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Qumica y Farmacia
FARMACOS COLINERGICOS I
1.- En la biosntesis de la Ach:
HO
COOH
H
NH2
NH2
HO
HO
colina
L-serina
O
H3C C O
CH3
N CH3
CH3
HSCoA
Acetilcolina
CH3
N CH3
CH3
O
H3C C SCoA
O
I
CH3
7.- El compuesto A es ms efectivo (ms reactivo) como inhibidor de la Achasa que el compuesto B.
Explique sus diferencias?
H3C
H3C
N CH
3
N CH
3
H
N
O
SH
O
SH
8.- Cul compuesto organofosforado que se muestra a continuacin debera ser capaz de producir
un mayor tiempo (permanente) inhibicin de Achasa y porque?
O
H3CH2CO P CH2CH3
H3CH2CO P SCH2CH3
OCH2CH3
H3CH2CO P Br
OCH2CH3
OCH2CH3
9. HS, a western Nebraska farmer, is brought by his wife to the emergency room of your local
hospital with a broken leg. His also complaining of weakness and dizziness, which he is attributing
to the pain of his break. You also note that he is salivating and sweating excessively, has a low
heart rate, and is breathing with some difficulty. You discover that, in the farm accident which
caused the broken leg, he came in contact with large quantities of the insecticide Parathion.
O
O2N
O
O
CH3
N
H3C H CH3
N
O
O
O
Br
O
OH
compound 1
compound 2
O
H2N
CH3
N
CH3
compound 3
CH3
Cl
NH
CH3
N
CH3
NOH
compound 4
Cl