Generic name Trade name Classification Route Time/Frequency Normal Dosage- 1-2 capsules daily.

hydrochlorothiazide Dyazide diuretic/anti-hypertensive/ PO 1 daily Hydrochlorothiazide 25 mg and triamterene

/ triamterene antikaliuretic 37.5 mg
Indications- DYAZIDE is indicated for the treatment of Contraindications/warnings/interactions- Thiazides have been shown to
hypertension or edema in patients who develop hypokalemia on decrease arterial responsiveness to norepinephrine. Thiazides have also been
hydrochlorothiazide alone. DYAZIDE is also indicated for those shown to increase the paralyzing effect of nondepolarizing muscle relaxants such
patients who require a thiazide diuretic in whom the development as tubocurarine; consequently caution should be observed in patients undergoing
of hypokalemia cannot be risked. DYAZIDE may be used alone or surgery. Triamterene and quinidine have similar fluorescence spectra; thus,
as an adjunct to other anti-hypertensive drugs, such as beta- DYAZIDE will interfere with the fluorescent measurement of quinidine. Concurrent
blockers. Since DYAZIDE may enhance the action of these use of hydrochlorothiazide with amphotericin B or corticosteroids or corticotropin
agents, dosage adjustments may be necessary. (ACTH) may intensify electrolyte imbalance, particularly hypokalemia, although the
presence of triamterene minimizes the hypokalemic effect. Antikaliuretic Therapy
and Potassium Supplementation, Impaired Renal Function, Hypersensitivity,
Hyperkalemia
Mechanism of action- The hydrochlorothiazide component blocks Common side effects- Anaphylaxis, rash, urticaria, subacute cutaneous lupus
the reabsorption of sodium and chloride ions, and thereby erythematosus-like reactions, photosensitivity, Arrhythmia, postural hypotension,
increases the quantity of sodium traversing the distal tubule and Jaundice, pancreatitis, nausea and vomiting, diarrhea, constipation, abdominal
the volume of water excreted. The triamterene component of pain, Acute renal, interstitial nephritis, renal stones composed primarily of
DYAZIDE exerts its diuretic effect on the distal renal tubule to triamterene, abnormal urinary sediment, Leukopenia, thrombocytopenia and
inhibit the reabsorption of sodium in exchange for potassium and purpura, megaloblastic anemia, Muscle cramps, Weakness, fatigue, dizziness,
hydrogen ions. headache, dry mouth, Impotence, sialadenitis, Paresthesias, vertigo, Xanthopsia,
transient blurred vision, Allergic pneumonitis, pulmonary edema, respiratory
distress, Necrotizing vasculitis, exacerbation of lupus, Aplastic anemia,
agranulocytosis, hemolytic anemia.
Lab value alterations- elevated BUN, and serum creatinine, hyperkalemia,
hypokalemia, hyponatremia, acidosis, hypercalcemia, hyperglycemia, glycosuria,
hyperuricemia, hypochloremia, liver enzyme abnormalities
Nursing Considerations- monitor fluid levels, BP, monitor calcium levels.
Interactions with other patient drugs, OTC, or herbal
medicines- Angiotensin-converting Enzyme Inhibitors Why would you hold or not give this Evaluation- I/O
Oral Hypoglycemic Drugs, Nonsteroidal Anti-inflammatory Drugs, med? Hyperkalemia
Lithium