1. A. Bound drug is filtered freely and find in tubule. A.B.

B. Active tubular secretion of drug usually occurs in the proximal

tubule. A.B.
2. A. Passive tubular reabsorption usually occurs in the proximal
tubule. A.B.
B. Tubular reabsorption requires ionized drug. A.B.
. A. Aminoglycoside antibiotics are poorly absorbed from the !"T.
A.B.
B. The #d of aminoglycoside antibiotics is smaller because of
distribution to the extracellular fluid $2%&2'( of B)*. A.B.
+. A. A '' yo female patient has a stable ,-r data at +mg.d/
$'%0g.1'%cm*. -alculate -r-l. A. 12.'+1 B. 1%.'+1 -.21'+1 3.
12.'+m/.min1 4. 1%.'+m/.min.
B. A 5' yo male patient has a stable ,-r data at .'mg.d/
$5%0g.15'cm*. -alculate -r-l. A. 16.251 B. 1%.251 -.
16.25m/.min1 3. 6.25m/.min1 4. 2.25m/.min.
'. A. Uremic patients may exhibit pharmacokinetic
changes in: 1. 3ecreasing in !781 2. #d1 .-l1 +.BA.
A.B.-.3.4.
B. 8" could be caused by9 1. 3:1 2.:etals1 . Allergens1 +. 3rugs.
A.B.-.3.4.
5. A. t1.2el ;ill be longer in 8" patients B4-A<,4 %f decreasing in
renal drug excretion. A.B.-.3.4.
B. ,
cr
;ill accumulate B4-A<,4 of loss of glomerular filtration
in 0idney. A.B.-.3.4.
6. A. -r-l usually used in estimation of renal function B4-A<,4 a
rapid and convenient. A.B.-.3.4.
B. =ypertension can cause 8" B4-A<,4 -hronic overloading of
0idney ;ith food. A.B.-.3.4.
2. A. A liver failure patient is treated using drug $6%( metabolized by
the liver*. Albumin mg.d/1 Bilirubine 12mg.d/1 Prothrombine
time 2seconds1 and severe acites > mild encephalohepatic.
-alculate the score $-P,* of drug > decereasing of dose $(*. A.
12.'%(1 B. 1%.2'(1 -. 1.2'(1 3. 1.'%(1 4. ?.2'(.
B. -l +'/.h1 #d 6'/. -pss 1%@g.m/. "# /3. A.1%mg1 B. 1%g1
-.+'%mg1 3. %.1g1 4.6'%mg
?. A. -l A% /.h1 #dA1%% /. -p
ss
1% mg./. :3. A..%mg.h1 B.
.%g.h1 -. %.%mg.h1 3. %%mg.h 4.%%%mg.h
B. A drug is inBected "#&ly bolus into patient B) of '%0g. #d is
2%/.0g. -p
ss
needed is 1%% ng.m/. /3 of the drug is9 A. %.%1mg1
B. %.1 mg1 -. 1mg1 3. 1% mg1 4. 1%%mg.
1%. A.The 0idney is an important organ in regulating9 1. Body
fluids1 2. 4lectrolyte balance1 . 8emoval of metabolic ;aste1 +.
3rug excretion from the body. A.B.-.3.4.
B.A patient ;as given an intravenous /3 of luminal 5%% mg over a
period of about an hour. Cne day > four days after luminal dosing1
-p ;ere 12.5 > 6.' mg./1 respectively. The elimination rate
constant of luminal9 A. %.16h
&1
B. %.16 h
&1
-. %.16 d
&1
3. %.%16
d
&1
4. %.16 d
&1
.