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l l l IMMUNOBIOLOGY
Cellular dynamics of
resolving
inflammation
----------------------------------------------------------------------------------------------------Juhi Bagaitkar
1701
The acute phase of inflammatory response is accompanied by rapid (within minutes) influx of neutrophils and
monocytes in response to soluble mediators released by tissue resident cells. During resolution, resident macrophages
clear apoptotic neutrophils and make iNOS and proresolving cytokines such as interleukin-10 (IL-10) and transforming
growth factor-b (TGF-b). Monocyte-derived macrophages (moMw) and MoDCs persist in the tissue along with MDSCs
and lymphocytes long after classical resolution. MoDCs preferentially drive T-cell proliferation and generation of
adaptive immunity in the postresolution phase.
1702
l l l TRANSPLANTATION
Exposure to apoptotic cells prior to BMT improves survival. BALB/c mice were injected with C57BL/6 BM plus
conventional T cells (Tcon) only (circles) or with prior injection of ECP-treated BALB/c-treated cells (triangles) or with
prior injection of BALB/c cells treated with 8MOP but no UV light (squares). See Figure 1A in the article by Florek et al
that begins on page 1832.
1703