different now. The impact of co-existing physical disability and the need to consider dysarthria in context was emphasised by all participants. CONCLUSION: Findings re-emphasise the need to consider the individual expe rience in clinical practice. The findings provide direction for assessment and intervention in the area. FAU - Walshe, Margaret AU - Walshe M AD - Department of Clinical Speech and Language Studies, Trinity College Dublin , Dublin 2, Ireland. walshema@tcd.ie FAU - Miller, Nick AU - Miller N LA - eng PT - Journal Article DEP - 20100824 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM MH - Adaptation, Psychological 20735274 NLM MEDLINE 20101222 20110506 1464-5165 (Electronic) 0963-8288 (Linking) 33 3 2011 Living with acquired dysarthria: the speaker's perspective. 195-203 10.3109/09638288.2010.511685 [doi] PURPOSE: To explore the speaker's experience of living with acquired chron dysarthria. METHOD: Ten people with dysarthria and progressive neurologica

MH - Adult MH - Aged MH - Cohort Studies MH - Communication MH - *Communication Barriers MH - Communication Disorders/diagnosis/psychology/rehabilitation MH - Dysarthria/etiology/*psychology/*rehabilitation MH - Female MH - Humans MH - Interviews as Topic MH - Male MH - Middle Aged MH - Psychology MH - *Quality of Life MH - Risk Assessment MH - Severity of Illness Index MH - Speech Intelligibility MH - Speech Therapy/methods MH - Stroke/complications/psychology/rehabilitation EDAT- 2010/08/26 06:00 MHDA- 2011/05/07 06:00 CRDT- 2010/08/26 06:00 PHST- 2010/08/24 [aheadofprint] AID - 10.3109/09638288.2010.511685 [doi] PST - ppublish SO - Disabil Rehabil. 2011;33(3):195-203. doi: 10.3109/09638288.2010.511685. Ep ub 2010 Aug 24. PMID- 20534423 OWN - NLM STAT- MEDLINE DA - 20100610 DCOM- 20110602 LR - 20110805 IS - 1522-6662 (Electronic) IS - 1098-3511 (Linking) VI - 13 IP - 3 DP - 2010 Jun TI - Giant floating thrombus localized in the ascending aorta. PG - E195-7 LID - 10.1532/HSF98.20091072 [doi] AB - We report the case of a 32-year-old male patient with symptoms of cerebrov ascular accident manifesting with dysarthria. A transesophageal echocardiogram sho wed a floating mass localized in the ascending aorta, and a multislice computed tomography evaluation confirmed the diagnosis. With a comprehensive assess ment of the mass, we decided on surgical intervention. A pedunculated and fragile mass was seen just near the right coronary ostium. The measured dimensions were 7.7 x 1.0 x 1.5 cm. The removed mass has been analyzed histopathologically and f ound to be the cause of the neurologic findings with an uncertain underlying etiol ogy. FAU - Akyildiz, Mahmut AU - Akyildiz M

AD . FAU AU FAU AU FAU AU FAU AU FAU AU FAU AU LA PT PT PL TA JT JID SB MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID AID PST SO -

Department of Cardiovascular Surgery, Maltepe University, Istanbul, Turkey Zorman, Yilmaz Zorman Y Aksoy, Tamer Aksoy T Yilmazer, Mustafa S Yilmazer MS Erturk, Esra Erturk E Onar, Cagatay L Onar CL Midi, Ahmet Midi A eng Case Reports Journal Article United States Heart Surg Forum The heart surgery forum 100891112 IM Adult Aorta/*pathology/surgery/ultrasonography Echocardiography Echocardiography, Transesophageal Humans Male Thrombosis/*diagnosis/pathology/surgery/ultrasonography Tomography, X-Ray Computed Ultrasonography, Doppler 2010/06/11 06:00 2011/06/03 06:00 2010/06/11 06:00 K86PG86720375828 [pii] 10.1532/HSF98.20091072 [doi] ppublish Heart Surg Forum. 2010 Jun;13(3):E195-7. doi: 10.1532/HSF98.20091072.

PMID- 20528177 OWN - NLM STAT- MEDLINE DA - 20101222 DCOM- 20110506 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) VI - 33 IP - 3 DP - 2011 TI - Anticipatory other-completion of augmentative and alternative communicatio n talk: a conversation analysis study. PG - 261-9 LID - 10.3109/09638288.2010.491574 [doi] AB - PURPOSE: The study described here investigates the practice of anticipator y completion of augmentative and alternative communication (AAC) utterances in progress. The aims were to identify and analyse features of this practice as they

occur in natural conversation between a person using an AAC system and a f amily member. METHOD: The methods and principles of Conversation Analysis (CA) w ere used to video record conversations between people with progressive neurolo gical diseases and a progressive speech disorder (dysarthria) and their family m embers. Key features of interaction were identified and extracts transcribed. Four extracts of talk between a man with motor neurone disease/amyotrophic late ral sclerosis and his mother are presented here. RESULTS: Anticipatory complet ion of AAC utterances is intimately related to the sequential context in which su ch utterances occur. Difficulties can arise from topic shifts, understanding the intended action of an AAC word in progress and in recognising the possible end point an utterance. CONCLUSIONS: The analysis highlights the importance of understanding how AAC talk works in everyday interaction. The role of co-participants is particularly important here. These results may have implications for both AAC software design and clinical intervention. FAU - Bloch, Steven AU - Bloch S AD - Language and Communication Research, University College London, Chandler H ouse, 2, Wakefield Street, London WC1N 1PF, UK. s.bloch@ucl.ac.uk LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20100607 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM MH - Adult MH - Amyotrophic Lateral Sclerosis/*complications/diagnosis/rehabilitation MH - *Communication MH - Communication Aids for Disabled MH - Comprehension MH - Disease Progression MH - Humans MH - Interpersonal Relations MH - Male MH - Mother-Child Relations MH - Speech Disorders/*etiology/rehabilitation MH - Video Recording EDAT- 2010/06/10 06:00 MHDA- 2011/05/07 06:00 CRDT- 2010/06/10 06:00 PHST- 2010/06/07 [aheadofprint] AID - 10.3109/09638288.2010.491574 [doi] PST - ppublish SO - Disabil Rehabil. 2011;33(3):261-9. doi: 10.3109/09638288.2010.491574. Epub 2010 Jun 7.

PMID- 20515326 OWN - NLM STAT- MEDLINE DA - 20100602 DCOM- 20100618 IS - 1933-0715 (Electronic) IS - 1933-0707 (Linking) VI - 5 IP - 6 DP - 2010 Jun TI - Chiari malformation Type I in children younger than age 6 years: presentat ion and surgical outcome. PG - 554-61 LID - 10.3171/2010.3.PEDS09489 [doi] AB - OBJECT: The authors conducted a study to evaluate the unique presenting si gns and symptoms of Chiari malformation Type I (CM-I) in children younger than 6 y ears of age and highlight the benefits of early surgical treatment in this patient population. METHODS: The authors reviewed the medical records of patients who presented to the neurosurgery department before their 6th birthday and subsequently underwent surgery for CM-I. They identified 39 patients who h ad been evaluated between 1984 and 2007 and examined the medical records for presentation, surgical intervention, and outcome. RESULTS: Children aged 0 -2 years commonly presented with oropharyngeal dysfunction (77.8%). Children aged 3-5 years more frequently presented with syringomyelia (85.7%), scoliosis (38.1%), and/or headache (57.1%). All patients underwent posterior fossa craniectomy. Additionally, in many patients cervical laminectomy and/or duraplasty was performed. A few patients required transoral decompression and occipitocervical fusion. In most cases, surgery led to resolution or drama tic improvement of initial symptoms. CONCLUSIONS: Early recognition and surgic al treatment of CM-I in young children leads to good outcomes in the majority of patients. Additional therapies for oropharyngeal dysfunction, syringomyeli a, and scoliosis can frequently be avoided. FAU - Albert, Gregory W AU - Albert GW AD - Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242, USA. FAU - Menezes, Arnold H AU - Menezes AH FAU - Hansen, Daniel R AU - Hansen DR FAU - Greenlee, Jeremy D W AU - Greenlee JD FAU - Weinstein, Stuart L AU - Weinstein SL LA - eng GR - 1K23DC009589-01A1/DC/NIDCD NIH HHS/United States PT - Journal Article

PT PL TA JT JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID PST SO -

Research Support, N.I.H., Extramural United States J Neurosurg Pediatr Journal of neurosurgery. Pediatrics 101463759 IM Arnold-Chiari Malformation/diagnosis/*surgery Cervical Vertebrae/surgery Child, Preschool Craniotomy/methods Decompression, Surgical/methods Deglutition Disorders/diagnosis/etiology/surgery Diagnosis, Differential Dysarthria/diagnosis/etiology/surgery Female Follow-Up Studies Gastroesophageal Reflux/diagnosis/*etiology/surgery Headache Disorders/diagnosis/etiology/surgery Humans Infant Laminectomy/methods Magnetic Resonance Imaging Male Neurologic Examination Occipital Bone/surgery Postoperative Complications/etiology Risk Factors Scoliosis/diagnosis/etiology/surgery Spinal Fusion/methods Syringomyelia/diagnosis/etiology/surgery 2010/06/03 06:00 2010/06/19 06:00 2010/06/03 06:00 10.3171/2010.3.PEDS09489 [doi] ppublish J Neurosurg Pediatr. 2010 Jun;5(6):554-61. doi: 10.3171/2010.3.PEDS09489.

PMID- 20445196 OWN - NLM STAT- MEDLINE DA - 20101115 DCOM- 20110225 IS - 1708-8283 (Electronic) IS - 0883-0738 (Linking) VI - 25 IP - 11 DP - 2010 Nov TI - Early globus pallidus internus stimulation in pediatric patients with gene ralized primary dystonia: long-term efficacy and safety. PG - 1355-61 LID - 10.1177/0883073810365369 [doi] AB - Primary generalized dystonia presents mainly at a young age and commonly i s severely disabling. The authors report the long-term follow-up (mean, 73 m onths; range, 50-101 months) of 5 pediatric patients (mean age at surgery 13 year s; range, 8-16 years) undergoing globus pallidus internus deep brain stimulat ion.

Mean improvement in the Burke-Fahn-Marsden movement score was 67.4% (range , 47.0%-87.5%), 75.4% (range, 61.5%-91.7%), and 83.5% (range, 72.0%-93.3%) a t 3 months, 12 months, and long-term follow-up (>36 months), respectively. Har dware problems (electrode dislocation/breakage of extension cable, and imminent perforation of extension cable) were observed in 2 patients (operative rev ision without sequelae). Except for mild dysarthria in 2 patients, no other therapy-related morbidity was observed. The authors found globus pallidus internus stimulation to offer a very effective and safe therapy in pediatr ic patients with primary dystonia. Early neurosurgical intervention seems to be crucial to prevent irreversible impairment of motor function. FAU - Mehrkens, Jan Hinnerk AU - Mehrkens JH AD - Department of Neurosurgery, Klinikum Grosshadern, Ludwig-Maximilians-Unive rsity, Munich, Germany. Jan.Mehrkens@med.uni-muenchen.de. FAU - Borggraefe, Ingo AU - Borggraefe I FAU - Feddersen, Berend AU - Feddersen B FAU - Heinen, Florian AU - Heinen F FAU - Botzel, Kai AU - Botzel K LA - eng PT - Journal Article DEP - 20100505 PL - United States TA - J Child Neurol JT - Journal of child neurology JID - 8606714 SB - IM MH - Adolescent MH - Child MH - Deep Brain Stimulation/*adverse effects MH - Dystonic Disorders/physiopathology/*therapy MH - Electrodes, Implanted MH - Female MH - Globus Pallidus/*physiology/surgery MH - Humans MH - Male MH - Retrospective Studies MH - Treatment Outcome EDAT- 2010/05/07 06:00 MHDA- 2011/02/26 06:00 CRDT- 2010/05/07 06:00 PHST- 2010/05/05 [aheadofprint] AID - 0883073810365369 [pii] AID - 10.1177/0883073810365369 [doi] PST - ppublish SO - J Child Neurol. 2010 Nov;25(11):1355-61. doi: 10.1177/0883073810365369. Ep ub 2010 May 5. PMID- 20233583

OWN STATDA DCOMLR IS IS VI DP TI s

NLM MEDLINE 20100611 20110125 20131024 1872-6240 (Electronic) 0006-8993 (Linking) 1341 2010 Jun 23 Targeted exercise therapy for voice and swallow in persons with Parkinson'

disease. PG - 3-11 LID - 10.1016/j.brainres.2010.03.029 [doi] AB - Sensorimotor deficits affecting voice and swallowing ability can have a devastating impact on the quality of life of people with Parkinson disease (PD). Recent scientific findings in animal models of PD pinpoint targeted exerci se therapy as a potential treatment to reduce neurochemical loss and decrease parkinsonian symptoms. Although there may be beneficial effects, targeted exercise therapy is not a standard component of therapy for the cranial sensiromotor deficits seen in PD. In this paper, we review the scientific evidence for targeted training for voice and swallowing deficits. The lite rature search revealed 19 publications that included targeted training for voice and only one publication that included targeted training for swallowing. We su mmarize 3 main findings: (1) targeted training may be associated with lasting chan ges in voice behavior; (2) targeted training of sensorimotor actions with anatomi cal or functional overlap with voice and swallowing may improve voice and swallow ing to some degree, but it is unknown whether these effects endure over time; and (3) evidence regarding cranial sensorimotor interventions for Parkinson diseas e is sparse. We concluded that targeted training for voice and swallow is a pro mising but understudied intervention for cranial sensorimotor deficits associated with PD and posit that animal models can be useful in designing empirically bas ed studies that further the science on targeted training. CI - Copyright 2010 Elsevier B.V. All rights reserved. FAU - Russell, John A AU - Russell JA AD - University of Wisconsin School of Medicine and Public Health, Otolaryngolo gy Head and Neck Surgery, USA. russell@surgery.wisc.edu FAU - Ciucci, Michelle R AU - Ciucci MR FAU - Connor, Nadine P AU - Connor NP FAU - Schallert, Timothy AU - Schallert T LA - eng GR - P30 DC010754-01/DC/NIDCD NIH HHS/United States

GR - R01 DC008149-01A1/DC/NIDCD NIH HHS/United States GR - R01 DC008149-05/DC/NIDCD NIH HHS/United States PT - Journal Article PT - Review DEP - 20100315 PL - Netherlands TA - Brain Res JT - Brain research JID - 0045503 SB - IM MH - Animals MH - Deglutition/*physiology MH - Deglutition Disorders/etiology/physiopathology/*therapy MH - Dysarthria/etiology/physiopathology/*therapy MH - Dysphonia/etiology/physiopathology/*therapy MH - Exercise Therapy/*methods MH - Humans MH - Parkinson Disease/complications/physiopathology/*therapy MH - Phonation/*physiology RF - 80 PMC - PMC2908992 MID - NIHMS200160 OID - NLM: NIHMS200160 OID - NLM: PMC2908992 EDAT- 2010/03/18 06:00 MHDA- 2011/01/28 06:00 CRDT- 2010/03/18 06:00 PHST- 2010/02/17 [received] PHST- 2010/03/08 [accepted] PHST- 2010/03/15 [aheadofprint] AID - S0006-8993(10)00573-1 [pii] AID - 10.1016/j.brainres.2010.03.029 [doi] PST - ppublish SO - Brain Res. 2010 Jun 23;1341:3-11. doi: 10.1016/j.brainres.2010.03.029. Epu b 2010 Mar 15. PMID- 20085536 OWN - NLM STAT- MEDLINE DA - 20101011 DCOM- 20110124 LR - 20110906 IS - 1460-6984 (Electronic) IS - 1368-2822 (Linking) VI - 45 IP - 6 DP - 2010 Nov-Dec TI - Non-speech oro-motor exercise use in acquired dysarthria management: regim es and rationales. PG - 617-29 LID - 10.3109/13682820903470577 [doi] AB - BACKGROUND: Non-speech oro-motor exercises (NSOMExs) are described in spee ch and language therapy manuals and are thought to be much used in acquired dysar thria intervention, though there is no robust evidence of an influence on speech outcome. Opinions differ as to whether, and for which dysarthria presentat ions,

NSOMExs are appropriate. AIMS: The investigation sought to collect development-phase data, in accordance with the Medical Research Council (M RC) evaluation of complex interventions. The aims were to establish the extent of use of NSOMExs in acquired disorders, the exercise regimes in use for dysarthr ia, with which dysarthric populations, and the anticipated clinical outcomes. A further aim was to determine the influencing rationales where NSOMExs were or were not used in dysarthria intervention. METHODS & PROCEDURES: Speech and language therapists throughout Scotland, Wales, and Northern Ireland, work ing with adult-acquired dysarthria, were identified by their service heads. Th ey received postal questionnaires comprising 21 closed and two open questions , covering respondent biographics, use of NSOMExs, anticipated clinical outc omes, and practice influencing rationales. OUTCOME & RESULTS: One hundred and ninety-one (56% response) completed questionnaires were returned. Eighty-o ne per cent of respondents used NSOMExs in dysarthria. There was no association w ith years of speech and language therapy experience. Those who used and those who did not use NSOMExs provided similar influencing rationales, including evidenc e from their own practice, and Higher Education Institute teaching. More experien ced speech and language therapists were more likely than those more recently qualified to be guided by results from their own practice. Input from the attended Higher Education Institute was more influential for those less experienced than for those more experienced. Clinical outcome aims were no t confined to speech, but also included improvements in movement, sensory awareness, appearance, emotional status, dysphagia and drooling. NSOMExs w ere used with many neurological disorders, especially stroke, all dysarthria c lasses, especially flaccid, and all severity levels. Tongue and lip exercises were more frequent than face, jaw and soft palate. The most common regimes were four to six repetitions of each exercise, during three practice periods daily, each of 6-10 min. CONCLUSIONS & IMPLICATIONS: NSOMExs are a frequent component of dysar thria management in the UK-devolved government countries. This confirmation, alo ng with the details of speech and language therapy practice, provides a foundation for clinical research which will compare outcomes for people with dysarthria, whose management includes and does not include NSOMExs. Speech and language ther apy practice may be guided by evidence that speech outcome is or is not affect ed by NSOMExs.

FAU - Mackenzie, Catherine AU - Mackenzie C AD - Educational and Professional Studies, University of Strathclyde, Glasgow, UK. c.mackenzie@strath.ac.uk FAU - Muir, Margaret AU - Muir M FAU - Allen, Carolyn AU - Allen C LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Int J Lang Commun Disord JT - International journal of language & communication disorders / Royal Colleg e of Speech & Language Therapists JID - 9803709 SB - IM MH - Adult MH - Apraxias/rehabilitation/therapy MH - Deglutition Disorders/rehabilitation/therapy MH - Dysarthria/rehabilitation/*therapy MH - Efferent Pathways/physiology MH - Evidence-Based Medicine MH - Exercise Therapy/*methods/*utilization MH - Great Britain MH - *Health Care Surveys MH - Humans MH - Language Therapy/methods MH - Mouth/innervation/physiology MH - Questionnaires MH - Speech Therapy/*methods EDAT- 2010/01/21 06:00 MHDA- 2011/01/25 06:00 CRDT- 2010/01/21 06:00 AID - 10.3109/13682820903470577 [doi] PST - ppublish SO - Int J Lang Commun Disord. 2010 Nov-Dec;45(6):617-29. doi: 10.3109/13682820903470577. PMIDOWN STATDA DCOMLR IS IS VI IP DP TI PG LID AB t for less 20023529 NLM MEDLINE 20091221 20100302 20131121 1524-4040 (Electronic) 0148-396X (Linking) 66 1 2010 Jan Severe aggressive acute disseminated encephalomyelitis-like reaction after aneurysm coiling. E222-3; discussion E223 10.1227/01.NEU.0000362001.81386.BE [doi] OBJECTIVE: Neurointerventional procedures are the first choice of treatmen a variety of cerebrovascular pathologies in many centers worldwide. Although

invasive than conventional traditional surgical approaches, interventional procedures are not exempt from complications. We describe a case of an unu sual complication after a coiling procedure where the patient developed severe brain edema induced by contrast media and resembling an aggressive acute dissemi nated encephalomyelitis-like reaction that was reversed with appropriate therapy . CLINICAL PRESENTATION: A 53-year-old, right-handed woman presented with an incidental 4 x 6-mm anterior communicating complex aneurysm, which was successfully coiled with balloon assistance. On the third postcoiling day, she presented to the emergency department with global aphasia, dysarthria, rig ht upper motor neuron pattern facial paresis, and right hemiplegia and hemianesthesia. INTERVENTION: The initial intervention was a microballoon-assisted coiling of the anterior communicating complex aneury sm. The intervention for the subsequent complication was high-dose intravenous methylprednisolone for 5 days followed by slow tapering of oral prednisolo ne. At a 4-month follow-up examination, the patient was asymptomatic and neurolog ically intact. CONCLUSION: We present a case of an unusual complication after a c oiling procedure. Considering that endovascular interventional procedures are par t of the therapeutic armamentarium for cerebrovascular pathologies, it is of fundamental importance to increase awareness of potential complications th at could arise from such interventions. FAU - Deus-Silva, Leonardo AU - Deus-Silva L AD - Neurointerventional and Neuroradiology Section, Department of Diagnostic I maging, University of Ottawa, The Ottawa Hospital-Civic Campus, Ottawa, Ontario, C anada. FAU - Lum, Cheemun AU - Lum C FAU - De Meulemeester, Christine AU - De Meulemeester C FAU - dos Santos, Marlise P AU - dos Santos MP LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Neurosurgery JT - Neurosurgery JID - 7802914 RN - 0 (Anti-Inflammatory Agents) RN - X4W7ZR7023 (Methylprednisolone) SB - IM MH - Aneurysm/*surgery MH - Anti-Inflammatory Agents/therapeutic use MH - Cerebral Angiography/methods MH - Embolization, Therapeutic/*adverse effects MH - Encephalomyelitis/drug therapy/*etiology MH - Female

MH MH MH MH MH EDATMHDACRDTAID AID PST SO -

Humans Methylprednisolone/therapeutic use Middle Aged Surgical Instruments/*adverse effects Tomography Scanners, X-Ray Computed 2009/12/22 06:00 2010/03/03 06:00 2009/12/22 06:00 10.1227/01.NEU.0000362001.81386.BE [doi] 00006123-201001000-00027 [pii] ppublish Neurosurgery. 2010 Jan;66(1):E222-3; discussion E223. doi: 10.1227/01.NEU.0000362001.81386.BE.

PMID- 19821391 OWN - NLM STAT- MEDLINE DA - 20091012 DCOM- 20100127 LR - 20140317 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) IP - 4 DP - 2009 TI - Speech therapy for children with dysarthria acquired before three years of age. PG - CD006937 LID - 10.1002/14651858.CD006937.pub2 [doi] AB - BACKGROUND: Children with motor impairments often have the motor speech di sorder dysarthria, a condition which effects the tone, power and coordination of any or all of the muscles used for speech. Resulting speech difficulties can rang e from mild, with slightly slurred articulation and low-pitched voice, to profoun d, with an inability to produce any recognisable words. Children with dysarthria a re often prescribed communication aids to supplement their natural forms of communication. However, there is variation in practice regarding the provi sion of therapy focusing on voice and speech production. Descriptive studies have suggested that therapy may improve speech, but its effectiveness has not b een evaluated. OBJECTIVES: To assess whether direct intervention aimed at impr oving the speech of children with dysarthria is more effective than no intervent ion at all. To assess whether individual types of intervention are more effective than others in improving the speech intelligibility of children with dysarthria . SEARCH STRATEGY: We searched CENTRAL, MEDLINE, EMBASE, CINAHL , LLBA, ERIC , PsychInfo, Web of Science, Scopus, UK National Research Register and Disse rtation Abstracts up to April 2009, handsearched relevant journals published betwe en 1980 and April 2009, and searched proceedings of relevant conferences between 1996-2009. SELECTION CRITERIA: We considered randomised controlled trials

and studies using quasi-experimental designs in which children were allocated to groups using non-random methods. DATA COLLECTION AND ANALYSIS: L Penningto n conducted searches of all databases and conference reports. L Pennington, N Miller and S Robson handsearched journals. All searches included a reliabi lity check in which a second review author independently checked a random sampl e comprising 15% of all identified reports. We planned that two review autho rs would independently assess the quality and extract data from eligible stud ies. MAIN RESULTS: No randomised controlled trials or group studies were identi fied. AUTHORS' CONCLUSIONS: We found no firm evidence of the effectiveness of sp eech and language therapy to improve the speech of children with early acquired dysarthria. No change in practice is warranted at the present time. Rigoro us research is needed to investigate if the positive changes in children's sp eech observed in small descriptive studies are shown in randomised controlled t rials. Research should examine change in children's speech production and intelligibility. It should also investigate the secondary education, healt h and social care outcomes of intervention, including children's interaction wit h family, friends and teachers, their participation in social and educationa l activities, and their quality of life. Cost and acceptability of intervent ions must also be investigated. FAU - Pennington, Lindsay AU - Pennington L AD - Institute of Health and Society, University of Newcastle, Sir James Spence Institute - Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK, NE1 4LP. FAU - Miller, Nick AU - Miller N FAU - Robson, Sheila AU - Robson S LA - eng GR - CDF/01/021/Department of Health/United Kingdom PT - Journal Article PT - Review DEP - 20091007 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM MH - Child MH - Child, Preschool MH - Dysarthria/*therapy MH - Humans

MH MH RF EDATMHDACRDTAID PST SO PMIDOWN STATDA DCOMIS IS VI IP DP TI m y:

Speech Intelligibility *Speech Therapy 37 2009/10/13 06:00 2010/01/28 06:00 2009/10/13 06:00 10.1002/14651858.CD006937.pub2 [doi] epublish Cochrane Database Syst Rev. 2009 Oct 7;(4):CD006937. doi: 10.1002/14651858.CD006937.pub2. 19625893 NLM MEDLINE 20090723 20091027 1524-4040 (Electronic) 0148-396X (Linking) 65 2 2009 Aug Successful stenting by combination technique of reverse flow and downstrea filtering for long chronic total occlusion of the cervical vertebral arter

technical case report. PG - E378-9; discussion E379 LID - 10.1227/01.NEU.0000348293.01482.0F [doi] AB - OBJECTIVE: To report a case of successful recanalization using the combina tion technique of reverse flow and downstream filtering in chronic total occlus ion of the bilateral vertebral artery (VA). CLINICAL PRESENTATION: A 59-year-old man had experienced attacks consisting of vertigo and/or dysarthria more than 1 ye ar before presentation. He experienced symptoms despite the administration of antiplatelet drugs and presented to our institution. Diagnostic cerebral angiography demonstrated that the right VA was not occluded at the ostium but, rather, along its midcervical portion and that the left VA ended in the le ft posterior inferior cerebellar artery. INTERVENTION: Long chronic total occ lusion of the right cervical VA was recanalized successfully and safely by revers e flow and downstream filtering with proximal flow blockade and a distal filter d evice positioned in the right brachial artery. Follow-up angiography at 1 year demonstrated no re-occlusion. The patient's symptoms disappeared after recanalization and did not recur. To our knowledge, there are no reports describing successful angioplasty and/or stenting for long chronic total occlusion of the cervical VA. CONCLUSION: Stenting using the combination technique of reverse flow and downstream filtering can safely open even lo ng chronic cervical VA occlusion and may be effective in the treatment of pat ients experiencing vertebrobasilar insufficiency due to bilateral chronic VA occ lusion. FAU - Iwata, Tomonori

AU - Iwata T AD - Department of Stroke Treatment, Shonan Kamakura General Hospital, Kamakura , Japan. FAU - Mori, Takahisa AU - Mori T FAU - Tajiri, Hiroyuki AU - Tajiri H FAU - Nakazaki, Masahito AU - Nakazaki M LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Neurosurgery JT - Neurosurgery JID - 7802914 RN - 0 (Platelet Aggregation Inhibitors) SB - IM MH - Angioplasty/*instrumentation/*methods MH - Brain Stem/blood supply/physiopathology MH - Catheterization/instrumentation MH - Cerebellum/blood supply/physiopathology MH - Cerebral Angiography MH - Cerebrovascular Circulation/physiology MH - Chronic Disease MH - Dysarthria/etiology MH - Humans MH - Male MH - Middle Aged MH - Platelet Aggregation Inhibitors/therapeutic use MH - *Stents MH - Treatment Outcome MH - Vertebral Artery/pathology/radiography/*surgery MH - Vertebrobasilar Insufficiency/pathology/radiography/*surgery MH - Vertigo/etiology EDAT- 2009/07/25 09:00 MHDA- 2009/10/29 06:00 CRDT- 2009/07/24 09:00 AID - 10.1227/01.NEU.0000348293.01482.0F [doi] AID - 00006123-200908000-00020 [pii] PST - ppublish SO - Neurosurgery. 2009 Aug;65(2):E378-9; discussion E379. doi: 10.1227/01.NEU.0000348293.01482.0F. PMIDOWN STATDA DCOMIS IS VI IP DP TI 19565392 NLM MEDLINE 20100105 20100421 1460-6984 (Electronic) 1368-2822 (Linking) 45 1 2010 Jan-Feb Effectiveness of Lee Silverman Voice Treatment (LSVT) on hypernasality in non-progressive dysarthria: the need for further research. PG - 31-46 LID - 10.3109/13682820802638618 [doi] AB - BACKGROUND: Hypernasality is a common feature of non-progressive dysarthri

a. However, limited research has investigated the effectiveness of treatments for this impairment. Preliminary research has revealed positive effects on nas alance when using increased loudness in certain non-progressive dysarthric speake rs. However, the long-term effects of loud speech on nasalance as part of a structured intervention such as Lee Silverman Voice Treatment (LSVT) are y et to be investigated in this population. AIMS: The study aimed to investigate t he short- and long-term effects of LSVT on hypernasality (perceptual ratings and degree of nasalance) in non-progressive dysarthria; and secondly, to evalu ate the effects of traditional dysarthria therapy on these same measures, in compa rison with the effects of LSVT. METHODS & PROCEDURES: Ten non-progressive dysart hric speakers with varying levels of hypernasality (taken from a larger researc h study) were randomly allocated to receive LSVT((R)) (n = 5) or individuall y tailored traditional dysarthria therapy (n = 5). Both treatments were administered four times weekly for 4 weeks (that is, 16 x 1-hour sessions) . Participants were assessed twice before treatment, twice immediately post-treatment, and twice at follow-up 6 months post-treatment using a per ceptual rating task performed by two independent speech pathologists, and the Naso meter. Changes to individual mean nasalance scores were compared against clinical ly significant criterion and perceptual ratings were analysed descriptively. OUTCOMES & RESULTS: Three out of five participants demonstrated reductions in perceived hypernasality immediately following LSVT, but these changes were maintained at follow-up for only one participant. Two of these three parti cipants demonstrated a corresponding reduction in mean nasalance. Limited changes in perceived hypernasality and nasalance scores were found following traditio nal dysarthria therapy, with only one participant exhibiting reduced nasalance at follow-up. CONCLUSIONS & IMPLICATIONS: Due to the small sample size in the present research and variability between participants, further exploration into the effects of LSVT on nasality with a larger population with different dysarthria types is essential. FAU - Wenke, Rachel J AU - Wenke RJ AD - daggerDivision of Speech Pathology, School of Health and Rehabilitation Sc iences, The University of Queensland, St Lucia, Australia. FAU - Theodoros, Deborah AU - Theodoros D FAU - Cornwell, Petrea AU - Cornwell P

LA PT PT PT PL TA JT e of JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID AID PST SO PMIDOWN STATDA DCOMLR IS IS VI IP DP TI sive

eng Comparative Study Journal Article Randomized Controlled Trial England Int J Lang Commun Disord International journal of language & communication disorders / Royal Colleg Speech & Language Therapists 9803709 IM Adult Aged, 80 and over Dysarthria/*therapy Female Follow-Up Studies Humans Male Middle Aged Severity of Illness Index Time Factors Treatment Outcome *Voice Quality *Voice Training Young Adult 2009/07/01 09:00 2010/04/22 06:00 2009/07/01 09:00 912782895 [pii] 10.3109/13682820802638618 [doi] ppublish Int J Lang Commun Disord. 2010 Jan-Feb;45(1):31-46. doi: 10.3109/13682820802638618. 19294553 NLM MEDLINE 20091120 20100527 20110906 1460-6984 (Electronic) 1368-2822 (Linking) 44 4 2009 Jul-Aug Cognitive-linguistic deficit and speech intelligibility in chronic progres

multiple sclerosis. PG - 401-20 LID - 10.1080/13682820802697879 [doi] AB - BACKGROUND: Multiple sclerosis is a disabling neurological disease with va ried symptoms, including dysarthria and cognitive and linguistic impairments. Association between dysarthria and cognitive-linguistic deficit has not be en explored in clinical multiple sclerosis studies. AIMS: In patients with ch ronic progressive multiple sclerosis, the study aimed to investigate the presenc e and nature of cognitive-linguistic deficit, the association between levels of

cognitive-linguistic ability and speech intelligibility, and of both of th ese with functional disability and time since onset of multiple sclerosis symp toms. METHODS & PROCEDURES: The Arizona Battery for Communication Disorders of D ementia (ABCD) (Bayles and Tomoeda 1993 ), The Assessment of Intelligibility of Dysarthric Speech (AIDS) Sentence Intelligibility Task (Yorkston and Beuke lman 1984 ), and the Modified Barthel Activities of Daily Living Index (MBADLI) (Shah 1998 ) were administered to 24 chronic progressive multiple sclerosis participants with dysarthria. A total of 24 non-neurologically impaired participants, matched for gender, age and education, formed a control grou p. OUTCOMES & RESULTS: For multiple sclerosis participants, linear regression analysis showed a strong association between ABCD and AIDS (beta = 0.89, p = 0.005), no association between ABCD and either MBADLI or time since onset, a strong association between AIDS and MBADLI (beta = 0.60, p = 0.001), and a trend towards an association between AIDS and time since onset (beta = -0.29, p = 0.08). Correlations between the four included ABCD construct scores and be tween these and the total ABCD score were significant (r>0.60, p<0.01). For each of the 15 included ABCD measures and for the four construct scores and the overal l ABCD score, multiple sclerosis and control group performances were significantl y different (p<0.01) and effect sizes were large (d>0.80). CONCLUSIONS & IMPLICATIONS: The results revealed a strong association between dysarthria , as measured by connected speech intelligibility testing, and cognitive-lingui stic deficit, in people with chronic progressive-type multiple sclerosis. While some of the impairments that are associated with multiple sclerosis, including motor speech disorder, may influence performance on the ABCD, the data support t he conclusion that marked cognitive-linguistic deficit is present in chronic progressive-type multiple sclerosis patients with dysarthria. Deterioratio n was global, rather than being indicative of a construct specific deficit, and encompassed language, both expression and comprehension. Episodic memory a nd linguistic expression were especially affected. Speech and language therap ists who work with dysarthric patients with chronic progressive multiple sclero sis should monitor cognitive-linguistic impairment. An awareness of this might influence assessment, intervention and management, including the informati on and advice given to patients and their relatives. FAU - Mackenzie, Catherine AU - Mackenzie C AD - Department of Educational and Professional Studies, University of Strathcl

yde, FAU AU LA PT PT PL TA JT e of JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID AID PST SO Glasgow, UK. Green, Jan Green J eng Journal Article Research Support, Non-U.S. Gov't England Int J Lang Commun Disord International journal of language & communication disorders / Royal Colleg Speech & Language Therapists 9803709 IM Activities of Daily Living Adult Aged Cognition Disorders/*etiology Dysarthria/*etiology Female Humans Male Middle Aged Multiple Sclerosis, Chronic Progressive/*psychology Neuropsychological Tests *Speech Intelligibility Speech Production Measurement/methods Young Adult 2009/03/19 09:00 2010/05/28 06:00 2009/03/19 09:00 909589594 [pii] 10.1080/13682820802697879 [doi] ppublish Int J Lang Commun Disord. 2009 Jul-Aug;44(4):401-20. doi: 10.1080/13682820802697879.

PMID- 19156018 OWN - NLM STAT- MEDLINE DA - 20090703 DCOM- 20100323 IS - 1973-9095 (Electronic) IS - 1973-9087 (Linking) VI - 45 IP - 2 DP - 2009 Jun TI - A Cochrane review of treatment for dysarthria following acquired brain inj ury in children and adolescents. PG - 197-204 AB - BACKGROUND: The expression ''acquired brain injury'' (ABI) incorporates a range of etiologies including cerebrovascular accident, brain tumour and traumat ic brain injury. ABI is a common cause of disability in the pediatric populat ion, and dysarthria is a common and often persistent sequelae associated with A BI in children. OBJECTIVES: The aim of this study was to assess the efficacy of

intervention delivered by Speech and Language Pathologists/Therapists targ eting dysarthric speech in children resulting from acquired brain injury. METHOD S: Several electronic databases were searched up to January 2007. The review considered randomised controlled trials (RCTs) and quasi-randomised studie s of children aged 3 to 16 years with acquired dysarthria grouped by aetiology (e.g., brain tumour, traumatic brain injury, cerebrovascular accident). Both auth ors independently assessed the titles and abstracts for relevance (100% interrater reliability) and the full text version of all potentially relevant article s was obtained. No studies met inclusion criteria. RESULTS: Of 2091 titles and abstracts identified, full text versions of only three were obtained. The remaining 2 088 were excluded, largely on the basis of not including dysar thria, being diagnostic or descriptive papers, and for concerning adults rather t han children. All obtained articles were excluded due to including populations without ABI, adults with dysarthria, or inappropriate design. Thus, no stu dies met inclusion criteria. CONCLUSIONS: The review demonstrates a critical la ck of studies, let alone RCTs, addressing treatment efficacy for dysarthria in c hildren with ABI. Possible reasons to explain this lack of data include 1) a lack of understanding of the characteristics or natural history of dysarthria asso ciated with this population; 2) the lack of a diagnostic classification system fo r children precluding the development of well targeted intervention programs ; and 3) the heterogeneity of both the etiologies and resultant possible dysarth ria types of pediatric ABI. Efforts should first be directed at modest well-controlled studies to identify likely efficacious treatments that may then be trialled in multicentre collaborations using quasi-randomised or RCT methodology. FAU - Morgan, A T AU - Morgan AT AD - Healthy Development [Theme], Language and Literacy, Murdoch Children Resea rch Institute, Melbourne, Australia. angela.morgan@mcri.edu.au FAU - Vogel, A P AU - Vogel AP LA - eng PT - Journal Article PT - Review DEP - 20090121 PL - Italy TA - Eur J Phys Rehabil Med JT - European journal of physical and rehabilitation medicine JID - 101465662 SB - IM MH - Adolescent

MH MH MH MH MH MH MH MH RF EDATMHDACRDTPHSTAID PST SO PMIDOWN STATDA DCOMLR IS IS VI IP DP TI ity PG LID AB ed,

Brain Injuries/*complications/*rehabilitation Child Child, Preschool Dysarthria/*etiology/*rehabilitation Evidence-Based Medicine Humans Randomized Controlled Trials as Topic Speech Therapy/*methods 39 2009/01/22 09:00 2010/03/24 06:00 2009/01/22 09:00 2009/01/21 [aheadofprint] R33092061 [pii] ppublish Eur J Phys Rehabil Med. 2009 Jun;45(2):197-204. Epub 2009 Jan 21. 19107655 NLM MEDLINE 20091120 20100527 20110906 1460-6984 (Electronic) 1368-2822 (Linking) 44 5 2009 Sep-Oct Acquired dysarthria in conversation: identifying sources of understandabil

problems. - 769-83 - 10.1080/13682820802546969 [doi] - BACKGROUND: Acquired progressive dysarthria is traditionally assessed, rat and researched using measures of speech perception and intelligibility. The fo cus is commonly on the individual with dysarthria and how speech deviates from a normative range. A complementary approach is to consider the features and consequences of dysarthric speech as it is produced as a turn-at-talk in e veryday interaction and in particular the ways in which this talk may be identifie d by its recipient as problematic to understand. AIMS: To investigate how dysar thric turns-at-talk in everyday conversation may be problematic to understand. F urther, to describe how recipients of dysarthric talk identify the source of probl ematic understandings to the dysarthric speaker. METHODS & PROCEDURES: Video data of natural conversation from two dyads were selected for this paper. The dyad s were video-recorded at home, at 3-monthly intervals, over a maximum period of 1 8 months. Using the methods of conversation analysis a collection of sequenc es was identified and transcribed. The sequences were analysed with reference to how the recipients of dysarthric talk, through the use of other-initiations of rep

air, identified some element of that talk as problematic. OUTCOMES & RESULTS: T his work shows how a recipient of a dysarthric talk turn in everyday conversat ion goes about displaying the problematicity of that turn to its speaker. Whil st displaying that a problem exists with a prior turn, the recipient may have difficulty in knowing what that problem actually is. CONCLUSIONS & IMPLICA TIONS: It is proposed that clinicians and researchers should consider the effects of dysarthric speech in interaction. Specifically, the nature of dysarthric t roubles and the practices used to signal understanding problems as they occur in e veryday interaction should be fully explored. This consideration may have relevanc e for clinical assessment and intervention. FAU - Bloch, Steven AU - Bloch S AD - Research Department of Language and Communication, University College Lond on, London, UK. s.bloch@ucl.ac.uk FAU - Wilkinson, Ray AU - Wilkinson R LA - eng PT - Journal Article PL - England TA - Int J Lang Commun Disord JT - International journal of language & communication disorders / Royal Colleg e of Speech & Language Therapists JID - 9803709 SB - IM MH - Aged MH - Comprehension MH - Dysarthria/etiology/*psychology MH - Female MH - Humans MH - *Interpersonal Relations MH - Male MH - Motor Neuron Disease/complications MH - *Speech Intelligibility MH - Speech Perception MH - Speech Production Measurement/methods MH - Video Recording EDAT- 2008/12/25 09:00 MHDA- 2010/05/28 06:00 CRDT- 2008/12/25 09:00 AID - 907201008 [pii] AID - 10.1080/13682820802546969 [doi] PST - ppublish SO - Int J Lang Commun Disord. 2009 Sep-Oct;44(5):769-83. doi: 10.1080/13682820802546969. PMIDOWN STATDA 18821230 NLM MEDLINE 20091120

DCOMLR IS IS VI IP DP TI -

20100527 20110906 1460-6984 (Electronic) 1368-2822 (Linking) 44 5 2009 Sep-Oct Dysarthria impact profile: development of a scale to measure psychosocial effects. PG - 693-715 LID - 10.1080/13682820802317536 [doi] AB - BACKGROUND: The psychosocial impact of acquired dysarthria on the speaker is well recognized. To date, speech-and-language therapists have no instrument ava ilable to measure this construct. This has implications for outcome measurement a nd for planning intervention. This paper describes the Dysarthria Impact Profile (DIP), an instrument that has the potential to meet this need in clinical practic e. AIMS: To describe the development of the DIP, which was devised as part of a larger study to measure psychosocial impact of acquired dysarthria from th e speaker's perspective. METHODS & PROCEDURES: The current psychometric prop erties of the DIP are examined. The scale was administered to 31 participants wit h acquired dysarthria. The internal consistency of the scale items and their intra-rater reliability were investigated. Concurrent validity was assesse d for the portion of the scale (Section A) assessing impact of acquired dysarthr ia on self-perception, self-concept and self-esteem by comparing the results wit h changes in self-concept as determined by the Head Injury Semantic Differen tial Scale (HISD II). OUTCOMES & RESULTS: The DIP shows good internal consisten cy and strong intra-rater reliability overall. There was a strong, statistically significant, correlation between results on Section A of the DIP and the r esults of the HISD II suggesting convergent validity for this portion of the scal e. There are some limitations to the scale in its current format and these ar e highlighted. CONCLUSIONS & IMPLICATIONS: The scale is now ready for furthe r refinement and development. Once validated, it should act as a robust outc ome measure for clinicians. FAU - Walshe, Margaret AU - Walshe M AD - Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Irel and. walshema@tcd.ie FAU - Peach, Richard K AU - Peach RK FAU - Miller, Nick

AU LA PT PT PL TA JT e of JID SB MH MH MH MH MH MH MH MH MH MH MH MH MH MH EDATMHDACRDTAID AID PST SO PMIDOWN STATDA DCOMIS IS VI IP DP TI ased

Miller N eng Journal Article Validation Studies England Int J Lang Commun Disord International journal of language & communication disorders / Royal Colleg Speech & Language Therapists 9803709 IM Adult Aged Aged, 80 and over Dysarthria/etiology/*psychology/rehabilitation Female Humans Male Middle Aged Observer Variation Pilot Projects Psychometrics Reproducibility of Results Self Concept Speech Intelligibility 2008/09/30 09:00 2010/05/28 06:00 2008/09/30 09:00 903088484 [pii] 10.1080/13682820802317536 [doi] ppublish Int J Lang Commun Disord. 2009 Sep-Oct;44(5):693-715. doi: 10.1080/13682820802317536. 18672403 NLM MEDLINE 20090324 20090511 1878-1632 (Electronic) 1529-9430 (Linking) 9 4 2009 Apr Infectious Collet-Sicard syndrome in the differential diagnosis of cerebrovascular accident: a case of head-to-neck dissociation with skull-b

osteomyelitis. PG - e6-e10 LID - 10.1016/j.spinee.2008.05.012 [doi] AB - BACKGROUND CONTEXT: Collet-Sicard syndrome (CSS) is a rare condition that includes palsies of cranial nerves IX, X, XI, and XII. There are multiple reported causes in the literature, although infection is particularly unus ual. PURPOSE: To report an unusual case of CSS as a result of infection causing head-to-neck dissociation with involvement of the upper cervical spine. ST UDY DESIGN: Case report. METHODS: A 56-year-old male with medical comorbiditie s developed a cranial-based infection secondary to initial incomplete treatm

ent of otitis media. The mass effect of the infection resulted in multiple crania l nerve palsies and extremity symptoms initially confused with a cerebrovascular accident. Clinical course of the patient and a review of CSS are presented . RESULTS: With progression of the disease, further evaluation revealed a disseminated upper cervical and skull-based infection causing destructive head-to-neck infectious instability. This was treated with posterior occipitocervical debridement, fixation, and fusion and appropriate long-te rm antibiotics. Over the course of several months, the infection resolved and there was a significant improvement in his dysphagia, dysarthria, and hearing. CONCLUSIONS: Delay in diagnosis of CSS is common, and this syndrome should be considered in patients who present with a constellation of lower cranial n erve palsies. Early recognition and treatment should result in successful recov ery, but even in cases of delayed detection, suitable intervention can result i n substantial clinical improvement. FAU - Sibai, Tarek A AU - Sibai TA AD - Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030, USA. FAU - Ben-Galim, Peleg J AU - Ben-Galim PJ FAU - Eicher, Susan A AU - Eicher SA FAU - Reitman, Charles A AU - Reitman CA LA - eng PT - Case Reports PT - Journal Article DEP - 20080731 PL - United States TA - Spine J JT - The spine journal : official journal of the North American Spine Society JID - 101130732 SB - IM MH - *Atlanto-Axial Joint/radiography/surgery MH - Cervical Vertebrae/radiography/surgery MH - Cranial Nerve Diseases/*etiology/radiography MH - Diagnosis, Differential MH - Humans MH - Joint Instability/*etiology/surgery MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Occipital Bone/radiography/surgery MH - Osteomyelitis/*etiology/radiography/surgery MH - Otitis Media/complications MH - Spinal Fusion MH - Stroke/*etiology/pathology MH - Syndrome MH - Tomography, X-Ray Computed EDAT- 2008/08/02 09:00

MHDACRDTPHSTPHSTPHSTPHSTAID AID PST SO 8 Jul

2009/05/12 09:00 2008/08/02 09:00 2008/01/21 [received] 2008/03/18 [revised] 2008/05/19 [accepted] 2008/07/31 [aheadofprint] S1529-9430(08)00215-5 [pii] 10.1016/j.spinee.2008.05.012 [doi] ppublish Spine J. 2009 Apr;9(4):e6-e10. doi: 10.1016/j.spinee.2008.05.012. Epub 200 31.

PMID- 21276116 OWN - NLM STAT- MEDLINE DA - 20110720 DCOM- 20120301 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 47 IP - 7 DP - 2011 Jul TI - Basilar artery occlusion in a 14-year old female successfully treated with acute intravascular intervention: case report and review of the literature. PG - 408-14 LID - 10.1111/j.1440-1754.2010.01974.x [doi] AB - Basilar artery occlusion (BAO) is a rare cause of paediatric stroke that m ay result in severe neurological disability including a 'locked-in' state. Ac ute interventional therapy for paediatric BAO is limited to a small number of published case reports. Of 13 previously published cases that have undergo ne acute intravascular therapy, six made a full neurological recovery, six ha d residual deficits ranging from mild dysarthria and ataxia to vegetative st ate and one patient died. The time from symptom onset to intervention was >/= 12 h in 77% (10/13). We reported a 14-year-old female patient presenting with altered sensorium that progressed to a 'locked-in' state due to idiopathic BAO who made a full clinical recovery after successful mechanical thrombectomy at 24 h fo llowing symptom onset. Acute neuro-interventional therapy for paediatric BAO can r esult in complete neurological recovery despite the presence of severe neurologi cal deficits and a prolonged period of time from symptom onset to clinical dia gnosis. CI - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011 Paediatrics and Child Health Division (Royal Australasian College of Physi cians). FAU - Taneja, Sanjeev R AU - Taneja SR AD - Department of Neurology, Liverpool Hospital, Liverpool, Sydney, New South Wales, Australia.

FAU AU FAU AU FAU AU FAU AU LA PT PT PT DEP PL TA JT JID SB MH MH MH MH MH EDATMHDACRDTPHSTAID PST SO PMIDOWN STATDA DCOMLR IS IS VI IP DP TI -

Hanna, Ibrahim Hanna I Holdgate, Anna Holdgate A Wenderoth, Jason Wenderoth J Cordato, Dennis J Cordato DJ eng Case Reports Journal Article Review 20110131 Australia J Paediatr Child Health Journal of paediatrics and child health 9005421 IM Adolescent Female Humans *Mechanical Thrombolysis Vertebrobasilar Insufficiency/diagnosis/*therapy 2011/02/01 06:00 2012/03/02 06:00 2011/02/01 06:00 2011/01/31 [aheadofprint] 10.1111/j.1440-1754.2010.01974.x [doi] ppublish J Paediatr Child Health. 2011 Jul;47(7):408-14. doi: 10.1111/j.1440-1754.2010.01974.x. Epub 2011 Jan 31.

20424549 NLM MEDLINE 20100428 20100805 20110614 1643-3750 (Electronic) 1234-1010 (Linking) 16 5 2010 May Speech intelligibility in cerebral palsy children attending an art therapy program. PG - CR222-31 AB - BACKGROUND: Dysarthia is a common sequela of cerebral palsy (CP), directly affecting both the intelligibility of speech and the child's psycho-social adjustment. Speech therapy focused exclusively on the articulatory organs does not always help CP children to speak more intelligibly. The program of art therapy described here has proven to be helpful for these children. MATERIAL/METHODS: From among all the CP children enrolled in our art thera py program from 2005 to 2009, we selected a group of 14 boys and girls (avera ge age 15.3) with severe dysarthria at baseline but no other language or cognitiv e disturbances. Our retrospective study was based on results from the Audito ry

Dysarthria Scale and neuropsychological tests for fluency, administered ro utinely over the 4 months of art therapy. RESULTS: All 14 children in the study gr oup showed some degree of improvement after art therapy in all tested paramete rs. On the Auditory Dysarthia Scale, highly significant improvements were noted i n overall intelligibility (p<0.0001), with significant improvement (p<0.001) in volume, tempo, and control of pauses. The least improvement was noted in t he most purely motor parameters. All 14 children also exhibited significant improv ement in fluency. CONCLUSIONS: Art therapy improves the intelligibility of speec h in children with cerebral palsy, even when language functions are not as such the object of therapeutic intervention. FAU - Wilk, Magdalena AU - Wilk M AD - Institute of Physiotherapy, Jan Kochanowski University, Kielce, Poland. magwilk@poczta.fm FAU - Pachalska, Maria AU - Pachalska M FAU - Lipowska, Malgorzata AU - Lipowska M FAU - Herman-Sucharska, Izabela AU - Herman-Sucharska I FAU - Makarowski, Ryszard AU - Makarowski R FAU - Mirski, Andrzej AU - Mirski A FAU - Jastrzebowska, Grazyna AU - Jastrzebowska G LA - eng PT - Journal Article PL - Poland TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental an d clinical research JID - 9609063 SB - IM MH - Adolescent MH - *Art Therapy MH - Cerebral Palsy/*physiopathology MH - Child MH - Female MH - Humans MH - Male MH - Retrospective Studies MH - *Speech EDAT- 2010/04/29 06:00 MHDA- 2010/08/06 06:00 CRDT- 2010/04/29 06:00 AID - 878542 [pii] PST - ppublish SO - Med Sci Monit. 2010 May;16(5):CR222-31.