Staff of Pathology Division: Staff of Pathology Division:
EKW, DRA, SES, EVH, WWN, BPP, HAHA, ASO, MSB
VETNIZAH J UNIANTITO VETNIZAH J UNIANTITO PATOLOGI SISTEMIK II (PAP 442) PATOLOGI SISTEMIK II (PAP 442) PATOLOGI SISTEMIK II (PAP 442) PATOLOGI SISTEMIK II (PAP 442) PATOLOGI ALAT REPRODUKSI PATOLOGI ALAT REPRODUKSI ALAT KELAMIN JANTAN ALAT KELAMIN JANTAN ALAT KELAMIN JANTAN ALAT KELAMIN JANTAN Dr. drh. Eva Harlina, MSi. Dr. drh. Eva Harlina, MSi. Bagian Patologi Bagian Patologi Departemen Klinik, Reproduksi dan Patologi Departemen Klinik, Reproduksi dan Patologi Fakultas Kedokteran Hewan Fakultas Kedokteran Hewan IPB IPB Fakultas Kedokteran Hewan Fakultas Kedokteran Hewan--IPB IPB Jl. Agatis Kampus IPB Darmaga, Bogor Jl. Agatis Kampus IPB Darmaga, Bogor -- 16680 16680 MALE REPRODUCTIVE SYSTEM MALE REPRODUCTIVE SYSTEM MALE REPRODUCTIVE SYSTEM MALE REPRODUCTIVE SYSTEM Testis Testis Excretory duct Excretory duct Accessory glands Accessory glands Accessory glands Accessory glands Penis and prepuce Penis and prepuce p p p p Patologi Alat Kelamin J antan 2 Patologi Alat Kelamin J antan 2 MALE REPRODUCTIVE SYSTEM MALE REPRODUCTIVE SYSTEM Testis Testis Seminiferous tubules (contain germcells Seminiferous tubules (contain germcells Seminiferous tubules (contain germ cells Seminiferous tubules (contain germ cells in various stage of maturation), Sertoli in various stage of maturation), Sertoli cell Leydig cells cell Leydig cells cell, Leydig cells cell, Leydig cells Excretory duct Excretory duct: epididymis, vas deferens : epididymis, vas deferens Accessory glands Accessory glands: seminal vesicles, : seminal vesicles, prostate prostate Penis and prepuce Penis and prepuce Patologi Alat Kelamin J antan 3 Patologi Alat Kelamin J antan 3 Patologi Alat Kelamin J antan 4 Patologi Alat Kelamin J antan 4 Patologi Alat Kelamin J antan 5 Patologi Alat Kelamin J antan 5 Patologi Alat Kelamin J antan 6 Patologi Alat Kelamin J antan 6 DISEASES OF THE MALE DISEASES OF THE MALE REPRODUCTIVE SYSTEM REPRODUCTIVE SYSTEM Developmental disorders Developmental disorders Diseases of the scrotum and contents Diseases of the scrotum and contents Diseases of the accessory glands Diseases of the accessory glands Diseases of the accessory glands Diseases of the accessory glands Diseases of the penis and prepuce Diseases of the penis and prepuce Patologi Alat Kelamin J antan 7 Patologi Alat Kelamin J antan 7 DEVELOPMENTAL DISORDERS DEVELOPMENTAL DISORDERS DEVELOPMENTAL DISORDERS DEVELOPMENTAL DISORDERS MAJ OR ANOMALIES MAJ OR ANOMALIES MAJ OR ANOMALIES MAJ OR ANOMALIES Sexual dimorphism Sexual dimorphism pp Segmental aplasia of epididymis Segmental aplasia of epididymis Cryptorchidism Cryptorchidism Testicular hypoplasia Testicular hypoplasia Testicular hypoplasia Testicular hypoplasia Spermatic granuloma Spermatic granuloma Patologi Alat Kelamin J antan 8 Patologi Alat Kelamin J antan 8 SEXUAL DIMORPHISM SEXUAL DIMORPHISM Errors of Errors of chromose chromose, , gonadal gonadal or phenotypic sex or phenotypic sex 1. Sex chromosomes (structure and number). 1. Sex chromosomes (structure and number). a. Abnormal structure of Y a. Abnormal structure of Y ((isochromosome isochromosome)) FFemale phenotype emale phenotype H l ti H l ti dd Hypoplasctic Hypoplasctic gonads gonads b. b. Duplicationof one of the sex chromosome Duplicationof one of the sex chromosome b. b. Duplication of one of the sex chromosome Duplication of one of the sex chromosome (XXY, XYY) (XXY, XYY) Testicular Testicular hypoplasia hypoplasia Kli f lt Kli f lt d (t i l l t) d (t i l l t) Klinefelters Klinefelters syndrome (tricolor male cat) syndrome (tricolor male cat) Patologi Alat Kelamin J antan 9 Patologi Alat Kelamin J antan 9 SEXUAL DIMORPHISM SEXUAL DIMORPHISM 22 Hermaprhodites Hermaprhodites 2. 2. Hermaprhodites Hermaprhodites XY genotype XY genotype Androgen receptor disorder Androgen receptor disorder Abnormal gonads (have both Abnormal gonads (have both g ( g ( testicular and testicular and ovarium ovariumtissue= tissue= Ovotestes Ovotestes Canine, porcine, Canine, porcine, caprine caprine, bovine , bovine freemartin freemartin Patologi Alat Kelamin J antan 10 Patologi Alat Kelamin J antan 10 SEXUAL DIMORPHISM SEXUAL DIMORPHISM 3. Male 3. Male Pseudohermaprhodites Pseudohermaprhodites pp Abnormal phenotypic sex Abnormal phenotypic sex XY t XY f l ( i XY t XY f l ( i XY genotype XY female rare (mice, XY genotype XY female rare (mice, horses, human being): horses, human being): stroma stroma ovarium ovarium ovarium ovarium Reproductive tract: ambiguous Reproductive tract: ambiguous Patologi Alat Kelamin J antan 10 Patologi Alat Kelamin J antan 10 Male pseudo- Male pseudo hermaphrodite: XY chromosome Patologi Alat Kelamin J antan 11 Patologi Alat Kelamin J antan 11 Patologi Alat Kelamin J antan 12 Patologi Alat Kelamin J antan 12 MINOR ANOMALIES MINOR ANOMALIES Patologi Alat Kelamin J antan 12 Patologi Alat Kelamin J antan 12 MINOR ANOMALIES MINOR ANOMALIES MINOR ANOMALIES MINOR ANOMALIES Patologi Alat Kelamin J antan 13 Patologi Alat Kelamin J antan 13 DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM AND CONTENTS AND CONTENTS The scrotum The scrotum The scrotum The scrotum T i d E idid i T i d E idid i Testis and Epididymis Testis and Epididymis Patologi Alat Kelamin J antan 14 Patologi Alat Kelamin J antan 14 DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM Dermatitis Dermatitis TTTrauma Trauma Frosbite Frosbite E i t l i it t E i t l i it t Environmental irritants Environmental irritants Chorioptes bovis Chorioptes bovis Neoplasma Neoplasma pp Mast cell tumor Mast cell tumor Melanoma Melanoma Hemangioma Hemangioma Patologi Alat Kelamin J antan 15 Patologi Alat Kelamin J antan 15 Patologi Alat Kelamin J antan 16 Patologi Alat Kelamin J antan 16 Patologi Alat Kelamin J antan 17 Patologi Alat Kelamin J antan 17 DISEASES OF TESTIS AND DISEASES OF TESTIS AND EPIDIDYMIS EPIDIDYMIS Decreased size Decreased size C t hidi C t hidi Cryptorchidism Cryptorchidism Hypoplasia Hypoplasia yp p yp p Testicular degeneration Testicular degeneration Segmental aplasia Segmental aplasia Patologi Alat Kelamin J antan 18 Patologi Alat Kelamin J antan 18 Increased size Increased size Spermatic granuloma of epididymis Spermatic granuloma of epididymis Epididymitis Epididymitis Orchitis Orchitis Testicular neoplasia: Testicular neoplasia: Seminoma Seminoma Sertoli cell tumor Sertoli cell tumor Interstitial cell tumor Interstitial cell tumor Patologi Alat Kelamin J antan 19 Patologi Alat Kelamin J antan 19 CRYPTORCHIDISM CRYPTORCHIDISM Decreased size Decreased size Incomplete descent of testis Incomplete descent of testis Oft il t l Oft il t l Often unilateral Often unilateral Hypoplasia Hypoplasia or atrophy or atrophy yp p yp p p y p y Testis is small, fibrotic, hyaline thickening Testis is small, fibrotic, hyaline thickening of tubular basement membrane, of tubular basement membrane, of tubular basement membrane, of tubular basement membrane, degeneration of germinal epithelium, only a degeneration of germinal epithelium, only a few few spermatogonia spermatogonia remain, normal remain, normal Sertoli Sertoli ll ll cells cells Prone to Prone to neoplasia neoplasia ((Sertoli Sertoli CT, CT, seminoma seminoma)) pp (( ,, )) Patologi Alat Kelamin J antan 20 Patologi Alat Kelamin J antan 20 Patologi Alat Kelamin J antan 21 Patologi Alat Kelamin J antan 21 Patologi Alat Kelamin J antan 22 Patologi Alat Kelamin J antan 22 HYPOPLASIA HYPOPLASIA Decreased size Decreased size Mild to severe Mild to severe Mild to severe Mild to severe Unilateral Unilateral hypoplasia hypoplasia Abnormality of specific genes, endocrine, Abnormality of specific genes, endocrine, cytogenic cytogenic Related to poor general nutrition, Zn Related to poor general nutrition, Zn deff deff HP: HP: hypoplastic hypoplastic tubules lined by tubules lined by sertoli sertoli HP: HP: hypoplastic hypoplastic tubules, lined by tubules, lined by sertoli sertoli cells, a few stem cells and cells, a few stem cells and spermatogonia spermatogonia Patologi Alat Kelamin J antan 23 Patologi Alat Kelamin J antan 23 Patologi Alat Kelamin J antan 24 Patologi Alat Kelamin J antan 24 TESTICULAR ATROPHY TESTICULAR ATROPHY Decreased size Decreased size Reduce in size after puberty Reduce in size after puberty Testicular degeneration Testicular degeneration Testicular degeneration Testicular degeneration HP: deg. of the HP: deg. of the seminiferous seminiferous tubules tubules Causes by: inflammation obstruction of Causes by: inflammation obstruction of Causes by: inflammation, obstruction of Causes by: inflammation, obstruction of flow of spermatozoa (segmental flow of spermatozoa (segmental aplasia aplasia injury of injury of epididymis epididymis torsion of torsion of aplasia aplasia, injury of , injury of epididymis epididymis, torsion of , torsion of spermatic cord) spermatic cord) Systemic injurious factor: Systemic injurious factor: Systemic injurious factor: Systemic injurious factor: hypovitaminosis hypovitaminosis A, Zn, antibiotic, A, Zn, antibiotic, toxins, estrogen produced by toxins, estrogen produced by sertoli sertoli cell cell tumor tumor Patologi Alat Kelamin J antan 25 Patologi Alat Kelamin J antan 25 Some Causes of Testicular Degeneration Some Causes of Testicular Degeneration Advancing age Advancing age Epididymitis Epididymitis Chemicals Chemicals Heat Heat Hormones Hormones Hormones Hormones Metal compound toxicosis Metal compound toxicosis Neoplasia Neoplasia Nutritional disorders Nutritional disorders Nutritional disorders Nutritional disorders Plants Plants Radiation Radiation Stress Stress Trauma Trauma Ultrasound Ultrasound Ultrasound Ultrasound Viral infection Viral infection Patologi Alat Kelamin J antan 26 Patologi Alat Kelamin J antan 26 Patologi Alat Kelamin J antan 27 Patologi Alat Kelamin J antan 27 Patologi Alat Kelamin J antan 28 Patologi Alat Kelamin J antan 28 EPIDIDYMITIS AND EPIDIDYMITIS AND SPERMATIC GRANULOMA SPERMATIC GRANULOMA Inflammation, testicular Inflammation, testicular neoplasia neoplasia SPERMATIC GRANULOMA SPERMATIC GRANULOMA Inflammation, testicular Inflammation, testicular neoplasia neoplasia Spermatic Spermatic granuloma granuloma: congenital : congenital obstruction inflammation as obstruction inflammation as respon respon to to obstruction, inflammation as obstruction, inflammation as respon respon to to spermiostatis spermiostatis Epididymitis Epididymitis is almost accompanied by is almost accompanied by spermatic spermatic granuloma granuloma and and periorchitis periorchitis Cause testicular degeneration Cause testicular degeneration BB abort s abort s E coli E coli B. B. abortus abortus, E. coli , E. coli Patologi Alat Kelamin J antan 29 Patologi Alat Kelamin J antan 29 Patologi Alat Kelamin J antan 30 Patologi Alat Kelamin J antan 30 Increased size Increased size c eased s e c eased s e Spermatic Spermatic granuloma granuloma of of epididymis epididymis Epididymitis Epididymitis Orchitis Orchitis Orchitis Orchitis Periorchitis Periorchitis Testicular Testicular neoplasia neoplasia Seminoma Seminoma Seminoma Seminoma Teratoma Teratoma Sertoli Sertoli cell tumor cell tumor Interstitial cell tumor Interstitial cell tumor Patologi Alat Kelamin J antan 31 Patologi Alat Kelamin J antan 31 Patologi Alat Kelamin J antan 32 Patologi Alat Kelamin J antan 32 Patologi Alat Kelamin J antan 33 Patologi Alat Kelamin J antan 33 Patologi Alat Kelamin J antan 34 Patologi Alat Kelamin J antan 34 ORCHITIS ORCHITIS Extension of epididymitis Extension of epididymitis Hematogenous Hematogenous B b t B i B b t B i B. abortus, B. suis, B. abortus, B. suis, C. pseudotuberculosis C. pseudotuberculosis Intratubular orchitis, Intratubular orchitis, necrotizing orchitis, necrotizing orchitis, l t hiti l t hiti (M b i (M b i granulomatous orchitis granulomatous orchitis (M. bovis, (M. bovis, mycotic orchitis mycotic orchitis)) Patologi Alat Kelamin J antan 35 Patologi Alat Kelamin J antan 35 Patologi Alat Kelamin J antan 36 Patologi Alat Kelamin J antan 36 Patologi Alat Kelamin J antan 37 Patologi Alat Kelamin J antan 37 TESTICULAR NEOPLASIA TESTICULAR NEOPLASIA Common in older dog Common in older dog TESTICULAR NEOPLASIA TESTICULAR NEOPLASIA gg Arise from germ cells Arise from germ cells Seminoma Seminoma I t titi l ll t I t titi l ll t Interstitial cell tumors Interstitial cell tumors Sertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect ((Gynecomastica Gynecomastica: enlargement of : enlargement of mammary gland) mammary gland) Patologi Alat Kelamin J antan 38 Patologi Alat Kelamin J antan 38 Patologi Alat Kelamin J antan 39 Patologi Alat Kelamin J antan 39 Patologi Alat Kelamin J antan 40 Patologi Alat Kelamin J antan 40 Patologi Alat Kelamin J antan 41 Patologi Alat Kelamin J antan 41 Patologi Alat Kelamin J antan 42 Patologi Alat Kelamin J antan 42