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BIOMEDICAL

Dr. Dan Rossignol Dr. Jeff Cantor Julie Matthews, CNC Dr. Amy Yasko Dr. Kenneth Bock

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Question 1 and their child began eating vegetables, not contributing factors to autism, I feel
How do you deal with children with meat, or other restricted foods for the first that they are, but I also believe that you
autism who have self-limiting diets? time. cannot say that metals or vaccines cause
How can you introduce new foods if autism per se, in most cases. I believe it is
they simply won’t eat them? Question 2 a combination of events or factors that all
Autistic children are exposed to come together to create the condition of
Response from no more heavy metals than typical autism.
Julie Matthews, CNC: children. Why do autistic children “hold When I spoke at ACAM several years
There are many reasons for self-limiting onto” heavy metals? ago, I showed a graphic with a revolving
diets. Addictions to foods such as gluten door in a building that also had a side
and casein can create self-restricting Response from Dr. Amy Yasko: door. I described the revolving door
diets, because the child wants to eat I think that the question as to why autistic as representing our methylation cycle
nothing but the foods that create opiates children seem to hold onto metals more that helps us to naturally detoxify on
that they are addicted to. Carbohydrate so than other children is an excellent a continual basis. When the revolving
craving can be due to yeast overgrowth point and relates to why we need to look door did not function it caused an
and other imbalances that can cause picky at all of the pieces of the puzzle in terms increase in toxins within the “building,”
eating. Nutrient deficiencies such as of what creates the condition of autism such that the graphic showed a building
zinc deficiency and yeast and microbial rather than simply looking at a single filled with a dark gray cloud. Those who
overgrowth are other common causes point. had a functional revolving door (i.e.
of poor appetite and restricted eating. I have felt for some time that any functional methylation cycle) might
Determining what a child is self-limiting analysis of autism needs to account for accumulate a very small amount of toxins
to can be helpful in addressing the the fact that ... yes, many children are represented by a gray cloud, but not to
underlying cause. The good news is that exposed to the same metal load and do the extent that those with no revolving
once the offending, addictive foods are not develop autism, as well as the fact door accumulated. This building also had
removed, their diet very often expands. I that many children are vaccinated and a side door that would allow toxins or
have heard countless stories from clients do not develop autism. This is not to the gray cloud to exit by. This side door
that have removed the addictive foods say that metals and / or vaccines are represented chelation. While the side door

Disclaimer
Information is not provided as medical advice. Parents / patients should research all information given. Every person’s physiology is unique. All
information provided as a reply should be discussed with the patient’s personal physician and / or autism or other specialist appropriate to the
symptom(s) or body system(s) involved in their individual situation, who provides the patient with regular medical oversight, monitoring, and lab
testing, and who keeps up-to-date on the most recent research and interventions. Beginning any significant biomedical or other interventions
that may impact physiology or making changes to an established regimen should be discussed with the patient’s physician in advance.

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on Autism One Radio with Polly snapping his jaws quickly ... this one he
Tommey, I was really excited that you does mainly while riding in the back of
are working with adolescents and my van. He seems to do these things
upwards. No one has ever said there more when in a stressful situation.
was hope for my son who is 22 now. Is GABA, Vitamin E, EFAs, B-6 and
it worth getting my hopes up, energy magnesium seem to help. I have never
and time to help my son? I couldn’t put seen these movements before this year
him or myself through something with and, except for this, he is a perfectly
no benefits. normal (good) looking 17-year-old
boy. Any insight would be greatly
Response from Dr. KenNETH Bock: appreciated.
From my perspective, there is hope for He has also regressed by many years
your 22-year-old son, but it is important since he had a tooth surgically removed
to have realistic hope and expectations. in 2005. I felt that he was slipping away
There is no question that younger children again as he had in 1992-93. He stopped
generally respond more rapidly and smiling again for several months, as
fully, i.e., have more chance of marked well. He was sedated with IV Versed for
improvement and even “recovery.” the procedure. I have reason to believe
However, I have seen improvements in that he woke during the procedure,
older children, adolescents and young chipping his front teeth and was
might not be as effective as the revolving adults by adding targeted biomedical possibly given a “push” of Versed to
door, it would help to eventually clear the interventions, and, therefore, I would put him back under ... any comments
building of the gray cloud. While having encourage you to pursue this path. I appreciated.
the side door open would not be enough must reiterate the importance of realism
to prevent the accumulation of toxins in regarding hope and possibility with the Response from Dr. Dan Rossignol:
the first place, it would help to lower the knowledge that a positive response to First, let me address the loss of speech.
toxin load. biomedical intervention is not guaranteed. Parents have noted for years that some
So... I feel that underlying genetic I in no way mean to imply pessimism in children develop normally and then
susceptibility, which affects methylation my answer to your question, but rather regress and develop autism. Recent
cycle function (the revolving door), is realism and balance. studies have validated this parental
what separates autistic individuals from observation in some children (Werner and
those without autism who are exposed Question 4 Dawson 2005; Goldberg, Thorsen et al.
to the same toxins. For this reason, I feel My son is 17, severely disabled with 2008). Several studies in the literature
that it is important to get that revolving autism since 18 months of age, tie regression in children with autism
door moving again, by working to bypass diagnosed at 22 months. He lost all to increased oxidative stress (Chauhan,
mutations in the methylation cycle. Also, speech at age 3 after a tetanus shot. Chauhan et al. 2004; James, Cutler et
the use of other types of support that aid He has no academic, personal care or al. 2004), brain inflammation (Connolly,
in chelation of metals and open that side social skills. His communication skills Chez et al. 1999), and mitochondrial
door can help. are extremely limited. He has recently dysfunction (Poling, Frye et al. 2006).
Finally, as I have discussed in the (in the past year?) developed some In some children with autism, regression
past, I feel that chronic microbial issues disturbing new tic-like behaviors. He may also be associated with seizure onset
in the body can allow metals to remain opens his mouth as wide as he possibly (Tuchman and Rapin 1997), although
“stuck” in the system. Again, underlying can with lips stretched over his teeth this is controversial. Some parents feel
genetic susceptibility can allow for and bugs his eyes out ... and wants me that thimerosal in vaccinations may have
increased microbial loads in the body. to close his mouth. He also turns his contributed to autism in their child, and
So, addressing the genetic weakness, as head in a twitching motion, flexing the thimerosal exposure may be linked to the
well as the actual microbes, can make a muscles in his neck and upper torso, development of tics (Verstraeten, Davis et
difference in getting those metals and bugs his eyes and purses his lips, then al. 2003).
toxins out of the system. throws his hands down by his side The recent symptoms that you
forcefully with his fingers outstretched describe sound suspicious for PANDAS
Question 3 forcibly, and jumps. He also throws his (Pediatric Autoimmune Neuropsychiatric
(This question was addressed hands behind him and then wiggles his Disorders Associated with Streptococcal
specifically to Dr. KenNETH Bock) fingers. He also throws his head back infections). Typically with PANDAS
Having listened to your radio interview and forth very fast and forcefully while there is worsening of the condition

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BIOMEDICAL email: info@autismfile.com

after streptococcal infections (“strep have some untoward affects on the DNA. these supplements improves behaviors
throat”). The supplements you are using There are several other possible sequelae in some children with autism including
(GABA, magnesium, etc.) may have to anesthesia that can cause lasting Vitamin C (Dolske, Spollen et al. 1993),
a calming effect in some children, so negative post-anesthesia effects. L-carnosine (Chez, Buchanan et al.
continued use of these would be fine. 2002), tetrahydrobiopterin (Danfors,
Certain medication may also be helpful Question 5 von Knorring et al. 2005), omega-3
in controlling these behaviors. I suggest What has been the most successful fatty acids (Amminger, Berger et al.
seeing a neurologist or a physician who type of therapy you have seen on a 2007), and a multivitamin containing
specializes in treating children with autism consistent basis when treating children antioxidants (Adams and Holloway 2004).
for further evaluation of these symptoms. with autism? Oxidative stress (caused, in part, by a
lack of antioxidants) is very common in
Response to the Dental portion Response from Dr. Dan Rossignol: individuals with autism (Chauhan and
of Question 4 above from If you are asking about behavior therapy Chauhan 2006; James, Melnyk et al.
Dr. Jeff Cantor: for autism, Applied Behavioral Analysis 2006) and is treatable with antioxidant
Since children on the spectrum may (ABA) is the best studied and published supplementation. For a list of what
have different receptors in their nervous therapy (Eikeseth, Smith et al. 2002; parents feel is the most helpful in treating
systems than neurotypical children, there Eikeseth, Smith et al. 2007). If you are their child with autism, you can check
is the theoretical possibility that they asking about medical therapy (besides out the Autism Research Institute’s
would have long term deficits after IV medication), the answer, in my opinion, “Biomedical Survey Analysis” of more than
Versed rather than the short term deficits would be anti-oxidant supplements 26,000 parents at http://www.autism.
seen in typical children. There is also the and omega-3 fatty acids. There are com/treatable/form34qr.htm.
possibility that if nitrous oxide was used 5 double-blind, placebo-controlled
that this could, in theory, cause regression studies in the medical literature
in that nitrous oxide has been found to demonstrating that treatment with

References for Questions 4 & 5:

References for Questions 4 & 5: Danfors, T., A. L. von Knorring, et al. (2005). James, S. J., S. Melnyk, et al. (2006). “Metabolic
“Tetrahydrobiopterin in the treatment of endophenotype and related genotypes are
Adams, J. B. and C. Holloway (2004). “Pilot children with autistic disorder: a double-blind associated with oxidative stress in children with
study of a moderate dose multivitamin / mineral placebo-controlled crossover study.” J Clin autism.” Am J Med Genet B Neuropsychiatr Genet
supplement for children with autistic spectrum Psychopharmacol 25(5): 485-9. 141(8): 947-56.
disorder.” J Altern Complement Med 10(6):
1033-9. Dolske, M. C., J. Spollen, et al. (1993). “A Poling, J. S., R. E. Frye, et al. (2006).
preliminary trial of ascorbic acid as supplemental “Developmental regression and mitochondrial
Amminger, G. P., G. E. Berger, et al. (2007). therapy for autism.” Prog Neuropsychopharmacol dysfunction in a child with autism.” J Child Neurol
“Omega-3 fatty acids supplementation in children Biol Psychiatry 17(5): 765-74. 21(2): 170-2.
with autism: a double-blind randomized, placebo-
controlled pilot study.” Biol Psychiatry 61(4): Eikeseth, S., T. Smith, et al. (2002). “Intensive Tuchman, R. F. and I. Rapin (1997). “Regression in
551-3. behavioral treatment at school for 4- to 7-year- pervasive developmental disorders: seizures and
old children with autism. A 1-year comparison epileptiform electroencephalogram correlates.”
Chauhan, A. and V. Chauhan (2006). “Oxidative controlled study.” Behav Modif 26(1): 49-68. Pediatrics 99(4): 560-6.
stress in autism.” Pathophysiology 13(3): 171-81.
Eikeseth, S., T. Smith, et al. (2007). “Outcome Verstraeten, T., R. L. Davis, et al. (2003). “Safety
Chauhan, A., V. Chauhan, et al. (2004). “Oxidative for children with autism who began intensive of thimerosal-containing vaccines: a two-phased
stress in autism: increased lipid peroxidation behavioral treatment between ages 4 and 7: a study of computerized health maintenance
and reduced serum levels of ceruloplasmin and comparison controlled study.” Behav Modif 31(3): organization databases.” Pediatrics 112(5): 1039-
transferrin--the antioxidant proteins.” Life Sci 264-78. 48.
75(21): 2539-49.
Goldberg, W. A., K. L. Thorsen, et al. (2008). “Use Werner, E. and G. Dawson (2005). “Validation of
Chez, M. G., C. P. Buchanan, et al. (2002). of home videotapes to confirm parental reports of the phenomenon of autistic regression using home
“Double-blind, placebo-controlled study of regression in autism.” J Autism Dev Disord 38(6): videotapes.” Arch Gen Psychiatry 62(8): 889-95.
L-carnosine supplementation in children with 1136-46.
autistic spectrum disorders.” J Child Neurol 17(11):
833-7. James, S. J., P. Cutler, et al. (2004). “Metabolic
biomarkers of increased oxidative stress and
Connolly, A. M., M. G. Chez, et al. (1999). “Serum impaired methylation capacity in children with
autoantibodies to brain in Landau-Kleffner variant, autism.” Am J Clin Nutr 80(6): 1611-7.
autism, and other neurologic disorders.” J Pediatr
134(5): 607-13.

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