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YOUR NAME, STUDENT NUMBER, AND BOOKLET CODE
ON THE SCANTRON SHEET
A.
B.
C.
D.
E.
Ans.
C
3.
Receptors
that
can
recognize
peptidoglycan
A. NOD1
B. TLR4
C. TLR3
D. NLRP3
E. None
of
the
above
Ans.
A
4.
RIG-I
is
a
receptor
for
A.
B.
C.
D.
E.
DAMPs
LPS
CpG
sequences
Viruses
Fungi
Ans.
D
A.
B.
C.
D.
E.
Mast
cells
Neutrophils
Eosinophils
NK
cells
Both
A
and
C
Ans.
E
6.
C1
inhibitor
is
A.
B.
C.
D.
E.
Ans.
C
7.
What
of
the
following
is
true
about
SARS
A.
B.
C.
D.
A.
B.
C.
D.
E.
Ans.
C
Dr. Watts (Influenza)
9.
Which
of
the
following
statements
about
Influenza
virus
is
NOT
correct
A.
B.
C.
D.
E.
Swine
Birds
Horses
Ferrets
Mice
Ans.
D
14.
Which
of
the
following
is
correct
about
2009
H1N1?
A. Considered
now
a
seasonal
strain
B. The
2009
epidemic
caused
the
same
death
rate
as
SARS
of
about
10%
C. It
represents
a
re-assortment
of
4
different
viruses
including
swine,
avian
and
human
viruses
D. During
the
epidemic
fewer
individuals
older
than
65
years
of
age
were
infected
when
compared
to
other
flu
outbreaks
E. A,
C
and
D
are
correct
Ans.
E
15.
Cell-culture
based
methods
of
flu
vaccine
production
A. Are
the
current
common
method
for
producing
the
current
seasonal
flu
vaccine
B. Are
promising
because
of
the
high
levels
of
virus
they
yield
C. Must
be
produced
by
using
live
embryonated
chicken
eggs
D. Are
based
on
a
plasmid
cassette
where
the
desired
HA
and
NA
combination
can
be
rapidly
introduced
into
cells
expressing
the
other
6
segments
E. Both
C
and
D
are
correct
Ans.
D
Dr.
Ratcliffe
(HIV
infection)
16.
HIV-1
is
A.
B.
C.
D.
E.
A
lentivirus
A
retrovirus
Thought
to
have
evolved
from
the
simian
immunodeficiency
virus
(SIV)
Considered
more
virulent
than
HIV-2
All
of
the
above
Ans.
E
17.
gp41
is
A.
B.
C.
D.
E.
A
fragment
of
gp120
Necessary
for
integration
into
the
cell
genome
A
protein
that
can
protrude
from
the
viral
envelope
A
matrix
protein
Both
A
and
C
Ans.
C
18.
Which
of
the
following
statements
about
the
course
of
HIV
infection
is
NOT
correct
A. During
the
acute
phase
the
levels
of
circulating
virus
are
high
B. During
the
acute
phase
the
levels
of
CD4+
T
cells
drop
considerably
C. During
the
clinical
latency
phase
CD4+
T
cells
return
to
normal
levels
and
stay
unchanged
until
the
symptomatic
phase
defined
as
AIDS
starts
D. The
length
of
the
latency
phase
is
variable
and
can
be
influenced
by
antiviral
therapy
E. Individuals
with
AIDS
suffer
of
many
opportunistic
infections
Ans.
C
19.
Drug-combination
treatments
are
preferred
for
HIV
infection
over
single-drug
treatments
because
Ans.
E
20.
The
most
important
region(s)
of
an
antibody
molecule
with
respect
to
antigen
binding
is/are
A.
B.
C.
D.
E.
FR1
FR2
FR3
FR4
HV
1-3
Ans.
E
21.
Antibodies
often
found
in
dimeric
form
are
A. IgM
B. IgE
C. IgA
D. IgG
E. All
of
the
above
Ans.
C
22.
The
ideal
vaccine
for
HIV
is
A.
B.
C.
D.
E.
Ans.
E
Dr.
Gommerman
(B
cell
and
T
cell
section)
23.
Cells
secreting
antibodies
are
A.
B.
C.
D.
E.
Nave
T
cells
Nave
B
cells
Plasma
cells
Pro-B
cells
Both
B
and
C
Ans.
C
24.
Which
of
the
following
would
be
recognized
by
the
B
cell
receptor
(BCR)
A.
B.
C.
D.
E.
Epitopes
on
self-antigens
Epitopes
on
tumor
antigens
Conformational
epitopes
Allergens
All
of
the
above
Ans.
E
25.
Which
of
the
following
would
NOT
be
recognized
by
the
T
cell
receptor
(TCR)
A. Epitopes
on
self-antigens
B. Epitopes
on
tumor
antigens
C. Conformational
epitopes
D. Linear
epitopes
E. All
of
the
above
Ans.
C
26.
VDJ
gene
rearrangement
of
the
immunoglobulin
gene
(Ig)
loci
happens
A.
B.
C.
D.
E.
In
developing
B
cells
In
developing
T
cells
In
mature
B
cells
During
the
germinal
center
reaction
In
plasma
cells
Ans.
A
27.
The
gene
segments
that
are
combined
to
generate
the
light
chain
of
the
BCR
does
NOT
include
A.
B.
C.
D.
E.
V
J
D
C
Transmembrane
region
Ans.
C
and
E
28.
Which
of
the
following
statements
is
NOT
true
A.
B.
C.
D.
E.
Ans.
B
29.
The
Ig
class
that
is
more
efficient
at
opsonizing
pathogens
is
A.
B.
C.
D.
E.
IgM
IgD
IgG
IgA
IgE
8
Ans.
C
30.
The
TCR
is
A.
B.
C.
D.
E.
Ans.
B
31.
Which
of
the
following
statements
is
NOT
true
A.
B.
C.
D.
E.
Ans.
B
32.
An
effector
T
cell
A.
B.
C.
D.
E.
Ans.
E
33.
The
cells
best
at
activating
nave
T
lymphocytes
in
the
paracortex
(T
cell
region)
are:
A.
B.
C.
D.
E.
Nave
B
cells
Activated
B
cells
Dendritic
cells
Macrophages
Follicular
dendritic
cells
Ans.
C
34.
Dendritic
cells
enter
lymph
nodes
via
A.
B.
C.
D.
E.
Arteries
High
Endothelial
venules
Afferent
lymphatics
Efferent
lymphatics
Any
of
the
above
Ans.
C
35.
Signal
2
for
T
cell
activation
is
provided
by:
A.
B.
C.
D.
E.
B7/CD28
interaction
TCR/MHC
plus
peptide
interaction
CD4/MHC
plus
peptide
interaction
CD8/MHC
plus
peptide
interaction
Cytokines/Cytokine
receptor
interaction
Ans.
A
36.
A
cell
type
producing
IL-4
is
a:
A.
B.
C.
D.
E.
TH1
cell
TH2
cell
TH17
cell
CTL
All
of
the
above
Ans.
B
37.
IL-2
is
A.
B.
C.
D.
E.
Ans.
D
38.
Some
features
of
effector
T
cells
are
that
they:
A. Leave
the
lymph
nodes
via
the
efferent
lymphatics
B. Can
enter
sites
of
infection
via
blood
10
Ans.
E
39.
Based
on
mouse
studies,
which
of
the
following
molecules
is
important
in
the
defense
against
Leishmania?
A.
B.
C.
D.
E.
TGF-
IL-10
IFN-
IL-4
IL-5
Ans.
C
40.
Nave
lymphocytes
enter
LN
through
A.
B.
C.
D.
E.
Afferent
lymphatics
Arterials
HEV
Efferent
lymphatics
Thoracic
duct
Ans.
C
41.
Molecules
required
for
entry
of
nave
lymphocytes
into
lymph
nodes
are:
A.
B.
C.
D.
E.
Chemokines
L-selectin
PNaD
All
of
the
above
None
of
the
above
Ans.
D
42.
The
B
cell
area
of
the
lymph
node
is
called
the:
A. Cortex
B. Paracortex
C. Medulla
11
D. Germinal
center
E. A,
B
and
C
Ans.
A
43.
Nave
T
cells
and
dendritic
cells
interact
in
which
area
of
the
lymph
node:
A.
B.
C.
D.
E.
The
cortex
The
paracortex
The
medulla
Germinal
Centers
The
subcapsular
sinus
Ans.
B
44.
T
cells
that
encounter
antigen
in
a
lymph
node
A.
B.
C.
D.
E.
Move
slower
than
T
cells
that
are
not
specific
for
the
same
antigens
Are
found
in
stable
interactions
with
dendritic
cells
Start
to
proliferate
Move
to
B
cell
areas
All
of
the
above
Ans.
E
45.
Which
of
the
following
sentences
is
correct
A.
B.
C.
D.
B
cells
that
have
encountered
antigen
move
from
follicles
to
germinal
centres
Activated
B
cells
can
present
antigens
to
T
cells
B
cells
need
T
cell
help
to
produce
most
antibodies
Cytokines
secreted
by
helper
T
cells
influence
the
type
of
antibody
produced
by
B
cells
E. All
of
the
above
Ans.
E
46.
What
is
NOT
true
about
the
germinal
center
(GC)
A.
B.
C.
D.
12
Ans.
D
47.
With
respect
to
CD4
and
CD8
expression,
what
types
of
T
cells
or
T
cell
precursors
are
found
in
the
thymus
A. Cells
negative
for
both
B. Cell
positive
for
both
C. CD4+
CD8-
cells
D. CD8+
CD4-
cells
E. All
of
the
above
Ans.
E
48.
What
is
NOT
true
about
negative
selection
in
the
thymus
Ans.
C
49.
AIRE
is
A. A
transcription
factor
expressed
in
thymocytes
B. A
receptor
mediating
apoptosis
of
self-reactive
thymocytes
C. A
transcription
factor
that
allows
the
expression
of
peripheral
self-antigens
in
the
thymus
D. A
transcription
factor
expressed
by
Tregs
E. An
autoimmune
disease
Ans.
C
50.
Mechanisms
of
peripheral
tolerance
include
A.
B.
C.
D.
E.
Antigen
sequestration
T
regulatory
cell
function
Negative
selection
in
the
thymus
All
of
the
above
Only
A
and
B
Ans.
E
51.
Which
of
the
following
sentences
is
NOT
true
about
multiple
sclerosis
13
A.
B.
C.
D.
E.
Ans.
D
52.
T
cell
subsets
involved
in
initiation
and/or
progression
of
MS
include
A.
B.
C.
D.
E.
TH2
CTL
TH1
TH17
Both
C
and
D
Ans.
E
53.
Disease-modifying
drugs
are
preferable
over
classical
immunosuppressive
drugs
to
treat
autoimmune
diseases
because
A. They
target
the
cell
type
or
immune
reactant
directly
responsible
of
the
disease
B. They
have
no
side
effects
C. They
can
be
used
in
lower
doses
D. They
acts
on
many
immune
cells
at
the
same
time,
a
feature
that
increases
their
efficacy
E. All
of
the
above
Ans.
A
54.
Tysabri
is
A. A
B-cell
depleting
drug
B. A
drug
that
has
been
tested
in
MS
C. A
drug
that
targets
cell
signaling
in
T
and
B
cells
D. An
anti-TNF
drug
E. Both
A
and
C
Ans.
B
14
15