SALUTA

REDUCED GLUTATHIONE
FOR INJECTION
with Sterilized Water

Presentation and Form

IV vial (sterile, white lyophilised powder) 600mg x 10’s

Product Description
Each vial contains glutathione sodium 646mg equivalent to
glutathione 600 mg

Pharmacodynamic properties
Glutathione is a physiological tripeptide – a chain of three amino
acids-cystein, glycine and glutamic acid; and irreversibly
consumed in the detoxification of electrophilic metabolites and
xenobiotics. It is a very efficient free radical scavenger and
protects cells from the noxious effects of reactive oxygen
compound.

Enhanced oxidative stress has been implicated in the

pathogenesis of several disorders; as made evident by low
glutathione levels found in immune-compromise individuals,
neurodegenerative diseases such as multiple sclerosis, ALS,
Alzheimer’s, and Parkinson’s disease, atherosclerosis, male
infertility, pregnancy complications, cataracts, cancer and HIV-
infected patients.

Published clinical and scientific research has demonstrated and

protective effect of glutathione in several pathologic situations
which cause cellular damage, as is the case of intoxication from
substances such of platinum within the peripheral nervous
system, especially in the dorsal root ganglia. A strategy optimal
for reducing the neurotoxicity associated with platinum drugs
may be the use of glutathione, which is able to prevent the initial
accumulation of platinum, adducts in the dorsal root ganglia.

Indication
Treatment of alcohol-associative liver diseases (alcoholic fatty
liver, alcoholic liver fibrosis, alcoholic liver cirrhosis, and acute
alcoholic hepatitis)
As an emergency antidote in treatment of poisoning by
radiotherapy, drugs and chemicals (chemotherapeutic drugs,
antituberculosis drugs, neurolytics, antidepressant, analgesics
and antipyretics)
Posology and mode of administration
Mild: 300-600mg slow IV or IM daily
Severe: 600-1200mg slow IV or IM daily
The dosage, however, is dependent on age, weight and clinical
conditions of the patient and should also be related to the dose
and the administration schedule of the chemotherapeutic agent.
In case of simultaneous administration of glutathione and the
chemotherapeutic agent, the intravenous use: Dissolve
lyophilised powder infusion should be completely administered
within 1-2 hours. Intramuscular use: Dissolve 0.3 lyophilised
powder with 3ml water for injection(reconstituted solution
contains 100 mg/ml of glutathione); dissolve 0.6g lyophilized
powder with 4ml water for injection (reconstituted solution
contains 150mg/ml of glutathione)

Contraindications
Hypersensitivity

Precautions
Products for parental use should be visually inspected before
administration, when the container or solution makes it possible,
in order to possibly detect the presence of particles or of an
abnormal colour. Do not use in case of presence of turbidity or
precipitates.

Use in pregnancy & lactation

The available data show that glutathione, being a substance
physiologically present in cells, does not cause unwanted effects
in women during pregnancy or breastfeeding. Nevertheless, as
with all drugs, glutathione should only be administered to
pregnant or lactating mothers on proper medical advice.

Interactions
Vitamine k3, Vitamine B12, Calcium Pantothenate, orotic acid,
antihistamines, sulfanilamides and tetracycline can affect the
bioavailability of glutathione. In the absence of compatibility
studies, glutathione should not be mixed with other products.

Undesirable effects
After intramuscular administration, rare instances of skin rash
have been reported which have disappeared after discontinuation
of treatment.

Overdosage
No cases of overdosage have been reported. If needed,
symptomatic treatments may be employed.

Storage
Store below 30 C. Constituted solutions of glutathione maintain
satisfactory potency at room temperature (up to 25 C)up to 8
hours.

Shelf Life
Two years from date of manufacture

Specification
Manufacturer’s specification

PRICE:
Php 7,500.00 / box
Php 750.00 / vial