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# 7/5/2014 six step calculation model - measurement uncertainty calculation tool

http://measurementuncertainty.net/index.php?module=products 1/2
25/03/2009
Measurement
Uncertainty
Monitoring
System(MUMS)
Measurement
Uncertainty
Monitoring
System(MUMS) is
a clinical
laboratory Q.C.
monitoring system
which is based on
uncertainty of
measurement.

measurement uncertainty calculation
tool

measurement uncertainty
anouncements
six step calculation model

uncertainty of
measurement calculator
messages
coments and questions
Duyurular
Ziyareti Says : 73804
six step calculation model
Before starting:
Always identify the main error sources, to make sure that they are
included in the calculations.
Step Action Measurand:
1) Specify Measurand (measurand) in (matrix) by (method)
The recommended expanded uncertainty for related analyte
2) Quantify u(Rw)
A type uncertainty is used if control and real patient samples are
processed by using same protocol
B type uncertainty is used if same steps of the protocol are not used for which are
possibly not covered by the control sample
Rw : root mean square of all of the different internal QC samples(lots) CVs
If a control sample is pass through the all steps of the real sample Rw 's enough to
calculate of this component but if real samples need to be processed before being
analysed every source of uncertainty components should be taken in to account. This
two types of uncertainty components are called A and B types uncertainty
respectively.
3) Quantify method and laboratory bias
Quantifying the laboratory bias is based onthe data obtained from
external QC reports. Root mean square of the RMS(bias) and u(cref) is
called u(bias).
RMS(bias) is the root mean square of the last three years inaccuracy
scores obtained from the end of cycle reports of external QC data.
u(cref) is basicly calculated by using the lab quantity which
shows participated laboratories to the concerning external QC
7/5/2014 six step calculation model - measurement uncertainty calculation tool
http://measurementuncertainty.net/index.php?module=products 2/2
programme and bias of method in which the related result is
assessed.
4) Converting all components of the uncertainty to a standard
uncertainty u(x)

5) Calculate combined standard uncertainty, uc

A combined standart uncertainty is calculated by using the root mean square of all
standart uncertainty components.

6) Calculate expanded uncertainty, U = 2 x uc

Expanded uncertainty is calculated by multiplying 2 of the combined
uncertainty. Two (1,96 in certain) is for the 95% confidence interval.

1) Specify Measurand (measurand)
in (matrix) by (method)
2)
Quantify
u(Rw)
3) Quantify method and
laboratory bias
Detay iin tklaynz.
Detay iin
tklaynz.
Detay iin tklaynz.
4) Convert components to
standard uncertainty u(x)
5) Calculate combined
standard uncertainty,
uc
6) Calculate expanded
uncertainty, U = 2 x uc
Detay iin tklaynz. Detay iin tklaynz. Detay iin tklaynz.
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