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Journal of Oral and Maxillofacial Pathology
144
REVIEW ARTICLE
Department of Oral Pathology, M.S. Ramaiah Dental College and Hospital, Bangalore, Karnataka, India
Address for correspondence:
Dr. Chaitanya Babu N,
Department of Oral Pathology, M.S. Ramaiah
Dental College and Hospital, MSRIT Post, New
BEL Road, Bangalore 560 054, Karnataka, India.
E-mail: nischay_chaitanya@yahoo.com
ABSTRACT
The oral cavity is the site of much infectious and inflammatory disease
which has been associated with systemic diseases such as diabetes,
cardiovascular disease and pre-term low births. This article emphasizes
on the oral-systemic disease connection which is now a rapidly advancing
area of research. The possible systemic diseases which arise from oral
microorganisms are hereby focused.
Key words: Cardiovascular disease, diabetes, oral microorganisms,
oral-systemic connection, pre-term low births
INTRODUCTION
The oral cavity might well be thought of as the window to
the body as oral manifestations accompany many systemic
diseases. But with recent research it may be said that the oral
cavity has opened a door for many systemic diseases. The
concept of focal infection was propounded by Dr. William
Hunter in 1910, whereby disease at a distant site, such as the
mouth, could contribute to diseases such as anaemia, gastritis,
colitis and so on. This theory is currently being carefully
reconsidered. At the landmark conference at the University
of North Carolina in Chapel Hill in March 1997 was devoted
to this theme, that periodontal disease itself can instigate
conditions such as cardiovascular disease, low birth weight
babies, and that periodontal therapy may contribute to the
control of diabetes.[1]
In addition, conditions such as diabetes have been shown
to increase the risk of periodontal disease. Conversely
periodontal therapy may improve the diabetic condition by
stabilizing the systemic blood sugar levels.
New studies reveals increased incidence of coronary heart
disease and stroke linked to high incidence of periodontal
bone loss.[1,2]
It is becoming increasingly clear that infections and chronic
inflammatory conditions such as periodontitis may influence
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DOI:
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Systemic manifestations of oral diseases
3.
Periodontal
infection
Inflammatory
mediators
Bacterial
products
Blood stream
145
Bacteria
Blood stream
Cardiovascular
disease
Invasion into
coronary cells
Journal of Oral and Maxillofacial Pathology: Vol. 15 Issue 2 May - Aug 2011
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Systemic manifestations of oral diseases
Periodontal infection
Inflammatory mediators
(prostaglandins)
Bacterial products
(lipopolysaccharides)
146
Bacteria
Blood stream
Diabetes
Journal of Oral and Maxillofacial Pathology: Vol. 15 Issue 2 May - Aug 2011
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Systemic manifestations of oral diseases
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How to cite this article: Babu NC, Gomes AJ. Systemic manifestations
of oral diseases. J Oral Maxillofac Pathol 2011;15:144-7.
Source of Support: Nil. Conflict of Interest: None declared.