Department of Pharmaceutical Department of Pharmaceutical

and Administrative Sciences and Administrative Sciences

- better HEALTH through RESEARCH and EDUCATION
University of Charleston
School of Pharmacy
Inside this issue
DPAS Faculty Bios ...2 - 11
Inside The DPAS ..........................2
Research and Scholarship ...3
Student Engagement ..4
Inside the PMH Program .............5
DPAS Course Listng .....................8
Inside Dr. Kaushals Lab.9
Inside Dr. Lingers Lab..10
Special points of interest
DPAS Departmental Mission and
Goals
DPAS Faculty Biographies
DPAS Research and Scholarship
Undergraduate and Pharmacy
Student Engagement
DPAS Pharmacy Courses
Future Issues
Introducing the DPAS
The Department of Pharmaceutcal and Administratve Sciences (DPAS) in the School of Pharma-
cy at the University of Charleston includes eleven faculty members and one administratve assistant.
DPAS faculty members teach the foundatonal and advanced basic science courses pertnent to
pharmacist training. In additon, DPAS faculty members are responsible for training student pharma-
cists in the economic, social, and administratve aspects of pharmacy.

The overarching goals of the DPAS department are threefold:
To contribute to the educaton and professionalizaton of future pharmacists who embrace
patent-focused care for their patents;

To advance the knowledge base related to the pharmaceutcal sciences and the economic,
social and administratve sciences via original research;

To provide leadership in addressing the signifcant health care needs of an increasingly
diverse patent populaton with emphasis placed on the Appalachian region of the United
States.
Meet the DPAS Faculty & Staf
Get to know our faculty!

In our inaugural issue we introduce the faculty and staf in the Department of Pharmaceutcal
and Administratve Sciences in the School of Pharmacy at the University of Charleston. Members of
our faculty have been trained in a wide range of disciplines, and all have advanced or terminal de-
grees. In order to keep up with the rapidly changing events health care and the educatonal needs of
our pharmacy students, the DPAS faculty have specialized training in areas including toxicology,
immunology, microbiology, pharmacology, pharmacogenomics, pharmaceutcs and public health, as
well as the economic, social and administratve aspects of pharmacy.

In additon to pharmacy educaton, many of the DPAS faculty are actvely engaged in biomedical
and health outcomes research. Further, the director of the university Ofce of Sponsored Programs
and Research is a DPAS member. Many members of our faculty provide summer and year-round
research training, employing undergraduate students as well as professional pharmacy students.
The DPAS faculty is proud to be actvely engaged in university and pharmacy actvites throughout
the academic year and summer.

Any partes interested in research collaboratons or who may be in need of consultng expertse
(review boards, commitees, legislatve, legal, etc.) are more than welcome to contact individual
faculty members to discuss how we can work together. Many of our faculty are actvely engaged in
collaboratve research as well as university and community afairs.
August 20, 2012
Volume 1, Issue 1
Image: FreeDigitalPhotos.net
Inside the DPAS
The Department of Pharmaceutcal
and Administratve Sciences consists
of eleven faculty members who
partcipate in the instructon of the
foundatonal basic sciences and
business administratve pharmacy
courses in the University of Charles-
ton School of Pharmacy.

In additon to teaching dutes, many
of our faculty members are actvely
engaged in pharmaceutcal, educa-
tonal and healthcare outcomes
research. Two large combined faculty
laboratories house equipment for
tssue culture, protein purifcaton,
molecular biology, pharmaceutcs
and gas chromatography facilites.
Our laboratories contain over half a
million dollars worth of research
equipment obtained through startup
and external equipment grants as
well as NIH-donated equipment. All
the current equipment is less than six
years old.

Both Dr. Alkhateeb and Dr. Latf have
developed a new and innovatve
program in pharmaceutcal &
healthcare management as part of
the executve masters of business
administraton. Further, Dr. Dennis
Flaherty, a departmental faculty
member, is director of the University
of Charlestons Ofce of Sponsored
Program and Research (OSPAR)
which housed in our department.
Dr. David A. Latf is Professor of Pharmaceutcal and Healthcare Management, and serves as
Department Chair of Pharmaceutcal and Administratve Sciences (DPAS) at the University of Charles-
tons School of Pharmacy. He has been in this positon since July of 2005. Dr. Latf earned a B.S. de-
gree in Agricultural Economics from the University of Georgia, a M.B.A. from Augusta State Universi-
ty, and a Ph.D. in Economic, Social, and Administratve Pharmacy from Auburn Universitys Depart-
ment of Pharmacy Care Systems. At Auburn, his doctoral research revolved around predictors of
clinical performance in pharmacists.

Dr. Latfs current research interests include:
Predictors of clinical performance among pharmacists;
Financial planning and management related to health care professionals;
Educatonal interventons and outcomes among pharmacy students.

Since obtaining his Ph.D. in 1997, Dr. Latf has published over 65 peer-reviewed artcles. Dr Latfs
research publicatons have appeared in several journals, including the American Journal of Pharma-
ceutcal Educaton, Annals of Pharmacotherapy, Journal of American Pharmacists Associaton, Journal
of Managed Care Pharmacy, Journal of Business Ethics, Research in Social and Administratve Phar-
macy, Internatonal Journal of Pharmacy Practce, Pharmacy World and Science, Pharmacy Educaton,
and the Journal of Medical Marketng. In additon, he has presented his research fndings at numer-
ous scholarly pharmacy and management conferences.

Courses
PHAR 510: Introducton to Pharmacy and the United States Healthcare System
PHAR 524: Clinical Research Methods
PHAR 715: Management Skills

Recent Publicatons
Alkhateeb F.M., Clauson, K.A., Latf, D.A, Masters of Business Administraton (MBA) in Pharmaceut-
cal Marketng and Management: New Horizons in Pharmacy Educaton. American Journal of Phar-
maceutcal Educaton, 2012; 76(4); Artcle 64.

Latf, D.A., Alkhateeb, F.M. Pharmacy faculty retrement at schools and colleges of pharmacy in the
United States and Canada. American Journal of Pharmaceutcal Educaton, 2012; 76(1); Artcle 4.

Latf, D.A. The Infuence of pharmacy educaton on students moral development at a school of phar-
macy in the United States. Internatonal Journal of Pharmacy Practce. 2009;17: 359-63.

2
David A. Latf, Ph.D., M.B.A.
Professor and Department Chair
M.B.A. (Healthcare Management Concentraton) Augusta State University; Ph.D.
Auburn University (Economic, Social, and Administratve Pharmacy)

Locaton: SOP 304L
Tel: (304) 357-4882
Email: davidlatf@ucwv.edu
3
Marea came to the University of Charleston with twenty two years of business management experience. As a business owner and manager,
she was directly responsible for the areas of Human Resources, Accountng, Risk Management, Informaton Technology, and Marketng. She
also oversaw Licensing Compliance and the intellectual property of the business.

Since coming to UC, Marea has been successful in developing databases to streamline various processes within the Department of Pharma-
ceutcal and Administratve Sciences, the Ofce of Sponsored Projects and Research, and the Insttutonal Review Board. For the department,
she keeps all budgetary records reconciled and grant reportng current. Her interests are in the area of HR legislaton, databases, and contnuing
educaton.
Marea Dodd
Administratve Assistant
BS, Organizatonal Leadership, Mountain State University
Certfed Professional in Human Resources (PHR), HRCI

School Of Pharmacy, Rm. 304
Tel: 304-357-4354
Email: mareadodd@ucwv.edu
DPAS Faculty Research and Scholarship
DPAS faculty, in additon to teaching as part of the pharmacy school curriculum, are also actvely involved in research and scholarship. In fact,
since the start of pharmacy program in 2006, faculty have been awarded over $736,000 in research grants and equipment and have provided
many thousands of dollars in potental F & A funding (indirect costs) to the University and School of Pharmacy. Department members have re-
ceived grant awards through WV-INBRE, the McKesson Corporaton, and the Charleston Area Medical Center (CAMC) among others. Research
conducted faculty members has been published in numerous peer reviewed journals and presented at professional meetngs around the country
and internatonally.
Our basic biological and chemical research facilites are located on the top two foors of the School of Pharmacy. These labs contain over half
a million dollars in equipment including tssue culture, protein purifcaton, molecular and cell biology, and pharmaceutcs facilites. Additonally,
DPAS faculty have obtained over $60,000 in equipment grants from WV-INBRE and EPSCOR since 2007. Faculty have also obtained upwards of
$200,000 in donated pieces of equipment through the NIH procurement program. We are proud of our frst rate research facilites and are dedi-
cated to conductng biomedical and scientfc research at the highest level.

Any partes interested in research collaboratons or who may be in need of consultng expertse (review boards, commitees, legislatve, legal,
etc.) are more than welcome to contact individual faculty members to discuss how we can work together. Many of our faculty are actvely en-
gaged in collaboratve research as well as university and community afairs.
Faculty have been awarded over $736,000 in research grants and equipment and have provided many thousands of
dollars in potential facilities and administrative funding (indirect costs) to the University and School of Pharmacy.
Student Engagement in Research and Education
Approximately 60 undergraduate and professional pharmacy students have had the opportunity to receive paid research intern-
ships while working alongside departmental faculty members. They have conducted biomedical research in our laboratories. In just
the last three years, over $75,000 in paid student internships have been funded by DPAS investgators primarily via external research
grants. Many of the undergraduates have worked in our laboratories for several years during the summer or throughout the year.
Additonally, a number of the undergraduate students have gone on to become students in the pharmacy program here at the Uni-
versity of Charleston. In the fall of 2012, three current student lab interns are entering their frst year of pharmacy schoolCongrats
Ciara, Kate, and Tammy!!!


DPAS faculty members also routnely accept fourth year pharmacy students for their Advanced Pharmacy Practce Experience
(APPE). Pharmacy students spend fve weeks engaged in biomedical or outcomes based research as part of a research APPE. Alterna-
tvely, the pharmacy student enters into an academic APPE rotaton where they work closely with members of our faculty conductng
pharmaceutcal course development and instructon in order to learn more about the rigors of academic pharmacy.

4
Summer research students working in the laboratory and presentng their research fndings at local and regional
symposia.
In just the last three years, over $75,000 in paid student summer research internships have been funded by
DPAS investigators via external research grants.
Inside the PHM Program
The University of Charleston has
developed, in conjuncton with the
EMBA program, a concentraton in
Pharmaceutcal and Health Care
Management. This new and inno-
vatve program has been imple-
mented for working individuals
who want to advance their careers
and broaden their educaton back-
ground in pharmaceutcal and
health care management.

Both theory and practcal experi-
ence will be used to provide stu-
dents with the knowledge of the
intricacies of a constantly changing
economic and health care environ-
ment.
Dr. Alkhateeb is the Director of the concentraton in Pharmaceutcal and Healthcare Man-
agement in the UC EMBA Program, and is an Associate Professor of Pharmaceutcal Marketng &
Management at the University of Charleston School of Pharmacy. Dr. Alkhateeb joined University
of Charleston School of Pharmacy in 2007. Dr. Alkhateeb earned his Bachelor of Science degree
in Pharmacy from Jordan University of Science & Technology, Jordan. In 2007, he earned his
doctorate in Pharmaceutcal Marketng from the University of Iowa. Later, in 2011, he fnished
his MBA in Pharmaceutcal Marketng & Management from Aspen University. He is considered
one of few experts who specialize in the Pharmaceutcal Marketng feld. Dr. Alkhateebs re-
search interests focus on pharmaceutcal marketng, pharmacy educaton, and pharmacy practce
issues.

Courses
PHAR 629 Communicatons & Ethics in Healthcare
PHAR 727 Pharmaceutcal Marketng
PHAR 741 Pharmacoeconomics & Health Policy

Recent Publicatons
Alkhateeb FM, Unni E, Latf DA, Shawaqfeh MS, Al-Rousan RM. Physicians attudes towards
collaboratve agreement with pharmacists and their expectatons of pharmacists responsibilites
in West Virginia. JAPhA. 2009, 49(6):48-51.

Alkhateeb FM. Baidoo P, Mikulskis Cavana M, Gill D, Howell A, Mehraeen B, Weidner C. Is certifi-
cation for pharmaceutical sales representatives necessary? International journal of pharmaceuti-
cal & healthcare marketing. 2011, 5(3): 222-233.

Alkhateeb FM, Clauson KA, Latif DA. Availability and perceived value of masters of business ad-
ministration degree programs in pharmaceutical marketing and management. AJPE . 2012; 76(4).
Artcle 64.
5
Fadi M. Alkhateeb, BSPharm, M.B.A, Ph.D.
Associate Professor & Director, EMBA Concentraton in Pharmaceutcal & Healthcare
Management Program (PHM)

B.S Pharmacy, Jordan University of Science & Technology, Jordan; MBA Pharmaceutcal
Marketng & Management, Aspen University, CO; Ph.D. Pharmaceutcal Socioeconomics,
University of Iowa, IA

Locaton: SOP 304N
Tel: (304) 357-4350
Email: fadialkhateeb@ucwv.edu
The University of Charleston EMBA-PHM program offers a student-focused and market-centered curriculum that ap-
plies the broader principles of an MBA specifically to the pharmaceutical and healthcare industries

Fadi Alkhateeb, Director
EMBA in Pharmaceutcal & Healthcare Management (PHM)
6
Dr. Al-Rousan is an Assistant Professor of Clinical Pharmacology in the Department of Phar-
maceutcal and Administratve sSciences. Dr. Al-Rousan joined the University of Charleston School of
Pharmacy in 2010. Dr. Al-Rousan earned her Bachelor of Science degree in Pharmacy from Jordan
University of Science & Technology, Jordan. In 2007, she earned her Master degree in Molecular Phys-
iology and Biophysics from the University of Iowa. In 2010, she earned her doctorate in Biomedical
Sciences with a concentraton in Clinical Pharmacology from Marshall University. Dr. Al-Rousan is also
a registered pharmacist (RPh). Her research interests are in the area of cardiovascular pharmacology and drug discovery.

Courses
PHAR 520 Pathophysiology
PHAR 612 Pharmacology I
PHAR 641 Pharmacology II

Recent Publicatons
Al-Rousan RM, Paturi S, Laurino JP, Kakarla SK, Guta AK, Walker EM, Blough ER. Deferasirox removes cardiac iron and atenuates oxidatve stress
in the iron-overloaded gerbil. Am J Hematol. 2009 Sep;84(9):565-70.

Al-Rousan RM, Rice KM, Kata A, Laurino J, Walker EM, Wu M, Triest WE, Blough ER. Deferasirox protects against iron-induced hepatc injury in
Mongolian gerbil. Transl Res. 2011 Jun;157(6):368-77.

Al-Rousan RM, Manzoor K, Paturi S, Arvapalli RK, Laurino JP, Darnon L, Walker EM, Blough ER. Long-term efcacy of deferasirox in preventng car-
diovascular complicatons in the iron-overloaded gerbil. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):117-25.
Rabaa M Al-Rousan, Ph.D.
Assistant Professor of Clinical Pharmacology

BS Pharmacy, Jordan University of Science and Technology; M.S. Molecular Physiology and
Biophysics, University of Iowa; Ph.D Biomedical Sciences with a concentraton in Clinical
Pharmacology, Marshall University; Registered pharmacist (RPh)

Locaton: SOP 304P
Tel: (304) 357-4353
Email: rabaaal-rousan@ucwv.edu
Dr. Flaherty came to the University of Charleston in 2006 from Lamar University in Beaumont,
Texas. He holds a M.S. degree in Medical Microbiology and a Ph.D. in Immunology from West Virginia
University. His research interests are in the toxic efects of pharmaceutcals on the immune system.

Courses
PHAR 512 Immunology
PHAR 520 Pathophysiology
PHAR 530 Toxicology (electve)
PHAR 545 Bad Bugs and Prions (electve)


Dennis K. Flaherty, Ph.D.
Associate Professor
Ph.D. Immunology, WVU; M.S. Medical Microbiology, WVU

Locaton: SOP 304K
Tel: (304) 357-4994
Email: dennisfaherty@ucwv.edu
Recent Publicatons
Flaherty, D.K. and Alkateeb, F. The human papilloma quadrivalent vaccine: a look behind the numbers. Annals of Pharmacotherapy. 43
(4):740-744, 2009.

Flaherty, D.K. The Vaccine-autsm connecton. A public health crisis caused by unethical medical practces and fraudulent science. Annals
of Pharmacotherapy October 2011 45:1302-1304

Flaherty, D. Immunology for Pharmacy students. Mosby/Elsevier, St. Louis, Mo. 2011
7
Michelle L. Herdman, Ph.D.
Assistant Professor

PhD in Biomedical Sciences from Marshall University, Huntngton, WV

Locaton: SOP 304D
Tel: (304) 357-4749
Email:michelleherdman@ucwv.edu

Dr. Herdman began working at the University of Charleston School of Pharmacy (UCSOP)in
June 2006. She graduated from Bridgewater College, Bridgewater, VA, in 1994 with a BS in Medi-
cal Technology. Afer several years spent working in hospital laboratories, including tme spent
as a lab supervisor, she began pursuing a PhD in 2001. In 2006, she graduated from Marshall
University, Huntngton, WV, with a PhD in Biomedical Sciences, with an emphasis in Pharmacolo-
gy and Toxicology. Dr. Herdmans current research focuses on drug interactons between die-
tary supplements and conventonal chemotherapy agents. She is currently investgatng interac-
tons between lycopene and docetaxel in prostate cancer.
Courses






Recent Publicatons/grants/presentatons
Smith B, Bowles S, and Herdman ML. From Classroom to Clinical and Beyond. School Poster for 2011 AACP Annual Meetng and Seminars
July 2011 (San Antonio, TX).

Herdman ML and Thompson K. Treatment of Clostridium difcile-associated diarrhea. Pharmaceutcal Press - Remington Pharmacy-
Complete Case Studies October 2011.

Roundtable Presentaton for 2012 AACP annual meetng (July 2012) Developing an Academic Pharmacy APPE: A Basic Science Perspectve.
PHAR 512 Immunology PHAR 561 Advanced Medical Communicatons (electve)
PHAR 520 Pathophysiology PHAR 612 Pharmacology I
PHAR 530 Toxicology (electve) PHAR 641 Pharmacology II
Dr. Jones joined the department in June 2006. She came to UC from The University of Texas M.D. An-
derson Cancer Center, Department of Epidemiology, Houston, TX. She received a B.A. in Studio Art from
The University of Texas at Austn, a M.S. in Animal Science from University of Arkansas at Fayeteville, and
a Ph.D. in Pharmacology and Toxicology from The University of Texas Medical Branch at Galveston. Her
research interest blends her educaton in pharmacology with her research experience in molecular genetc
epidemiology to build studies in pharmacogenomics research. Pharmacogenomics is a relatvely new feld
that explores genetc causes for individual variaton in treatment response.

Her teaching goal is to teach our pharmacy students the skills and knowledge in the felds of phar-
macogenomics and medical genetcs that will meet ACPEs standards for a PharmD curriculum, prepare
them for the NAPLEX exam, prepare them to adjust to the rapid current and future inclusion of phar-
macogenomics in pharmacy practce, and to give them a compettve edge in the market place due to the
slow integraton of the topic in PharmD programs of other schools. Dr. Jones main personal interest is her
7-year-old daughter, Rachel. She and her daughter just began learning Tae Kwon Do together, and they
are looking forward to their annual summer zoo and museum trip, which is currently planned for San Anto-
nio, TX this year.

Courses
PHAR 612 Pharmacology I
PHAR 632 Advanced Topics in Pharmacogenomics (electve)
PHAR 641 Pharmacology II
PHAR 718 Pharmacogenomics & Medical Genetcs

Recent Publicatons/grants/presentatons
Nang Oo, Michelle Herdman and J. Shawn Jones, Characterizaton of prostate cancer cell lines for DNA
Rrepair enzyme genotype. Proceedings: 45th ASHP Midyear Clinical Meetng, December 5-9, 2010, Ana-
heim, CA.
J. Shawn Jones, PhD, MS
Assistant Professor
Ph.D. in Pharmacology and Toxicology;
M.S. in Animal Science

Locaton SOP 304H
Tel: (304) 357-4748
Email: shawnjones@ucwv.edu
Chen, J., Sen, S., Amos, C.I., Jones, J.S., Lynch, P.M., Rodriguez-Bigas, M. and Frazier, M.L. Associaton between aurora-A kinase polymorphisms and age
of onset of hereditary nonpolyposis colorectal cancer in a caucasian populaton. Mol Carcinog 46(4):249-56, 2007.

Jones, J.S., Gu, X., Lynch, P.M., Rodriguez-Bigas, M., Amos, C.I.,and Frazier, M.L. DNMT3b Ppolymorphism and hereditary nonpolyposis colorectal can-
cer (HNPCC) age of onset. Cancer Epidemiol Biomarkers Prev 15(5):886-891, 2006, May.
8
DPAS Taught Pharmacy Courses (required courses)
First Year Pharmacy Second Year Pharmacy
PHAR 501L Prof. Awareness Prep. Seminar PHAR 610 Pharmacokinetc Principles
PHAR 512 Immunology PHAR 612 Pharmacology I
PHAR 513 Biochemistry PHAR 641 Pharmacology II
PHAR 514 Pharmaceutcs I (Calculatons) PHAR 614 Medicinal Chemistry
PHAR 515L Pharmaceutcal Science Lab PHAR 629 HC Communicatons & Ethics
PHAR 520 Pathophysiology
PHAR 522 Pharmaceutcs II
PHAR 523L Pharmaceutcal Compounding
PHAR 524 Clinical Research Methods
Third Year Pharmacy Fourth Year Pharmacy
PHAR 715 Pharmacy Management PHAR 8XX APPE (advance experiental rotaton)
PHAR 718 Pharmacogenomics & Med Genetcs
PHAR 725 Pharmaceutcal Marketng
Phar 741 Pharmacoeconomics & Health Policy
Dr. Flaherty Mr. Linger
PHAR 530 Toxicology & PHAR 545 Bad bugs and Prions PHAR 531 Ethnopharmacology of Appalachia
Dr. Herdman Dr. Reardon
PHAR 561 Advanced Medical Communicatons PHAR 631 Human Cancer
Dr. Jones Dr. Siddig
PHAR 632 Advanced Topics in Pharmacogenomics PHAR 630 Pharmaceutcal Biotechnology
DPAS Pharmacy Elective Courses (by Coordinator)
Inside Dr. Kaushals Lab
Dr. Kaushal is involved in various
projects dealing with the use of a
drug (D-cycloserine) in anxiety
disorders and back pain. D-
cycloserine (DCS), an FDA ap-
proved antbiotc for tuberculosis,
has been used in numerous clinical
trials as an enhancer for exposure
therapy for anxiety disor-
ders. Based on the studies carried
out in his lab, it was observed that
current capsule-based formula-
tons of DCS need signifcant im-
provement in order to have a more
efectve delivery of this drug for
pain and anxiety disorders.

Currently, signifcant eforts are
being put forth to develop trans-
dermal and nasal formulatons for
this drug in Dr. Kaushals lab. He is
also involved in the clinical trial
studies of this drug being carried
out at West Virginia University
(dental phobia and acrophobia)
and Northwestern University
(chronic back pain). The aim of
this clinical trial study is to identfy
the clinical efcacious dose of DCS
and gene expression profles asso-
ciated with this treatment in pa-
tents with neuropathic back pain
and phobia.


Gagan Kaushal, Ph.D.
Associate Professor
Ph.D. in Industrial Pharmacy, St. Johns University, NY.

Locaton: SOP 304F
Tel: (304) 357-4351
Email: gagankaushal@ucwv.edu
9
Dr. Kaushal received his Ph.D. in Industrial Pharmacy from St. Johns University, NY. He
also holds a B.S. of Pharmacy from Panjab University, Chandigarh, India. His Ph.D. dissertaton
topic was Lactococcus lacts subsp. lacts as a protein delivery vehicle through oral and vaginal
routes. Afer graduatng from St. Johns University, he joined Biosyn, Inc., as a Senior Research
Scientst, where he worked on a major project for formulaton of vaginal gels for 3 ant-HIV drugs
(Microbicides). Afer spending one year in industry, he took a postdoctoral positon at University
of the Sciences in Philadelphia. He joined the UC School of Pharmacy in July 2007 as an assistant
professor .

His area of research interest is in pharmaceutcs, with principle areas of expertse in; drug
delivery systems, formulaton development, controlled drug delivery, drug stability, drug solubili-
ty, pharmacokinetcs, etc. Dr. Kaushals research actvites are usually infused with novel ideas
from interdisciplinary approaches. He is actvely collaboratng with clinicians, doctors, pharma-
cists, and other health-care professionals on diferent research projects. He has also conducted
and published original research with potental for beneftng the pharmaceutcal industry and
millions of patents requiring invasive delivery of life-saving drugs. Dr. Kaushal has received
around $150,000 in external funding for his various research projects over the past fve years.

Courses
PHAR 514 Pharmaceutcal Calculatons
PHAR 522 Pharmaceutcs II

Recent Publicatons
Gagan Kaushal, Brian E. Sayre, and Terrence Prettyman, Stability-indicating HPLC method for the
determination of the stability of extemporaneously prepared norepinephrine parenteral solu-
tions. Journal of Liquid Chromatography & Related Technologies (In Press).

Gagan Kaushal, Ronaldo Ramirez, Demelash Alambo, Wacharah Taupradist, Krunal Choksi, and
Cristian Sirbu, Initial characterization of D-cycloserine for future formulation development for
anxiety disorders. Drug Discoveries & Therapeutics, Volume 5 (2011) Pages 253-260.

Gagan Kaushal, Million Woldemariam, Brian E. Sayre, and Terrence Prettyman, Stability study of
famotidine in polypropylene syringes using a stability-indicating HPLC assay. Journal of Liquid
Chromatography & Related Technologies, Volume 34 (2011) Pages 1283-1294.
Inside Dr. Lingers Lab
B. cenocepacia is an opportunistc
pathogen that was frst identfed
as a soil bacterium in 1950 that
caused sour skin rot in onions. The
bacterium has also been isolated
from the lungs of individuals with
chronic obstructve pulmonary
disease (COPD) or cystc fbrosis
(CF). Infecton by the highly viru-
lent strain B. cenocepacia causes
reduced lung functon and is highly
transmissible between patents.
Infected patents have to be hospi-
talized and placed in isolaton
which can afect the social, psycho-
logical and physical wellbeing of
the patent. Bacterial infecton can
also lead to necrotzing pneumonia
and septcemia, the so-called
cepacia syndrome, which results
in rapid decline in the health of the
patent. The overall fatality rate
associated with B. cenocepacia
infecton is 50%.

B. cenocepacia has been classifed
as an emerging, highly virulent
opportunistc and nosocomial
pathogen. This bacterium has
multple mechanisms to induce
antbiotc resistance. Dr. Lingers
laboratory is currently researching
the mechanisms of antbiotc re-
sistance with the hope of identfy-
ing potentally new antbiotc ther-
apies to treat infected patents.
10



Rebecca S. Linger, Ph.D.
Assistant Professor
Ph.D. Medicinal Chemistry, Purdue University,
West Lafayete, IN


Locaton: SOP 304G
Tel: (304) 357-4998
Email: rebeccalinger@ucwv.edu

Dr Linger has been with UCSOP since the founding of the school in 2006. Trained as a mechanistc
enzymologist, she is primarily interested in understanding how enzymes functon to interact with
small molecules in metabolic pathways or in discreet systems within living organisms. One of the
projects in her laboratory investgates the mechanism of acton of a putatve hydrolase, LlpE, whose
gene resides within an operon including those of an efux pump in the opportunitstc pathogen,
Burkholderia cenocepacia. In a trimethoprim/sulfamethoxazole resistant strain of B. cenocepacia,
J2315-T, the efux pump and hydrolase are consitutvely expressed and confer increased resistance
to fuoroquinolones, chloramphenicol and tetracyclines. It is theorized that the protein, LlpE, cleaves
fuoroquinolones and tetracyclines as they are pumped back into the periplasmic space of the gram
negatve bacterium. Dr. Linger has received $72,500 in external funding for her research projects
over the past six years.

Dr. Linger has given lectures on the medicinal uses of natve plants at the Clay Center in Charles-
ton, West Virginia Community and Technical Colleges in Logan and Williamson and to various local
clubs and professional organizatons. She received the Golden Apple award for outstanding teaching
in April 2011.
Courses
PHAR 513 Biochemistry
PHAR 515 L Integrated Pharmaceutcal Sciences Laboratory
PHAR 531 Ethnopharmacology of Appalachia (electve )
PHAR 614 Medicinal Chemistry

Recent Publicatons
DOrdine, R.L., Linger, R.S., Thai, C.J., Davisson, V.J. The catalytc zinc site and mechanism of the
metalloenzyme PR-AMP cyclohydrolase. Biochemistry, 2012, 51, 5791-5803.

Amaro, R.E., Sethi, A., Myers, R.S., Davisson, V.J., Luthey-Schulten, Z.A. A network of conserved inter-
actons regulates the allosteric signal in a glutamine amidotransferase. Biochemistry, 2007, 46, 2156-
2173.

Myers, R.S., Amaro, R.E., Luthey-Schulten, Z.A., Davisson, V.J. Reacton coupling through interdomain
contacts in imidazole glycerol phosphate synthase. Biochemistry 2005, 44, 11974-11985.
11
experience in a number of felds, including bacteriology, virology, parasitology and food bacteriology.

In 2006, Ronaldo Ramirez joined the UC School of Pharmacy. Ronaldo and his wife, Tina, are natve West Virginians and reside in Clendenin, West Vir-
ginia with their two sons: Christopher and Gavin.

Courses
PHAR 515 L Integrated Pharmaceutcal Sciences Laboratory
PHAR 523L Pharmaceutcal Compounding
PHAR 545 Bad Bugs and Prions (electve)
Ronaldo V. Ramirez, MPH
Instructor
Master of Public Health, West Virginia University, Morgantown, WV

Locaton: SOP 304E
Tel: (304) 357-4394
Email: ronaldoramirez@ucwv.edu

Ronaldo Ramirez is the laboratory instructor for the integrated pharmaceutcal sciences and
compounding courses. Mr. Ramirez earned his B.A. in biology and a Master of Public Health
(MPH) from West Virginia University. For approximately 13 years, Ronaldo was a microbiologist
with the Bureau for Public Health; a reference laboratory that aided in the surveillance and iden-
tfcaton of agents of infectous disease. Mr. Ramirez has clinical microbiology
Dr. Reardon joined the DPAS in 2007 and has 14 years of experience teaching in pharmacy
schools. From 2008 2009 he was the interim Associate Dean for Academic Afairs in the school
of pharmacy. Dr. Reardons research interest is in the area of metastatc control of cancer, par-
tcularly breast cancer. Since joining the school of pharmacy, he has garnered over $46,000 in
research and equipment grants since joining the School of Pharmacy. In the summer of 2011 Dr.
Reardon hosted a local high school teacher involved in a summer research internship through
the WV-INBRE HSTA program. He was chosen the P1 pharmacy teacher of the year in 2009 & 2012 as well as receiving the Golden Apple award for
teaching excellence in April 2012.

In additon to teaching and research, Dr. Reardon has been actvely involved in the pharmacy school accreditaton process. He currently serves as
an ACPE site team member and conducts accreditaton reviews of various pharmacy schools around the country. In his spare tme, Dr. Reardon can
ofen be found skiing down the West Virginia slopes during the winter and riding his motorcycle through the mountains during the spring, summer
and fall.

Courses





Recent Posters and Presentatons
Reardon, D. B. (2008) Modulaton of breast tumor metastasis and the use of somatostatn analogs in the therapeutc treatment of cancer. Charleston
Area Medical Center, Didactc Tumor Board, Charleston, West Virginia.

McCaferty, R., Kaushal, G., Capehart, K., Euler, M., Bowles, S., Hodges, D., and Reardon, D. B. (2010). Using a server hosted microsof access database
instrument to map curricular competencies, American Associaton of Colleges of Pharmacy Annual Meetng, Seatle, WA.

Norman, R. and Reardon, D.B. (2011). In vitro combinatorial treatment with octreotde and taxol: Modulaton of tumor cell growth and metastatc
potental, WV-INBRE Summer Symposium, Huntngton, WV.
Dean B. Reardon, Ph.D.
Associate Professor
MS, Biology, Virginia Commonwealth University; Ph.D., Cancer Biology, Univ Texas HSC
Houston & The MD Anderson Cancer Center

Locaton: SOP 304J
Tel: (304) 357-4996
Email: deanreardon@ucwv.edu
PHAR 513 Biochemistry
PHAR 520 Pathophysiology
PHAR 545 Bad Bugs and Prions (electve)
PHAR 612 Pharmacology I
PHAR 630 Human Cancer (electve )
PHAR 641 Pharmacology II
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Aladin Siddig joined the faculty of the School of Pharmacy as Assistant professor in July 2007. He came from Mercer University, College of
Pharmacy and Health Sciences, Atlanta, Georgia. He received his B. Sc. in Chemistry and Zoology from the University of Khartoum, a M.S. in Biolo-
gy from Jackson State University, and a Ph.D. in Pharmaceutcal Sciences from Mercer University College of Pharmacy and Health Sciences.

In 2001, Dr. Siddig joined the HIV and Retrovirology Branch at Centers of Disease Control, Atlanta, Georgia. His work focused on evaluaton
of the efcacy of several synthetc and natural microbicides against HIV infecton. He also studied immune responses and infammaton in genital
tract micorevironment following HIV infecton. In 2004, Dr. Siddig worked on microencapsulaton of drugs, proteins and vaccines at Mercer Uni-
versity. In 2006, he joined the College of Pharmacy and Health Sciences, Mercer University as a postdoctoral fellow. Dr. Siddigs work focused on
the pharmacokinetcs of microencapsulated drugs and proteins in animal models. Dr. Siddig is a member of the American Associaton of Pharma-
ceutcal Scientst (AAPS).

Courses
PHAR 522 Pharmaceutcs II
PHAR 514 Pharmaceutcs I (Calculatons)
PHAR 610 Pharmacokinetcs principles
PHAR 630 Pharmaceutcal Biotechnology (electve)

Recent Publicatons
Aladin Siddig, Linda Musik, Richard Addo, and Kwame Yeboah. Formulaton and characterizaton of albumin/glycine microspheres encapsulated
with Rribofavin as a Mmodel drug. Accepted for presentaton at the conference being held October 14 - 18, 2012 in Chicago, IL

Mohammad N. Uddin, Aladin Siddig, Carl W. Oetnger, Martn J. DSouza. Potentaton of pro-infammatory cytokine suppression and survival by
microencapsulated dexamethasone in the treatment of experimental sepsis. J. Drug Target. November 2011, Vol. 19, No. 9, Pages 752-760

Addo RT, Siddig A, Siwale R, Patel NJ, Akande J, Uddin AN, D'Souza MJ. Formulaton, characterizaton and testng of tetracaine hydrochloride-loaded
albumin-chitosan micropartcles for ocular drug delivery. J Microencapsul. 2010;27(2):95-104
Aladin Siddig, Ph.D.
Assistant Professor

MS. Biological Sciences, Jackson State University, Jackson, Mississippi; Ph.D. Pharmaceu-
tcal Sciences, Mercer University College of Pharmacy and Health Sciences, Atlanta,
Georgia

Locatons: SOP 304A
Tel: (304) 357-4352
Email: aladinsiddig@ucwv.edu
University of Charleston
School of Pharmacy
Department of Pharmaceutical and
Administrative Sciences
2300 MacCorkle Ave., SE
Charleston, WV 25304

Phone: 304-357-4354
Fax: 304-357-4868
E-mail: DPAS@ucwv.edu
We hope you enjoyed the inaugural issue of our Department of Pharmaceutcal
and Administratve Sciences newsleter. We welcome any and all interest from those
with concerns for the importance of health, research and educaton in our region. We
have a very vibrant faculty whose talents, achievements, and actvites extend beyond
just a single issue!

Our next semi-annual issue, slated for January 2013, will delve into the details of
individual DPAS faculty achievements in the laboratory, classroom and collaboratve
actvites. Plus, youll learn more about our terrifc students and their eforts to push
the envelope in medical research and healthcare outcomes.

Come get to know more about our department, faculty and students. Were
dedicated to achieving beter health through research and educaton!
Future Issues