Pl M PlazMax

AdvantagesofPlasmaTechnology
LowTemperatureSterilization
Cansterilizeheatsensitiveloadsthatcannotbesubjectedtosteam j
Lowenergyrequirements
L tilit i t ( l t ili i t d l t i it ) Lowutilityrequirements(onlysterilizingagentandelectricity)
Nodryingstage
Noventilationneeded(likeEtO)
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Pl M PlazMax
CostEffective
Aftersterilizationloadsaredryandavailableforimmediateuseorstoragewhich
reducestheneedforexpensivebackupinventories.
Itisrecommendedtowaitforasuccessfulbiologicaltest
beforeusingthesterilizedloads.
Sterilizedloadscanremaininpackaging(noneedforrepackaging)
Fastturnaroundmeansincreasedinventoryutilization
Gentlesterilizationextendsyourinstrumentsusefullifespanby
minimizingdamageandreducingcostlyrepairorreplacement
Environmentallyfriendlyduetonowaterconsumption,notoxicexhaust,
and low electric power needs
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andlowelectricpowerneeds
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What is Plasma? WhatisPlasma?
PlasmawasnamedafteranAmericanphysicist,IrvingLangmuir.
When gas is applied with a greater energy it turns into Whengasisappliedwithagreaterenergy,itturnsinto
plasmawithionizedelements,whicharedifferentfromthepriorphases.
Asthenumberofpositiveandnegativeionscompensates eachother,theoverall
electricalpropertyofplasma.isneutralized electrical property of plasma. is neutrali ed
Plasmaisknownasthefourthstateofmatterand99%ofallthematerialsin
spaceisknowntobeplasma.Solidhasthelowestenergyamongstalltypesof
matter.Whensolidacquiresheat(energy),ittransformstophasesofliquid q ( gy) p q
andgas,sequentially.
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TheapplicationofPlasmainPlazMax
HowissterilizationaccomplishedwithH2O2?
The PlazMax utilizes the microbicidal (bacterium killing) power of free radicals ThePlazMaxutilizesthemicrobicidal(bacteriumkilling)poweroffreeradicals
releasedbyapplyingenergy(heatingliquidintogasviathevaporizer)tohydrogenperoxide.
Bydefinition,afreeradicalisanyatom(e.g.oxygen,nitrogen)withatleastone
unpairedelectronintheoutermostshell,andiscapableofindependentexistence p , p p
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The application of Plasma in PlazMax TheapplicationofPlasmainPlazMax
A free radical is easily formed when a covalent
Hydroxyl(OH)
Freeradical
Afreeradicaliseasilyformedwhenacovalent
bondbetweenentitiesisbroken(duetoheatinginourcase)andoneelectron
remainswitheachnewlyformedatom.Whenfreeradicalsstealanelectronfroma
surrounding compound or molecule a new free radical is formed in its place. surroundingcompoundormoleculeanewfreeradicalisformedinitsplace.
Inturnthenewlyformedradicalthenlookstoreturntoitsgroundstateby
stealingelectronswithantiparallelspinsfromcellularstructuresormolecules.
Thus,thechainreactioncontinuesandcanbe"thousandofeventslong , g
Hydrogenperoxideisuniqueinthatitcanbeconvertedtothe
Hydroxylradical(OH)orbecatalyzed(withtheBurnerinourcase)andexcreted
harmlesslyaswaterand/oroxygen
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The application of Plasma in PlazMax TheapplicationofPlasmainPlazMax
ThesterilizingagentinPlazMaxisH2O2,
namely Hydrogen Peroxide namely,HydrogenPeroxide.
Hydrogenperoxidewasfirstisolatedin1818byLouisJacquesThnard,
andH
2
O
2
haslongbeenwidelyusedinthepharmaceuticalindustry.
Hydrogen peroxide has been utilized for a decade or more in a wide variety of Hydrogenperoxidehasbeenutilizedforadecadeormoreinawidevarietyof
facilitiesandhasprovencompatiblewithmaterialsincludingsensitiveelectronics,
microscopes,stainlesssteel,andHEPAfilters.
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The application of Plasma in PlazMax TheapplicationofPlasmainPlazMax
ApplyingenergycausesalterationofOH(Hydroxyl)fromabonderbetweenthe
moleculesintheliquidstateintoafreeradicalinthegasstate
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Free
Radical
ExampleofanElectronstealingfromthebacteriabythefreeradical
Bacteria
Free
Bacteria
Radicals
Afterthealteration,theBacteriaceasestofunctionasBacteriaandbecomesafreeradicalofitsown.Asone,
stealsanElectronfromanotherBacteria,andaltersittoafreeradicalandsoforth.Achainreactionoccurs
effectinganddestroyingallBacteriumandthus,sterilizingthematerial.
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The application of Plasma in PlazMax TheapplicationofPlasmainPlazMax
The Plasma application is used in the Plazmax expressed by utilizing the Burner ThePlasmaapplicationisusedinthePlazmax,expressedbyutilizingthe Burner
ItspurposeistobreaktheH2O2 moleculesdownafterthesterilizingphase.
Thesystemconsistsofahighvoltagegenerator,whichapplieshigh
voltage to two electrodes located a few millimetres apart from each other voltagetotwoelectrodeslocatedafewmillimetresapartfromeachother
InsidetheBurner.
Whenhighvoltageisappliedtotheelectricplatesfacingeachother, g g pp p g ,
theH2O2 thatpassesthroughthespacebetweentheplatesisionizedand
Plasmaisgeneratedandbreaksdownthegasintomoleculesofwaterandoxygen.
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The application of Plasma in PlazMax TheapplicationofPlasmainPlazMax
VaporizedHydrogenPeroxide (H
2
O
2
) (A) Vaporized Hydrogen Peroxide (H
2
O
2
) (A)
High
Voltage
Plasma
otage
(B)
(C)
GND
2H
2
O (Water) +O
2
(Oxygen)
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The application of Plasma in PlazMax TheapplicationofPlasmainPlazMax
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Cycle graphs Cyclegraphs
Normalcycle
Averagecycletemp.50 C
1000mBar
Preparation
Aeration
Exhaustion
Preparation
For
diffusion
Diffusion
1
Plasma
1
Preparation
For
diffusion
Diffusion
2
Plasma
2
0
Vaporization
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Cycle graphs Cyclegraphs
Advancedcycle
Averagecycletemp.50 C
1000mBar
Preparation
Aeration
Exhaustion
Preparation
For
diffusion
Diffusion
1
Plasma
1
Preparation
For
diffusion
Diffusion
2
Plasma
2
0
Vaporization
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Cyclegraphs y g p
Preparation
Endoscopecycle
Averagecycletemp.40 C
1000mBar
For
diffusion
Aeration
Exhaustion
Preparation
For
diffusion
Diffusion
1
Plasma
1
Diffusion
2
Plasma
2
0
Vaporization
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Cyclegraphs y g p
Leakagetest
1000mBar
Achievingdeep vacuum Chamberissealed
andmonitoredforleaks
Thelinerepresents
theallowedlimitof
pressureincrease
0
p
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Cyclegraphs y g p
Penetrationtest
1000mBar
Aeration
Exhaustion Preparation
For
diffusion
Diffusion Plasma
00
Vaporization
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Cyclegraphs y g p
Penetration&leaktestcombined
1000mBar
Achievingdeep
vacuum
Chamberissealed
andmonitoredforleaks
Preparation
For
diffusion
Diffusion
Plasma Aeration
0
Vaporization
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Indicators&consumables
Biologicalindicator
TheBiologicalindicatorcontainsadefinedquantityof
inoculatedsporesinpopulationof1.9x10,placedona
stainlesssteeldisc.
The BI (biological indicator) has a breakable glass ampoule TheBI(biologicalindicator)hasabreakableglassampoule
whichincludesaculturemediatoallowthegrowthofthe
spores.Thediscandtheampoulearebothplacedinsidea
plastictube.
The BI has a chemical indicator which will indicate if the BI TheBIhasachemicalindicator,whichwillindicateiftheBI
wasexposedtoH2O2.
TheBIisdesignedforhydrogenperoxideplasmasterilization
processes,andutilizesGeobacillusStearothermophilusspores.
As the spores are highly resistant sterilizing them serves as a Asthesporesarehighlyresistant,sterilizingthemservesasa
goodindicationofthePlazMaxabilities.
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Indicators&consumables
Biologicalindicator
Plastic tube
Cap
Plastictube
Breakableglassampoule
Discinoculatedwithspores
ExposedtoH2O2
andsterilized
ExposedtoH2O2
andwasnot
sterilized
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Indicators&consumables
Incubators
Th i b t i d i d t t i th BI d l th t t TheincubatorisdesignedtocontaintheBIsandsupplythecorrectamount
ofheatneededforthesporestogrow.
Wecurrentlyhave24hoursresultsusingthestandardBrownincubator,
During the coming weeks we should have the Smart well incubator DuringthecomingweeksweshouldhavetheSmartwellincubator,
Whichincludesprinter,touchscreenandresultsgatheredin610hours.
Smart Well incubator
Brownincubator
SmartWellincubator
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Indicators&consumables
Chemicalindicator
Thechemicalindicator
Indicatesthatthesterilizingagentunderwentexposure.
IfitwasexposedtoH2O2 thecolorwillchangefrompurpletopink.
.
H O H2O2
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Indicators&consumables
ChemicalTape
Thechemicaltapehastwoapplications:
1. IndicatesexposuretoH2O2.
2. TapesareusedtoclosepolypropylenePackagingmaterials
Before After
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Indicators&consumables
LumensPCDkit
Monitoringthesterilizationprocesscanbeperformedwithflexiblelumenkits.
Th PCD (P Ch ll D i ) ki i 4 fl ibl l ThePCD(ProcessChallengeDevice)kitcontains4flexiblelumens;
2withopeningsonbothsides,
And2withopeningsononeside:
10meterLumen:
Consistsofacylinderforpositioningtheindicators.
Oneachsideofthecylinderisalumenof5meters
longwith1mmdiameter. g
5meterLumen:
Consistsofacylinderforpositioningtheindicators.On y p g
eachsideofthecylinderisalumenof2,5meterslongwith1mmdiameter.
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Indicators&consumables
LumensPCDkit
3meterLumen:
Consistsofacylinderforpositioningtheindicators.
It is sealed on one end with a lumen of 3 meters Itissealedononeendwithalumenof3meters
longwith1mmdiameterontheotherside.
2meterLumen:
Consistsofacylinderforpositioningtheindicators.
Itissealedononeofthesideswithalumenof2meterslongwith
1mmdiameterontheotherside.
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Indicators&consumables
LumensPCDkit
PCD di t ib ti di t l PCDsusagedistributionaccordingtocycles:
AdvancedCycle 4PCDs(10meters,5meters,3metersand2meters)
Normal Cycle 2 PCDs (5 meters and 2 meters) NormalCycle 2PCD s(5metersand2meters)
EndoscopesCycle 4PCDs(10meters,5meters,3metersand2meters)
PenetrationCycle 2PCDs(5metersand2meters)
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Indicators&consumables
Packagingmaterials
TyvecReels TyvecPouches
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Pl M PlazMax
Sterilizingagentconsumption
H2O2 Bottle
cat. no.
Supplier cat. No.
PlazMax
Model
No. of cycles
PLZ094-0001 AS040400 P50 12
PLZ094-0002 AS080400 P80 7
PLZ094-0003 AS100400 P110 5
PLZ094-0004 AS150400 P160 4
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Pl M d i i J&J PlazMaxadvantagesincomparisontoJ&J
Cycleduration:
1.Shortercycledurationscomparedtoboth100s&NXsystems:
Cycle name Tuttnauer J&J Cyclename Tuttnauer J&J
Tuttnauer J&J PlazMax NX system 100s
Normal Standard 26Min. 28Min. 51Min.
Advanced Advanced 34Min. 38Min. 72Min.
Endoscope
Not
Applicable
25Min.
NA NA
Applicable
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Pl M d i i J&J PlazMaxadvantagesincomparisontoJ&J
Testcycles:
3testcyclesincomparisontononeonJ&J,
Theyclaimtodoitaspartofthecycle wereachdeepervacuumonatestcycle
h h i l i Thantheoperationcyclessetpoints.
Installation:
V t i t ll l 1 h 230 i d i l i t d d Veryeasytoinstall;only1phase230vrequired,nospecialrequirementsneeded
fromtheclient.
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Pl M d i i J&J PlazMaxadvantagesincomparisontoJ&J
Endoscopecycle:
WeofferaspecificcycleforEndoscopes,J&Jperformitontheiradvancedcycle
atahighertemperatureandexposuretoH2O2.
Theshortcycletimehelpsinsurethatnodamagingmethodisapplied
Add d l l (4
th
l ) Addedvaluecycle(4
th
cycle):
Wegivetheabilitytosuitaspecialneededprogramtospecificinstrumentsthatwillallow
Theclienttomonitortheminaccordancetothestrictmanufacturerlimitations.
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Pl M d i i J&J PlazMaxadvantagesincomparisontoJ&J
Flexibility:
Themachinescanbechangedfromsingledoorintoa2doormachineduetothe
Designappliedandtheupgradecanbeperformedonsite.
Comfortableoperation:
UnlikeJ&Jthechamberisnotsensitivetotouch.
O ti i d d t bli th li t t t k i l Operatingisveryeasyanddoesnotobliges theclienttotakespecial
careintheloadpositioning.
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Pl M d i i J&J PlazMaxadvantagesincomparisontoJ&J
H2O2decomposingmethod:
J&Jperformthedecomposinginthechamber.Itislessreliablethanour
systemthatforceallparticlesthroughtheburneranddecompose.
Maintenancecosts:
UnlikeJ&Jthatchargebigamountsonmaintenancekitsandserviceagreements
O i t t i l t d l b h Ourmaintenancesystemrequireslesspartsandlaborhours.
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Pl M d i i J&J PlazMaxadvantagesincomparisontoJ&J
CompleteCSSDsolution:
TuttnauerhastheabilitytoprovidefullCSSDsolutionandturnkeyprojects
UnlikeJ&Jthathasnoothertechnologies.
UseableVolume:
I i t 100 d l th t h d d h b Incomparisonto100smodelthathasroundedchambers,
resultinginalossofabout30%involume,weofferarectangular
chamberwithfullusablevolume.
In comparison to NX system that has an inner casing we have also an advantage on IncomparisontoNXsystemthathasaninnercasing,wehavealsoanadvantageon
of15%usablevolume.
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s
PlazMax
Materials that can be sterilized by PlazMax
Common materials to sterilize with Plasma: Common materials to sterilize with Plasma:
Stainless steel
Polyethylene
Teflon Teflon
Metals
Stainless steel 300 series
Aluminum 6000 series
Titanium
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Non-Metals
PlazMax
Materials that can be sterilized by PlazMax
NonMetals
Acrylnitritebutadienestyrene(ABS)
Delrin
EVA(Etheylvinylacetate)
Fluorinated ethylene propylene (PTFE)
Polycarbonate
Polyethyleneterephthalate(PET)
Polymethylmethacrylate(PMMA)
Polyphenyl sulfone
Fluorinatedethylenepropylene(PTFE)
Glass,USPtypeIborosilicate
Lowdensitypolyethylene
Latex
Low density polyethylene
Polyphenylsulfone
Polypropylene
Polystyrene
Polysulfone
Teflon (PTFE)
Lowdensitypolyethylene
Monel
Neoprenerubber(polychloroprene)
Nylon
Phenolic resin
Teflon(PTFE)
Polyurethane
Polyvinylchloride(PVC)
Silicone
Phenolicresin
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PlazMax
MaterialsthatcannotbesterilizedbythePlazMax
Paper(butverysmallamountsofpaperarepossible.e.g:smallbarcodelabel).
Absorbentmaterials(cellulose)
Wood linen paper spongy materials Wood,linen,paper,spongymaterials
Liquids
Powder
Oil Oil
Instrumentswithlumen,havinglessthan1mmdiameterand/orover10mlength
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Whatever your application may be, Tuttnauer makes the right
A t l ith th i ht it ! Autoclave with the right capacity !
Tuttnauer Europe b.v.
Paardeweide 36 P.O.B. 7191
4800GD Breda, The Netherlands
Tuttnauer USA Co. Ltd.
25 Power Drive
Hauppauge, NY,11788,USA
Tel: (31) 76 5423510,
Fax: (31) 76 5423540
Email: tuttnauer@tip.nl
Tel: (631) 737 48 50, (800) 624 5836
Fax: (631) 737 07 20
Email: info@tuttnauer.com
98
www.tuttnauer.com www.tuttnauer.com
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