alasan penambahan bahan

vitamin c 60 mg/ HARI ------RDA

ncompatible with alkalis, heavy metal ions, especially copper and
iron, oxidizing materials, methenamine, phenylephrine hydrochloride, pyrilamine maleate, salicylamide, sodium nitrite, sodium
salicylate, theobromine salicylate, and picotamide.(4,5) Additionally,
ascorbic acid has been found to interfere with certain colorimetric
assays by reducing the intensity of the color produced.(6)
(excipient : 45)
Tribasic calcium phosphate is widely used as a capsule diluent and
tablet filler/binder in either direct-compression or wet-granulation
processes. The primary bonding mechanism in compaction is plastic
deformation. As with dibasic calcium phosphate, a lubricant and a
disintegrant should usually be incorporated in capsule or tablet
formulations that include tribasic calcium phosphate. In some cases
tribasic calcium phosphate has been used as a disintegrant.(1) It is
most widely used in vitamin and mineral preparations(2) as a filler
and as a binder.
(excipient: 100)
Adsorbents such as silicon dioxide (Syloid, Cab-O- Sil, Aerosil) are capable
of retaining large quantities of liquids without becoming wet. This allows
many oils, fluid extracts, and eutectic melts to be incorporated into tablets.
Capable of holding up to 50% of its weight of water, silicon dioxide adsorbed
systems often appear as free-flowing powders. This adsorbent characteristic
explains why these materials function well in tablet formulations to alleviate
picking, especially with high-level vitamin E tablets. Silicon dioxide also exhibits glidant properties and can play both a glidant and an adsorbent role in
the formula.
Other potential adsorbents include clays like bentonite and kaolin, magnesium silicate, tricalcium phosphate, magnesium carbonate, and magnesium oxide.
Usually the liquid to be adsorbed is first mixed with the adsorbent prior to
incorporation into the formula. Starch also displays adsorbent properties.
(pdf tablet : 140)
Alginic acid is a polymer derived from seaweed comprising D-mannuronic
and L- glucuronic units. Its affinity for water and high sorption capacity
make it an excellent disintegrant. It is insoluble in water, slightly acid
in reaction, and should be used only in acidic or neutral granulations. It
can be used with aspirin and other analgesic drugs. If used with alkaline
salts or salts of organic acids, it tends to form soluble or insoluble alginates
that have gelling properties and delay disintegration. It can be successfully used with ascorbic acid, multivitamin formulations, and acid salt s of
organic bas
(pdf tablet: 194)
CONTOH FORMULA: PDF TABLET 1 195)
penambahan asam folat sebab asam folat pada makanan mudah rusak oleh pemanasan;
FT....

fosfor kalsium, mangan, zinc, asam folat

TALK...nggak boleh.....karena dapat mengganggu absorpsi cyanocobalamin (aulton:

244)
Khan and Rhodes [59] reviewed the disintegration properties of dibasic
calcium phosphate dihydrate tablets employing insoluble and soluble disintegrating agents. The insoluble disintegrants showed a greater effect when
compressional forces were varied than did the soluble disintegrants.
The use of a medium coarse dicalcium phosphate dihydrate has been
reported [60,61]. It has interesting applications in vitamin-mineral formulations as both a direct-compaction vehicle and as a source of calcium and
phosphorus.
(pdf tablet 1: 122)
Polyvinylpyrrolidone (PVP) is an alcohol-soluble material which is used
in concentrations between 3 and 15%. Granulations using a PVP-alcohol
system process (granulate) well, dry rapidly, and compress extremely well.
PVP finds particular application in multivitamin chewable formulations where
moisture sensitivity can be a problem.
(pdf tablet : 126)
Ethylcellulose (Ethocel) is used as alcohol solutions of 0.5 to 2.0% and
affords moisture-sensitive components a protective coating. Vitamin A and
D mixtures, which are usually sensitive to moisture, may be coated with
ethylcellulose solution, dried, and granulated with conventional aqueous
systems. Ethylcellulose may have a serious retardant effect on tablet disintegration and drug dissolution release.
*(pdf tablet:127)
BAHAN TAMBAHAN
ASAM ALGINAT desintegrant 1-5 persen--------------penghancur dalam 2 persen
penghancur luar 3 persen
mgstearat pelincir 0, 1 persen bibe kayaknya 1 persen
PVP dalam alkohol (pengikat) 3-15 persen
Povidone
pengisi
tribasic calsium posfat
absorben silicon dioxide
SALUT FILM
Etil selulosa 0,5-2 persen
alkohol ad 100 persen
SATU
1. ferro fumarat ditambahkan dengan sebagian pengisi, dan pvp dalam alkohol
2. granulasi dan kempa menjadi tablet
3.salut dengan etil selulosa dalam larutan alkohol.
DUA
1. semua mineral yang tersisa dicampur dnegan povidone dalam air dan metanol
2. granulasi dan keringkan
TIGA
1. campur semua vitamin, kecuali vitamin A,D, C dan K.
2 granulasi dengan menggunakan air.keringkan pada suhu 120 derajat celsius dan a
yak pada ayakan 15 mesh
EMPAT
1.campur asam askorbat dengan asam alginat (penghancur dalam)

2 campurkan dengan A,D, dan K dan adsorben Silikon dioxida

LIMA
1. campur campuran empat, tiga, penghancur luar dan tribasic calsium posfat (pen
gisi)
ENAM
1. Campuran dua dan lima dicampur dan dikompressi untuk melapisi tablet inti fer
ro (besi)
2. salut tablet dengan salut film etil selulosa dalam alkohol