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BuzzNutrition
This
information
is
provided
for
reference
only.
Anne
Buzzelli
is
a
Registered
Dietitian,
not
a
physician.
Always
consult
a
qualified
and
experienced
health
care
provider
for
their
opinion
about
your
care
plan.
Pyroluria
treatment
requires
physician
care
because
of
the
multiple
serious
consequences
of
mineral
imbalance.
Symptoms
of
Pyroluria/HPU
This
is
a
list
of
the
most
common
Pyroluria
symptoms1.
If
you
relate
to
15
or
more
of
these
symptoms,
you
may
want
to
get
tested!
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
Insomnia
White
spots
on
finger
nails
Poor
morning
appetite
/
tendency
to
skip
breakfast
Morning
nausea
Pale
skin
(especially
face)
/
poor
tanning
/
burn
easy
in
sun
Sensitivity
to
bright
light
Hypersensitive
to
loud
noises
Reading
difficulties
(e.g.
dyslexia)
Poor
ability
to
cope
with
stress
Mood
swings
or
temper
outbursts
Argumentative/enjoy
argument
A
tendency
toward
feeling
anxious,
fearful
and
carrying
lifelong
inner
tension
Much
higher
capability/alertness
in
the
evening,
versus
mornings
White
spots
under
fingernails
Dry
skin
Tendency
to
be
edgy
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
o
Hypoglycemia
New
situations
or
changes
in
routine
particularly
stressful
(i.e.,
traveling,
new
school
schedule)
Tendency
to
overreact
to
tranquilizers,
barbiturates,
alcohol
or
other
drugs
(small
amount
produces
a
powerful
response)
Dramatic
(histrionic)
tendency
History
of
mental
illness
or
alcoholism
in
family
Little
or
no
dream
recall
Delayed
puberty;
stunted
growth,
late
growth
spurt
Stretch
marks
on
skin
Sweet
smell
(fruity
odor)
to
breath
or
sweat
when
ill
or
stressed
Abnormal
body
fat
distribution
Belong
to
an
all-girl
family
with
look-alike
sisters
About
Pyroluria/HPU2,11
What
is
Pyroluria?
A
genetic
abnormality
in
hemoglobin
synthesis
which
occurs
with
stress.
Too
much
kryptopyrrole
is
produced
resulting
in
deficiency
of
zinc
and
vitamin
B6
o Hemoglobin:
protein
that
holds
iron
in
red
blood
cells
&
allows
transportation
of
oxygen
o Kryptopyrrole:
byproduct
of
hemoglobin
synthesis
that
tightly
binds
zinc
and
B6,
and
pulls
it
out
of
the
body
Whats
the
problem?
Everyone
produces
kryptopyrroles
as
natural
byproducts
of
hemoglobin
synthesis
Kryptopyrroles
bind
to
zinc,
vitamin
B6
(pyridoxine)
and
remove
them
from
the
body.
People
with
Pyroluria
make
way
too
many
kryptopyrroles,
which
remove
too
much
zinc
and
B6
and
cause
deficiencies.
Anne Buzzelli MS RD CBP CMTA
110 W Johnson St #228/12, Staunton VA
Anne@BuzzNutrition.com
phone: 540.414.7525, fax: 206.309.7493
Pyroluria / HPU
BuzzNutrition
Whats
the
fallout?
Deficiency
in
these
key
nutrients
can
predispose
a
person
to
numerous
problems.
Immune
Weakened
as
white
blood
cells
are
less
able
to
fight
infection
&
clear
out
toxins
System
May
predispose
a
person
to
chronic
illness
(Lyme
infection,
fibromyalgia,
chronic
fatigue,
etc.)
and
prevent
them
from
ever
fully
recovering.Error!
Bookmark
not
defined.
With
defective
heme,
less
oxygen
is
carried
on
the
blood
(anemia).
This
promotes
the
proliferation
of
microbes
because
they
love
low-oxygen
environments.Error!
Bookmark
not
defined.
Zinc,
copper,
and
iron
are
extremely
important
to
the
white
blood
cells,
the
soldiers
of
the
immune
system.
Vitamin
B6
(P5P)
is
required
to
absorb
zinc,
manganese,
magnesium
and
chromium.Error!
Bookmark
not
defined.
This
is
especially
the
case
in
the
presence
of
susceptible
HLA
haplotypes.
Anxiety,
B6
is
required
in
the
last
step
of
serotonin
synthesis.
Serotonin
is
one
of
the
Depression
neurotransmitters
that
modulate
mood
by
creating
a
sense
of
peace
and
wellbeing.
Heavy
metals
Deficiency
of
zinc
may
result
in
excess
copper
and
heavy
metals
like
mercury,
lead
and
cadmium.
When
supplementing
with
zinc,
these
heavy
metals
will
leave
and
a
binder,
such
as
chlorella,
should
be
added
to
the
supplement
menu.
Alcoholism
Some
people
with
Pyroluria
use
alcohol
to
calm
their
anxiety,
feel
more
sociable
and
experience
normalcy
for
a
short
time.
As
a
result,
some
people
with
Pyroluria
may
become
alcoholics.
Mineral
Zinc
and
copper
compete
with
each
other
and
must
stay
in
balance.3
imbalance
300
of
1500
known
metabolic
enzymes
are
zinc
dependent.
Zinc
and
copper
arent
just
minerals-
theyre
also
regarded
as
neurotransmitters
and
the
right
ratio
is
required
for
stable
mood
and
behavior.
Sources
of
copper:
chocolate,
nuts,
beans,
seeds,
grains,
some
multis,
fungicides/pesticides,
IUDs/birth
control
pills.
(*Meat
has
copper
but
its
balanced
by
plenty
of
zinc.)
When
zincs
deficient,
there
will
likely
be
excess
copper.
Copper
toxicity
can
have
troubling
effects,
such
as
sensitive
skin
and
PMS
symptoms/painful
menstruation
Anne Buzzelli MS RD CBP CMTA
110 W Johnson St #228/12, Staunton VA
Anne@BuzzNutrition.com
phone: 540.414.7525, fax: 206.309.7493
Pyroluria / HPU
BuzzNutrition
Is
Pyroluria
more
than
just
genetics?
Its
never,
ever
possible
to
separate
the
body,
mind
and
emotions.
Every
condition
has
something
to
do
with
the
way
a
person
perceives
their
environment
and
what
emotions
are
triggered.
Never
underestimate
the
power
of
the
subconscious
mind.
Dr.
Dietrich
Klinghardt
believes
there
are
3
potential
causes:
genetics,
early
childhood
trauma
and
chronic
infections
(its
possible
that
biotoxins
can
block
enzymes
involved
with
heme
synthesis).11
A
person
diagnosed
with
Pyroluria
should
alert
their
family
since
it
is
a
genetic
disorder.
There
is
great
hope
for
those
with
chronic
illness
who
find
they
have
Pyroluria:
Once
all
of
the
bodily
systems
are
back
online
and
functioning
properly,
a
few
months
after
introducing
the
HPU
protocol,
patients
are
essentially
made
invulnerable
to
Lyme
disease,
to
molds,
even
to
heavy
metals.11
Pyroluria / HPU
BuzzNutrition
o
o
o
o
o
*Proper
urine
handling
is
very
important
(I
hope
you
laughed
at
that)
Kryptopyrroles
are
very
sensitive
to
heat
and
bright
light.
If
the
lab
result
is
<3.0,
it
was
probably
degraded
by
heat
or
light.
Pyroluria / HPU
BuzzNutrition
Diagnosis
of
Pyroluria/HPU
Kryptopyrrole
lab
test
o Normal:
<10mcg/dl
o Mild
Pyroluria:
10-20
mcg/dl
o Moderate
Pyroluria:
20-50
mcg/dl
o Severe
Pyroluria:
>50
mcg/dl
Other
lab
results
can
be
suggestive
of
HPU11
o White
blood
cells
<5000/mcL
(from
zinc
deficiency)
o High
LDL
cholesterol,
low
HDL
o High
MCV
(mean
corpuscular
volume;
indicates
macrocytic
anemia
from
deficiency
of
folate,
B6
or
B12)
o Low
manganese,
lithium
and
molybdenum
in
a
hair
mineral
test
o Very
low
or
very
high
hair
zinc:
both
correlate
with
low
plasma
levels.
Pyroluria
causes
a
very
high
Zn
excretion
in
both
urine
and
hair.
o Low
normal
alkaline
phosphatase
(<60
U/L)
o Low
omega-6
fatty
acids
in
red
cell
membrane
test
o Low
taurine
in
amino
acid
profile
If
all
the
symptoms
fit,
yet
the
test
comes
back
negative:
Assume
a
false
negative
and
retest.
Try
the
supplementation
regimen
(under
doctors
supervision)
and
if
you
feel
better
you
can
assume
the
test
was
a
false
negative.
Pyroluria / HPU
BuzzNutrition
Simpler
alternative:
Core,
a
product
made
by
BioPure
USA
that
contains
B6,
zinc,
manganese,
chromium,
molybdenum,
boron,
L-Taurine
and
Magnesium9.
o Caution:
Contains
2
forms
of
vitamin
B6
(Pyridoxine
HCl
and
Pyridoxal-5-Phosphate).
Some
may
not
tolerate
both,
in
which
case,
the
more
extensive
protocol
is
necessary.
Still
need
to
supplement
with
Arachidonic
acid:
o Foods:
eggs,
butter,
red
meat
and
liver
o Supplements
of
GLA
(gamma
linolenic
acid):
black
currant
seed
oil
and
evening
primrose
oil.
Another
option
for
zinc
supplementation
is
4-6
oysters
per
day.
More
details
on
supplements
*Since
every
body
is
different,
adjustment
will
be
necessary
to
find
the
right
levels
of
each
nutrient.
Manganese
is
added
because
it
is
depleted
by
high
levels
of
zinc
Anne Buzzelli MS RD CBP CMTA
Anne@BuzzNutrition.com
Pyroluria / HPU
BuzzNutrition
Results
can
be
very
fast!10
For
mild
cases,
major
improvements
can
be
seen
within
a
couple
days.
The
more
severe
the
symptoms,
the
longer
it
will
take
to
see
results.
Its
common
to
see
early
improvement,
then
a
plateau
followed
by
further
improvement.
Will
take
longer
if
person
has
severe
mental
illness,
other
significant
chemical
imbalance
or
a
malabsorptive
condition.
(A
few
weeks
to
notice
improvement
and
3-6
months
to
become
stable.)
o Malabsorption
can
be
caused
by
reactions
to
food,
especially
gluten.
Real
success
may
not
be
realized
until
problem
foods
are
removed.
Treatment
must
include
stress
management
&
trauma
resolution.
The
body
will
not
recover
unless
the
mind
is
onboard.
Unresolved
emotions
and
damaging
subconscious
beliefs
will
perpetuate
stress.
*Supplementation
must
continue
for
life.
Lower
maintenance
doses
will
be
needed
for
life
to
compensate
for
bodys
genetic
tendency
to
produce
defective
heme
proteins.
Once
supplementation
is
stopped,
symptoms
will
return
in
7-14
days.
Checking
on
progress:
Recheck
kryptopyrroles
with
urine
test.
Enough
zinc?:
test
with
zinc
tally
test
(liquid
taste
test
available
from
Thorne)
o If
its
hard
to
replete
zinc,
heavy
metal
toxicity
may
be
an
issue,
especially
mercury,
cadmium,
lead
and
copper.
Enough
B6?:
subjective
assessment
of
ability
to
regularly
remember
dreams/daydreams.
Caution:
Since
zinc
competes
with
copper
for
entrance
to
cells,
high
doses
of
zinc
may
prevent
copper
from
being
absorbed
(called
a
functional
deficiency).
Copper
is
important
for
the
immune
system
and
may
need
to
be
supplemented
at
3-6
mg/day.
Copper
levels
should
be
evaluated
between
months
3
&
4
of
an
HPU
treatment
protocol.11
Anne Buzzelli MS RD CBP CMTA
Anne@BuzzNutrition.com
Pyroluria / HPU
BuzzNutrition
Zinc
also
displaces
heavy
metals.
Two-six
weeks
after
treatment,
symptoms
of
heavy
metal
detox
could
come
up.
May
as
well
have
a
proper
binding
agent
on
board
early
to
mop
up
the
metals.
Chlorella
is
the
binder
of
choice
(12g/day
total:
4
grams,
3
times/day,
30
minutes
before
meals.
After
a
few
months
and
symptoms
disappear,
a
lower
maintenance
dose
can
be
taken-
ideally
for
life).
Pyroluria
in
Children
Symptoms
of
Pyroluria
increase/intensify
with
age.
In
children,
it
may
be
less
easy
to
detect.
The
following
may
be
indications
of
Pyroluria.12
Testing
a
child
cant
hurt
its
fun
to
pee
in
a
cup!
paleness
of
the
skin,
especially
the
face
crowded
teeth,
many
cavities
recurrent
ear
infections,
colds
hypermobility
of
the
joints
allergy,
hay
fever,
skin
reactions
growing
pains,
especially
of
the
left
knee
headache,
migraine
changes
in
handwriting
easy
bruising
white
marks
on
the
nails
anemia
sensitivity
to
sunlight
upper
left
abdominal
pain
loss
of
appetite
constipation,
or
mucus
in
stool
with
bloating
stretch
marks
on
the
skin
light
colored
stool
sweetish
breath
odor
learning
and
behavioral
problems
convulsions
Since
people
with
Pyroluria
are
stress-sensitive,
the
ideal
discipline
for
a
child
with
Pyroluria
is
something
that
is
"short
and
sweet"
and
non-violent,
rather
than
"long
and
lingering."2
Pyroluria
likely
results
in
copper
toxicity
because
zinc
and
copper
compete
for
entrance
to
cells.
Because
copper
activates
MAO
and
DAO
enzymes
the
histamine
level
normally
is
very
low
in
HPU-
children.
These
children
may
look
healthy,
but
they
are
often
over
stimulated,
hyperactive,
depressive
and
have
a
high
threshold
for
pain.
Because
of
their
insomnia
they
turn
night
into
day.12
Resources
Gedgaudas,
N.
www.primalbody-primalmind.com/?p=398
(lots
of
good
references
at
end
of
article)
2
Kaslow,
J.
http://drkaslow.com/html/pyroluria.html
(lots
of
good
references
here,
too)
3
Kresser,
C.
http://chriskresser.com/rhr-could-copper-zinc-imbalance-be-making-you-sick
4
Vernon,
T.
http://www.tvernonlac.com/copper-toxicity.html
5
Health
Diagnostics
and
Research
Institute:
www.EuropeanLaboratory.nl
(Click
Lab
Tests
Specific
Tests
Kryptopyrrol
in
urine)
6
Great
Plains
Laboratory:
www.greatplainslaboratory.com/home/eng/kryptopyrrole.asp
7
Riordan
Clinic/
Bio-Center
Laboratory:
www.riordanclinic.org/mm5/merchant.mvc?Screen=PROD&Store_Code=BCL&Product_Code=LPyr&Category_Code
8
Pyroluriatesting.com:
www.pyroluriatesting.com/?page=shop/flypage&product_id=136&CLSN_1407=13264006121407bab69e96684c534d5e
9
About
Core
supplement:
http://www.biopureeurope.com/core-mineral.html
10
Walsh,
W.
http://www.alternativementalhealth.com/articles/walshMP.htm
1
Pyroluria / HPU
BuzzNutrition
11