Академический Документы
Профессиональный Документы
Культура Документы
11| P a g e
2013
2013
Plan summary:
Company profile:
o Vision
o Mission
Medical over view:
o Causes
o Risk factors
o Sign & Symptoms
o Acid reflux syndrome
Product knowledge:
o Drug info.
o Swot (strength ,weakness ,opportunity ,threat)
o Ansoff Matrix
o Competitor analysis
o Market analysis
o PlS (product life cycle)
o STP (segmentation, targeting, positioning)
o 4Ps (product, place, promotion, price)
Time frame
Budget
11| P a g e
2013
Medical information:
Stomach acid is produced in the stomach as a normal part of the digestive process.
Normally the linings of the stomach and duodenum (an area of the intestine directly
after the stomach) are protected by a layer that resists acid attack. However, if this
layer is damaged, or large amounts of stomach acid are formed, an ulcer can develop
on the lining of the stomach or duodenum. This is called a peptic ulcer.
GERD:
At the entrance to your stomach is a valve, which is a ring of muscle called the lower
esophageal sphincter (LES). Normally, the LES closes as soon as food passes through
it. If the LES doesn't close all the way or if it opens too often, acid produced by your
stomach can move up into your esophagus. This can cause symptoms such as a
burning chest pain called heartburn. If acid reflux symptoms happen more than twice
a week, you have acid reflux disease, also known as gastroesophageal reflux disease
(GERD)
Causes of Gerd:
One common cause of acid reflux disease is a stomach abnormality called a hiatal
hernia. This occurs when the upper part of the stomach and LES move above the
diaphragm, a muscle that separates your stomach from your chest. Normally, the
diaphragm helps keep acid in our stomach. But if you have a hiatal hernia, acid can
move up into your esophagus and cause symptoms of acid reflux disease.
These are other common risk factors for acid reflux disease:
2013
11| P a g e
11| P a g e
2013
2013
Product knowledge:
Brand name for:
Omeprazole
Dose:
20 mg once daily for 4-8 weeks
Indications:
Short-term (4-8 weeks) treatment of active duodenal ulcer disease or active
benign gastric ulcer; treatment of heartburn and other symptoms associated
with gastroesophageal reflux disease (GERD); short-term (4-8 weeks)
treatment of endoscopically-diagnosed erosive esophagitis; maintenance
healing of erosive esophagitis; long-term treatment of pathological
hypersecretory conditions (eg, Zollinger-Ellison syndrome); as part of a
multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer
recurrence
Pharmacodynamics/Kinetics
Absorption: Rapid
Metabolism: Hepatic via CYP2C19 primarily and (to a lesser extent) via
3A4 to hydroxy, desmethyl, and sulfone metabolites (all inactive);
saturable first-pass effect
11| P a g e
2013
Warnings/Precautions:
Atrophic gastritis: Long-term omeprazole therapy has caused atrophic
gastritis (identified by biopsy).
Carcinoma: In long-term (2-year) studies in rats, omeprazole produced a
dose-related increase in gastric carcinoid tumors. While available endoscopic
evaluations and histologic examinations of biopsy specimens from human
stomachs have not detected a risk from short-term exposure to omeprazole,
further human data on the effect of sustained hypochlorhydria and
hypergastrinemia are needed to rule out the possibility of an increased risk for
the development of tumors in humans receiving long-term therapy.
Clostridium difficile-associated diarrhea (CDAD): Use of proton pump
inhibitors (PPIs) may increase risk of CDAD, especially in hospitalized
patients; consider CDAD diagnosis in patients with persistent diarrhea that
does not improve. Use the lowest dose and shortest duration of PPI therapy
appropriate for the condition being treated.
Fractures: Increased incidence of osteoporosis-related bone fractures of the
hip, spine, or wrist may occur with proton pump inhibitor (PPI) therapy.
Patients on high-dose (multiple daily doses) or long-term (1 year) therapy
should be monitored. Use the lowest effective dose for the shortest duration of
time, use vitamin D and calcium supplementation, and follow appropriate
guidelines to reduce risk of fractures in patients at risk.
Hypomagnesemia: Reported rarely, usually with prolonged PPI use of >3
months (most cases >1 year of therapy). May be symptomatic or asymptomatic;
severe cases may cause tetany, seizures, and cardiac arrhythmias. Consider
obtaining serum magnesium concentrations prior to beginning long-term
therapy, especially if taking concomitant digoxin, diuretics, or other drugs
known to cause hypomagnesemia; and periodically thereafter.
Hypomagnesemia may be corrected by magnesium supplementation, although
discontinuation of omeprazole may be necessary; magnesium levels typically
return to normal within 1 week of stopping.
Disease-related concerns:
Gastric malignancy: Relief of symptoms does not preclude the presence of a
gastric malignancy.
Gastrointestinal infection (eg, Salmonella, Campylobacter): Use of proton
pump inhibitors may increase risk of these infections.
Hepatic impairment: Bioavailability may be increased in patients with hepatic
dysfunction; consider dosage reductions, especially for maintenance healing of
erosive esophagitis.
Special populations:
Asian ethnicity: Bioavailability may be increased in patients of Asian descent;
consider dosage reductions, especially for maintenance healing of erosive
esophagitis.
Elderly: Bioavailability may be increased in the elderly.
Other warnings/precautions:
11| P a g e
2013
Pregnancy Considerations:
Adverse events were observed in some animal reproduction studies. Based on
data collected by the Teratogen Information System (TERIS), it was concluded
that therapeutic doses used during pregnancy would be unlikely to pose a
substantial teratogenic risk (quantity/quality of data: fair). Because the
possibility of harm still exists, the manufacturer recommends use during
pregnancy only if the potential benefit to the mother outweighs the possible
risk to the fetus.
Lactation:
Enters breast milk/not recommended
Breast-Feeding Considerations
Following administration of omeprazole 20 mg, peak concentrations detected
in the breast milk were <7% of the maternal serum concentration.
Swot analysis:
(S)
(w)
No promotion
No bonus
Expired not taken
Active const. on hepatic people is
harmful
Side effect on pregnant women
(O)
2013
(T)
Ansoff Matrix:-
Maintain or increase the market share of current products, this can be achieved by
a combination of competitive pricing strategies, advertising and sales promotion.
Introduce a loyality scheme
11| P a g e
2013
Audience Analysis:
Targeted audience:
1-Physicians
2-Patients
1-Physicians: Physicians are one of the main audience that should be targeted as
they are the authorized prescriber who could prescribe losec.
Targeted physicians :
1-oncologist
2-Bone specialist
3-genral Practitioner
4-gyncolagist
Targeting methods:
1- Medical Representatives
2-Confrences
2- patients: they will be targeted as losec is authorized as an OTC product both
males and females will be targeted equally.
Segments selected :
Middle class
Smokers
patients suffer from chronic diseases as HTN w bone disorders
age range from 40-60 and above
Targeting methods:
1-promotional campaigns
2-advertisement
11| P a g e
2013
ACTIVE
CONISTITUENT
DOSAGE
FORM
H2-Blocker
Ranitdine
Tablet
and amp.
20 LE
PPI
Pantoprazol
Tablet
90LE
RANI
H2-Blocker
Ranitdine
Effervesc
ence
4.5LE
ANTODINE
H2-Blocker
Famotidine
TAB
9LE
Constipation
, insomnia
NAPIZOLE
PPI
Omeprazole
TAB
21LE
Hairloss
Diarrhoea
NEXIUM
PPI
Esomeprazol
TAB
73LE
Constipation
muscle pain
ANTOPRAL
PPI
Pantoprazloe
TAB
17.5LE
Diarrhea
Headach
PARIET
PPI
Rabeprazole
TAB
32.5LE
Rash mouth
sores
PEPZOL
PPI
Pantoprazole
TAB
16LE
Rashes
weight
changes
H2-Blocker
Ranitdine
TAB
12
PPI
Pantoprazole
TAB
25
OMEPAK
PPI
Omeprazole
TAB
16.5
OMEZ
PPI
Omeprazole
CAP
13.5
PANTAZOL
PPI
pantoprazole
TAB
25
PPI
Omeprazole
CAP
42.5
PPI
Omeprazole
CAP
42
PPI with
Antibiotic
Omeprazole
CAP
60
rabeprazole
tab
21
ZANTAC
CONTROLOC
RANITIDINE
PANTOLOC
GASTRAZOLE
GASTROLOC
HELI-CURE
BEPRA
11| P a g e
CLASS
PPI
PRICE
SIDE
EFFECTS
Constipation
,headach,mu
sle pain
Blurred
Vision
constipation
Constipation
, insomnia.
Nausea
abdominal
pain
Blurred
vision
Diarreha
Constipation
Vomiting
Constipation
blurred
vision weight
loss
Tongue sore
nausea
diarreha
INCREASE
LEVELS OF
WARFARIN
2013
ACILOC
PPI
Omeprazole
TAB
Weight loss
GASEC 20
PPI
Omeprazole
CAP
22
RANITAK
H2-Blocker
Ranitidine
TAB
14
Constipation
nausea
vertigo
Dizziness
Bradycardia
RISEK
PPI
Omeprazole
20mg
CAP
40
HEALSEC
PPI
Omeprazole
20mg
CAP
12
RANTIDOL
H2-Blocker
Ranitidine
TAB
9.5
PEPTAZOL
PPI
Pantoprazole
CAP
45
OMEPRAL
PPI
Omeprazole
TAB
21
ESTOHALT
PPI
Omeprazole
TAB
22
PERLOC
PPI
Pantoprazole
TAB
17.5
IDIZOLE
PPI
Omeprazole
TAB
16
Prostaglandi
ne
Rebamipide
TAB
30
PPI
Rabeprazole
TAB
40
H2-Blocker
Famotidine
TAB
9.35
Constipation
skin rashes
EZOGAST
PPI
Esomeprazole
TAB
40
FASTCURE
PPI
Omeprazole
CAP
30
Constipation
weight loss
nausea
Abdominal
pain
TRIO-CLAR
PPI and
Antibiotic
Omeprazole
CAP
105
H2-Blocker
Famotidine
TAB
10.35
MUCOSTA
RABICID
GASTRODOMINA
FAMOTIN
11| P a g e
Nausea
constipation
weight loss
Hair loss
insomnia
Diarreha
nausea
dizziness
Nausea
Diarreha
abdominal
pain
Weight loss
Constination
abdominal
pain
Nausea
Vomiting
Skin Rashes
Weight loss
Hair loss
Breathing
difficulty
low BP
Dry mouth
sore throat
Diarreha
abdominal
pain
2013
Also losec is first PPI in antiulcer market and achieve high market share
(100%) but it is now reach decline phase and it is market share become 0.5 %
because of lake of promotion.
11| P a g e
We will target doctors in Cairo mainly class A,B,C doctors in areas like
masr el gededa, nasr city, el maady, el tagamoo Al kames . .
2013
Demographic segmentation:
Age:
Under 6
Male
6-11
12-19
20-34
35-49
50-65
65 and over
As it is mentioned in our market research that
patients who suffer from heartburn are mainly
from 20 to 65 and over.
Gender:
Female
Both male and female suffer from heartburn but male are little more.
Income:
Class A
Class B
Class C
Class D
Education:
Highly educated
Moderate educated
As they when suffer from heartburn will visit doctors
but low educated will not.
Low educated
Generation:
Baby
youth
As they eating many fast
foods and heavier smoking
and they are main causes
of heartburn.
11| P a g e
Elder
Elder always suffer from
peptic ulcer and GERD
that mainly cause
heartburn.
2013
Psychographic segmentation:
Lifestyle:
Achievers
I will target achievers also but
less than strikers because of
their good income and because
losec have a long action dose
and in the tablet form ,since
this social class members need
a prolonged effect drug to be
able to do their daily tasks so
losec will be their preferable
choice .
Strikers
my target mainly will be Strikers because
they are always under stress which cause
ulcer directly also stress lead to smoking
cigarettes that is considered o of the
main causes of Ulcer .strikers are people
who struggle in their life they may work
for more than 8 hrs daily so they deal
with junk food more than any other
social class that will lead to ulcers ,also
those people care about their health very
much so they need an effective drug to
cure them as soon as possible to be able
to complete their work that makes losec
is their best choice .finally losec is
consider affordable to this class of the
society that have moderate income .
Survivors
Social class:
Lower
lowers
Upper
lowers
Working
class
Middle
class
Upper
middles
Lower
uppers
Upper
uppers
Behavioral Segmentation:
I. Occasion:
1-Ramadan: - Thats because all people eat a lot of food in small time interval which easily
may cause heartburn &gerd.
2-Sham El-Neseem: - Because people eat very salty food which for sure can cause heartburn easily.
3-El-Syam El-Kber (Christian occasion):
-
Because Christians at this time eat a lot of oily food which also can cause a
heartburn.
11| P a g e
2013
II-Benefits:
Quality
Economy
Service
Convince
Speed
Well
target this one
thats because
losec has a
special
property
which is one
dose given
form.
Ex-user
Potential user
It is easy to target
him because he has
an idea about losec
and its effective
dosage.
11| P a g e
Regular user
2013
Medium
We should also target the
medium to not lose a
valuable market share of
the medium patients (
patients that dont have a
chronic case but take
peptic ulcer drugs) also
High
This one will be targeted
by a lot of other companies
so we must cover this
category of people to
benefit us in the future and
to compete the other
products
V- Loyalty:
Low
Medium
High
Differentiated
Marketing
(Segmented
Marketing)
Concentrated
Marketing
(Niche
Marketing)
Micromarketing
( Local or
individual
marketing )
11| P a g e
2013
Tablets
Intravenous
1-Patients in coma.
2- Patients in ICU.
H2 Blockers Market
11| P a g e
2013
the competitive advantages for LOSEC:- The only product that has the complete HEALING effect concerning ulcers.
- The original PPI from AstraZeneca
- The complete course 3 months.
-Symptoms get relieved after 2 months.
-Suitable price.
Choosing the Right Competitive Advantages:- we choose the HEALING effect of LOSEC as it is the most effective
advantages against other product and LOSEC is unique in that.
11| P a g e
2013
LOSEC value proposition:More for More ( as losec gives the patient more benefit (healing power of the ulcers)
but at the same time for the more price in comparison to the competitors)
Recommendations:
1-Instead of manufacturing losec in a drug bottle the company may use tablet stips
which will cost less and so the company mau use the difference in production money
in decreasing the drug price in market
2- use other dosage forms like effervescence with lower price
3-Promotions and campaigns
4- Increase losec 40mg in the market to compete with controlloc 40
5- Increase losec 20mg to be able to take the market share of controlloc 20 as its not
available these days
6-develop a 14 tablet package with suitable price to last for a longer period with
customer
Developing a position statement:To (peptic ulcer patients)....... LOSEC is the first Proton Pump Inhibitor developed
that has superior healing power in gastric & duodenal ulcers permanently with
11| P a g e
2013
4PS:
1. Product:
o Core :First genuine proton pump inhibitor ( PPI ) for heartburn and ulcer
treatment
Actual product: Features: Plastic container
Contains 7 cabsules
1 tablet per day under normal conditions
Package lasts for 7 days
11| P a g e
Quality level: Losec is moderate in PPI class but has superior activity in H2
blocker class
2013
These are the prototypes and sketches of the brand and brochures:Brand:-
Package:-
11| P a g e
11| P a g e
2013
2013
2. Promotion:
Ramadan campaign :- During the holy month of Ramadan people tend t eat a lot
at Al-eftar so this may be one of the reasons they can have GERD die to large
quantity of food eaten during this period
Easter campaign :- people tend to eat salty food and food containing a lot of
citrus juice which may cause acid reflux and GERD
El seam el keeper campaign:- Christians will be eating a lot of food containing
plant oils before ( el seam el keeper ) which is also a reason and cause for GERD
Drs Campaign: at the start of the year we will establish a DRs Campaign to
describe the new market plain and how we tend to make our drug one of the top
10 antiulcer drug in the market and the drug features.
Drs conferences:- at the start of the year we will establish a DRs conference to
talk about losec features and how it is efficacy and it is low price
Pharmacy campaign:- Its also important to do a pharmacy campaign in order to
keep the pharmacist and any customer entering the pharmacy up to date with our
drug
News paper advertisement :- people tend to read the newspaper every morning
so it will be a good way to advertise our drug
Medical reps:- this will be through out the year to keep the pharmacist and drs up
to date with our drug and its action
Speaker meeting:- It will be as a way to encouraging the doctors and pharmacists
in our company by giving them a speaker meeting containing all the informations
and knowledge behind our drug
Cycle meeting:- At the end of the year as a way of conclusion to our profit and
our market status
Marathon advertisement :- to encourage people to join an activity and we can
give them some hints abt our product in a fun day
Offer pharmacies to make the theme of billboard the losec package:- so that the
drug package and name will be in the streets infront of the eyes of any customer or
people in the streets
Tv advertisement during Ramadan:- so people can have knowledge about the
drug during their eftar and during Ramadan.
Facebook & twitter groups and games: to increase awareness about GERD and
how losec is effective with low price.
3- Price:
market growth:
2012
11| P a g e
2013
2013
843,887,721.0
1,054,859,651.0
losec:
market share will increase 50% and will reach to .75
2012
4,389,125
2013
7,911,447.383
Other drugs:
Drug
ZANTAC
CONTROLOC
ESTOHALT
PERLOC
IDIZOLE
MUCOSTA
RABICID
GASTRODOMINA
EZOGAST
FASTCURE
TRIO-CLAR
FAMOTIN
Decrease
15%
5%
1%
2%
1%
4%
1%
4%
1%
0%
0%
0%
Market share
12.155
9.215
.792
.784
.792
.768
.693
.672
0.693
0.6
0.5
0.5
Current sales
128,218,190.6
97,205,316.84
8354488.44
8,270,099.66
835,448.44
810,1322
7310177.38
7088656.85
7310177.38
6329157.9
5274298.25
5274298.25
Month
1/1/2013
Campaign
Ramadan campaign
Easter campaign
El seam el keeper
campaign
Drs Campaign
Drs conferences
Pharmacy
campaign
News paper
advertisement
Medical reps
Speaker meeting
Cycle meeting
11| P a g e
1/2/2013
1/3/2013
1/4/2013
1/5/2013
1/6/2013
2013
Marathon
advertisement
Tv advertisement
Month
1/7/2013
1/8/2013
1/9/2013
Campaign
Ramadan
campaign
Easter campaign
El seam el keeper
campaign
Drs Campaign
Drs conferences
Pharmacy
campaign
News paper
advertisement
Medical reps
Speaker meeting
Cycle meeting
Marathon
advertisement
TV advertisement
Budget:
Speaker:
2*100000
Marathon: 2*100000
2013
1,495,000
Drs room:
- Put on it is desk something looks like sand timer but has stomach
shape suffer from ulcer and sand like losec and make healing.
11| P a g e
Will make big package as a maket and put cards inside it about ulcer
and losec and how it is like magic in relief pain.
Cards have info about ulcer, what should w do to control it and what
should we eat and don't eat that will help doctor and patient to control
the disease.
2013
Sponsors:
1- Scops: company will get benefits from many sides as trainees will
talk about it is drugs with doctors and pharmacies and they will
know a lot about AstraZeneca.
11| P a g e
2013
Charity:
-
11| P a g e
Astra will pay all fees for patients in one of the hospitals and make it
is products for free if doctor write it that will make people know a lot
about AstraZeneca and doctors write it is drugs.