Table 2.

1: Bacterial moonlighting proteins binding to host components, (Kainulainen & Korhonen, 2014)
Moonlighting protein Moonlighting function Bacterial species
Glyceraldehyde-3-
phosphate
dehydrogenase
Binding to plasminogen
Bacillus anthracis, Escherichia coli, Listeria monocytogenes, Staphylococcus
aureus, Steptococcus agalactiae, Streptococcus anginosus, Streptococcus
oralis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus suis
Binding to urokinase receptor on human pharyngeal cells,
lysozeme, actin, myosin, fibronectin and C5a complement
protein
Streptococcus pyogenes
Binding to actin, fibronectin Streptococcus agalactiae
Binding to albumin and porcine tracheal rings Streptococcus suis
Binding to fibronectin and intestinal epithelial cells Escherichia coli
Binding to other bacterial species Group B Streptococcus
Coadhesin of Porfyromonas gingivalis in periodontal tissue Streptococcus oralis
Binding to colonic, porcine or vaginal mucin Mycoplasma genitalium
EGF-receptor Mycobacterium avium, Mycobacterium tuberculosis
Enolase
Binding to plasminogen
Bacillus anthracis, Borrelia burgdorferi, Listeria monocytogenes, Mycoplasma
pneumoniae, Staphylococcus aureus, Streptococcus mutans, Streptococcus
oralis, Streptococcus pneumoniae, Streptococcus pyogenes
Binding to laminin and collagen Staphylococcus aureus
Binding to albumin Streptococcus pyogenes
Binding to salivary mucin Streptococcus gordonii, Streptococcus mutans
Binding to intestinal epithelial cells Streptococcus suis
Binding to C4b-binding proteins Streptococcus pneumoniae
Aldolase Binding to flamingo cadherin Streptococcus pneumoniae
Phosphofructokinase Binding to plasminogen Streptococcus oralis
Phosphoglycerate
kinase
Binding to plasminogen Streptococcus anginosus, Streptococcus oralis, Group B streptococci
Binding to actin Group B streptococci
Phosphoglycerate
mutase
Binding to plasminogen Streptococcus anginosus, Streptococcus oralis
Triose phosphate
isomerase
Binding to plasminogen Streptococcus anginosus, Streptococcus oralis
Glutamine synthetase
Binding to plasminogen Mycobacterium tuberculosis
Binding to fibronectin Mycobacterium tuberculosis
Moonlighting protein Moonlighting function Bacterial species
Ribonucleotide
reductase
Binding to plasminogen Staphylococcus aureus
Inosine 5-
monophosphate
dehydrogenase
Binding to plasminogen Staphylococcus aureus
Alcohol acetaldehyde
dehydrogenase
Binding to Caco-2 cells and eukaryotic Hsp60 Listeria monocytogenes
Malate synthase Binding to laminin and fibronectin Mycobacterium tuberculosis
SarA; oligopeptide-
binding protein
Binding to salivary mucin Streptococcus gordonii
Pyruvate
dehydrogenase
Binding to plasminogen and fibronectin Mycoplasma pneumoniae
Pyruvate kinase Binding to salivary mucin Streptococcus gordonii
DnaK
Binding to plasminogen Mycobacterium tuberculosis, Listeria monocytogenes
Stimulation of dendritic cell maturation by binding CCR5 and
competition with HIV for CCR5 binding
Mycobacterium tuberculosis
Elongation Factor Tu
Binding to plasminogen Listeria monocytogenes, Pseudomonas aeruginosa
Binding to plasma Factor H and Factor H-related protein 1
(FHR-1)
Pseudomonas aeruginosa
Binding to salivary mucin Streptococcus gordonii
Binding to fibronectin Mycoplasma pneumoniae
Elongation Factor G Binding to salivary mucin Streptococcus gordonii
Ag85 complex of M.tb Binding of plasminogen and fibronectin Mycobacterium tuberculosis
DNA-directed RNA
polymerase
betasubunit
Binding to salivary mucin Streptococcus gordonii
Endopeptidase O
Binding to plasminogen, fibronectin and invasion to epithelial
and endothelial cells
Streptococcus pneumoniae
SecA Binding to salivary mucin Streptococcus gordonii
Superoxide dismutase Binding to epithelial cell ldolase, GAPDH and cyclophilin A Mycobacterium avium