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1. Which of the following diseases develop due to structural change in the chromosome?

(a) Phenylketonurea (b) Retinoblastoma (c) Hyperglycemia (d) Hemophilia 2. A cloning vector used in genetic engineering differs from the expression vector with respect to the absence of (a) Origin of replication (b) Promoter (c) Unique sites for Restriction Enzymes (d) Selectable marker 3. When a single base substitution in the DNA replaces a single amino acid in the polypeptide but drastically affects the activity of the protein, it is known as (a) Frame-shift mutation (b) Non-sense mutation (c) Mis-sense mutation (d) Silent mutation 4. Which of the following statement is true? (a) Sexuality in bacteria was discovered by Griffith (b) Bacteria do have sexuality involving genetic recombination but lack true sexual reproduction (c) The sexual reproduction in bacteria involves formation of gametes and primitive type of zygote (d) Bacteria may reproduce sexually by binary fission 5. Which one of the following methods of genetic recombination in bacteria has been considered as the basis of gene transfer in vitro? (e) Conjugation (f) Transformation (g) Transduction (h) Sexduction 6. The significance of Type II restriction enzyme in RDT lies in their ability to make (a) a symmetric cut (b) an asymmetric cut (c) a random cut (d) changes in base composition 7. PolyA/T or PolyG/C tails may be artificially created in a double stranded DNA by (e) T4 DNA ligase (f) Polynucleotide kinase (g) Terminal transferase (h) Methylase

8. Which of the following enables scientists to take nucleotide fragments from one organism and reassemble fragments into a new nucleotide sequence? (a) Enzyme DNA technology (b) Enzyme technology (c) Recombinant DNA technology (d) Recombinant enzyme technology

9. First classification system for living organisms was described by: (a) Carl Linnaeus (b) Louis Pasteur (c) Robert Koch (d) Antony Van Leeuwenhoek 10. Insulin is (a) Protein (b) Enzyme (c) Amino Acid (d) Nucleic Acid 11. First antibiotics (Penicillin) discovered by (a) Alexander Fleming (b) Paul Berg (c) Joseph Lister (d) Edward Jenner 12. Living Organisms are also known as; (a) Biological machine (b) Physiological machine (c) Chemical machine (d) Both (a) and (c) 13. Compounds contain polar or ionized group at one end of the molecule and a nonpolar region at the opposite site end are known as: (a) Polar compounds (b) Non polar compounds (c) Amphipathic compounds (d) Hydrophobic compounds 14. Animals use sterol to synthesize: (a) Vitamin A (b) Vitamin D (C) Steroid hormones (d) Both (b) and (c) 15. Ratio of A to T or G to C in double stranded DNA is always: (a) 2:1 (b) 1:2 (c) 2:3 (d) 1:1

16. RNA differs from DNA because it contains: (a) Cytosine (b) Thymine (c) Both (a) and (b) (d) Uracil 17. A DNA molecule is composed of molecules called: (a) Nucleotides (b) Nucleosides (c) Nucleic acids (d) Polypeptides 18. Combination of apoenzyme and coenzyme is known as: (a) Enzyme (b) Proteins (c) Holoenzyme (d) Both (a) and (c) 19. Enzyme in which formation of bonds with cleavage or breakage of ATP occurs is known as: (a) Transferases (b) Isomerases (c) Ligases (d) Hydrolases 20. Concept of Cell-Theory was developed by the scientist named: (a) Robert Koch (b) Mendel (c) Leeuwenhoek (d) Matthias Schleiden and Theodore Schwann

21. Single-celled organisms are known as: (a) Multicellular (b) Unicellular (c) Complex organisms (d) Both (b) and (c) 22. Collection of strains with similar characteristics especially similarity in their hereditary: (a) Genus (b) Species (c) Phylum (d) Taxon 23. Science of the classification, nomenclature and identification of living organisms is known as: (a) Physiology (b) Cytology (c) Taxonomy

(d) Microbiology 24. Prokaryotic sedimentation co-efficient is: (a) 70 S (b) 80 S (c) 60 S (d) 40 S 25. Fungi are: (a) Eukaryotic organisms (b) Prokaryotic organisms (c) Either unicellular or multicellular (d) Both (a) and (c) 26. Compounds related to methane are called: (a) Alkanes (b) Alkenes (c) Alkynes (d) Aromatic hydrocarbons 27. Which one of these is a petrocrop? (a) Sorghum (b) Maize (c) Jatropha (d) Saccharum 28. Itai-Itai disease was caused by: (a) Cadmium (b) Mercury (c) Chromium (d) Lead 29. Biodiversity hotspots in India are located in: (a) Industrialization (b) Grazing (c) Afforestation (d) Water pollution 30. Probiotics in food contain: (a) Bacterial products (b) Dead bacteria (c) Live bacteria (d) Artificial colour 31. The Black foot disease is caused by exposure to excess of: (a) Chromium (b) Arsenic (c) Lead (d) Cadmium

32. DBT is abbreviation of: (a) Department of BT-cotton (b) Division of Bioinformatics technology (c) Department of Biotechnology (d) Both (a) and (c) 33. Sexuality in bacteria was discovered by: (a) Watson and Crick (b) Khorana and Nireberg (c) Lederberg and Tatum (d) Kornberg and Ochoa 34.Blue baby syndrome is caused by excessive exposure to: (a) Phosphate (b) Nitrate (c) Chlorine (d) Selenium 35. Plasmodesmata connect the adjoining cells in: (a) Plants and animals (b) Animals only (c) Plants only (d) Mycoplasma 36. Crossing-over occurs in which stage? (a) Pachytene (b) Leptotene (c) Zygotene (d) Diakinesis 37. The modern approach in bacterial taxonomy relies mostly on (a) Morphological characters (b) Physiological characters (c) Biochemical characters (d) Polyphasic approaches 38. Most of the metabolic activities in bacterial cells are localized in (a) Capsule (b) Cell wall (c) Cell membrane (d) Ribosome 39. A bacteria which produces bluish-green colour in the presence of light of lower wavelength (200-300 nm) is most likely to be (a) Bacillus licheniformis (b) Pseudomonas fulorescence (c) Agrobacterium rubi (d) Sinorhizobium chinense 40. The best method of studying the bacterial growth in broth is by measuring the

(a) Colony diameter (b) Colony morphology (c) Optical density (d) All of the above 41. The protein which helps in aggregation of two ribosomal subunits during protein synthesis is (a) Ribophorin (b) Ribonuclease (c) Ribosides (d) Ribotides 42. The linker histone in nucleosomes is (a) H1 (b) H2A (c) H2B (d) H3 43. The selfing of a heterozygous tall plant bearing red flower (TtRr) produced 512 seed. How many of the progeny plants would be pure dwarf and impure red (ttRr)? (a) 32 (b) 64 (c) 128 (d) 256

44. The physiological state which enables a recipient strain of bacteria take-up DNA may be induced by growing cells in medium supplemented with (a) Mg2+ (b) Fe2+ (c) Se2+ (d) Ca2+ 45. Which one of the following organelles produces hydrolytic enzyme? (a) Mitochondria (b) Lysosome (c) Endoplasmic Retuculum (d) Nucleus 46. Which one of the following is also known as Physical Basis Of Pairing? (a) Synaptonemal complex (b) Restriction endonuclease (c) DNA ligase (d) Both (a) and (c) 47. Which one of the following cell organelle is known as Semi-autonomous? (a) Mitochondria (b) Chloroplast

(c) Nucleus (d) Both (a) and (b) 48. Linkage was discovered by: (a) Boveri and Sutton (b) Gregor Johann Mendel (c) Smith and Nathans (d) None of the above 49. Which one of the following is the cyclic photosystem? (a) P-680 (b) P-870 (c) P-700 (d) Both (a) and (c) 50. Which one of the part of chloroplast has role in photosynthesis? (a) Stroma (b) Granum (c) Cytosol (d) Matrix