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Культура Документы
for Dermatology Specialists
Discover the most complete and
clinically proven line of dermatologic
nutrition from Hills
Hills
Prescription Diet
d/d
Formulated to help manage infammatory skin conditions such as atopy,
fea allergy dermatitis and otitis externa, as well as adverse reactions to
food, including food allergy and intolerance
Increased omega-3 fatty acids, including EPA, to nourish the skin and
help manage infammation
Added antioxidants to help support skin barrier function
Available in a wide range of novel protein options: venison, duck,
salmon, lamb, egg and rabbit
Hills
Prescription Diet
z/d
Effective as the gold standard (home prepared foods) for
diagnosing and managing adverse reactions to food including food
allergies and intolerance
Formulated with hydrolyzed animal proteins to eliminate the potential
for an allergic response
Added antioxidants to help support skin barrier function
Hills
Science Diet
Sensitive Skin
Formulated to meet the nutrient and energy needs of adult pets with
sensitive skin
Increased levels of omega-6 and omega-3 fatty acids to nourish skin
and coat
Added antioxidants to help support skin barrier function
/ Hills, Prescription Diet, Science Diet, d/d, n/d, z/d, a/d, b/d, j/d and Evidence-Based Clinical Nutrition are trademarks owned by Hills Pet Nutrition, Inc. Eukanuba, Eukanuba Veterinary Diets and Response are trademarks
owned by The Iams Company. Royal Canin, Royal Canin Veterinary Diet, IVD, Limited Ingredient Diets, Skin Support SS21, Hypoallergenic HP19, Feline Hypoallergenic HP 23, Royal Canin Skin Care 30, Royal Canin Adult Fit
32, Royal Canin Indoor 27, Royal Canin Persian 30, Feline Sensitivity RD 30 and Sensitivity RC21 are trademarks of Royal Canin USA. Nutro and Nutro Ultra are trademarks of Nutro Products, Inc. Purina Veterinary Diets and
LA Limited Antigen are trademarks of Socit des Produits Nestl S.A. 3V Caps and DermCaps are trademarks owned by DVM Pharmaceuticals. NutriVed is a trademark owned by Zinpro Company. EicosaDerm is a trademark
owned by DermaPet. Welactin is a trademark owned by Nutramax Laboratories, Inc. Nordic Naturals is a trademark of Nordic Naturals, Inc. 2007 Hills Pet Nutrition, Inc.
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P-9208
Veterinary Consultation Service
Your resource for case management and nutritional support.
1-800-548-VETS (8387) HillsVet.com
Hills Evidence-Based Clinical Nutrition
for Dermatology Specialists
Discover the most complete and
clinically proven line of dermatologic
nutrition from Hills
Hills
Prescription Diet
d/d
Formulated to help manage infammatory skin conditions such as atopy,
fea allergy dermatitis and otitis externa, as well as adverse reactions to
food, including food allergy and intolerance
Increased omega-3 fatty acids, including EPA, to nourish the skin and
help manage infammation
Added antioxidants to help support skin barrier function
Available in a wide range of novel protein options: venison, duck,
salmon, lamb, egg and rabbit
Hills
Prescription Diet
z/d
Effective as the gold standard (home prepared foods) for
diagnosing and managing adverse reactions to food including food
allergies and intolerance
Formulated with hydrolyzed animal proteins to eliminate the potential
for an allergic response
Added antioxidants to help support skin barrier function
Hills
Science Diet
Sensitive Skin
Formulated to meet the nutrient and energy needs of adult pets with
sensitive skin
Increased levels of omega-6 and omega-3 fatty acids to nourish skin
and coat
Added antioxidants to help support skin barrier function
/ Hills, Prescription Diet, Science Diet, d/d, n/d, z/d, a/d, b/d, j/d and Evidence-Based Clinical Nutrition are trademarks owned by Hills Pet Nutrition, Inc. Eukanuba, Eukanuba Veterinary Diets and Response are trademarks
owned by The Iams Company. Royal Canin, Royal Canin Veterinary Diet, IVD, Limited Ingredient Diets, Skin Support SS21, Hypoallergenic HP19, Feline Hypoallergenic HP 23, Royal Canin Skin Care 30, Royal Canin Adult Fit
32, Royal Canin Indoor 27, Royal Canin Persian 30, Feline Sensitivity RD 30 and Sensitivity RC21 are trademarks of Royal Canin USA. Nutro and Nutro Ultra are trademarks of Nutro Products, Inc. Purina Veterinary Diets and
LA Limited Antigen are trademarks of Socit des Produits Nestl S.A. 3V Caps and DermCaps are trademarks owned by DVM Pharmaceuticals. NutriVed is a trademark owned by Zinpro Company. EicosaDerm is a trademark
owned by DermaPet. Welactin is a trademark owned by Nutramax Laboratories, Inc. Nordic Naturals is a trademark of Nordic Naturals, Inc. 2007 Hills Pet Nutrition, Inc.
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Discover the most complete and
clinically proven line of dermatologic
nutrition from Hills
2
Hills
Prescription Diet
d/d
Canine Canned
Adverse Reactions to Food & Inflammatory Skin Conditions
Gastrointestinal Disorders
KEY BENEFITS
Protein
Number of Novel
Protein Formulas
Carbohydrate
Antioxidants
Single, novel animal source
Highly digestible
Reduced
Four
Potato or rice
Added
Helps avoid common food allergens.
Limits the amount of undigested protein in the gastrointestinal tract able to provoke an
allergic reaction.
Duck, salmon, venison and lamb provide more choices related to a suspected allergy or
patient preference.
Allergies to potato or rice are uncommon.
Help maintain a healthy immune system and the skin barrier function.
Indications
Inflammatory skin conditions such as atopy, flea allergy dermatitis and otitis externa.
Adverse reactions to food (food allergy or intolerance).
Additional information
Prescription Diet d/d Canine canned foods contain a single, novel animal protein source
(duck, salmon, venison and lamb) which is not generally associated with adverse reactions to
food in dogs. A limited number of digestible novel meat protein and carbohydrate ingredients
help avoid common food allergies.
Prescription Diet d/d Canine foods can help aid in the management of pruritic dermatitis,
chronic gastroenteritis or colitis, inflammatory bowel disease (IBD), chronic otitis externa, flea
allergy dermatitis, and contact dermatitis.
Supplementation is unnecessary (including fatty acid supplements) and may decrease the
effectiveness of the food.
Other products to consider
For use as an elimination diet (for maximum reliability in the identification of dietary
sensitivity): Prescription Diet
z/d
z/d
ULTRA
Allergen-Free Canine or Prescription Diet
z/d
d/d
Prescription Diet
d/d
Canine Dry
Adverse Reactions to Food & Inflammatory Skin Conditions
Gastrointestinal Disorders
Indications
Inflammatory skin conditions such as atopy, flea allergy dermatitis and otitis externa.
Adverse reactions to food (food allergy or intolerance).
Additional information
Prescription Diet d/d Canine foods contain a single, novel animal protein source (egg,
duck, salmon and venison) which is not generally associated with adverse reactions to food
in dogs. A limited number of digestible novel meat protein and carbohydrate ingredients help
avoid common food allergies.
Prescription Diet d/d Canine foods can help aid in the management of pruritic dermatitis,
chronic gastroenteritis or colitis, inflammatory bowel disease (IBD), chronic otitis externa, flea
allergy dermatitis, and contact dermatitis.
Supplementation is unnecessary (including fatty acid supplements) and may decrease the
effectiveness of the food.
Other products to consider
For use as an elimination diet (for maximum reliability in the identification of dietary
sensitivity): Prescription Diet
z/d
z/d
ULTRA
Allergen-Free Canine or Prescription Diet
z/d
d/d
Prescription Diet
z/d
d/d
Canine.
For dogs with colitis, gastroenteritis (acute or chronic), inflammatory bowel disease (IBD) or
vomiting (acute or chronic): Prescription Diet
i/d
Canine.
Not recommended for
Growing puppies, pregnant or nursing dogs.
These characteristics make Prescription Diet z/d ULTRA Allergen-Free Canine veterinary
exclusive pet food useful as a nutritional aid for dogs with adverse reactions to food or certain
gastrointestinal disorders:
Disease Category:
Animal feeding tests using AAFCO procedures substantiate
that Prescription Diet
z/d
ULTRA Allergen-Free
Canine provides complete and balanced nutrition for the
maintenance of adult dogs. The smooth, moist texture
is perfect for mixing with z/d ULTRA Allergen-Free
Canine or z/d Low Allergen Canine Dry. The following
ranges are a starting point only and should be adjusted
as needed to maintain proper weight. Supplementation is
unnecessary (including fatty acid supplements) and may
decrease the effectiveness of the food. Mix increasing
amounts of the pets new food with decreasing amounts
of the old food over a 7-day period.
Body
Weight
(lb)
Can(s)
(5.5 oz)
Can(s)
(13 oz) Dry Cups
5 1 - 1
2
/3 -
2
/3
2
/3 - 1
10 2 - 2 - 1 1 - 1
5
/8
20 3
1
/3 - 4
2
/3 1
1
/3 - 2 2 - 2
40 5
2
/3 - 7 2
1
/3 - 3 3
1
/3 - 4
2
/3
60 7
2
/3 - 10 3 - 4 4 - 6
1
/3
80 9 - 13 4 - 5 5
2
/3- 7
100 11 - 15 4 - 6 6
2
/3 - 9
1 cup is equal to 1
2
/3 cans (5.5 oz).
1 can (5.5 oz) is equal to
5
/8 cup.
1 cup is equal to
2
/3 can (13 oz).
1 can (13 oz) is equal to 1
3
/8 cups.
DAILY FEEDING AMOUNTS
z/d ULTRA Allergen-Free Canine:
Cans in 5.5 oz (5403) in cases of 24 and 13 oz (7018) in cases of 12
Bags of 8 lbs (7901) and 18 lbs (7902)
9
As Fed
1
Dry Matter
2
As Fed, Caloric Basis
3
Protein 4.8 % 19.6 % 4.9 g
Fat 3.4 % 13.9 % 3.5 g
Carbohydrate (NFE) 13.9 % 56.7 % 14.3 g
Crude Fiber 1.1 % 4.5 % 1.1 g
Calcium 0.18 % 0.73 % 185 mg
Phosphorus 0.14 % 0.57 % 144 mg
Sodium 0.05 % 0.20 % 51 mg
Potassium 0.16 % 0.65 % 164 mg
Magnesium 0.014 % 0.057 % 14 mg
Total Omega-3 Fatty Acids 0.12 % 0.49 % 123 mg
Total Omega-6 Fatty Acids 0.99 % 4.04 % 1,017 mg
METABOLIZABLE ENERGY
kcal/kg 973 3,971
kcal/can small (5.5 oz): 152; large (13 oz): 360
% Calories From: Protein 18 Fat 31 Carbohydrates 51
CANNED INGREDIENTS
AVERAGE NUTRIENT CONTENTS
Water, Hydrolyzed Chicken Liver, Corn Starch, Powdered Cellulose, Soybean Oil, Dicalcium Phosphate,Calcium Carbonate, Potassium Citrate, DL-Methionine, Choline Chloride,
Iodized Salt, Vitamin E Supplement, Taurine, Ascorbic Acid (source of vitamin C), L-Threonine, Zinc Oxide, Ferrous Sulfate, L-Tryptophan, Beta-Carotene, Thiamine Mononitrate,
Copper Sulfate, Manganous Oxide, Niacin, Calcium Pantothenate, Vitamin B12 Supplement, Pyridoxine Hydrochloride, Biotin, Calcium Iodate, Vitamin D3 Supplement,
Riboflavin, Sodium Selenite, Folic Acid.
DRY INGREDIENTS
AVERAGE NUTRIENT CONTENTS
Starch, Hydrolyzed Chicken Liver, Soybean Oil (preserved with BHA, propyl gallate and citric acid), Hydrolyzed Chicken, Powdered Cellulose, Dicalcium Phosphate, Calcium
Carbonate, Glyceryl Monostearate, Potassium Chloride, Iodized Salt, Choline Chloride, Vitamins (vitamin E supplement, niacin, thiamine mononitrate, vitamin A supplement,
l-ascorbyl-2-polyphosphate [source of vitamin C], calcium pantothenate, biotin, vitamin B12 supplement, pyridoxine hydrochloride, riboflavin, folic acid, vitamin D3 supplement),
DL-Methionine, Minerals (ferrous sulfate, zinc oxide, copper sulfate, manganous oxide, calcium iodate, sodium selenite), Taurine, Ethoxyquin (a preservative), Beta-Carotene.
As Fed
1
Dry Matter
2
As Fed, Caloric Basis
3
Protein 17.5 % 19.0 % 4.7 g
Fat 12.8 % 13.9 % 3.4 g
Carbohydrate (NFE) 54.6 % 59.3 % 14.7 g
Crude Fiber 2.5 % 2.7 % 0.7 g
Calcium 0.61 % 0.66 % 164 mg
Phosphorus 0.47 % 0.51 % 126 mg
Sodium 0.27 % 0.29 % 73 mg
Potassium 0.61 % 0.66 % 164 mg
Magnesium 0.050 % 0.054 % 13 mg
Total Omega-3 Fatty Acids 0.50 % 0.54 % 134 mg
Total Omega-6 Fatty Acids 3.86 % 4.20 % 1,037 mg
METABOLIZABLE ENERGY
kcal/kg 3,724 4,048
kcal/cup 254
Weight oz/cup 2.4
Cups per lb 6.6
% Calories From: Protein 17 Fat 30 Carbohydrates 53
1-800-548-VETS (8387)
.
www.HillsVet.com
1. Differs from label guarantees which are either maximums or minimums. 2. The nutrient in the product after moisture is removed. It is used to make direct
comparisons of nutrient profiles with differing moisture contents. 3. Nutrient intake for every 100 kilocalories consumed.
10
Hills
Prescription Diet
z/d
d/d
Canine or
Prescription Diet
z/d
i/d
Canine.
Not recommended for
Growing puppies, pregnant or nursing dogs.
These characteristics make Prescription Diet z/d Low Allergen Canine veterinary exclusive pet food useful as a nutritional aid for dogs with adverse reactions
to food or certain gastrointestinal disorders:
Disease Category:
Animal feeding tests using AAFCO procedures substantiate
that Prescription Diet
z/d
Prescription Diet
d/d
Feline
Adverse Reactions to Food & Inflammatory Skin Conditions
Gastrointestinal Disorders
KEY BENEFITS
Protein
Number of Novel
Protein Formulas
Carbohydrate
Antioxidants
Single, novel animal source
Highly digestible
Three
Green pea
Added
Helps avoid common food allergens.
Limits the amount of undigested protein in the gastrointestinal tract able to provoke an
allergic reaction.
Duck, rabbit or venison provide more choices related to a suspected allergy or
patient preference.
Allergies to green pea are uncommon.
Help maintain a healthy immune system and the skin barrier function.
Indications
Inflammatory skin conditions such as atopy, flea allergy dermatitis and feline
eosinophilic granuloma complex
Adverse reactions to food (food allergy or intolerance).
Additional information
Prescription Diet d/d Feline foods contain a single, novel animal protein source (duck, rabbit, or
venison) which is not generally associated with adverse reactions to food in cats.
Prescription Diet d/d Feline foods may help aid in the management of the following:
Pruritic dermatitis: Adverse food reactions in cats typically occur as pruritic dermatitis, with or
without concurrent gastrointestinal signs.
Chronic gastroenteritis, chronic colitis: Adverse food reactions can result in chronic vomiting
and/or diarrhea associated with gastrointestinal inflammation; mildly affected cats may only show an
increase in the number of bowel movements or may have occasional vomiting.
Inflammatory bowel disease (IBD): Adverse reactions to food may potentiate IBD.
Atopic dermatitis, food allergy and flea allergy can occur in the same patient concurrently.
Allergic dermatitis patients may have clinical signs of eosinophilic granuloma complex.
Contact dermatitis.
Supplementation beyond the analogous canned or dry formula (including fatty acid supplements) is
unnecessary and may decrease the effectiveness of the food.
Other products to consider
For use as an elimination food, for patients with IBD, or to manage and eliminate
adverse reactions to food: Prescription Diet
z/d
z/d
Low Allergen Feline.
Not recommended for
Growing kittens, pregnant or nursing cats.
Patients with concurrent use of urinary acidifiers.
These characteristics make Prescription Diet d/d Feline veterinary exclusive pet foods useful as a nutritional aid for dogs with adverse reactions to food:
d/d Duck Formula Feline: Cans of 5.5 oz (5364) in cases of 24
d/d Venison Formula Feline: Cans of 5.5 oz (5365) in cases of 24
d/d Duck & Green Pea Formula Feline: Bags of 3.5 lbs (5351) and 8.5 lbs (5355)
d/d Rabbit & Green Pea Formula Feline: Bags of 3.5 lbs (5352) and 8.5 lbs (5357)
d/d Venison & Green Pea Formula Feline: Bags of 3.5 lbs (5350) and 8.5 lbs (5356)
Disease Category:
Animal feeding tests using AAFCO procedures substantiate
that Prescription Diet
d/d
Prescription Diet
z/d
d/d
Feline.
For cats with colitis, diarrhea (acute or chronic) gastroenteritis (acute or chronic), inflammatory
bowel disease or vomiting (acute or chronic): Prescription Diet
i/d
Feline.
Not recommended for
Growing kittens, pregnant or nursing cats.
Patients with concurrent use of urinary acidifiers.
These characteristics make Prescription Diet z/d ULTRA Allergen-Free Feline veterinary exclusive pet foods useful as a nutritional aid for cats with adverse
reactions to food:
z/d ULTRA Allergen-Free Feline: Cans of 5.5 oz (5238) in cases of 24
Disease Category:
Animal feeding tests using AAFCO procedures substantiate
that Prescription Diet
z/d
ULTRA Allergen-Free
Feline provides complete and balanced nutrition for the
maintenance of adult cats. The following ranges are a
starting point only and should be adjusted as needed to
maintain proper weight. Mix increasing amounts of the
pets new food with decreasing amounts of the old food
over a 7-day period.
Body Weight (lb)
ALL CANNED FORMULAS
Can(s) (5.5 oz)
5
3
/4 - 1
10 1 - 1
3
/4
15 1
3
/4 - 2
1
/3
DAILY FEEDING AMOUNTS
1 cup is equal to 2
1
/3 cans.
1 can is equal to
3
/8 cup.
17
As Fed
1
Dry Matter
2
As Fed, Caloric Basis
3
Protein 8.9 % 33.7 % 8.2 g
Fat 4.8 % 18.2 % 4.4 g
Carbohydrate (NFE) 10.7 % 40.5 % 9.9 g
Crude Fiber 0.4 % 1.5 % 0.4 g
Calcium 0.19 % 0.72 % 176 mg
Phosphorus 0.17 % 0.64 % 157 mg
Sodium 0.08 % 0.30 % 74 mg
Potassium 0.21 % 0.80 % 194 mg
Magnesium 0.017 % 0.064 % 16 mg
Taurine 0.10 % 0.38 % 93 mg
Total Omega-3 Fatty Acids 0.12 % 0.45 % 111 mg
Total Omega-6 Fatty Acids 1.07 % 4.05 % 990 mg
METABOLIZABLE ENERGY
kcal/kg 1,081 4,095
kcal/can 169
% Calories From: Protein 28 Fat 37 Carbohydrates 35
CANNED INGREDIENTS
AVERAGE NUTRIENT CONTENTS
Hydrolyzed Chicken Liver, Water, Corn Starch, Soybean Oil, Powdered Cellulose, Calcium Carbonate, DL-Methionine, Potassium Chloride,
Dicalcium Phosphate, Choline Chloride, Iodized Salt, Vitamin E Supplement, Taurine, Calcium Sulfate, Thiamine Mononitrate, Zinc Oxide,
Ascorbic Acid (source of vitamin C), Ferrous Sulfate, Niacin, Beta-Carotene, Manganous Oxide, Copper Sulfate, Pyridoxine Hydrochloride, Calcium
Pantothenate, Vitamin B12 Supplement, Riboflavin, Biotin, Vitamin D3 Supplement, Calcium Iodate, Folic Acid, Sodium Selenite.
1-800-548-VETS (8387)
.
www.HillsVet.com
1. Differs from label guarantees which are either maximums or minimums. 2. The nutrient in the product after moisture is removed. It is used to make direct
comparisons of nutrient profiles with differing moisture contents. 3. Nutrient intake for every 100 kilocalories consumed.
18
Hills
Prescription Diet
z/d
d/d
Feline.
For cats with colitis, diarrhea (acute or chronic) gastroenteritis (acute or chronic), inflammatory
bowel disease or vomiting (acute or chronic): Prescription Diet
i/d
Feline.
Not recommended for
Growing kittens, pregnant or nursing cats.
Patients with concurrent use of urinary acidifiers.
These characteristics make Prescription Diet z/d Low Allergen Feline veterinary exclusive pet foods useful as a nutritional aid for cats with adverse
reactions to food:
z/d Low Allergen Feline: Bags of 4 lbs (7905) and 10 lbs (9623)
Disease Category:
Animal feeding tests using AAFCO procedures substantiate
that Prescription Diet
z/d
Science Diet
z/d
d/d
Canine.
Not recommended for
Puppies, pregnant or nursing dogs.
Sensitive Skin Adult Canine:
Bags of 4.5 lbs (8533), 17.5 lbs (8534) and 35 lbs (8535)
Disease Category:
Animal feeding tests using AAFCO procedures substantiate
that Science Diet
Science Diet
z/d
d/d
Feline.
Not recommended for
Kittens, pregnant or nursing cats.
Sensitive Skin Adult Feline:
Bags of 3.5 lbs (8526) and 8.5 lbs (8527)
Disease Category:
Animal feeding tests using AAFCO procedures substantiate
that Science Diet
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
n/d
Prescription Diet
z/d
Prescription Diet
z/d
Prescription Diet
z/d
Prescription Diet
a/d
Prescription Diet
b/d
Prescription Diet
j/d
Prescription Diet
j/d
Science Diet
Science Diet
Science Diet
Lamb Meal & Rice Recipe Adult Canine Dry 162 4,815 1,002
Hills
Science Diet
Science Diet
Science Diet
Science Diet
Science Diet
Response
Response
IVD
IVD
IVD
IVD
Hypoallergenic HP19,
Sensitivity RC21,
Ultra
Ultra
LA Limited Antigen
Liquid HR 1 ml 0 450
DermCaps
Liquid 1 ml 621 65
(Table 1 continues on next page)
Table 1
29
Table 1. The total essential fatty acid intake for a 10-kg dog eating 600 kcal per day of selected commercial foods or being given one of the selected supplements.
Table 2. The total essential fatty acid intake for a 4.5-kg cat eating 260 kcal per day of selected commercial foods or being given one of the selected supplements.
Foods Food consumed (g)
Total
omega-6
consumed
(mg)
Total
omega-3
consumed
(mg)
Hills
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
d/d
Prescription Diet
z/d
Prescription Diet
z/d
Prescription Diet
a/d
Science Diet
Science Diet
Advanced Protection
Science Diet
Science Diet
Advanced Protection
Science Diet
Science Diet
Response
IVD
Feline Hypoallergenic HP 23
Feline Sensitivity RD 30
Liquid HR 1 ml 0 450
DermCaps
Liquid 1 ml 621 65
DermCaps
1 pump 0 330-364
Nordic Naturals
1 pump 0 600
Welactin
1 pump 0 330-364
Nordic Naturals
Prescription Diet
z/d
and d/d
and Hills
Science Diet
Adult, ProPlan
Max
and a
dry skin and coat food with flaxseed as a plant source of
omega-3 fatty acids. The skin and coat were evaluated for
parameters of shine, scale, ease of epilation of hairs, and
skin surface character. Transepidermal water loss (TEWL), skin
hydration and skin lipid concentration were also evaluated on
days 0, 28 and 56. Dogs consuming the food containing flaxseed
had increased serum and cutaneous concentrations of omega-3
fatty acids compared with the other three groups; these dogs also
tended to have shinier hair coats and significantly lower TEWL.
Flaxseed is a good source of dietary omega-3 fatty acids and
increases omega-3 fatty acid concentrations in both serum and
skin. These changes often lead to improved skin and hair coat.
Cave NJ. The nutritional management of food hypersensitivity in
dogs and cats: an assessment of a protein hydrolysate. Masters
Thesis, Massey University, Palmerston North, New Zealand, 2001.
A candidate chicken-protein hydrolysate was subjected to high
performance size-exclusion chromatography to characterize
its molecular weight profile. An inhibition ELISA assay was
developed to assess the residual antigenicity, using canine serum
IgG produced by dogs sensitized to the intact protein through
electrophoresis and immunoblotting. The chicken hydrolysate
had a suitable molecular weight profile with 96.9% reduced to
less than 10kDa peptides. The inhibition ELISA demonstrated
a residual antigenic mass of 1.5% compared with the intact
protein. Immunoblotting demonstrated a strong immunoreactive
band at 68 to 70kDa consistent with chicken serum albumin in
the intact protein, which was absent in the hydrolysate. These
results demonstrate the suitability of the chicken hydrolysate for
use in a protein hydrolysate food.
Cave NJ, Guilford WG, Roudebush P. In vivo assessment of
antigenicity of a protein hydrolysate and characterisation of a
major antigen in chicken (abstract), in Proceedings. Veterinary
Medical Forum (ACVIM), Seattle, Washington, 2000.
A chicken hydrolysate showed a 25-fold reduction in antigenicity
over the intact protein. Western blots of the intact proteins using
chicken-sensitized dog serum identified a strong immunogenic
band at 70kDA that was absent in the hydrolysate. It is
speculated that this major chicken protein antigen is chicken
serum albumin.
Cave NJ, Guilford WG. A method for in vitro evaluation of protein
hydrolysates for potential inclusion in veterinary diets. Res Vet Sci
2004;77:231-238.
A chicken-protein hydrolysate was subjected to high-performance
size-exclusion chromatography to characterize its molecular
weight profile. An inhibition ELISA assay was developed to assess
the residual antigenicity, using canine serum IgG produced by
dogs sensitized to the intact protein. Finally, the hydrolysate
was compared to the intact protein through electrophoresis
and immunoblotting. The chicken hydrolysate had a suitable
molecular weight profile with 96.9% reduced to less than 10kDa
peptides. The inhibition ELISA demonstrated a residual antigenic
mass of 1.5% compared with the intact protein. Immunoblotting
demonstrated a strong immunoreactive band at 68 to 70kDa
consistent with chicken serum albumin in the intact protein,
which was absent in the hydrolysate. Chicken hydrolysates are
acceptable for use in foods designed for dogs with suspected
adverse food reactions.
Crass K. An underweight Gordon setter with brittle claws. Vet Med
2004;99:511-514.
A 4-year-old female Gordon setter dog was examined because
of brittle claws of one years duration. Diagnostic evaluation
eventually confirmed a diagnosis of inflammatory bowel disease
contributing to systemic dermatologic signs. Treatment with a
combination of antibiotics, corticosteroids and Hills
Prescription Diet
z/d
Prescription Diet
d/d
Prescription Diet
d/d
formulas containing
pork fat and has found no evidence of pork protein in any
finished products. Testing for pork allergens cannot be conducted
because no specific pork allergen has been identified in people
or animals (www.allergen.org).
Q: What is the target urine pH of the Hills
Prescription Diet
d/d
and z/d
Science Diet
for Dermatology Specialists
Discover the most complete and
clinically proven line of dermatologic
nutrition from Hills
Hills
Prescription Diet
d/d
Formulated to help manage infammatory skin conditions such as atopy,
fea allergy dermatitis and otitis externa, as well as adverse reactions to
food, including food allergy and intolerance
Increased omega-3 fatty acids, including EPA, to nourish the skin and
help manage infammation
Added antioxidants to help support skin barrier function
Available in a wide range of novel protein options: venison, duck,
salmon, lamb, egg and rabbit
Hills
Prescription Diet
z/d
Effective as the gold standard (home prepared foods) for
diagnosing and managing adverse reactions to food including food
allergies and intolerance
Formulated with hydrolyzed animal proteins to eliminate the potential
for an allergic response
Added antioxidants to help support skin barrier function
Hills
Science Diet
Sensitive Skin
Formulated to meet the nutrient and energy needs of adult pets with
sensitive skin
Increased levels of omega-6 and omega-3 fatty acids to nourish skin
and coat
Added antioxidants to help support skin barrier function
/ Hills, Prescription Diet, Science Diet, d/d, n/d, z/d, a/d, b/d, j/d and Evidence-Based Clinical Nutrition are trademarks owned by Hills Pet Nutrition, Inc. Eukanuba, Eukanuba Veterinary Diets and Response are trademarks
owned by The Iams Company. Royal Canin, Royal Canin Veterinary Diet, IVD, Limited Ingredient Diets, Skin Support SS21, Hypoallergenic HP19, Feline Hypoallergenic HP 23, Royal Canin Skin Care 30, Royal Canin Adult Fit
32, Royal Canin Indoor 27, Royal Canin Persian 30, Feline Sensitivity RD 30 and Sensitivity RC21 are trademarks of Royal Canin USA. Nutro and Nutro Ultra are trademarks of Nutro Products, Inc. Purina Veterinary Diets and
LA Limited Antigen are trademarks of Socit des Produits Nestl S.A. 3V Caps and DermCaps are trademarks owned by DVM Pharmaceuticals. NutriVed is a trademark owned by Zinpro Company. EicosaDerm is a trademark
owned by DermaPet. Welactin is a trademark owned by Nutramax Laboratories, Inc. Nordic Naturals is a trademark of Nordic Naturals, Inc. 2007 Hills Pet Nutrition, Inc.
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