Submitted Manuscript: Confidential 27 December 2011

Science Manuscript Template

General Instructions on using this template and submitting a manuscript to Science: Thank you for preparing
a manuscript for submission to Science !sing this template" or follo#ing the guidelines belo#" #ill help us in
processing your paper $ur goal is to be able to identify each section of your manuscript so that #e can accurately
record the title" authors" abstract" etc and also be able to enrich it by including reference links and an accurate
layout
%lease use the actual template" #hich starts on page 2 &hen you are ready to submit" please delete the te't on this
co(er page
)ou can submit your paper at ###submit2scienceorg
*dditional instructions are a(ailable at http:++###sciencemagorg+site+feature+contribinfo+inde''html
,f you are using -aTe. " please con(ert your paper into a &ord or /T0 file if possible ,f this is not possible" please
use our -aTe. template and upload a %D0 (ersion of your paper Some con(ersion approaches are a(ailable here:
http:++###tugorg+utilities+te'con(+te'topchtml
So that #e can identify the parts of your paper" and e(en if you do not use our template" please begin each section
#ith the specific key #ords listed belo#" some of #hich are follo#ed by a colon %lease do not use paragraph
breaks in the title" author list" or abstract
Title:
Authors:
Affiliations:
One Sentence Summary:
Abstract:
Main Text:
References and Notes 1follo#ed by a numbered list2
Acno!ledgements:
"ig# $: 13egin each figure caption #ith a label" 4"ig# %5 for e'ample" as a ne# paragraph2
Table $: 13egin each table caption #ith a label 4Table %#&" etc2 as a ne# paragraph
Supplementary Materials: a list of the supplementary materials" follo#ed by the actual te't of the Supplementary
Materials
Se(eral of these headings are optional" for e'ample" not all papers #ill include a one6sentence summary" figures or
tables" or supplementary material
%lease use the doc' format if possible 1all (ersion after &ord 20072
More specific formatting instructions are pro(ided in the actual template" #hich follo#s
Title: 'o! to "ormat a Science (aper )replace !ith your real title*
Authors: The author list should be one single paragraph 1no breaks2 *uthors should be listed
by first name or initial follo#ed by last name and separated by commas !se superscript numbers
to link affiliations" and symbols 789 for author notes 0or e'ample" . :ones
1
7" % Smith
1"2
Affiliations:
1
*ffiliations should be preceded by superscript numbers corresponding to the author list" and
each affiliation should end #ith a period
2
;ach affiliation should be a separate paragraph
<
)ou can include group authors" but please include a list of the actual authors in the
Supplementary Materials
7Correspondence to: include the email addresses of the corresponding author1s2 %lease use the
asterisk 172 symbol for the corresponding author information
8*dditional author notes should be indicated #ith symbols 1for e'ample" for current addresses2
Abstract: The abstract should be about 10061=0 #ords" and organi>ed in this structure: *n
opening sentence that sets the ?uestion that you address and is comprehensible to the general
reader" background content specific to this study" results" and a concluding sentence ,t should
be one paragraph only
One Sentence Summary: * brief summary of the main result of your paper" #ithout e'cessi(e
@argon and less than 1=0 characters
Main Text: ,n general" this should include a brief 1162 paragraph2 introduction" follo#ed by a
statement of the specific scope of the study" follo#ed by results and then interpretations %lease
a(oid statements of future #ork or claims of priority" and a(oid repeating the conclusions at the
end *ll of the 0igures and Tables should be cited in order" including those in the supporting
online material 1#hich should be cited as" for e'ample" figure S1" and table S12 )ou can
include page breaks if you #ould like to place the figures #ithin the te't
Subheads These can be included in /esearch *rticles or /e(ie#s and should be brief
/eferences should be cited in parentheses #ith an italic number 112 Multiple reference
citations are separated by commas 12" <2 or if a series" dashes 1A6B2 /eferences are cited in order
by #here they first are called out" through the te't" then the notes" captions" then through the
supplementary material
;?uations can be included &e do not recommend using the nati(e &ord 2007" 200C"
2010 or 2011 e?uation editor This can in some cases produce less reliable MathM-" the online
markup language #e use" #hich may result in display errors ,nstead" use the legacy e?uation
editor in #ord 1,nsert menuD select insert ob@ectD select #ord e?uation2 or use Mathtype
1recommended2 ,f you enter e?uations in simple -aTe." check that they #ill con(ert accurately
1&ord 2007 and higher can con(ert simple -aTe. e?uations2
References and Notes:
1 There is only one reference list spanning the te't" figure captions and supplementary
materials Do not include a second reference list in the supplementary materials section
/eference only cited in the supplementary materials section are not counted to#ard length
guidelines
2 ;ach reference should be on a separate line ending in a period 0or a style guide" see
###sciencemagorg+about+authors+prep+res+refs'html
< )ou can include titles in references and full page ranges Titles are not counted to#ard
length guidelines
A %lease include the abo(e heading 4/eferences and Eotes:5
= )ou can use a numbered list in &ord
B ;ach references should ha(e a separate number
7 %lease do not mi' in references #ith e'planatory notes
Acno!ledgments: The ackno#ledgments should include a statement about #here the data
reported in the paper are presented" archi(ed" or a(ailable 1for e'ample" in the
Supplementary Materials or in a community archi(e2 ,f in an archi(e" include the
accession number or a placeholder for it %lease also include rele(ant funding information
such as grant numbers and funding agencies )ou can also include a statement of author
contributions here or in the Supplementary Materials
The ackno#ledgements can be multiple paragraphs *ckno#ledgments follo# the references
and notes but are not numbered
"ig# % The figure caption should begin #ith an o(erall descripti(e statement of the figure
follo#ed by additional te't They should be immediately after each figure 0igure parts are
indicated #ith capital letters 1A2 ,f you prefer" you can place both the actual figures and
captions logically through the te't near #here they are cited rather than at the end of the file 1but
not both2 ,f a paragraph in the main te't begins #ith the name of a figure" #rite out 40igure5 in
full 1eg" FparaG40igure 1 sho#sH52
"ig# +# )ou can place graphics abo(e each e?uation as part of this file
Table %# Start this caption #ith a short description of your table 0ormat tables using the &ord
Table commands and structures Do not create tables using spaces or tabs characters
Supplementary Materials:
Materials and Methods
0igures S16SI
Tables S16SI
Mo(ies S16SI
*udio 0iles S16SI
;'ternal Databases S16SI
/eferences 1##-##2
Supplementary Materials:
This section includes the actual te't of the Supplementary Materials" #hich can include any or all
of the preceding items" and figure captions and tables that can easily be incorporated into one
supplementary material file %lease edit the list abo(e as appropriate and include it at the end of
your main paper ,f there are additional files that cannot be easily accommodates 1eg" mo(ies
or large tables2" please include captions here
Materials and Methods: Can include the Materials and Methods here *dditional
references should be cited here and included in the main reference list
Any Additional Author notes: 0or e'ample" author contributions or a list of group
authors