SKIN PATHOLOGY PRACTICE SHEET

By Tortang Talong Duo

TUMORS OF THE _____________ LAYER OF THE SKIN
CASE NO. 1
Describe:

Microscopic features:
________________ - increase in keratinisation
________________ - thickening of the epidermis
________________ - elevation of the rete ridges
________________ - proliferating cells that resemble the basal cells
________________ - accounts for the color and clinical diagnosis of mole

Distinct characteristic:
________________ - varied cystic spaces containing horny materials
- contains keratinous materials
Diagnosis:
Classification: (eg. Benign, Malignant, etc.)
CASE NO. 2
Describe:

Microscopic features:
________________ - elevation of rete ridges
________________ - increase in keratinisation
________________ - loose, pale staining area in between the projections
Each projection is composed of central core of fibrous tissue and chronic inflammatory
cells surrounded by acanthotic epidermis.

________________ - corresponds to the core with fibrous tissue and blood vesssels
Diagnosis:
Classification:

CASE NO. 3
Describe:

Microscopic features:
________________ - contains compact keratinous material with few slits/clefts
Take note the absence of the _____________ layer in the wall of the cyst.
Keratinous material is generally ___________.
Normal skin, including the _______ (layer), covers the cyst.
Diagnosis:
Classification:
CASE NO. 4
Describe:

Microscopic features:
Cyst wall lining composed of several layers of _____________ (layer) only.
The cystic cavity contains laminated horny material (_________).
Take note of the presence of distinct ____________ layer lining the cyst wall.
Contents of the cyst are generally ___________. (as compared to the previous one.)
Diagnosis:
Classification:
CASE NO. 5
Describe:

Microscopic features:
Shown in the picture (from top to bottom) is the _______, ______, and _____________.
Tumor is confined in the dermal region from the epidermis.
Tumor is composed of nodules of ___________ (cells resembling basal cells).

Seen at the edge of the tumor is _________________ of tumor cells.

Retraction of the adjacent stroma clearing around the tumor nest.

Under the epidermis are nodular masses of dark staining, large oval to elongated
basaloid cells with scant, ill defined cytoplasm resembling the basal cells of the
epidermis. The cells at the periphery of this tumor nests are arranged in a palisading
fashion to assume a picket fence configuration. Focal cystic areas within the tumor
masses are seen as a result of necrosis. Several mitotic figures are likewise noted. A
moderate amount of chronic inflammatory infilitrates is seen in the stroma, most
pronounced at the base of the tumor.
Diagnosis:
Classification:
CASE NO. 6
Describe:

Microscopic features:
Sheets of squamous cells exhibiting _____________ (abnormal keratin), formation of
______________ (proliferation of keratin), and presence of ______________ which
makes it well differentiated.

KERATIN PEARLS VS. HORNY CYSTS:

In horny cysts, adjacent cells are __________ while in keratin pearls, adjacent cells are
___________ which is characterized by presence of nucleated cells.
Diagnosis:
Classification:
Degree of Differentiation:

TUMORS OF THE ____________ LAYER OF THE SKIN

CASE NO. 7
Describe:

Microscopic features:
Tissue is a dense area composed of interlacing and whorled bundles of spindly cells
with spindle-shaped nuclei and cytoplasmic prolongation giving rise to collagen fibrils.

Dermis composed of fibrous tissue, fibroblasts.

Diagnosis:
Classification:

CASE NO. 8
Descibe:

Microscopic features:
__________ appearing. Spindle cell stroma and large numbers of pleomorphic
histiocytes or __________ cells, with pink granular or occasionally foamy cytoplasm and
bizarre mononucleated and multinucleated giant cells.
Diagnosis:
Classification:
Degree of Differentiation:
CASE NO. 9
Describe:

Microscopic features:
Sheets and nests of compactly arranged uniform round to ovoidnevi cells in the dermis
with intracystoplasmic brown melanin pigment seen predominantly in the upper layer:
____________ - Round uniform looking cells with melanin pigments. Granular powdery
browny substance. Cells more or less have the same shape and size. No abnormal
mitoses.
Diagnosis:
Classification:
CASE NO. 10
Describe:

Microscopic features:
Solid nests of round, ovoid, to spindly tumor cells supported by delicate strands and
bands of connective tissue. Tumor cells show all hallmarks of malignancy namely:
_____________ (different shapes), _________________ and _______________
(something to do with nucleus).

Diagnosis:
Classification:

Tumor cells vs. Lymphocytes:

CASE 11
Describe:

Microscopic features:
Marked hyperkeratosis, focal parakeratosis, acanthosis and papillomatosis.
Feature which differentiates this with other papillomatous lesion is the presence of
____________________ in the upper stratum malphigi which contains deeply stained,
eosinophilic, irregularly shaped bodies.
______________ - granular layer is thickened & shows clumped keratohyalin granules.
Rete ridges sgow irregular _________________ patterns.
______________ - slightly pyknotic, atypical nuclei
______________ - layer of basophilic material indicative of viral etiology.
Distinct features: ________________ and _________________ as seen in _____.
Diagnosis:
Classification: