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The Importance of HMGB1 ELISA Kits
EIAab's mission is to provide the scientific community with a protein related to comprehensive,
high quality products including ELISA, CLIA, antibodies, etc

!he ELISA built upon an important lab process, radioimmunoassay, and made it into one
of the most powerful research tools available to scientists today "ith it, discoveries have
been made all over the world in every possible discipline, and the research is still e#ploding
As such a valuable tool, the ELISA has been speciali$ed to wor% with hundreds of different
genes, including the &'()*, which produces the high+motility group protein )*, also %nown
as amphoterin
&'()* is one of the most vital chromatin proteins "hile in the nucleus, it interacts with
transcription factors, histones and nucleosomes to organi$e ,-A and regulate transcription
.nce &'()* is bound to ,-A, it bends the ,-A and encourages other proteins to bind as
well, facilitating transcription for many genes &'(-* helps to remodel the chromatin by
interacting with and altering nucleosomes of loose ,-A as well

/nowing these things about the &'()* molecule has allowed e#tensive research to be
performed using the ELISA technique ,uring ELISA, an &'()* specific antibody is coated
onto a microplate !he necessary samples and standards are place into the %it0s wells and
the immobili$ed antibody that remains fi#ed on the plate binds to any &'()* that may be
present in either the standards or the samples .nce the unbound substances are removed,
another &'()* antibody, this time biotin+con1ugated, is placed into the wells After washing
to remove unbound reagent, the wells are filled with a substrate solution Any color that
develops does so in proportion to how much &'()* originally bound to starting samples
Intensity is measured to determine the quantifiable results of the assay
!he &'()* ELISA test is highly sensitive and specific for &'()* detection ,epending on
the type of %it that your research calls for, the technology can be applied to many animals,
including human, pig, dog, bovine, mouse rat and chic%en !his variety of applications can
benefit many researchers who are on a quest to study the causes of many diseases via
various routes and testing mechanisms

&'()* is such an important gene because it has been shown to play an important part in
disease pathogenesis, for malignant diseases in particular !umors often disconnect cells0
o#ygen supplies, which leads to cell death, whereupon &'()* is released !his causes
angiogenetic blood vessels to form in the tumor0s ad1acent environment towards the tumor,
assuring the tumor0s survival and growth 2sing the &'()* ELISA, scientists can
differentiate between necrosis, or pathological cell death, and apoptosis, or physiological
cell death
"hen applied to e#periments regarding medical research, the true effect that these ELISA
test %its have had on scientists comes to light It may be a simple %it, but it provides a lot of
hope for future advances in the scientific arena
HMGB1 Structure
HMGB1 Structure

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