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Adverse events associated with pericardiocentesis in dogs: 85 cases (19992006). Incidence of adverse events 10.7% within 1 hour and 15.2% within 48 hours. Most adverse events identified were dysrhythmias. Forty-one percent of those dogs with adverse events were euthanized or died within 48 hours.
Adverse events associated with pericardiocentesis in dogs: 85 cases (19992006). Incidence of adverse events 10.7% within 1 hour and 15.2% within 48 hours. Most adverse events identified were dysrhythmias. Forty-one percent of those dogs with adverse events were euthanized or died within 48 hours.
Adverse events associated with pericardiocentesis in dogs: 85 cases (19992006). Incidence of adverse events 10.7% within 1 hour and 15.2% within 48 hours. Most adverse events identified were dysrhythmias. Forty-one percent of those dogs with adverse events were euthanized or died within 48 hours.
in dogs: 85 cases (1999^2006) Karen R. Humm, MA, VetMB, DACVECC, MRCVS; Elizabeth A. Keenaghan-Clark, MA, VetMB, MRCVS and Amanda K. Boag, MA, VetMB, DACVIM, DACVECC, FHEA, MRCVS Abstract Objective To quantify the frequency of adverse events occurring during or post pericardiocentesis and to determine if adverse events are related to the cause of the pericardial effusion or frequency of pericardiocentesis. Design Retrospective study. Setting Referral hospital. Animals, Intervention and Measurements Medical records of 85 dogs that underwent 112 episodes of pericardiocentesis were reviewed. Any adverse events during pericardiocentesis and in the 48 hours post pericardiocentesis were noted. The frequency of adverse events was compared between dogs with a suspected neoplastic cause and a suspected nonneoplastic cause of their pericardial effusion and also between the rst and subsequent pericardiocenteses. Main Results The incidence of adverse events was 10.7% within 1 hour of pericardiocentesis and 15.2% within 48 hours. There was no signicant difference in the frequency of adverse events between the groups. Most adverse events identied were dysrhythmias. Forty-one percent of those dogs with adverse events were euthanized or died within 48 hours. Conclusion The incidence of adverse events seen within 48 hours of pericardiocentesis was 15.2%. (J Vet Emerg Crit Care 2009; 19(4): 352356) doi: 10.1111/j.1476-4431.2009.00436.x Keywords: arrhythmia, cardiac, death, dysrhythmia, pericardial effusion Introduction Pericardial effusion is a well-described clinical condition in the dog. Increasing levels of pericardial uid lead to elevated intrapericardial pressure; if this pressure increases to a level greater than or equal to right ven- tricular pressure, tamponade occurs. Clinical signs con- sistent with right-sided congestive heart failure and decreased cardiac output result. Pericardiocentesis is the most effective and rapid way of resolving the clinical signs and is often performed as an emergent procedure. Pericardial uid obtained during pericardio- centesis may also be useful for diagnostic purposes. 15 Pericardial effusions most commonly have a neoplastic or idiopathic etiology in the dog. 6,7 Other potential causes include congestive heart failure, 6 hypoproteinemia, 6 per- icardioperitoneal diaphragmatic hernia, 8 infection, 9,10 atri- al rupture, 11 and coagulopathy. 12,13 The technique for pericardiocentesis has been well described. 14,15 While it is often noted that complications may occur during or following pericardiocentesis, the frequency and nature of these complications has not been reported previously in dogs. 14,15 A study in hu- mans of 1127 cases of therapeutic pericardiocentesis found a major complication (an undesirable event oc- curring due to pericardiocentesis requiring interven- tion) rate of 1.2% and a minor complication (events which required no management other than appropriate monitoring and follow up) rate of 3.5%, 16 giving a total complication rate of 4.7%. This retrospective study describes the frequency and nature of adverse events occurring during or following pericardiocentesis in dogs and evaluates whether the frequency of these events varies between different patient groups. A portion of this work was presented in abstract form at the British Small Animal Veterinary Association Congress in 2005. Address correspondence and reprint requests to Dr. Karen R. Humm, Department of Veterinary Clinical Sciences, The Queen Mother Hospital for Animals, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK. Email: khumm@rvc.ac.uk From the Department of Veterinary Clinical Sciences, The Queen Mother Hospital for Animals, The Royal Veterinary College, Hertfordshire AL9 7TA, UK. Journal of Veterinary Emergency and Critical Care 19(4) 2009, pp 352356 doi:10.1111/j.1476-4431.2009.00436.x & Veterinary Emergency and Critical Care Society 2009 352 Materials and Methods Selection of cases Medical records of a large referral hospital (The Queen Mother Hospital for Animals, The Royal Veterinary Col- lege) were searched for the period January 1999 to June 2006 for all dogs that had undergone pericardiocentesis. Patients were excluded from the study if the medical records were unavailable or incomplete or if the peri- cardiocentesis had not been performed at the hospital. Procedures The age, sex, breed, clinical examination ndings, and echocardiographic results were recorded. ECG results before pericardiocentesis and cytologic analysis of the uid were also recorded if performed. If a dog subse- quently underwent thoracotomy or necropsy, the nal diagnosis was recorded. For patients that underwent multiple pericardiocenteses, each episode of pericardio- centesis was recorded and analyzed separately. Patients were monitored closely, generally with ECGs for 24 hours post pericardiocentesis and regular physical examination was performed. The kennel sheets and daily summary notes of the patients were then examined for the day of pericardiocentesis and the following 48 hours for any adverse events. An adverse event was dened as a deterioration in the patients condition resulting in the need for further intervention including drug therapy or that resulted in death or euthanasia of the patient. The dogs were classied into 2 groups dependent on whether they were suspected to have a neoplastic (mass positive) or nonneoplastic (mass negative) cause of pericardial effusion. Dogs were included in the mass positive group if a mass was visualized on echocardio- graphic examination, if neoplastic cells were found on cytologic examination of the pericardial uid or if a neoplasm was noted at surgery or on postmortem ex- amination. All other dogs were classied as mass neg- ative. If an animal was thought to have a mass negative effusion and was later found to be mass positive, all previous pericardiocentesis episodes were included in the mass positive group. Pericardiocentesis episodes were also classied into 2 groups dependent on whether they represented a rst or subsequent episode. Descriptive statistics were performed using commer- cially available software. a The incidence of adverse events was compared between the mass positive and mass negative groups and between rst and subsequent pericardiocentesis groups using chi-squared analysis with a result being considered signicant if P 0.05. a Results One hundred and eight cases had pericardiocentesis performed in the period identied. Twenty-three cases were excluded due to absent or incomplete records. One hundred and twelve episodes of pericardiocentesis were performed on 85 dogs. Sixty-one of the 85 dogs (71.8%) were male (37 entire and 24 neutered) and 24 (28.2%) were female (5 entire and 19 neutered). A large number of breeds were represented including 14 mixed breeds (16.5%), 13 Golden Retrievers (15.3%), 12 Ger- man Shepherd Dogs (14.1%), and 5 Labrador Retrievers (5.9%). Other breeds were represented by 3 dogs or fewer. The median age at time of the rst pericardio- centesis episode was 8.5 years (range 0.912.4 y). Physical examination before each episode of per- icardiocentesis revealed poor pulse quality, pulsus para- doxus, or tachycardia in 77 of 112 (68.8%) dogs. Pulse decits or an irregular rhythmwere noted in 5 dogs and 4 of these animals had an ECG before pericardiocentesis that detected a dysrhythmia. The fth dog was consid- ered to have sinus arrhythmia and no ECG was per- formed. ECG ndings before pericardiocentesis were noted in the records for 48 of the 112 (43%) pericardiocentesis episodes. The most common abnormalities seen were electrical alternans in 22 of 48 cases (45.8%), sinus tachycardia in 16 of 48 cases (33.3%), decreased QRS amplitude in 9 of 48 cases (18.8%) and intermittent ventricular premature complexes in 5 of 48 cases (10.4%). Six of the 48 (12.5%) dogs with ECG records were within normal limits. Several cases had more than 1 ECG abnormality noted. Other abnormalities seen were runs of ventricular tachycardia in 2 cases and sinus arrhythmia, atrial brillation, intermittent supra- ventricular tachycardia, and intermittent atrial prema- ture complexes in 1 case each. One dog was treated with lidocaine before pericardiocentesis due to frequent ventricular premature complexes. In 17 of 112 (15.2%) pericardiocentesis procedures an adverse event was documented within the 48-hour pe- riod following the procedure. Adverse events were noted most frequently during or shortly after peri- cardiocentesis with 11 of 17 (65%) adverse events occurring within 1 hour. No dog had an adverse event on more than 1 episode of pericardiocentesis. Adverse events seen included dysrhythmias requir- ing drug therapy in 11 of 17 (65%) cases (see Table 1), cardiopulmonary arrest in 4 of 17 (24%) cases, and continued bleeding into the pericardium that resulted in euthanasia of the dog in 3 of 17 (18%) cases. One dog had ventricular tachycardia requiring lidocaine therapy at the time of pericardiocentesis and also underwent cardiopulmonary arrest 13 hours later. Of the dogs un- dergoing cardiopulmonary arrest, the arrest occurred at 1, 2, 13, and 26 hours post pericardiocentesis. Three dogs underwent cardiopulmonary arrest of unknown cause and 1 was seen to proceed rapidly from ventric- & Veterinary Emergency and Critical Care Society 2009, doi: 10.1111/j.1476-4431.2009.00436.x 353 Adverse events associated with pericardiocentesis ular tachycardia, to ventricular brillation, to asystole. Three dogs were euthanized due to continued bleeding into the pericardium. Continued bleeding was visualized by echocardiography immediately post pericardiocentesis in 1 case and in the other 2 cases PCVand total solids values were noted to decrease over a 24-hour period resulting in the presumption of con- tinued bleeding. All of these dogs had a concurrent deterioration in their clinical status. Two were mass positive and the third was coagulopathic with elevated prothrombin and partial thromboplastin times. Eight of the 17 dogs that had adverse events had ECG results before pericardiocentesis noted in their medical records. Three of those dogs had dysrhythmias noted and went on to have dysrhythmic adverse events. One had a worsening of a supraventricular tachycardia with the development of novel ventricular premature complexes, 1 developed atrial brillation with the previous abnormality noted being intermittent ventric- ular premature complexes, and 1 developed ventricular tachycardia with intermittent ventricular premature complexes noted before pericardiocentesis. Five dogs having adverse events did not have a dysrhythmia noted on their ECG before pericardiocentesis. Three of these dogs developed a dysrhythmia (all were ventric- ular tachycardia), 1 underwent a cardiopulmonary ar- rest of unknown cause and 1 was suspected to have continued bleeding. Nine of the 17 dogs (53%) with adverse events post pericardiocentesis were discharged from the hospital compared with 56 of 68 dogs (82%) that did not experience an adverse event. Sixty-four of 112 (57.1%) pericardiocentesis episodes were performed on mass negative effusions and 48 of 112 (42.9%) episodes on mass positive effusions. Of those classied as mass positive, 27 of 36 (75%) were diagnosed with echocardiography, 7 of 36 (19.4%) were diagnosed at surgery or with the aid of surgical biop- sies, and 2 were diagnosed with cytologic analysis of uid. There was no signicant difference in the fre- quency of adverse events between these 2 groups (P50.52). Eighty-ve of the 112 (75.9%) procedures were rst time episodes and 27 of 112 (24.1%) were second or subsequent episodes (25 animals had a sec- ond pericardiocentesis and 2 had a third). There was no signicant difference in the frequency of adverse events dependent on whether the pericardiocentesis was a rst or subsequent procedure (P50.33). Discussion The population of dogs reported here as undergoing pericardiocentesis is similar to previously reported populations of dogs presenting for pericardial effusion. Forty-two percent of dogs in the study were suspected to have a neoplastic cause for their pericardial effusion. Pericardial effusions have been shown to have a neo- plastic etiology in 3168% of dogs. 2,3,7,17 The breeds that appear with high frequency in this study (German Shepherd Dogs, Golden Retrievers, and Labrador Retrievers) are similar to those reported to be at risk in previous studies. 6,7,17 The mean age of the dogs is similar to previous studies; mean age ranges between 6.8 and 9.1 years. 6,17,18 The rate of complications during or following peri- cardiocentesis has not been reported previously in dogs. We chose to use the term adverse events as op- posed to complications as it is not possible to know whether the events occurred as a result of the proce- dure itself or secondary to the underlying disease. The adverse event rate of 15% is greater than the compli- cation rate of 4.7% reported in a human study. 16 Inter- estingly, only 3 cases of dysrhythmia were noted in the human study (0.27% overall), whereas these constituted the majority of adverse events reported here. In hu- mans, the most commonly noted complications were pneumothoraces (some minor and some requiring chest tube placement). Small pneumothoraces may not have been noted in our patient population as radiography post pericardiocentesis is not performed routinely. The difference in the frequency of dysrhythmias seen may be due to the fact that pericardiocentesis in humans is usually guided by imaging modalities such as echocar- diography or computerized tomography whereas in Table1: Dysrhythmias seen post pericardiocentesis requiring drug therapy Dysrhythmia Number of cases Treatment Ventricular tachycardia n 8 Lidocaine (n 58)w Procainamide (n 52)z Magnesium (n 51) Sotalol (n 51)z Mexilitine (n 51)k Atrial brillation 1 Benazapril nn and Digoxinww Atrial premature complexes 1 Atenololzz Supraventricular tachycardia 1 Diltiazem n All dogs were treated with lidocaine. One dog was also treated with procainamide and magnesium, another with sotalol and mexilitine, and another with procainamide. wLidocaine, B Braun Medical Ltd, Shefeld, UK. zPronestyl, Squibb Bristol-Myers Pharmaceuticals Ltd, Dublin, Ireland. Magniject 9, Norbrook Laboratories Ltd, Newry, UK. zSotacor, Bristol Myers Pharmaceuticals, Hounslow, UK. k Mexitil, Boehringer Ingelheim, Bracknell, UK. nn Fortekor, Novartis, Waterford, Ireland. wwLanoxin, GlaxoSmithKline UK, Uxbridge, UK. zzAtenolol, Bristol Laboratories Ltd, Berkhampstead, UK. Diltiazem, Hospira, Lake Forest, IL. & Veterinary Emergency and Critical Care Society 2009, doi: 10.1111/j.1476-4431.2009.00436.x 354 K.R. Humm et al. dogs it is more commonly a blind procedure leading to increased likelihood of contact with the epicardium and possibly increased likelihood of dysrhythmia. 14,16,19 Alternatively, the canine heart with a pericardial effu- sion may be more prone to dysrhythmias due to species differences, or perhaps due to the difference in under- lying cause of the effusion. The underlying cause of pericardial effusions does vary between humans and dogs with a large study of 1,127 human patients show- ing that effusions requiring pericardiocentesis were most commonly due to malignancy (33.3%) or were postoperative (24.6%) although 8.0% were idiopathic. 16 It is possible that hypovolemia and myocardial hypoxia are more common in dogs due to the increased prev- alence of bleeding neoplasms and that this may result in dysrythmias. Neoplastic cardiac tissue may also be more vulnerable to dysrhythmias secondary to reper- fusion once the pericardial effusion has been drained. No relationship was found between the cause of the pericardial effusion and the likelihood of adverse events in this study, however. Ultrasound guidance was not used during peri- cardiocentesis in this study, although frequently it was used before the procedure to guide the needle or catheter insertion point. The use of ultrasound guid- ance during the procedure could decrease the likeli- hood of adverse events by decreasing the likelihood of epicardial contact. However, needle placement under ultrasound guidance can be technically challenging and the veterinarians performing pericardiocentesis in this study had varying levels of expertise. Dysrhythmias (other than sinus arrhythmia) were noted in 8.9% of patients before pericardiocentesis. Although prepericardiocentesis ECG ndings were documented for only 43% of patients, the authors sug- gest that it is unlikely that a much higher proportion of patients had clinically signicant dysrhythmias requir- ing specic treatment on presentation as these are likely to have been noted on a physical examination. Further, we also believe that it is possible that a higher number of patients had a prepericardiocentesis ECG performed but that unremarkable ndings may not have been documented in the record. A previous study docu- mented dysrhythmias in 26% of dogs in which an ECG was taken before pericardiocentesis though it was not noted why this subpopulation of dogs underwent ECG assessment. 6 It is possible they were selected due to suspicion of dysrhythmia suggesting that this level of dysrhythmia may not be representative of all dogs with pericardial effusion. 6 Dysrhythmias either during or post pericardiocentesis were not reported in this study. 6 Dysrhythmias were only classed as adverse events if they required drug therapy or resulted in the death or euthanasia of the patient. The clinical decision as to whether a dysrhythmia warrants drug treatment is subjective possibly leading to variation between clini- cians, although standard criteria are used to aid deci- sion making. 20 Considering the retrospective nature of this study, the decision to treat was considered to pro- vide the best available marker for the severity of dysrhythmia seen. When clinically insignicant rhythm abnormalities such as occasional ventricular premature complexes were noted post pericardiocentesis they were not classed as an adverse event. Future prospec- tive studies would be required to dene more precisely the severity of dysrhythmias seen. Of the 4 dogs that died suddenly during the 48 hours post pericardiocentesis, the cause of death was only clearly documented in 1, which was seen on ECG to progress from ventricular tachycardia to ventricular - brillation and death. Although it is possible that the others suffered a fatal dysrhythmia, ECG ndings were not recorded immediately precardiopulmonary ar- rest. One of these dogs had been noted to have intermit- tent ventricular premature complexes immediately post pericardiocentesis. Placement of an ECG is routine post pericardiocentesis at the hospital in this study and is generally continued for 24 hours or longer if a dysrhythmia is noted. However, they can be difcult to maintain in some patients and if not observed at the moment of arrest then the preceding rhythm is unknown. Other than dysrhythmias and sudden death, ongoing bleeding into the pericardium resulting in the decision to euthanize occurred in 3 dogs. It is possible the bleeding was a direct result of the pericardiocentesis although there was no information in the records to suggest that the clinician was aware of a problem at the time they were performing the procedure. If inadver- tent cardiac puncture or laceration of a coronary vessel had occurred during pericardiocentesis, dysrhythmias can be induced 14 and none were documented in these cases. It is also possible that alleviation of the pressure within the pericardium post pericardiocentesis allowed further bleeding to occur. All 3 dogs had evidence of a mass. This ongoing bleeding was severe enough to cause deterioration in the animals clinical status lead- ing to the decision to euthanize. The retrospective nature of this study means that the management of the cases was neither controlled nor uniform. Ideally this study should be repeated in a prospective fashion with all dogs having ECG analysis before pericardiocentesis, have pericardiocentesis per- formed in a standardized fashion by a small group of clinicians and with a set protocol for the decision of when to treat a dysrhythmia. This study did not nd any relationship between ei- ther frequency of pericardiocentesis, or the underlying cause of pericardial effusion, and the risk of adverse & Veterinary Emergency and Critical Care Society 2009, doi: 10.1111/j.1476-4431.2009.00436.x 355 Adverse events associated with pericardiocentesis events. However, due to the numbers involved, all ad- verse events were evaluated as 1 group as opposed to being separated (eg, dysrhythmias and ongoing bleed- ing). It is possible that larger numbers may reveal an association that is currently unidentied. The number of animals requiring multiple pericardiocenteses was also small meaning a weak relationship may not have been identied. A prospective study with larger numbers of cases would help to investigate these areas further. Pericardiocentesis is usually an emergent procedure performed solely for therapeutic purposes and to re- verse serious cardiovascular compromise. 14 The knowl- edge that adverse events may occur should not prevent the use of pericardiocentesis. This study has shown that adverse events occur at a level of 15% following peri- cardiocentesis. This can be communicated to the client to aid their understanding of potential problems that may occur after this essential procedure. As most of the adverse events seen were dysrhythmias we would rec- ommend that continuous ECG is performed during pericardiocentesis and for at least 24 hours afterwards as the risk of dysrhythmia and sudden death was most marked during this period. Footnote a GraphPad Software, San Diego, CA. 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Cardiovascular emergencies, In: Boag AK, King LG. eds. BSAVA Manual of Canine and Feline Emergency and Critical Care, 2nd ed. Gloucester: BSAVA; 2007, pp. 5784. & Veterinary Emergency and Critical Care Society 2009, doi: 10.1111/j.1476-4431.2009.00436.x 356 K.R. Humm et al.
A Comparison of Total Calcium, Corrected Calcium, and Ionized Calcium Concentrations As Indicators of Calcium Homeostasis Among Hypoalbuminemic Dogs Requiring Intensive Care
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