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NSC 4354—Integrative Neuroscience—Fall 2007

GR 4.428 Tues-Thurs 1:00–2:15 PM


Dr. Tres Thompson tres@utdallas.edu http://www.utdallas.edu/~tres
JO 4.310 972-883-4933 Office hours: Thurs. 3 PM -4 PM
T.A. (other times by appt.)
Gef Farmer farmerg@utdallas.edu Office hours: Fri. 10-11:30 pm, GR4.512

Prerequisite: NSC 4352 (Cellular Neuroscience) or NSC 4354 Required Texts:

(Integrative Neuroscience)
Principles of Neuroscience (Kandel et al.), 4nd ed. [K].
Course Description: A course in the neurosciences must take aim at a
constantly moving target. The present course covers three core areas of Neuroscience (Purves et al.), 4th Ed. [P]
modern neuroscience: (1) the cellular properties of different types of other readings as needed will be posted online
neurons that suit them to (and/or limit) the specific tasks they carry out;
(2) the organization of functional neural systems that determine the The texts and any additional assigned readings serve as background
behavioral and cognitive properties of living organisms; (3) a critical material for our class discussion, not as a final voice of authority.
evaluation of the research methods used to assess (1) and (2). The Neuroscience is a rapidly advancing field, and textbooks (unfortunately)
overall aim is to familiarize you with systems level analyses of the brain cannot be revised quickly enough to keep up thoroughly.
and its function, which when fully developed should take into account all Exams: There will be three (3) multiple choice exams plus a
known neurobiological and psychological data. Since no current
cumulative final exam, each worth 25 points of your final grade (a
framework meets these comprehensive goals, you will be trained to
total of 100 points). Material for these exams is taken from class
critically evaluate current and future theories purporting to do so. Class
discussion is strongly encouraged. lectures, the texts, and discussion, so attendance is strongly
encouraged. The exams are designed to be challenging and to
Student Learning Objectives: After completing the course, students encourage integrative thought about the material. READ THE
should be able to: ASSIGNED TEXTS BEFORE EACH CLASS – you will
1.1 Describe the historical development of neuroscience as a cross-
sometimes be called on to explain aspects from the text in class.
disciplinary science.
1.2 Describe and analyze the contributions of anatomical, physiological, Your T.A. is a professional resource you can call upon for help.
behavioral, pharmacological, developmental, and cell and molecular Grading Policy: Grading is based on a set of a priori criteria: 90%
biological studies to the bases of neuroscience, and:
correct for A’s, 80% for B’s, 70% for C’s, and 60% for D’s. Grades will
c) describe the principles of (1) feedback, (2) reciprocal connectivity, and
(3) distributed processing fundamental to self-organizing neural systems, be based on the total number of points across the course.
d) describe neural mechanisms of (1) motor control, (2) sensory Course & Instructor Policies. Discussions begin promptly, so lateness
processing, (3) homeostatic maintenance, and (4) higher cognitive is rude to all present. Excused absences for exams/presentations will be
functions (including learning, memory and emotions), given only if: (a) you are seriously ill and have verifiable documentation
g) describe the anatomical and functional organization of the autonomic
from a physician, or (b) you were legally detained at the exam time or
nervous system and neuroendocrine systems.
2.1 Identify and explain why research questions rather than methods ideally (c) you made prior arrangements to attend a verifiable religious or family
drive advances in neuroscience, and: event. In all cases except (b) you must notify the instructor/T.A. in
a) describe and analyze common behavioral methods used to interpret advance of the scheduled exam (email preferred). Otherwise, you will
neuronal function in current studies, and limits of these techniques, receive a zero (0) for that exam. A maximum extension of one week (7
c) describe and analyze use of different lesions (natural, accidental and days) beyond the scheduled exam date can be granted, except for the
induced) in nervous systems to infer function, & limits of these techniques, final exam, which must be taken on the final exam date.
f) describe and analyze non-invasive imaging techniques used to assess
nervous system structure and function, and the temporal and spatial limits Lecture recording is at the instructor's discretion; abuse of this privilege
of these techniques compared to other available methodology. will halt all future recording. Recording devices must be in place no later
2.2 Describe how current methods sometimes limit our understanding of the than 5 min before the lecture starts – no exceptions! Late arrivals forfeit
nervous system, and drive innovation to develop new and better methods. this privilege for the day. Cell phone use is prohibited in the classroom.
2.3 Describe why multiple research techniques & multiple levels of analysis Web surfing, IMing, text messaging, video watching etc. is also not
(systems, network, cellular, synaptic, etc.) are preferred to address basic
allowed. Use common sense and courtesy, please.
questions in the neurosciences, not reliance on a single technique or level.
30.1 Students will be able to describe basic components of the laws of nature DO NOT make early travel arrangements for Finals week.
as developed in the various scientific courses in the core program.
Grades cannot be posted, but exams will be discussed in class in a
30.2 Students will be able to set up scientific problems in feasible and solvable
ways as illustrated in the various subjects in the core curriculum. timely fashion to give you feedback to study for your next exam. Your
30.3 Students will be able to make reasoned arguments about major issues of a instructor will answer questions in class, but exams must be returned to
scientific nature. earn credit for the exam.
Class schedule

(These descriptions and timelines are subject to change at the discretion of the instructor.)

Date Topic Readings

Aug. 16 Intro. to neural systems (review K1-2, P1-3)
21 motor systems 1: ANS P21; K44, 49
23 motor systems 2: spinal cord P16; K33-36
28 motor systems 3: descending systems P17; K17, 18, 38, 41
30 motor systems 4: basal ganglia P18; K43
Sept. 4 motor systems 5: cerebellum P19; K42
6 Exam I Motor systems
11 sensory systems 1: somatic I P9; K21-22
13 sensory systems 2: somatic II P10; K23-24
18 sensory systems 3: visual I P11; K26
20 sensory systems 4: visual II P12; K25, 27
25 sensory systems 5: auditory/vestibular P13-14; K30, 31, 40
27 sensory systems 6: chemical P15; K32
Oct. 2 Exam II Sensory systems
4 homeostasis 1: eating & drinking I K51
9 homeostasis 2: eating & drinking II P21
11 homeostasis 3: sleep / waking P28; K47-48, 45
16 homeostasis 4: emotion & motivation P29; K50-51
18 homeostasis 5: sex & language P30, 27; K57, 59
23 Exam III Homeostasis
25 plasticity 1: cognition P26; K19-20
30 plasticity 2: learning & memory I P24; K62
Nov. 1 plasticity 3: learning & memory II P31; K63
6, 8 SFN Annual Meeting, San Diego NO CLASS MEETING
13 plasticity 4: learning & memory III TBA
15 plasticity 5: learning & memory IV TBA
20 plasticity 6: aging P25; K58
22 Thanksgiving NO CLASS MEETING
Nov. 29 Final exam 11 a.m. Thurs.
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