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completely free of artifact that is the only algorithm which has reliably produced images using data taken
from human subjects. Metherall et al. [1996] used a version of this algorithm for 3D imaging and Brown
et al. [1994] for multi-frequency imaging, in this case imaging changes in conductivity with frequency.
The principle disadvantage of this algorithm is that it can only image changes in conductivity, which
must be either natural or induced. Figure 68.3 shows a typical differential image. This represents the
changes in the conductivity of the lungs between expiration and inspiration.
Multifrequency Measurements
Differential algorithms can only image changes in conductivity. Absolute distributions of conductivity
cannot be produced using these methods. In addition, any gross movement of the electrodes, either
because they have to be removed and replaced or even because of signicant patient movement, make
the use of this technique difcult for long-term measurements of changes. As an alternative to changes
in time, differential algorithms can image changes in conductivity with frequency. Brown et al. [1994]
have shown that if measurements are made over a range of frequencies and differential images produced
using data from the lowest frequency and the other frequencies in turn, these images can be used to
compute parametric images representing the distribution of combinations of the circuit values in Fig. 68.1.
For example, images representing the ratio of
S
to
R,
a measure of the ratio of intracellular to extracellular
volume, can be produced, as well as images of
f
o
= 1/2'(RC + SC), the tissue characteristic frequency.
Although not images of the absolute distribution of conductivity, they are images of absolute tissue
properties. Since these properties are related to tissue structure, they should produce images with useful
contrast. Data sufcient to reconstruct an image can be collected in a time short enough to preclude
signicant patient movement, which means these images are robust against movement artifacts. Changes
of these parameters with time can still be observed.
68.4 Areas of Clinical Application
There is no doubt that the clinical strengths of EIT relate to its ability to be considered as a functional
imaging modality that carries no hazard and can therefore be used for monitoring purposes. The best
spatial resolution that might become available will still be much worse than anatomic imaging methods
such as magnetic resonance imaging and x-ray computed tomography. However, EIT is able to image
small changes in tissue conductivity such as those associated with blood perfusion, lung ventilation, and
FIGURE 68.3 A differential conductivity image representing the changes in conductivity in going from maximum
inspiration (breathing in) to maximum expiration (breathing out). Increasing blackness represents increasing conduc-
tivity.
2000 by CRC Press LLC
uid shifts. Clinical applications seek to take advantage of the ability of EIT to follow rapid changes in
physiologic function.
There are several areas in clinical medicine where electrical impedance tomography might provide
advantages over existing techniques. These have been received elsewhere [Brown et al., 1985; Dawids,
1987; Holder and Brown, 1990; Boone et al., 1997].
Possible Biomedical Applications
Gastrointestinal System
A priori, it seems likely that EIT could be applied usefully to measurement of motor activity in the gut.
Electrodes can be applied with ease around the abdomen, and there are no large bony structures likely
to seriously violate the assumption of constant initial conductivity. During motor activity, such as gastric
emptying or peristalsis, there are relatively large movements of the conducting uids within the bowel.
The quantity of interest is the timing of activity, e.g., the rate at which the stomach empties, and the
absolute impedance change and its exact location in space area of secondary importance. The principal
limitations of EIT of poor spatial resolution and amplitude measurement are largely circumvented in
this application [Avill et al., 1987]. There has also been some interest in the measurement of other aspects
of gastro-intestinal function such as oesophageal activity [Erol et al., 1995].
Respiratory System
Lung pathology can be imaged by conventional radiography, x-ray computed tomography, or magnetic
resonance imaging, but there are clinical situations where it would be desirable to have a portable means
of imaging regional lung ventilation which could, if necessary, generate repeated images over time.
Validation studies have shown that overall ventilation can be measured with good accuracy [Harris et
al., 1988]. More recent work [Hampshire et al., 1995] suggests that multifrequency measurements may
be useful in the diagnosis of some lung disorders.
EIT Imaging of Changes in Blood Volume
The conductivity of blood is about 6.7 mS/cm, which is approximately three times that of most intratho-
racic tissues. It therefore seems possible that EIT images related to blood ow could be accomplished.
The imaged quantity will be the change in conductivity due to replacement of tissue by blood (or vice
versa) as a result of the pulsatile ow through the thorax. This may be relatively large in the cardiac
ventricles but will be smaller in the peripheral lung elds.
The most interesting possibility is that of detecting pulmonary embolus (PE). If a blood clot is present
in the lung, the lung beyond the clot will not be perfused, and under favorable circumstances, this may
be visualized using a gated blood volume image of the lung. In combination with a ventilation image,
which should show normal ventilation in this region, pulmonary embolism could be diagnosed. Some
data [Leathard et al., 1994] indicate that PE can be visualized in human subjects. Although more sensitive
methods already exist for detecting PE, the noninvasiveness and bedside availability of EIT mean that
treatment of the patient could be monitored over the period following the occurrence of the embolism,
an important aim, since the use of anticoagulants, the principal treatment for PE, needs to be minimized
in postoperative patients, a common class of patients presenting with this complication.
68.5 Summary and Future Developments
EIT is still an emerging technology. In its development, several novel and difcult measurement and
image-reconstruction problems have had to be addressed. Most of these have been satisfactorily solved.
The current generation of EIT imaging systems are multifrequency, with some capable of 3D imaging.
These should be capable of greater quantitative accuracy and be less prone to image artifact and are likely
to nd a practical role in clinical diagnosis. Although there are still many technical problems to be
answered and many clinical applications to be addressed, the technology may be close to coming of age.
2000 by CRC Press LLC
Dening Terms
Absolute imaging: Imaging the actual distribution of conductivity.
Admittivity: The specic admittance of an electrically conducting material. For simple biomedical
materials such as saline with no reactive component of resistance, this is the same as conductivity.
Anisotropic conductor: A material in which the conductivity is dependent on the direction in which
it is measured through the material.
Applied current pattern: In EIT, the electric current is applied to the surface of the conducting object
via electrodes placed on the surface of the object. The spatial distribution of current ow through
the surface of the object is the applied current pattern.
Bipolar current pattern: A current pattern applied between a single pair of electrodes.
Conductivity: The specic conductance of an electrically conducting material. The inverse of resistivity.
Differential imaging: An EIT imaging technique that specically images changes in conductivity.
Distributed current: A current pattern applied through more than two electrodes.
Dynamic imaging: The same as differential imaging.
EIT: Electrical impedance tomography.
Forward transform or problem or solution: The operation, real or computational, that maps or
transforms the conductivity distribution to surface voltages.
Impedivity: The specic impedance of an electrically conducting material. The inverse of admittivity.
For simple biomedical materials such as saline with no reactive component of resistance, this is
the same as resistivity.
Inverse transform or problem or solution: The computational operation that maps voltage measure-
ments on the surface of the object to the conductivity distribution.
Optimal current: One of a set of a current patterns computed for a particular conductivity distribution
that produce data with maximum possible SNR.
Pixel: The conductivity distribution is usually represented as a set of connected piecewise uniform
patches. Each of these patches is a pixel. The pixel may take any shape, but square or triangular
shapes are most common.
Resistivity: The specic electrical resistance of an electrical conducting material. The inverse of con-
ductivity.
Static imaging: The same as absolute imaging.
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Further Information
All the following conferences were funded by the European commission under the biomedical engineering
program. The rst two were directly funded as exploratory workshops, the remainder as part of a
Concerted Action on Electrical Impedance Tomography. Electrical Impedance TomographyApplied
Potential Tomography. 1987. Proceedings of a conference held in Shefeld, U.K., 1986. Published in Clin
Phys Physiol Meas 8:Suppl.A. Electrical Impedance TomographyApplied Potential Tomography. 1988.
Proceedings of a conference held in Lyon, France, November 1987. Published in Clin Phys Physiol Meas
9:Suppl.A. Electrical Impedance Tomography. 1991. Proceedings of a conference held in Copenhagen,
Denmark, July 1990. Published by Medical Physics, University of Shefeld, U.K. Electrical Impedance
Tomography. 1992. Proceedings of a conference held in York, U.K., July 1991. Published in Clin Phys
Physiol Meas 13:Suppl.A. Clinical and Physiologic Applications of Electrical Impedance Tomography.
1993. Proceedings of a conference held at the Royal Society, London, U.K. April 1992. Ed. D.S. Holder,
UCL Press, London. Electrical Impedance Tomography. 1994. Proceedings of a conference held in Bar-
celona, Spain, 1993. Published in Clin Phys Physiol Meas 15:Suppl.A.