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cholera epidemics
1817 epidemic in India 25 million deaths
1829 epidemic in Moscow 33,000 deaths
1831 epidemics in England 130,000 deaths
1832 epidemics in Paris 18,000 deaths (2 % of the population)
So many cholera victims were being buried inside churches and church yards already
full that infection was constantly breaking out. Illustrated London News, 1849.
William Farr
founding figure in medical
statistics
pioneering research on cholera in
1840s 1850s London
initial focus on miasma
John Snow
A Natural Laboratory
People of both sexes, of every age and occupation, and of every rank
and station were divided into two groups without their choice, and, in
most cases, without their knowledge.
- John Snow
Company
Houses
Deaths
Southwark
40,046
1,263
32
Lambeth
26,107
98
3.8
Rest of London
256,423
1,422
5.6
bacteriological revolution
1880
1882
Tuberculosis (Koch)
1883
1884
Diphtheria, tetanus
1886
Pneumonia
1894
Plague, botulism
1898
Dysentery
Kochs Postulates
microorganisms are found in abundance in diseased organisms
they can be isolated from the organism, grown in a pure culture, and
reintroduced into healthy organisms to induce sickness
disease-causing microorganisms are sometimes also found in
abundance in asymptomatic individuals