Jan Faergemann, MD, PhD; A. K. Gupta, MD, FRCPC; A. Al Mofadi, MD, FRCPC; A. Abanami, MD, FRCP(Edin); A. Abu Shareaah, MD; Greet Marynissen, PhD Background: Pityriasis (tinea) versicolor has a high tendency to recur after being treated successfully. Pro- phylactic treatment to reduce recurrence is needed. Objective: To determine whether recurrence of pity- riasis versicolor could be prevented by prophylactic itraconazole treatment. Design: Open treatment followed by a randomized, double-blind, placebo-controlled phase. Setting: Multinational outpatient centers. Patients: A total of 239 consecutive patients were in- cluded; 238 started open treatment. A total of 209 pa- tients started prophylactic treatment: 106 in the itra- conazole group and 103 in the placebo group. Interventions: Open treatment: itraconazole, 200 mg once daily for 7 days. Prophylactic treatment: itracona- zole, 200 mg, or placebo twice daily 1 day per month for 6 consecutive months. Main Outcome Measures: Mycological cure rates at the end of open treatment and at the end of prophylac- tic treatment. Results: Mycological cure at the end of open treatment was 92%(205/223). At the prophylactic treatment endpoint (6months), mycological cure was 88%(90/102) inthe itra- conazole group and 57% (56/99) in the placebo group (P.001). In open treatment, 11 patients were not able to be evaluated for efficacy. In prophylactic treatment, 4 patients in the itraconazole group and 4 in the placebo group were not able to be evaluated. Adverse events were reported during open treatment by 26 patients (11%) and during prophylactic treatment by 17 (16%) in the itra- conazole group and 14 (14%) in the placebo group. No patients experienced any serious adverse events. Conclusions: Prophylactic itraconazole treatment is ef- ficacious for pityriasis versicolor after 6 months, as is itraconazole in the treatment of pityriasis versicolor. Arch Dermatol. 2002;138:69-73 P ITYRIASIS (TINEA) versicolor may be treatedwithtopical or oral agents, with the latter being used especially when the disease is widespread or does not respond to topical measures. Sys- temic agents usedfor treating pityriasis ver- sicolor include itraconazole, ketocona- zole, and fluconazole. 1,2 Itraconazole is a triazole antimycotic agent with strong keratophilic and lipo- philic properties. 3 Similar toother azole an- tifungal agents, the mode of action of itra- conazole involves inhibition of 14-- demethylase, resulting in impaired sterol synthesis infungal cell membranes. Invitro, itraconazole is active not only against yeasts suchas Malassezia andCandida species but also against dermatophytes and nonder- matophyte molds. 4,5 When itraconazole is used to treat pityriasis versicolor, a suggested regimen is 200mg/dfor 7days, witha minimumcu- mulative dose of at least 1000 mg being re- quired for effective therapy. 6,7 Four weeks after the start of therapy, cure rates of 80% to 90%have been reported. 7 Although the fungal organisms may be nonviable, the color of the affected skin may take several weeks or months to normalize. Pityriasis versicolor recurs at a vari- able rate in treated individuals, and 60% to 90% of patients relapse within 2 years in some series. 8 Therefore, it is important to evaluate a prophylactic regimen that may be effective and safe in preventing the recurrence of pityriasis versicolor. We evaluated the efficacy of treat- ment with itraconazole, 200 mg once daily for 1 week, and the efficacy of placebo- controlled prophylactic treatment with itraconazole, 200 mg taken 12 hours apart 1 day per monthfor 6 consecutive months, in terms of clinical and mycological out- come and frequency of recurrence of pity- riasis versicolor. To our knowledge, this STUDY From the Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden (Dr Faergemann); the Division of Dermatology, Department of Medicine, Sunnybrook and Womens College, Health Sciences Center, Sunnybrook, and the University of Toronto, Toronto, Ontario (Dr Gupta); the Division of Dermatology, King Fahad National Guard Hospital, Riyadh, Saudi Arabia (Dr Al Mofadi); the Departments of Dermatology, Riyadh Armed Forces Hospital, Riyadh (Dr Abanami) and Mafraque Hospital, Ministry of Health, Abu Dubai, United Arab Emirates (Dr Abu Shareaah); and Medisearch International, Mechelen, Belgium (Dr Marynissen). (REPRINTED) ARCH DERMATOL/ VOL 138, JAN 2002 WWW.ARCHDERMATOL.COM 69 2002 American Medical Association. All rights reserved. Downloaded From: http://archderm.jamanetwork.com/ on 10/09/2014 is the first study to evaluate this regimen of itracona- zole as a prophylactic measure against pityriasis versi- color. RESULTS PATIENT DISPOSITION There were 239 patients recruited. One patient with- drewconsent and received no treatment. Therefore, 238 patients entered the open treatment phase and received itraconazole, 200 mg/d for 7 days. Demographic and other baseline characteristics of the patients are given in Table 1. Data are presented on an on-protocol basis (ie, having excluded patients who were characterized as hav- ing a major protocol deviation). Twenty-nine patients who received treatment in the open phase did not continue into the double-blind pro- phylactic phase. Of these, 18 were not cured and 11 were lost to follow-upor were noncompliant. At the endof open treatment, mycological cure was recorded in 205 (92%) of 223 patients (Table 2). All patients randomized into the double-blindprophylactic phase were mycologically nega- tive at the time of randomization. At the end of the pro- phylactic phase, 90 (88%) of 102 patients in the itracona- zole group and 56 (57%) of 99 in the placebo group were still mycologically negative (P.001) (Table 2). CLINICAL GLOBAL EVALUATION Findings were scoredas cured, markedimprovement, mod- erate improvement, unchanged, or deteriorated. Global PATIENTS AND METHODS This multicenter, multinational trial was characterized by an open, active treatment phase with itraconazole, 200 mg once daily for 1 week, followed by 4 weeks without active therapy. In patients in whom pityriasis versicolor cleared, active treatment was followed by a double-blind prophy- lactic treatment phase with itraconazole, 200 mg, or pla- cebo twice on 1 day per month for 6 consecutive months. Patients were randomly allocated to 1 of the 2 treatments in the prophylactic phase. Patients who fulfilled the inclusion and exclusion cri- teria at the first visit (baseline) received itraconazole therapy for 7 days (treatment phase). Five weeks from the start of therapy (ie, 4 weeks after treatment), patients who were my- cologically cured (no hyphae present) were randomized into the double-blind prophylactic phase to receive either itra- conazole or placebo treatment for 6 months. Inclusion cri- teria for subjects included those aged 12 to 70 years who had a clinical diagnosis of pityriasis versicolor confirmed by my- cological examination and who provided written informed consent before inclusion into the trial. Exclusion criteria for subjects included those with (1) known sensitivity to itra- conazole or its excipients, (2) chronic mucocutaneous can- didiasis or systemic fungal infection, (3) immunosuppres- sion caused by disease or treatment, (4) any other disease or condition that in the investigators opinion should exclude the patient from the trial, and those who (5) participated in an investigational drug trial within 30 days of selection, (6) were pregnant or breastfeeding, and(7) were womenof child- bearing potential without adequate contraception. The fol- lowing therapies were not allowed: (1) topical antifungal agents, topical corticosteroids, shampoos with active ingre- dients against Malassezia, or tar shampoos usedwithin2weeks of the randomization visit or during the trial (topical corti- costeroid nasal sprays or eye ointments were allowed dur- ingthe trial); (2) systemic corticosteroidtherapyeither within 1 month of the randomization visit or during the trial; (3) systemic antifungal therapy within2 months of the random- ization visit or during the trial; (4) use of the enzyme- inducing drugs rifampin, phenytoin, rifabutin, carbamaz- epine, and isoniazid; and (5) use of some drugs metabolized by cytochrome P4503A4 with concomitant increase in their concentrations (eg, terfenadine, astemizole, cisapride, oral midazolam hydrochloride, triazolam, quinidine gluconate, pimozide, and 3-hydroxy-3-methylglutaryl coenzyme A re- ductase inhibitors). Other medications knowntointeract with itraconazole were monitored if they were being taken con- currently. Becauseabsorptionof itraconazoleis impairedwhen gastric acidity is decreased, acid-neutralizing agents (eg, alu- minum hydroxide) should be administered at least 2 hours after the intake of itraconazole. Itraconazole should be ad- ministeredwith2glasses of a cola beverage inindividuals with achlorhydria or those taking acid secretion suppressors (eg, H 2 -antagonists and proton pump inhibitors). Patients could be withdrawn from the trial if (1) a se- rious adverse event occurred or (2) the investigator con- sidered it in the best interest of the patient for safety rea- sons. Patients were withdrawnfromthe trial if they withdrew their consent or if the randomization code was broken. METHODS OF ASSIGNING PATIENTS TO TREATMENT GROUPS All patients admitted to the trial entered the open treat- ment phase. Patients who were mycologically cured (no hy- phae present) at the end of week 5 fromthe start of therapy were allocated to one of the treatment groups in the double- blind prophylactic phase using a predetermined random- ization code generated at a central site. At each participat- ing medical center, medication numbers were assigned consecutively starting with the lowest available number. Therefore, the investigator was not aware of the random- ization code. DETERMINATION OF SAMPLE SIZE The primary variable was the mycological cure rate at the end of open treatment and at the end of prophylactic treat- ment. Mycological cure was described as negative findings on light microscopic examination. Mycological cure was ex- pected to occur in 85%of patients who underwent itracona- zole treatment in the first treatment phase, in 89% who underwent prophylactic treatment with itraconazole, and in 71%who underwent placebo prophylaxis. To be able to de- tect this difference with a power of 80% at the 5% level of significance, 74 patients are required in each treatment group. Assuming a mycological cure rate of 85%, 174 pa- tients would be required to start the first treatment phase to have 148 patients to randomize between the groups receiving placebo and active therapy in the prophylactic (REPRINTED) ARCH DERMATOL/ VOL 138, JAN 2002 WWW.ARCHDERMATOL.COM 70 2002 American Medical Association. All rights reserved. Downloaded From: http://archderm.jamanetwork.com/ on 10/09/2014 evaluation scores were significantly better in the itracona- zole group compared with the placebo group when evalu- atedat the prophylactic treatment endpoint (P.001). For all variables (erythema, hypopigmentation, desquama- tion, and itching), the itraconazole group showed signifi- cantly superior changes at the prophylactic treatment end point compared with the placebo group. ADVERSE EVENTS Adverse events were reported by 26 patients (11%) dur- ing open treatment and 31 (15%) during prophylactic treatment (17 patients [16%] in the itraconazole group and 14 [14%] in the placebo group). Adverse events considered to be possibly, prob- ably, or very likely drug related were reported in 10 pa- tients during the open treatment phase and in 2 in the itraconazole group during the prophylactic treatment phase. All these adverse events were mild to moderate in intensity, except for severe pruritus in 1 patient. All patients continued in the trial except for 1 in open treat- ment who experienced urticaria and was withdrawn. Two patients in open treatment and 4 in the placebo group of prophylactic treatment were withdrawn fromthe trial be- cause of adverse events. Moderate urticaria in 1 patient was the only adverse event leading to withdrawal that was considered to be very likely related to trial medication use. No patients experienced a severe adverse event. The most commonadverse events during opentreat- ment were gastrointestinal tract complaints, which were reported by 9 patients (4%). There were no reports of gas- trointestinal tract complaints during prophylactic treat- treatment phase of the study. To account for a dropout rate of approximately 10%, at least 194 patients needed to be recruited for the trial. SAFETY ANALYSIS An evaluation of adverse events was performed on all pa- tients who received the trial medication at least once. An additional intent-to-treat analysis was performed on all ran- domized patients who had at least 1 administration of the prophylactic treatment medication and who had efficacy data after visit 2. INITIAL CHARACTERIZATION OF PATIENT SAMPLE For the opentreatment phase, all data were tabulatedandwere descriptively presentedwith95%confidence intervals. Com- parability between treatment groups was evaluated with re- spect to the demographic and baseline data. For continuous data (eg, age), the Van Elteren test was applied. For nominal categorical data (eg, sex and race), the Cochran-Mantel- Haenszel test for general association was used. For ordinal categorical data(eg, clinical global evaluationscores), theCoch- ran-Mantel-Haenszel row mean scores differences test was used. All data were analyzed descriptively. EFFICACY VARIABLES The primary variable was the mycological cure rate at the end of open treatment and at the end of prophylactic treat- ment. Mycological cure was defined as no hyphae present. Samples for microscopy were always taken from the same area. The cure rate at the end of the open treatment phase was tabulated. Itraconazole and placebo prophylaxis were compared at the end of the prophylactic treatment phase using the Cochran-Mantel-Haenszel test for general as- sociation. Secondary variables included clinical global evalua- tionscores and signs and symptoms of disease. All data were analyzed descriptively per time point. In the open treat- ment phase, all data were analyzed descriptively only. Changes from visit 1 (baseline) were analyzed using the Wilcoxon signed rank test for ordinal and continuous data and the McNemar test for dichotomous data. In the pro- phylactic treatment phase, between-group differences for dichotomous data were investigated using the Cochran- Mantel-Haenszel test for general association. Groups were compared for ordinal data using the Cochran-Mantel- Haenszel row mean scores differences test. Comparisons were performed for continuous data using the Van El- teren test. Within-group changes fromrandomization visit 2 were analyzed using the Wilcoxon signed rank test for ordinal and continuous data and the McNemar test for di- chotomous data. Time-to-recurrence data were analyzed using the Mantel-Cox test. ASSESSMENTS For efficacy evaluations, patients had to be seen prefer- ably by the same physician at each trial visit to maintain uniformity across clinical evaluations. Primary Efficacy Variable The primary efficacy variable was the mycological cure rate assessed at the end of weeks 5 and 29. Mycological cure was defined as negative microscopic results (negative potassium hydroxide preparation). For mycological evaluation, skin scrapings were taken from the active border of the lesion. Secondary Efficacy Variables Signs and Symptoms. Hyperpigmentation, hypopigmen- tation, itching, erythema, and latent desquamation were as- sessed according to absence or presence at each visit. Clinical Global Evaluation. At eachvisit, findings fromclini- cal evaluation were rated as follows: cured (absence of all symptoms vs baseline, except hyperpigmentation or hy- popigmentation); marked improvement (clinical improve- ment 50%vs baseline); moderate improvement (clinical improvement 0% to 50% vs baseline); unchanged (no change in symptoms vs baseline); and deterioration (wors- ening of symptoms vs baseline). Patient Compliance. Compliance was measured by pa- tient self-assessment and by blister card reconciliation at the end of open treatment and during prophylactic treat- ment. Self-assessment consisted of the patient recording in a diary the number of capsules taken per dose of trial medi- cation, the time of each intake, and the dates. (REPRINTED) ARCH DERMATOL/ VOL 138, JAN 2002 WWW.ARCHDERMATOL.COM 71 2002 American Medical Association. All rights reserved. Downloaded From: http://archderm.jamanetwork.com/ on 10/09/2014 ment. The most common adverse events during prophy- lactic treatment were upper respiratory tract infection (reported by 4 patients [4%] in the itraconazole group and4 [4%] inthe placebo group) andinfluenza-like symp- toms (reportedby 1 patient [1%] inthe itraconazole group and 4 [4%] in the placebo group). COMMENT Itraconazole was effective in this study in the treatment of pityriasis versicolor, with mycological cure in 92% of patients evaluated 5 weeks after the start of therapy. The efficacy rate was consistent with that reported in previ- ous studies. 9-18 The excellent in vitro activity of itracona- zole against Malassezia species and its high lipophilicity and accumulation in sebaceous glands 19 support the high efficacy rates recorded when patients were evaluated 5 weeks after the start of therapy and for the placebo pro- phylactic group at the end of 6 months follow-up. The highrate of recurrence, reaching as muchas 60% in 1 year and 80% in 2 years, is an important consider- ation in pityriasis versicolor. 8 Clinical disease manifests itself when there is conversion of the saprophytic (blas- topore) form of Malassezia species to the mycelial form. In immunocompetent individuals, factors predisposing to recurrence may be difficult to eradicate, including a tendency toward seborrhea and heavy sweating in the presence of high temperature and high humidity. There may be an inherited predisposition to the disease. Aper- manent cure may therefore be difficult to achieve, and this may explainthe long-termnature of the disease. Con- sequently, a prophylactic regimen may help avoid recur- rence of pityriasis versicolor. Prophylactic regimens us- ing ketoconazole include 200 mg given on 3 consecutive days every month 20 or a single dose of 400 mg taken once a month. 21,22 Topical therapies have been used as a pro- phylactic, but patient compliance is lower, and no con- trolled studies have been reported in the literature, to our knowledge. The present study was designed to determine whether recurrence of pityriasis versicolor could be pre- vented by administering prophylactic itraconazole, 400 mg once a month. To our knowledge, such a study has not been reported previously. Our results demonstrate that prophylactic therapy with itraconazole was effec- tive in preventing development of the disease during the 6-month study. There are no documented studies of topical pro- phylactic treatment in the literature, to our knowledge. Compliance with topical treatment is probably lower be- cause it is more time-consuming and therefore more dif- ficult to convince the patient to perform than oral treat- ment. This prophylactic treatment procedure with 1 treatment day per month with itraconazole could be used primarily in patients with frequent recurrences. The pro- phylactic regimen of itraconazole, 400 mg adminis- trated once a month, was not only effective but also safe and had high compliance. Accepted for publication May 23, 2001. This study was supported by an unrestricted educa- tional grant from Janssen Pharmaceutica. We thank the following individuals for recruiting pa- tients for the study: T. Novak Gregurek (Croatia); H. El- tonsy, A. Farag, N. Saleh, and Z. Tosson (Egypt); M. Guima- raes and A. Massa (Portugal); A. Abanami and A. Mofadi (Saudi Arabia); P. Procter, N. Rabobee, W. Sinclair, and J. van Heerden (South Africa); J. Faergemann (Sweden); and A. Abu Shareeah (United Arab Emirates). Corresponding author and reprints: Jan Faergemann, MD, PhD, Department of Dermatology, Sahlgrenska Uni- versity Hospital, S-41345 Gothenburg, Sweden (e-mail: jan.faergemann@derm.gu.se). REFERENCES 1. Sunenshine PJ, Schwartz RA, Janniger CK. Tinea versicolor. Int J Dermatol. 1998; 37:648-655. 2. Faergemann J. Management of seborrheic dermatitis and pityriasis versicolor. Am J Clin Dermatol. 2000;1:75-80. 3. Heres J, Backx LJ, Van CustemJ, et al. Antimycotic azoles, part 7: synthesis and antifungal properties of a series of novel triazole-3-ones. J Med Chem. 1984;27: 894-900. 4. Van Custem J. The in-vitro antifungal spectrum of itraconazole. Mycoses. 1989; 32(suppl 1):7-13. 5. Van Custem J. Oral and parenteral treatment with itraconazole in various super- Table 1. Demographic and Other Baseline Characteristics of the Study Population Open Treatment Phase (n = 29) Prophylactic Treatment Phase Itraconazole (n = 106) Placebo (n = 103) Sex, No. (%) M 14 (48) 56 (53) 60 (58) F 15 (52) 50 (47) 43 (42) Age, median (range), y 30 (14-53) 30 (12-62) 30 (12-65) Race, No. Black 1 2 4 White 20 70 73 Hispanic 0 0 1 Asian 6 26 21 Other 2 8 4 Height, median (range), cm 170 (150-187) 170 (150-189) 170 (140-195) Weight, median (range), kg 67 (50-95) 70 (45-97) 69 (41-142) Table 2. Results of Open and Prophylactic Treatment With Itraconazole in Patients With Pityriasis (Tinea) Versicolor Patients, No./Total No. (%) Cured Protocol Deviation (Lost) Open treatment end point 205/223 (92) 15/238 (6)* Prophylactic treatment end point Itraconazole 90/102 (88) 1/103 (1) Placebo 56/99 (57) 3/102 (3) *Lost to follow-up (n = 8); noncompliant (n = 6); and withdrew consent (n = 1). Insufficient data (n = 1). Intercurrent therapy (n = 2) and insufficient data (n = 1). (REPRINTED) ARCH DERMATOL/ VOL 138, JAN 2002 WWW.ARCHDERMATOL.COM 72 2002 American Medical Association. All rights reserved. Downloaded From: http://archderm.jamanetwork.com/ on 10/09/2014 ficial and systemic experimental fungal infections: comparisons with other an- tifungal and combination therapy. Br J Clin Pract. 1990;44(suppl 71):32-36. 6. De Doncker P, Gupta AK, Marynissen G, et al. Itraconazole pulse therapy for ony- chomycosis and dermatomycoses: an overview. J Am Acad Dermatol. 1997;37: 969-974. 7. Delescluse J, Cauwenbergh G, Degreef H. Itraconazole, a new orally active an- tifungal in the treatment of pityriasis versicolor. Br J Dermatol. 1986;14:701- 703. 8. Faergemann J. Pityrosporum infections. J Am Acad Dermatol. 1994;31(suppl): S18-S20. 9. Estrada RA. Itraconazole in pityriasis versicolor. Rev Infect Dis. 1987;9:S128- S130. 10. Kose O. Fluconazole versus itraconazole in the treatment of tinea versicolor. Int J Dermatol. 1995;34:498-499. 11. Shemer A, Nathansohn N, Kaplan B, Trau H. Itraconazole versus ketoconazole in the treatment of tinea versicolor. J Dermatol Treat. 1999;10:19-23. 12. Montero-Gei F, Robles ME, Suchil P. Fluconazole vs itraconazole in the treat- ment of tinea versicolor. Int J Dermatol. 1999;38:601-603. 13. Hernanz ADP, Frias-Iniesta J, Gonzalez-Valle O, Borgers M, Van Cutsem J, Cau- wenbergh G. Itraconazole therapy in pityriasis versicolor. Br J Dermatol. 1986; 115:217-225. 14. Faergemann J. Treatment of pityriasis versicolor with itraconazole: a double- blind placebo controlled study. Mycoses. 1988;31:377-379. 15. Hickman JG. A double-blind, randomized, placebo-controlled evaluation of short- termtreatment with oral itraconazole in patients with tinea versicolor. J AmAcad Dermatol. 1996;34:785-787. 16. Robertson LI. Itraconazole in the treatment of widespread tinea versicolor. Clin Exp Dermatol. 1987;12:178-180. 17. Panconesi E, Difonzo E. Treatment of dermatophytoses and pityriasis versicolor with itraconazole. Rev Infect Dis. 1987;9(suppl 1):S109-S113. 18. Morales-Doria M. Pityriasis versicolor: efficacy of two five-day regimens of itra- conazole. Rev Infect Dis. 1987;9(suppl 1):S131-S133. 19. Cauwenbergh G, Degreef H, Heykants J, Wostenborghs R, Van Rooy P, Haever- ans K. Pharmacokinetic profile of orally administered itraconazole in human skin. J Am Acad Dermatol. 1988;18:263-268. 20. Faergemann J, Djarv L. Tinea versicolor: treatment and prophylaxis with keto- conazole. Cutis. 1982;30:542-545. 21. Rausch LJ, Jacobs PH. Tinea versicolor: treatment and prophylaxis with monthly administration of ketoconazole. Cutis. 1964;34:470-471. 22. Gupta AK, Del Rosso JQ. An evaluation of intermittent therapies used to treat onychomycosis and other dermatomycoses with the oral antifungal agents. Int J Dermatol. 2000;39:401-411. News and Notes R ichard B. Stoughton Memorial Travel Fellowship applications are invited from US dermatology residents. The fellowship will enable a dermatologist in training to present a poster and attend the British Association of Dermatologists Annual Scientific Meeting in Edinburgh fromJuly 9 to July 12, 2002. The winner will receive free registration and admittance to the presidents reception and annual dinner. Accommodation will also be of- fered free of charge. The closing date for completed applications is Friday, February 8, 2002. For further details and application forms please contact the BAD Fellowship Co-ordinator, British Association of Dermatologists, 19 Fitzroy Square, Lon- don W1T 6EH, England. Phone: 44-20-7383-0266; Fax: 44-20-7388-5263 (e-mail: admin@bad.org.uk). (REPRINTED) ARCH DERMATOL/ VOL 138, JAN 2002 WWW.ARCHDERMATOL.COM 73 2002 American Medical Association. All rights reserved. Downloaded From: http://archderm.jamanetwork.com/ on 10/09/2014
Bertram G. Katzung, Marieke Kruidering-Hall, Anthony J. Trevor - Katzung & Trevor's Pharmacology Examination and Board Review (2019, McGraw-Hill Education) PDF