Dear Dr.

Brahmaiah
Kindly refer to your online submission of a paper entitled Morphometric
evaluation of corpus callosum in healthy individuals for publication in the
Indian Journal of Medical Research.
Your paper has been carefully eamined by the !ditorial Board of our Journal.
"he Board is of the opinion that the paper# in its present form# is not suitable
for publication for the reasons $iven in the attached note.
"han% you for submittin$ to the IJMR.
&ith %ind re$ards#
Yours sincerely
'()J* +,(RM(-
Dr *ppuruti Brahmaiah
,YD# ,yderabad.India
/R!0I!&!R 123
1. )one of these results contain ne4 information. (ll eamined parameters
are etensively studied 4ith more and better selected patients# better
techni5ues.
................................................
/R!0I!&!R 623
6. In this study# the authors attempted to find se.related differences in
morpholo$ical attributes of the corpus callosum '77- in the Indian sub8ects
usin$ 5uantitative MRI and their correlation 4ith a$in$. "hey believe that
because the cortical and subcortical brain re$ions often suffer in diseases and
in a$in$# correspondin$ chan$es in the 77 morpholo$y should be evident and
may be useful in dia$nosis certain disease processes. ( number of eistin$
reports indicate se differences of the 77. 9or eample# men possess lar$er
77 than that in 4omen: the splenium is lar$er in 4omen than in men# the
splenium is more tubular.shaped in males# but bulbous in females. ,o4ever#
other 77 attributes are not so clear.cut in their phenotypes.
;. My opinion about their overall findin$s is that nothin$ si$nificant came out of
this 4or% as ne4 observation# other than leavin$ some impressive ideas for
future 4or%ers.
<. "he authors found the len$th of 77 to be increased 4ith increasin$ a$e of
the individuals... but did not hi$hli$ht the probable reasons for this important
observation. &hy should this happen 4ith normal a$in$= (lthou$h not entirely
ne4# "a%eda et al. '6>>;- and +u$anthy et al. '6>>;- also reported the same
for the Japanese and Indian sub8ects# respectively: so this is an additional
support of their findin$s concernin$ the Indian sub8ects. But a$ain# consider
the report of &itelson '1?@?- /Brain 1163 A??.@;B2 describin$ 77 siCe to be
decreased 4ith chronolo$ical a$e in males# but not in females. Do you see
any reason to be so=
B. "he authors stated that the morphometric differences of the 77 in different
populations of the 4orld may be due to ethnic factors Dthis is acceptable# but
note that this is also due to other associated factors 'non.$enetic- that
influence postnatal brain $ro4th and connectivity. 9or eample# see a paper of
&itelson +9. '1?@B-. "he brain connection3 the corpus callosum is lar$er in
left.handers. +cience 66?'<A1<-3 EEB.EE@.
E. &idth of body and isthmus increases 4ith a$e.... Flease read a paper that
reported si$nificant decrease in 77 area 4ith a$in$ in a relatively lar$er $roup
of adults '(llen et al. 1??1: J )eurosci 113 ?;;.?<6-. (lso cite this 4or% 4ith
your relevant comment.
A. &idth of body and isthmus increases 4ith a$e. "hese structural alterations
may be probably due to the differences in co$nitive function of brain..... &hat
are those established differences in a$in$ brain that could influence
co$nition= (re there sufficient reasons to thin% alon$ this line# particularly
since no evidence or others vie4s presented in favour of this 'co$nition vs
a$in$ brain chan$es-=
@. Delete 77# as you have not used later in the abstract
?. limited data is %no4n... data are...
1>. +o in the present study attempt is made... an attempt isG '+ee also in
introduction-
11. !pand MRI
16. 7orpus callosumDshould be the corpus callosum 'also throu$hout the
tet-
1;. nonsi$nificantly hi$her in females... compared to 4hich $roup=
1<. Interpretation H conclusions
1B. &e 4ould li%e to conclude that... is not technically sound
1E. 4hile some of the parameters are contradictory... mention cate$orically
4hat those are# since you are concludin$ here.
1A. +o it is very essential to state that... modify this phrase
1@. studies comprisin$ of hu$e human samples... meanin$ of Ihu$eJ is
ambi$uous
1?. an important dia$nostic tool... cannot be a tool# better parameter
6>. Key 4ords3 delete 'MRI- from Ma$netic Resonance Ima$in$ 'MRI-
61. "he corpus callosum is an important interhemispheric commissural
structure connectin$ the ri$ht and left cerebral hemispheres... delete the
redundant 4ord interhemispheric
66. &here areas# there are reports 4here no se related differences in the
siCe and various other measurements of corpus callous.... meanin$ is unclear
6;. Kuantitative measures of the corpus callosum have been ...
measurementG has been
6<. on 7aucasian brains... on the 7aucasian brains
6B. Galso measurements of distance bet4een corpus callosum and cortical
re$ions have been attempted.... delete Ihave been attemptedJ.
6E. Fut inclusion and eclusion criteria to$ether
6A. "he MRI scanner used 4as +iemens Ma$netom of 1.B tesla... Mention the
full name of the model# name of the 7ompany it provided# and its 7ity of ori$in
or 4here it 4as installed. *se correctly IteslaJ.
6@. &hich method 4as adopted to measure the various 77 attributes=
6?. 9urther the data 4as sub8ected... 4ere
;>. (ll the data 4as... 4ere
;1. (ll the data 4as tabulated and the data 4as $rouped into... should be all
data 4ere tabulated and $rouped intoG
;6. In both the sees rostrum# 77 to frontal lobe and 77 to top most cortical
surface has a ne$ative correlation.... any si$nificance=
;;. 4idth of body# isthmus 'pL >.>B- and len$th of corpus callosum 'pL >.>1-
sho4ed a positive correlation 4hich 4as statistically si$nificant 4ith a$e '"able
III-... is an incomplete eplanation.
;<. It is stated that in males eamined# the len$th of 77 and splenium
increased si$nificantly as the a$e advances ... any si$nificance=
;B. "he present study results... the results of the present study
;A. +u$anthy et al. and Mupta et al. reported that the 77 len$th in males 4as
si$nificantly hi$her than that in the females
;@. In Mupta et al. study usin$ MRI sho4ed the similar results 'A.BANO.>.E6 in
males and A.1>NO.>.<1 in females in centimetres-.... convert these values in
the same unit as in +u$anthy et al to compare
;?. Mohammadi MR et al.6< reported that the len$th of 77 increased as the
a$e of the individual is increasedDshould be Mohammadi et al.6< reported
that the len$th of 77 increased 4ith increasin$ a$e of the individuals
<>. &ith these results bein$ inconsistent from study to studyGG the sample
siCe need to be hu$e to $et to the consistent data 4hich 4ill help to create a
database of authenticity..... delete Ihu$eJ from this line. 9urthermore#
inconsistency in findin$s from study to study is not only due to small sample
siCe used# but also due to variations in measurements of the features
considered.
<1. Different se across the $lobe... modify it
<6. +tyle of the 8ournal names are not uniform# adhere to the prescribed
pattern for the 8ournal
<;. "able II3 &hat do the stars of p values indicate=
<<. "he use of !n$lish and $rammar has to be improved critically throu$hout
the tet
<B. "he ne4 observations in this M+ are limited and overall their relevance is
not discussed properly.
<E. "he M+ is poorly 4ritten# from both technical and lin$uistic vie4.points and
cannot be an ecuse. "here is a lac% of scientific reasonin$ in authors
interpretation of data.
<A. (ll eistin$ 4or%s are not cited
................................................
/R!0I!&!R ;23
1. "he authors have studied the morphometric details of corpus callosum in A6
normal midsa$ittal MRI scans. Mood effort by the authors. ,o4ever# the
sub8ect studied is not ne4/1#62 and# unfortunately# there is no novel
informationOfindin$ in this paper. (s there are lar$e variations in the
morphometric aspects of the corpus callosum# the sample siCe should have
been much lar$er to ma%e this study of any use.
6. "here should be a set patternOstandardiCed pattern for selection of sub8ects.
)eurolo$ical problems or psychiatric disorders canJt be ruled out solely on the
basis of history. 7linicianOneuro.physician should rule out these diseases in
the healthy sub8ects.
;. (uthors should specifically mention the source of the study population# and
ho4 did they select them.
<. +ample siCe should have been much lar$er.
B. "able 1: Ro4 <3 7ouldnJt understand# 4hat does this mean denote=
E. "able 63 ,eadin$ is $iven belo4 the table. It should be at top of the table.
9urther# Cero should be used before the decimal point.
A. Reference citation needs revision. (ll authors are to be listed 4hen there
are si or fe4er: 4hen seven or more# list the first si contributors follo4ed by
et al.
................................................
/Meneral 7omments2
1. "he place and period of the study is not $iven.
6. &ho provided the MRI scans=
;. &hy is no radiolo$ist included= 9rom 4here 4ere the MRI scans obtained=
<. ,o4 4as the sample siCe decided=
B. ,o4 4ere the eclusion and inclusion criterion determined for the sub8ects=