31.05.

2013 Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome (thoracic)
www.atsjournals.org/doi/abs/10.1164/rccm.200405-579OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed 1/4
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American Journal of Respiratory and Critical Care Medicine >
Volume 171, Issue 2 >
Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome
Volume: 171,
Issue: 2 (January
15, 2005)

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31.05.2013 Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome (thoracic)
www.atsjournals.org/doi/abs/10.1164/rccm.200405-579OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed 2/4
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cardiovascular
risk
continuous
positive airway
pressure
obesity
sympathetic
nervous system
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Joaquin
Durn-Cantolla
Mnica de la
Pea
Ferran Barb
Alvar G. N.
Agust
Antonia
Barcel
Antoni
Ladaria
Elena
Llompart
Lourdes
Guerra

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Cited By
Antonia Barcel, Ferran Barb, Elena Llompart, Mnica de la Pea,
Joaquin Durn-Cantolla, Antoni Ladaria, Margalida Bosch, Lourdes
Guerra, and Alvar G. N. Agust "Neuropeptide Y and Leptin in Patients
with Obstructive Sleep Apnea Syndrome", American Journal of
Respiratory and Critical Care Medicine, Vol. 171, No. 2 (2005), pp.
183-187.
doi: 10.1164/rccm.200405-579OC
Neuropeptide Y and Leptin in
Patients with Obstructive Sleep
Apnea Syndrome
Role of Obesity
Antonia Barcel, Ferran Barb, Elena Llompart, Mnica de la Pea,
Joaquin Durn-Cantolla, Antoni Ladaria, Margalida Bosch, Lourdes
Guerra, and Alvar G. N. Agust
+ Author Affiliations
Serveis de Anlisis Cliniques and Pneumologia, Hospital
Universitari Son Dureta, Institut Universitari de Ciencies de la
Salut, Palma de Mallorca; and Servicio de Neumologia, Hospital
Txagorritxu, Vitoria-Gasteiz, Spain
Abstract
Neuropeptide Y (NPY) and leptin are two peptides involved in the
regulation of body weight, energy balance, and sympathetic tone. This
study investigates the independent role of apneas and obesity on NPY
and leptin plasma levels in patients with obstructive sleep apnea
syndrome (OSAS). To this end we compared their values in 23 obese
(body mass index > 30 kg/m
2
) and 24 nonobese (body mass index < 27
kg/m
2
) patients with OSAS, and in 19 obese and 18 nonobese control
subjects without OSAS. Patients who used continuous positive airway
pressure for more than 4 hours/night were reexamined 3 and 12 months
later. We found that NPY levels were increased (p < 0.01) in patients
with OSAS independently of obesity. Leptin levels were also increased
in OSAS but this was mostly associated to obesity. Continuous positive
airway pressure treatment reduced NPY levels in all patients and leptin
levels only in nonobese patients (p < 0.01). We concluded that NPY
and leptin plasma levels are increased in patients with OSAS. Yet,
whereas the former appear independent of obesity, the latter are mostly
associated with obesity.

31.05.2013 Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome (thoracic)
www.atsjournals.org/doi/abs/10.1164/rccm.200405-579OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed 3/4
Guerra
Margalida
Bosch
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KEYWORDS: cardiovascular risk, continuous positive airway pressure, obesity,
sympathetic nervous system
Correspondence and reprint requests should be addressed to Ferran
Barb, M.D., Servei de Pneumologa, Hospital Universitari Son Dureta,
C/ Andrea Doria 55, 07014 Palma de Mallorca. E-mail: fbarbe@hsd.es
Accepted October 17, 2004
Received May 3, 2004
2005 The American Thoracic Society
Supported by ABEMAR, SEPAR and Fondo de Investigaciones
Sanitarias (Red Respira [RTIC C03/11], 01/0786, 02/0334. Mnica de
la Pea was supported by a personal research grant from FIS, CM-
0300049).
Conflict of Interest Statement: A.B. does not have a financial
relationship with a commercial entity that has an interest in the subject of
this manuscript; F.B. does not have a financial relationship with a
commercial entity that has an interest in the subject of this manuscript;
E.L. does not have a financial relationship with a commercial entity that
has an interest in the subject of this manuscript; M.d.l.P does not have a
financial relationship with a commercial entity that has an interest in the
subject of this manuscript; J.D.-C. does not have a financial relationship
with a commercial entity that has an interest in the subject of this
manuscript; A.L. does not have a financial relationship with a
commercial entity that has an interest in the subject of this manuscript;
M.B. does not have a financial relationship with a commercial entity that
has an interest in the subject of this manuscript; L.G. does not have a
financial relationship with a commercial entity that has an interest in the
subject of this manuscript; A.G.N.A. does not have a financial
relationship with a commercial entity that has an interest in the subject of
this manuscript.
Cited by
Esra Tasali
1
, and Mary S. M. Ip
2
. (2008) Obstructive Sleep Apnea
and Metabolic Syndrome. Proceedings of the American Thoracic
Society 5:2, 207-217
Online publication date: 15-Feb-2008.
Abstract | Full Text | PDF (153 KB)
Oscar Sans Capdevila
1
, Leila Kheirandish-Gozal
1
, Ehab Dayyat
1
,
and David Gozal
1

,

2
. (2008) Pediatric Obstructive Sleep Apnea.
Proceedings of the American Thoracic Society 5:2, 274-282
Online publication date: 15-Feb-2008.
Abstract | Full Text | PDF (208 KB)
Richard L. Horner, and T. Douglas Bradley. (2006) Update in Sleep
and Control of Ventilation 2005. American Journal of Respiratory
and Critical Care Medicine 173:8, 827-832
Online publication date: 15-Apr-2006.
Citation | Full Text | PDF (95 KB)


31.05.2013 Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome (thoracic)
www.atsjournals.org/doi/abs/10.1164/rccm.200405-579OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed 4/4



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