BY Usman Ali Akbar

1 Virology Made Awesome

Associated
condition
Viruses Associated
condition
Viruses
Diarrhea 1. Norwalk
2. Rotavirus
3. Polio

4. Adenovirus
5. Influenza (rare)
6. Measles

Enteroviruses except polio dont cause gastric
symptoms
Hepatitis 1. Hep A to E
2. Hanta
3. Yellow fever
4. Dengue
5. CMV (postnatal)
EBV
6. Rubella
Tumour 1. Hep B (HCC)
2. Hep C (HCC)

3. HHV 8(Kaposis)
4. EBV (lymphomas, NPC, Burkits, Hodgkins)
5. HSV 2 (cervical/ vulvar)

6. HPV 16,18 (cervical)


Maculopapular
rash
1. Measles
2. Rubella
3. HHV 6
(roseola/exanthum
subitum)
4. B19 (erythema
infeciousum)
5. Dengue (initial
stages)
Aseptic
meningitis
MMR
1. Mumps (mild, rarely severe)

Herpes
2. HSV 1, 2
3. VZV
4. HHV 6 (transplant pts)

Enteroviruses
5. EV71
6. Polio
7. Echoviruses
8. Coxsackie B

9. Rotavirus (rarely)


Hemorrhagic
rash

1. Hantavirus
2. Dengue
3. Chikungunya
Conjunctivitis 1. HSV 1 (keratoconjunctivitis)
2. VZV

3. Measles
4. Rubella

5. Chikungunya
6. Adenoviruses (keratoconjunctivits)

Hemorrhagic
fever
(Arena, Bunya, Flavi, Filo,
Toga)

Junin
Dengue
Hanta
Ebola

Conjunctival
hemorrhage
1. Adeno
2. Hanta
3. Cox A
4. EV70
5. Echo


Encephalitis 1. HSV1
2. VZV

3. Measles (SSPE)
4. Rubella (post-infectious encephalitis)

5. Polio
6. EV 71
Vesicles 1. Smallpox
2. Molluscum contagiosum
3. HSV 1 and 2
4. VZV (papulovesicular
rash: papules to
vesicles, pustules and
crusting)
5. Cox A(HFMD)

BY Usman Ali Akbar
2 Virology Made Awesome
7. Coxsackie A/B

8. Rotavirus (rarely)
9. Nipah
10. JE
11. Dengue (atypical manifestation)
12. Rabies


13. West Nile
14. Slow viruses diseases
15. Vaccinia


Do not cause
viremia
Guillain Barre CMV
Influenza

Otitis media 1. RSV
2. Measles
3. Rhinovirus
Progress onto
chronicity
HBV
HCV
TRANSMISSION

STDs HSV 2
Molluscum Contagiosum
HHV 8
CMV
Hep B
Hep C
HIV

Vertical
transmission
CMV
Rubella
VZV
HIV
Hep B
Hep C (rare except in HIV+)
HSV-2 (birth canal)
Blood
transfusion
HIV
Hep B
Hep C
Dengue
CMV
EBV
Fecal-oral Enteroviruses
Polio
Coxsackie
Echoviruses
EV 71
Gastroenteritis viruses
Rotavirus
Norwalk
Hep A
Hep E
Respiratory
droplets
Influenza
Parainfluenza
Respiratory syncitial
Measles
VZV
Rhinovirus
Coronavirus
Adenovirus
CA 16,24
EV 71

Uro-hand-
mouth
CMV
Kissing HSV 1
CMV
EBV
Animal vectors Dengue
Chikungunya
Japanese encephalitis
Hantavirus
Rabies
Nipah
Yellow fever
DIAGNOSTIC TESTS / VACCINES / OTHERS
Lymphocytosis
in CSF
HSV 1 (acute necrotizing encephalitis)

Other diseases with encephalopathies???
Atypical
lymphocytosis
Rubella
CMV
EBV

BY Usman Ali Akbar
3 Virology Made Awesome
Post exposure
prophylaxis
Hep B
Rabies (incubation period long)

Depresses CMI VZV
CMV
HIV

Incomplete
immunity
1. HSV
2. RSV
3. Hep E
4. Coxsackie
CPE 1. RSV, paramyxo 2, adeno,
corona, rhino

2. Herpes

3. All enteroviruses except
COX

4. MM (R interferes with
echovirus CPE)

NO CPE!!
Fevers all NO (neut tests
used)
Rotavirus and Norwalk NO
Hepatitis NO
Parvo B19, rabies, molluscum
contagiosum, smallpox NO


Live vaccine
(the rest are
inactivated)
1. VZV
2. Polio
3. Vaccinia
4. Yellow fever
5. MMR
6. Adeno
EM for
morphology
1. VZV / Pox
2. Molluscum C.
3. CMV
4. Rabies












BY Usman Ali Akbar
4 Virology Made Awesome
Mneumonics
Rubella Virus
Aunt Rubella is a single women(single stranded), she wears a cape,(enveloped) She is very
positive. (+ve sense) She kisses their eyes ( bilateral cataracts-important diagnostic sign).They
go to CPE Clinic and measure their antibody there. (Diagnostics)
Rabies Virus
Aunt Rabies loves dogs, She is single (single stranded) but she is very negative.(-ve sense) She
holds a rod (rod shaped virus) .She hates water (hydrophobia) . She is a negro ( neigri bodies )
Her Husband works at Bank named IF Ab and remains isolated ( Isolation of virus)-Diagnostics

Viruses Transmitted Congenitally
Torches
Toxo ==> chorioretinitis + hydrocephalus + intracranial calcifications
Rubella ==> PDA/pulm artery hypoplasia + cataracts + deafness + blueberry rash
CMV ==> Rubella with NO heart conditions
HIV
HSV2 ==> encephalitis and herpes lesions
Syph ==>saddle nose, saber shins, deafness, hydrops fetalis

Viral Polymerases
Retrovirus: RNA dependant DNA polymerase (reverse transcriptase)
Poxvirus: DNA dependant RNA polymerase
(-)RNA ss viruses: RNA dependant RNA polymerase
Hepatitis B: DNA dependant DNA polymerase (acts as a reverse transcriptase
Please Help, Friends Dont Hurt
P icornavirus => Hep A
H epadnavirus => Hep B

BY Usman Ali Akbar
5 Virology Made Awesome
F lavivirus => Hep C
D efective => Hep D
H epevirus => Hep E

The order of appereance follows that direction in & out And remember, first the Ag and
then the Ab
1. HBsAg
2. HBeAg
3. Anti-HBcAb
4. Anti-HBeAb
5. Anti-HBsAb
Hepatitis B Serology
Acute Infection: well see the Antigens and a new (acute) antibody.
HBsAg (+)
HBeAg (+)
HBV-DNA (+)
HBcAb IgM (+)
Window period: is the period between the end of the detection of HBsAg and the beginning
of HBsAb. Well see a new antibody
HBcAb IgM (+)
Prior Infection: well see old (chronic) antibodies
HBcAb IgG (+)
HBsAb IgG (+)
Immunization: old antibodie
HBsAb IgG (+)
Chronic Infection: well see everything positive, except for the immunization Ab
HBsAg (+)
HBeAg (+)
HBV-DNA (+)
HBcAb IgM (+)
HBcAb IgG (+)

BY Usman Ali Akbar
6 Virology Made Awesome
Which viruses or bacterias use RETROGRADE TRANSPORT?
PH RT => Ph ReTweet
P oliomyelitis (Picornavirus)
H erpes Virus (Herpesvirus)
R abies (Rhabdovirus)
T etanus (Clostridium tetani)