DRUG DESCRIPTION

Ascorbic Acid (vitamin C) is a water-soluble vitamin. It occurs as a white or slightly yellow crystal or powder
with a slight acidic taste. It is an antiscorbutic product. On exposure to air and light it gradually darkens. In
the dry state it is reasonably stable in air but in solution it rapidly oxidi!es. Ascorbic Acid is "reely soluble in
water# sparingly soluble in alcohol# insoluble in chloro"orm ether and ben!ene.
$he chemical name o" Ascorbic Acid is %-ascorbic acid. $he molecular "ormula is C&'(O& and the molecular
weight is )*&.)+.
Ascorbic Acid In,ection is a clear colorless to slightly yellow sterile solution o" Ascorbic Acid in -ater "or
In,ection "or intravenous intramuscular or subcutaneous use. .ach m% contains Ascorbic Acid /00 mg
.detate 1isodium 0.02/3 -ater "or In,ection 4.s. p' (range /./-*.0) ad,usted with 5odium 6icarbonate.
Brand Name: Ascorbic Acid
Generic Name: 7itamin C
Ascorbic Acid
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Indications & Dosage
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INDICATIONS
Ascorbic acid is recommended "or the prevention and treatment o" scurvy. Its parenteral administration is
desirable "or patients with an acute de"iciency or "or those whose absorption o" orally ingested ascorbic acid
is uncertain.
5ymptoms o" mild de"iciency may include "aulty bone and tooth development gingivitis bleeding gums and
loosened teeth. 8ebrile states chronic illness and in"ection (pneumonia whooping cough tuberculosis
diphtheria sinusitis rheumatic "ever etc.) increase the need "or ascorbic acid.
DOSAGE AND AD!INISTRATION
Ascorbic acid is usually administered orally. -hen oral administration is not "easible or when malabsorption
is suspected the drug may be administered intramuscularly intravenously or subcutaneously. -hen given
parenterally utili!ation o" the vitamin reportedly is best a"ter I9 administration which is the pre"erred
parenteral route.
8or intravenous in,ection dilution into a large volume parenteral such as :ormal 5aline or ;lucose is
recommended to minimi!e the adverse reactions associated with intravenous in,ection.
$he average protective dose o" ascorbic acid "or adults is *0 to )/0 mg daily. In the presence o" scurvy
doses o" +00 mg to ) gram daily are recommended. 'owever as much as & grams have been administered
parenterally to normal adults without evidence o" toxicity.
$o enhance wound healing doses o" +00 to /00 mg daily "or a week to ten days both preoperatively and
postoperatively are generally considered ade4uate although considerably larger amounts have been
recommended. In the treatment o" burns doses are governed by the extent o" tissue in,ury. 8or severe
burns daily doses o" ) to 2 grams are recommended. In other conditions in which the need "or ascorbic acid
is increased three to "ive times the daily optimum allowances appear to be ade4uate.
"O# SUPP$IED
Ascorbic Acid In,ection <5= (/00 mg>m%)
:1C 0/)*-/0/0-0) /0 m% 5terile 1ispensing 7ial Individually =ackaged
=?O$.C$ 8?O9 %I;'$. 5$O?. I: CA?$O: <:$I% $I9. O8 <5.. 5tore at controlled room temperature
not to exceed 2/@C (**@8).
#ARNING
=?.55<?. 9AA 1.7.%O= -I$'I: $'. 7IA% <=O: 5$O?A;.B .xercise care when withdrawing and>or
relieve pressure by "irst inserting sterile empty syringe into vial thus allowing pressure to e4uilibrate.
-hen using dispensing vials use aseptic techni4ue. 1ispense entire contents in ali4uots under a laminar
"low hood without delay or within C hours a"ter entry or discard remaining contents a"ter "irst withdrawal.
=repare stoppers with a suitable antiseptic solution. 1o not use unless solution is clear and seal is intact.
=arenteral drug products should be inspected visually "or particulate matter and discoloration prior to
administration whenever the solution and container permit.
CAUTION: 8ederal (<5A) law prohibits dispensing without prescription.
Brand Name: Ascorbic Acid
Generic Name: 7itamin C
Ascorbic Acid
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Side E%%ects & Dr&g Interactions
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SIDE EFFECTS
$ransient mild soreness may occur at the site o" intramuscular or subcutaneous in,ection. $oo-rapid
intravenous administration o" the solution may cause temporary "aintness or di!!iness.
DRUG INTERACTIONS
%imited evidence suggests that ascorbic acid may in"luence the intensity and duration o" action o"
bishydroxycoumarin.
Brand Name: Ascorbic Acid
Generic Name: 7itamin C
Ascorbic Acid
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#arnings & Preca&tions
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#ARNINGS
1iabetics patients prone to recurrent renal calculi those undergoing stool occult blood tests and those on
sodium restricted diets or anticoagulant therapy should not take excessive doses o" ascorbic acid over an
extended period o" time.
PRECAUTIONS
Genera'
$oo-rapid intravenous in,ection is to be avoided.
$aborator( Tests
1iabetics taking more than /00 mg o" ascorbic acid daily may obtain "alse readings o" their urinary glucose
test. :o exogenous ascorbic acid should be ingested "or C( to *2 hours be"ore amine dependent stool occult
blood tests are conducted because possible "alse-negative results may occur.
Dr&g Interactions
%imited evidence suggests that ascorbic acid may in"luence the intensity and duration o" action o"
bishydroxycoumarin.
Usage In Pregnanc(
Pregnancy Category C - Animal reproduction studies have not been conducted with Ascorbic Acid
In,ection. It is also not known whether Ascorbic Acid In,ection can cause "etal harm when administered to a
pregnant woman or can a""ect reproduction capacity. Ascorbic Acid In,ection should be given to a pregnant
woman only i" clearly needed.
N&rsing !ot)ers
Caution should be exercised when Ascorbic Acid In,ection is administered to a nursing woman.
Brand Name: Ascorbic Acid
Generic Name: 7itamin C
Ascorbic Acid
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O*erdosage & Contraindications
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O+ERDOSE
CONTRAINDICATIONS
$here are no contraindications to the administration o" ascorbic acid.
Brand Name: Ascorbic Acid
Generic Name: 7itamin C
C'inica' P)armaco'og(
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C$INICA$ P"AR!ACO$OG,
Ascorbic Acid
Dr&g Descri-tion
Indications & Dosage
Side E%%ects & Dr&g Interactions
#arnings & Preca&tions
O*erdosage & Contraindications
C'inica' P)armaco'og(
Patient In%ormation
In humans an exogenous source o" ascorbic acid is re4uired "or collagen "ormation and tissue repair.
Ascorbic acid is reversibly oxidi!ed to dehydroascorbic acid in the body. $hese two "orms o" the vitamin are
believed to be important in oxidation-reduction reactions. $he vitamin is involved in tyrosine metabolism
conversion o" "olic acid to "olinic acid carbohydrate metabolism synthesis o" lipids and proteins iron
metabolism resistance to in"ections and cellular respiration.
Ascorbic acid de"iciency results in scurvy. Collagenous structures are primarily a""ected and lesions develop
in bones and blood vessels. Administration o" ascorbic acid completely reverses the symptoms o" ascorbic
acid de"iciency.
C)'or.Trimeton
Indications & Dosage
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INDICATIONS
=rovides e""ective temporary relie" o" snee!ing watery and itchy eyes and runny nose due to hay "ever and
other upper respiratory allergies.
DOSAGE AND AD!INISTRATION
Ad&'ts and c)i'dren /0 (ears o% age and o'der: One tablet every C to & hours not to exceed & tablets in
2C hours or as directed by a physician.
C)i'dren 1 t)ro&g) // (ears: One hal" the adult dose (break tablet in hal") every C to & hours not to
exceed + whole tablets in 2C hours.
C)i'dren &nder 1 (ears o% age: Consult a physician.
"O# SUPP$IED
Chlorpheniramine 9aleate $ablets are supplied as "ollowsB
C mg - ?ound convex yellow tablets bisected and imprinted with CC over )DC on one side.
:1C /)0*D-)&+-20- <nit dose blister packages o" )00 ()0 strips o" )0 tablets each).
Storage: 5tore at controlled room temperature )/@ to +0@ C (/D@ to (&@ 8).
=rotect product "rom excessive moisture.
Brand Name: Chlor-$rimeton
Generic Name: Chlorpheniramine 9aleate
C)'or.Trimeton
C'inica' P)armaco'og(
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C$INICA$ P"AR!ACO$OG,
C)'or.Trimeton
Dr&g Descri-tion
Indications & Dosage
Side E%%ects & Dr&g Interactions
#arnings & Preca&tions
O*erdosage & Contraindications
C'inica' P)armaco'og(
Patient In%ormation
Competes with histamine "or ')-receptor sites on e""ector cells in the gastrointestinal tract blood vessels
and respiratory tract.
C)'or.Trimeton
O*erdosage & Contraindications
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O+ERDOSE
:o in"ormation provided.
CONTRAINDICATIONS
'ypersensitivity to chlorpheniramine maleate or any component o" the "ormulation# narrow-angle glaucoma#
bladder neck obstruction# symptomatic prostate hypertrophy# during acute asthmatic attacks# stenosing
peptic ulcer# pyloroduodenal obstruction. Avoid use in premature and term newborns due to possible
association with 5I15.
Brand Name: Chlor-$rimeton
Generic Name: Chlorpheniramine 9aleate
C)'or.Trimeton
O*erdosage & Contraindications
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O+ERDOSE
:o in"ormation provided.
CONTRAINDICATIONS
'ypersensitivity to chlorpheniramine maleate or any component o" the "ormulation# narrow-angle glaucoma#
bladder neck obstruction# symptomatic prostate hypertrophy# during acute asthmatic attacks# stenosing
peptic ulcer# pyloroduodenal obstruction. Avoid use in premature and term newborns due to possible
association with 5I15.
Brand Name: Chlor-$rimeton
Generic Name: Chlorpheniramine 9aleate
C)'or.Trimeton
Dr&g Descri-tion
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DRUG DESCRIPTION
Eac) tab'et contains: Chlorpheniramine 9aleate C mg.
!a( a'so contain: 1EC Aellow F)0 %actose 9agnesium 5tearate 9icrocrystalline Cellulose and
=regelatini!ed 5tarch.
Brand Name: Chlor-$rimeton
Generic Name: Chlorpheniramine 9aleate