MYSOL

381
A new additive makes the impossible possible,
turning physically incompatible ingredients into the
components of a single, stable and homogeneous liquid.
Easy to use, MYSOL 381 is the key to solubilizing
fragrance oils, lipophilic vitamins and other apolar substances
in highly polar solvents, such as water and ethyl alcohol.

solubilizer No. 1000381

01. IDENTIFICATION OF THE PRODUCT
Trade name: MYSOL 381
ID code / catalog No. 1000381
Short description: liquid solubilizer composed of nonionic surfactants and rheology modifying solvents
INCI name: PEG-40 Hydrogenated Castor Oil; Trideceth-9; Propylene Glycol; Water (Aqua)
02. WORKING PRINCIPLES
Surfactants and surfactant systems can greatly increase the solubility of non-polar liquids in polar solvents, and
vice versa. This phenomenon, which involves incorporation of the solute by aggregates of surfactant molecules, is
known as solubilization.
Under suitable condition, liquid substances with high polarity differences can be turned into a single liquid phase
thanks to surfactants and the intrinsic duality of their molecular characteristic. Surfactant molecules, which have a
polar headgroup (hydrophilic group) and a nonpolar tail group (lipophilic group), arrange themselves around small
portions of solute, thus forming soluble microstructures, namely micelles where the group of the surfactant molecule
that is soluble in the solvent is facing outward (see the following illustration).
LIPOPHILIC/HYDROPHOBIC CHEMICAL MATRICE
(essential oils, fragrance oils, other lipophilic substance)
POLAR/HYDROPHILIC CHEMICAL MATRICE
(water/ethyl alcohol/water-alcohol mix)
HYDROPHILIC HEADGROUP
LIPOPHILIC TAIL
MYSOL 381 IS A COMPOUND SPECIALTY DESIGNED TO SOLUBILIZE HYDROPHOBIC
CHEMICAL MATRICES (ESSENTIAL OILS, FRAGRANCES AND OTHER LIPOPHILIC
CHEMICALS) IN WATER OR WATER-ALCOHOL SOLVENTS.
SMALL QUANTITIES OF MYSOL 381 FORCE THE CREATION OF A STABLE
HOMOGENEOUS PHASE FROM TWO OR MORE LIQUIDS THAT OTHERWISE SEPARATE
INTO DIFFERENT PHASES DUE TO POLARITY DIFFERENCES.
SOLUBILIZATION OF IMMISCIBLE OR SLIGHTLY MISCIBLE LIQUIDS IS ACHIEVED THROUGH
THE FORMATION OF ORDERED AGGREGATES (MICELLES) OF SOLUBILIZER AND
NON-POLAR MOLECULES, WHICH ARE SOLUBLE IN THE INTENDED SOLVENT
AND ARE SMALL ENOUGH (TYPICALLY 1 TO 3 nM) TO KEEP LIMPID THE SOLUTION.
MYSOL 381 EASY TO USE AND REQUIRES NO SPECIFIC MIXING TECHNOLOGY.
SURFACTANT SOLUBILIZER
03. SOLUBILIZATION METHOD / PROCESSING NOTES
Gently mix the substance to be solubilized with the amount of solubilizer which is assumed as strictly necessary
to obtain the desired result. Once that is done, slowly add the solvent matrix (e.g. water, water-alcohol mix) with
gentle mixing, avoiding trapping air in the mixture or fragmenting the substance to be solubilized (thereby forming
an undesirable emulsion).
The process can be generally facilitated by slightly warming the mixture. However, this option must be carefully
evaluated to ensure safety and to avoid undesirable chemical and chemical-physical transformations.
In the event that a gel forms, attempt to repeat the process at a higher temperature, while maintaining safe working
conditions.
If a cloudy mixture is produced, the entire process has to be repeated with a larger amount of solubilizer.
Note: Before beginning, make sure the individual ingredients are actually homogeneous.
04. SOLUTION TESTS
Test conditions:
4% solubilizer MYSOL 381
Y% (values on the y-axis) quantity of solubilized essential oil/ fragrance oil
qs to 100% distilled water
NTP (20C; 1 atm)
04.1 WATER SOLUTIONS
%

o
f

s
o
l
u
b
i
l
i
z
e
d

e
s
s
e
n
t
i
a
l

o
i
l

/

f
r
a
g
r
a
n
c
e

o
i
l
2%
3%
1,5%
2,5% 2,5%
2% 2%
4%
3%
5%
O
R
A
N
G
E

B
R
A
Z
I
L

E
O
W
H
I
T
E

M
U
S
K

9
7
P
A
T
C
H
O
U
L
Y

E
O
S
P
I
C
Y

F
I
G
S

9
1
C
I
T
R
O
N
E
L
L
A

J
A
W
A

E
O

O
Z
O
N
I
C

B
L
O
S
S
O
M

2
6
L
E
M
O
N

S
A

E
O
G
R
E
E
N

T
E
A

5
3
S
I
B
E
R
I
A
N

P
I
N
E

E
O

G
E
R
A
N
I
U
M

E
G
Y
P
T

E
O
ESSENTIAL OILS FRAGRANCE OILS
05. GENERAL DISCLAIMER
The information contained herein represents the extent of Moellhausens understanding of the art and must not in
any way be considered an intimation or warranty of the tness of the product for any particular purpose.
The product referred to herein is sold on the basis of its compliance with the respective specications (material
technical data sheet), and the manufacturer makes no warranties, express or implied, as to the tness of the
product for any particular purpose and on the condition that the purchaser/user performs the necessary controls
and tests to verify the tness of the product for the intended use.
Moellhausen shall not be liable for any irresponsible, improper or illegal use, direct or indirect, of the information or of
the product represented herein, and it shall not be liable for any damage arising from any use in connection therewith.
Test conditions:
5% essential oil/ fragrance oil
Y% (values on the y-axis) quantity of solubilizer MYSOL 381
qs to 100% water-alcohol solvent 60/40 wt/wt (60% distilled water + 40% ethyl alcohol)
NTP (20C; 1 atm)
04.2 WATER-ALCOHOL SOLUTIONS
D
o
c
u
m
e
n
t

M
3
2
1

-

C
o
p
y
r
i
g
h
t

2
0
1
2
,

b
y

M
o
e
l
l
h
a
u
s
e
n

S
.
p
.
A
.

-

A
l
l

r
i
g
h
t
s

r
e
s
e
r
v
e
d
.
%

o
f

s
o
l
u
b
i
l
i
z
e
r

M
Y
S
O
L

3
8
1
13%
5%
4% 4%
12%
6% 6%
4% 4%
2%
O
R
A
N
G
E

B
R
A
Z
I
L

E
O
W
H
I
T
E

M
U
S
K

9
7
P
A
T
C
H
O
U
L
Y

E
O
S
P
I
C
Y

F
I
G
S

9
1
C
I
T
R
O
N
E
L
L
A

J
A
W
A

E
O

O
Z
O
N
I
C

B
L
O
S
S
O
M

2
6
L
E
M
O
N

S
A

E
O
G
R
E
E
N

T
E
A

5
3
S
I
B
E
R
I
A
N

P
I
N
E

E
O

G
E
R
A
N
I
U
M

E
G
Y
P
T

E
O
ESSENTIAL OILS FRAGRANCE OILS
D
o
c
u
m
e
n
t

M
3
2
1

-

C
o
p
y
r
i
g
h
t

2
0
1
2
,

b
y

M
o
e
l
l
h
a
u
s
e
n

S
.
p
.
A
.

-

A
l
l

r
i
g
h
t
s

r
e
s
e
r
v
e
d
.
STRONG POINTS
GREATLY INCREASES THE SOLUBILITY OF
HYDROPHOBIC SUBSTANCES
IN WATER AND WATER-ALCOHOL SOLVENTS
SUITABLE FOR BOTH ACIDIC AND ALKALINE
MATRICES ( pH 3-11)
LOW QUANTITIES REQUIRED
GOOD RESISTANCE TO FOAM FORMATION
RELATIVELY LOW VISCOSITY
VERSATILE / MODERATE MATRIX DEPENDENCY
HLB (HYDROPHILIC-LIPOPHILIC BALANCE) VALUE: ~ 15
EASY USE AND HANDLING
Moellhausen S.p.A. - Head Ofce
Via Torri Bianche, 9
20871 Vimercate (MB), Italy
Tel. + 39 039.685.6262
Fax + 39 039.685.6263
E-mail ho@moellhausen.com
Website www.moellhausen.com