REFERENCES

Akiyama, T. and M. C. Savin (2010). Populations of antibiotic-resistant coliform bacteria

change rapidly in a wastewater effluent dominated stream. Science of the Total Environment,
Volume 408 (24), 6192-6201.
Al-Rifai, J. H., et al, (2007). Occurrence of pharmaceutically active and non-steroidal
estrogenic compounds in three different wastewater recycling schemes in Australia.
Chemosphere, Volume 69, 803-815.
Arikan, O. A., et al, (2006). The fate and effect of oxytetracycline during the anaerobic
digestion of manure from therapeutically treated calves. Process Biochemistry, Volume 41,
1637-1643.
Auerbach, E. A., E. E. Seyfried and K. D. McMahon (2007). Tetracycline resistance genes in
activated sludge wastewater treatment plants. Water Research, Volume 41 (5), 1143-1151.
Austin, S. T. (1998). Shreves Chemical Process Industries, 5th Edition, McGraw-Hill, U.S.A.
Backhaus, T. and L. H. Grimme (1999). The toxicity of antibiotic agents to the luminescent
bacterium Vibrio fischeri. Chemosphere, Volume 38 (14), 3291-3301.
Baguer, A. J., et al, (2000). Effects of the antibiotics oxytetracycline and tylosin on soil
fauna. Chemosphere, Volume 40 (7), 751-757.
Barrett, F. F., et al, (1968). Methicillin-resistant Staphylococcus aureus at Boston City
Hospital. Bacteriologic and epidemiologic observations. The New England Journal of
Medicine, Volume 279 (9), 441-448.
Beyer, A. and M. Matthies (2001). Criteria for atmospheric transport potential and
persistence of pesticides and industrial chemicals. Preliminary Final Report FKZ 299 65 402,
German Federal Environmental Agency, Berlin, Germany.
Bjorklund, H., et al, (1991). Residues of oxolinic acid and oxytetracycline in fish and
sediments from farms. Aquaculture, Volume 97, 85-96
Boxall A. B., et al, (2003). Are veterinary medicines causing environmental risks?.
Environmental Science and Technology, Volume 37 (15), 286A-294A.
Boxall, A. B., et al, (2006). Uptake of veterinary medicines from soils into plants. Journal of
Agricultural and Food Chemistry, Volume 54 (6), 2288-2297.
Brown, K. D., et al, (2006). Occurrence of antibiotics in hospital, residential, and dairy
effluent, municipal wastewater, and the Rio Grande in New Mexico. Science of the Total
Environment, Volume 366, 772-783.
Cars, O. and P. Nordberg (2005). Antibiotic resistance The faceless threat. Internation
Journal of Risk and Safety in Medicine, Volume 17, 103-110.

Choo, P. S. (1994). Degradation of oxytetracycline hydrochloride in fresh and seawater.

Asian Fisheries Science, Volume 7, 195-200.
Clive, D. L. J. (1968). Chemistry of tetracyclines. Quarterly Review of the Chemical Society,
Volume 22, 435-457.
Cohen, M. L., et al, (1982). Common R-plasmids in Staphylococcus aureus and
Staphylococcus epidermidis during a nosocomial Staphylococcus aureus outbreak.
Antimicrobial Agents and Chemotherapy, Volume 21 (2), 210-215.
Cosgrove, S. E. and Y. Carmeli (2003). The impact of antibiotic resistance on health and
economic outcomes. Clinical Infectious Diseases, Volume 36 (11), 1433-1437.
Delepee, R., H. Pouliquen, and H. Le Bris (2004). The bryophyte Fontinalis antipyretica
Hedw. Bioaccumulates oxytetracycline, flumequin, and oxolinic acid in the freshwater
environment. Science of the Total Environment, Volume 322, 243-253.
Doi, A. M. and M. K. Stoskopf (2000). The kinetics of oxytetracycline degradation in
deionized water under varying temperature, pH, light, substrate, and organic matter. Journal
of Aquatic Animal Health, Volume 12, 246-253.
Dolliver, H., et al, (2008). Antibiotic degradation during manure composting. Journal of
Environmental Quality, Volume 37 (3), 1245-1253.
Froehner, K., et al, (2000). Bioassays with Vibrio fischeri for the assessment of delayed
toxicity. Chemosphere, Volume 40 (8), 821-828.
Gomez, M. J., et al, (2007). Pilot survey monitoring pharmaceuticals and related compounds
in a sewage treatment plant located on the Mediterranean coast. Chemosphere, Volume 66
(6), 993-1002.
Gonsalves, D. and D. P. H. Tucker (1977). Behaviour of oxytetracycline in Florida citrus and
soils. Archives of Environmental Contamination and Toxicology, Volume 6, 515-523.
Grote, M., et al, (2007). Incorporation of veterinary antibiotics into crops from manured soil.
Landbauforschung Volkenrode 1, Volume 57, 25-32.
Hiramatsu, K. (2001). Vancomycin-resistant Staphylococcus aureus: a new model of
antibiotic resistance. Lancet Infectious Diseases, Volume 1, 147-155.
Holmberg, S. D., et al, (1987). Health and economic impacts of antimicrobial resistance.
Reviews of Infectious Diseases, Volume 9 (6), 1065-1078.
Huang, J. J., et al, (2012). Monitoring and evaluation of antibiotic-resistant bacteria at a
municipal wastewater treatment plant in China. Environment International, Volume 42, 3136.
Jacobsen, P. and L. Berglind (1988). Persistence of oxytetracycline in sediments from fish
farms. Aquaculture, Volume 70 (4), 365-370.

Katz, S. E. (1985). Environmental impact assessment for the use of oxytetracycline to

treat/control respiratory and digestive tract infections in captively-reared alligators.
Department of Biochemistry and Microbiology, Rutgers The State University of New
Jersey, New Jersey, pp. 15.
Kim, S. C. and K. Carlson (2007). Quantification of human and veterinary antibiotics in
water and sediment using SPE/LC/MS/MS. Analytical and Bioanalytical Chemistry, Volume
387 (4), 1301-1315.
Klecka, G. M. (2000). Evaluation of Persistence and Long-Range Transport of Organic
Chemicals in the Environment. Society of Environmental Toxicology and Chemistry,
Pensacola, pp. 362.
Kolpin, D. W., et al, (2002). Pharmaceuticals, hormones, and other organic wastewater
contaminants in US streams, 1999-2000: A national reconnaissance. Environmental Science
and Technology, Volume 36, 1202-1211.
Kumar, A. and H. P. Schweizer (2005). Bacterial resistance to antibiotics: active efflux and
reduced uptake. Advanced Drug Delivery Reviews, Volume 57 (10), 1486-1513.
Kumar, K., et al, (2005). Antibiotic Uptake by Plants from Soil Fertilized with Animal
Manure. Journal of Environmental Quality, Volume 34 (6), 2082-2085.
Kummerer, K. (2004). Resistance in the environment. Journal of Antimicrobial
Chemotherapy, Volume 54, 311-320.
Kummerer, K. (2008). Pharmaceuticals in the Environment, 3rd Edition, Springer, U. S. A.
Kummerer, K. (2009). Antibiotics in the aquatic environment A review. Chemosphere,
Volume 75, 417-434.
Lai, H. T., et al, (1995). Transformation of chloramphenicol and oxytetracycline in
aquaculture pond sediments. Journal of Environmental Science and Health, Volume A30,
1897-1923.
Laxminarayan, R. and D. L. Heymann (2012). Challenges of drug resistance in the
developing world. BMJ (Clinical Research Ed.), Volume 344, 1567.
Le Bris, H., et al, (1995). Laboratory study on the effect of dichlorvos on two commercial
bivalves. Aquaculture, Volume 138, 139-144.
Levy, S. B. (2002). Factors impacting on the problem of antibiotic resistance. Journal of
Antimicrobial Chemotherapy, Volume 49 (1), 25-30.
Levy, S. B. and B. Marshall (2004). Antibacterial resistance worldwide: causes, challenges
and responses. Nature Medicine Supplement, Volume 10 (12), S122-S129.
Lewis, R. J., Sr., editor (1997). Hawleys Condensed Chemical Dictionary, John Wiley and
Sons, New York, pp. 1229.

Li, D., et al, (2008). Determination and fate of oxytetracycline and related compounds in
oxytetracycline production wastewater and the receiving river. Environmental Toxicology
and Chemistry, Volume 27, 80-86.
Loke, M. L., et al, (2002). Determination of the distribution coefficient (Log Kd) of
oxytetracycline, tylosin A, olaquindox, and metronidazole in manure. Chemosphere, Volume
48, 351-361.
Mackay, D. (2001). Multimedia Models: The Fugacity Approach, 2 nd Edition, Lewis
Publishers, Boca Raton, FL, U.S.A.
Mackay, D., et al, (1991). Assessment of chemical fate in Canada. Continued development of
a fugacity model. Health Canada, Bureau of Chemical Hazards, Ottawa, ON.
Mackay, D., et al, (1996). Evaluating the environmental fate of types of chemicals using the
EQC model. Environmental Toxicology and Chemistry, Volume 15, 1627-1637.
McKone, T. E. (1993). CalTox, a multimedia total-exposure model for hazardous waste sites
part II the dynamic multimedia transport and transformation model. Department of Toxic
Substances Control Lawrence Livermore National Laboratory, California.
Miao, X. S., et al, (2004). Occurrence of antimicrobials in the final effluents of wastewater
treatment plants in Canada. Environmental Science and Technology, Volume 38 (13), 35333541.
Miege, C., et al, (2009). Fate of pharmaceuticals and personal care products in wastewater
treatment plants conception of a database and first results. Environmental Pollution,
Volume 157, 1721-1726.
Nikaido, H. (1996). Multidrug efflux pumps of gram-negative bacteria. Journal of
Bacteriology, Volume 178 (20), 5853-5859.
Ntakirutimana, T. (2012). Pollution and potential ecological risk assessment of heavy metals
in a lake. Polish Journal of Environmental Studies, Volume 22 (4), 1129-1134.
Pouliquen, H., et al, (1993). Experimental study on the decontamination kinetics of seawater
polluted by oxytetracycline contained in effluents released from a fish farm located in a salt
marsh. Aquaculture, Volume 112, 113-123.
Rubin, R. J., et al, (1999). The economic impact of Staphylococcus aureus infection in New
York City hospitals. Emerging Infectious Diseases, Volume 5 (1), 9-17.
Samuelsen, O. B. (1989). Degradation of oxytetracycline in seawater at two different
temperatures and light intensities, and the persistence of oxytetracycline in the sediment from
a fish farm. Aquaculture, Volume 83, 7-16.
Simon, N. S. (2005). Loosely bound oxytetracycline in riverine sediments from two
tributaries of the Chesapeake Bay. Environmental Science and Technology, Volume 39,
3480-3487.

Smith, R. D. and J. Coast (2002). Antimicrobial resistance: a global response. Bulletin of the
World Health Organization, Volume 80 (2), 126-133.
Stohr, K. and H. C. Wegener (2000). Animal use of antimicrobials: impact on resistance.
Drug Resistance Updates, Volume 3 (4), 207-209.
Tenover, F. C. (2006). Mechanisms of Antimicrobial Resistance in Bacteria. The American
Journal of Medicine, Volume 119 (6A), S3-S10.
Thomulka, K. W., et al, (1993). Use of the bioluminescent bacterium Photobacterium
phosphoreum to detect potentially biohazardous materials in water. Bulletin of
Environmental Contamination and Toxicology, Volume 51 (4), 538-544.
US Department of Agriculture (1999). Agricultural Chemical Usage 1999: fruit and nut
summary, USDA National Statistics Service, pp. 212.
US Environmental Protection Agency (2012). Estimating Physical/Chemical and
Environmental Fate Properties with EPI Suite. Sustainable Futures/ P2 Framework Manual,
Environmental Protection Agency, U.S.A.
Vidaver, A. K. (2002). Uses of Antimicrobials in Plant Agriculture. Clinical Infectious
Diseases, Volume 34, S107-S110.
Walsh, F. M. and S. G. Amyes (2004). Microbiology and drug resistance mechanisms of
fully resistant pathogens. Current Opinion in Microbiology, Volume 7 (5), 439-444.
Wania, F. (1998). An integrated criterion for the persistence of organic chemicals based on
model calculations. WECC-Report 1/1998.
Wania, F., et al, (2000). A fugacity-based multi-compartmental mass balance model of the
fate of persistent organic pollutants in the coastal zone. WECC-Report 1/2000.
Wassef, M. K. (1983). Environmental assessment: Finalization for oxytetracycline watersoluble and pre-mix formulations for food producing animals. Environmental Impact Staff,
Bureau of Veterinary Medicine, US FDA, 52.
Watkinson, A. J., et al, (2009). The occurrence of antibiotics in an urban watershed: From
wastewater to drinking water. Science of the Total Environment, Volume 407, 2711-2723.
World Health Organization (2005). Containing Antimicrobial Resistance. WHO Policy
Perspectives on Medicine, pp. 1-6.
Xu, W. H., et al, (2007). Occurrence and elimination of antibiotics at four sewage treatment
plants in the Pearl river delta (PRD), South China. Water Research, Volume 41 (19), 45264534.
Yalkowsky, S. H. and R. M. Dannenfelser (1992). Aquasol Database of Aqueous Solubility,
Version 5, College of Pharmacy University of Arizona, Tuscon, Arizona.

Yoshikawa, T. T. (2002). Antimicrobial Resistance and Aging: Beginning of the End of the
Antibiotic Era?. Journal of the American Geriatrics Society, Volume 50, S226-S229.
Zhang, X. X., T. Zhang and H. H. Fang (2009). Antibiotic resistance genes in water
environment. Applied Microbiology and Biotechnology, Volume 82, 397-414.