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•When A.Pressure of ATMOSPHERE is GREATER than the A.Pressure INSIDE the lungs, air is
forced into the alveoli. This is INSPIRATION
•When the A.Pressure in the LUNGS is GREATER than the in the ATMOSPHERE, air is forced
OUT of the lungs. This is EXPIRATON
•Pressure changes brought about by two sets of muscles: THE DIAPRHAGM = SHEET of
MUSCLE seperating THORAX from ABDOMEN
•The Intercostal muscles: 1) INTERNAL INTERCOSTAL MUSCLES - contract -> inspiration, 2)
EXTERNAL INTERCOSTAL MUSCLES - contract -> expiration
Inspiration = EXTERNAL contract, INTERNAL relax. Ribs pulled UP and OUT, increasing volume
of THORAX. Diaphragm muscles CONTRACT, it flattens, which further increases volume of
THORAX. Increased volume in thorax = LUNG PRESSURE DROPS => Atmospheric pressure is
GREATER than LUNG pressure so AIR is FORCED in!
Expiration = INTERNAL contract, EXTERNAL relax. Ribs pulled DOWN and INWARDS, reducing
volume of THORAX. Diaphragm muscles RELAX, it goes back to dome position, which reduces
volume of THORAX. Reduced volume in thorax = LUNG PRESSURE INCREASES =>
Atmospheric pressure is LESS than LUNG pressure so AIR is FORCED out! NOTE: The SPRING
BACK OF LUNGS causes air out in normal situations. ONLY IN EXERCISE MUSCLES AID!
Tidal Volume = Volume NORMALLY taken in at EACH BREATH when the body is at REST.
Usually ~0.5dm^3
Ventilation Rate = the number of breaths taken in ONE minute. This is ~12-20 breaths in a
HEALTHY adult.
Fick's Law:
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Alveoli Bonuses:
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Tubercu:
•1) Bacteria grow + divide in upper lung regions with big O2 supply [ respi ]
•2) The body's immune system responds and W.B.Cells accumulate at bacteria to INGEST!
•3) This leads to inflammation + enlargement of lymph nodes that drain that area of the lungs.
This is called PRIMARY INFECTION and usually occurs in children.
•4)In a healthy person there are FEW symptoms, if ANY, and the infection is under controll in a
few weeks. Good Job White Blood Cells! Wait a minute, some bacteria Dr. Evils remain!
•5)Many years later these can come back to cause a second infection. This is called post-
primary tuberculosis and occurs in adults
•6)This is also in upper lungs but not so easily controlled. Bacteria destroy lung tissue => cavities
=> scars where lungs repair!
•7) Sufferer coughs up damaged lung tissue [EWW] containing bacteria along with blood. Without
treatment TB spreads to rest of body and can be fatal!!
---
Pulm Fibro: Microscopic injuries cause lung tissue to turn fibrous + thick. This reduces lung
elasticity. Symptoms + causes below:
•Shortness of breath = considerable air space occupied by fibrous tissue. Less air, less oxygen! +
Thickened alveoli Epithelium = diffusion pathway increased = slower rate!
•Chronic Dry Cough = Air meats fibrous tissue as obstacle. Body's like ''WTF'' and tries to cough
it out! But it's unmovable and coughing = futile!
•Pain + Chest discomfort due to pressure damage from the mass of the fibrous tissue and
scarring due to coughing.
•Weakness + Fatigue due to reduced O2
Exact cause is unclear, but microscopic lung injuries are bad! AVoid harmful particulates!
--
Asthma:
This is an ALLERGY. Caused by ALLERGENS. Common ones:
•pollen, animal fur, faeces of house dust mite, air pollutants [sulfur diox, nitrogen ox, ozone] cold
air, infection, anxiety, and stress!
•These cause W.B.Cells on linings of the Bronchi and Bronchioles to release HISTAMINE: 1)
Lining of airways becomes inflamed, 2) Cells of ephitleial lining secrete big mucus
quantities, 3) Fluid leaves capillaries and enters airways [flooding], 4) Muscles
surrounding bronchioles contract + constricts airways
Overall, big resistance to flow of air into alveoli => Hard to ventilate lungs => diffusion gradient
low. Symptoms : expla below:
•Breathing difficulty, wheezing sound [air passing through constricted bronchi+oles],a tight chest
feeling [constricted and pressured lungs], coughing [reflex to obstructed bronchi]
Genetics play a role in which allergens youre more allergic too! Cleaner lifestyles = less exposure
= more susceptability.
--
Emphy:
Elastin permanently stretched = lungs no longer able to contract and force air out of alveoli.
Surface Area of alveoli reduced, and they sometimes burst, arrgh! Little or any exchange of O2
can take place across these f'd up lungs. Symptoms + expla below:
•Shortness of Breath [Hard to exhale therefore old air remains + general amount of gas exchange
= low]
•Chronic cough [ Body wants to remove bad things but theyre stuck inside cause theyre tissue]
•Blue skin tint [ Lack of O2 in blood]