FC Path(SA) Viro

THE COLLEGES OF MEDICINE OF SOUTH AFRICA

Incorporated Association not for gain
Reg No 1955/000003/08

Examination for the Fellowship of the
College of Pathologists of South Africa - Virologists

19 March 2012
Paper 1 Basic Clinical Virology (3 hours)

All questions are to be answered. Each question to be answered in a separate book (or books if more than
one is required for the one answer)
Al die vrae moet beantwoord word. Elke vraag moet in n aparte boek (of boeke indien meer as een nodig is
vir n vraag) geskryf word

1 Describe the replication of hepatitis B, the variants which may develop and the
implications thereof. [25]

1 Beskryf die replikasie van hepatitis B, die variante wat mag ontstaan en die
implikasies daarvan. [25]


2 Write notes on hepatitis E virus. [25]

2 Skryf notas oor hepatitis E virus. [25]


3 Write short notes on FOUR of the following
a) Micro-array technology.
b) Nanotechnology.
c) Synthetic interfering RNA (siRNA).
d) Prion hypothesis.
e) Ultra-deep sequencing.

3 Skryf kort notas oor VIER van die volgende
a) Mikro-reeks (array) tegnologie.
b) Nanotegnologie.
c) Sintetieseinmengende RNS (siRNS).
d) Prion hipotese.
e) Ultra-diepnukleiensuur basis paaropeenvolging. [25]


4 Discuss the impact of molecular recombination on the pathogenesis and laboratory
diagnosis of viral infections using specific examples. [25]

4 Bespreek die impak van molekulre herkombinasie op die patogenese en
laboratorium diagnose van virus infeksies, met die gebruik van spesifieke
voorbeelde. [25]





FC Path(SA) Viro

THE COLLEGES OF MEDICINE OF SOUTH AFRICA
Incorporated Association not for gain
Reg No 1955/000003/08

Examination for the Fellowship of the
College of Pathologists of South Africa - Virologists

20 March 2012
Paper 2 Applied Clinical Virology an Viral Immunology (3 hours)

All questions are to be answered. Each question to be answered in a separate book (or books if more than
one is required for the one answer)
Al die vrae moet beantwoord word. Elke vraag moet in n aparte boek (of boeke indien meer as een nodig is
vir n vraag) geskryf word

1. Discuss the concept of treatment as prevention with regard to HIV. [25]

1 Bespreek die begrip behandeling as voorkoming met betrekking tot MIV. [25]


2. Discuss the clinical management of a patient presenting with a possible viral
haemorrhagic fever infection. [25]

2 Bespreek die kliniese hantering van n pasint wat voordoen met moontlike virale
hemorragiese koors infeksie. [25]


3. Write concise notes on common endocrine abnormalities described in HIV-infected
patients receiving antiretroviral therapy. [25]

3 Skryf kort notas oor die algemeenste endokrien abnormaliteite beskryf in MIV-
geinfekteerde pasinte wat antiretrovirale terapie ontvang. [25]


4. Discuss the community health impact of three selected viral zoonotic diseases in
Southern Africa. [25]

4 Bespreek die gemeenskaps gesondheids impak van drie geselekteerde virus
zoonotiese siektes wat voorkom in Suidelike Afrika. [25]