_ j

PROJECT INITIATION - REVIEW SU,:'.ARY

PnOJ^CT TITLE: riung Beans

TECN`,ICr;L OBJECTIVE: To define optimal conditions for the commercial production of mung
bean sprouts.

VALUE: Since mung bean sprouts constitute a major portion of the contents of Chung King
products, and since factory yields of sprouts are erratic, improved yields would mean a
significant savings in factory costs.

PROGRESS; STATUS: Good progress has been made in defining the optimum growth conditions.
Sev^r
- aT-critical factors have been identified and are now under study.

✓ .
PROBABILITY OF SUCCESS: L ^ L
0 25 50 75 100%

MN GE:

Short Medium ; Long ; Continuous

Estimated Completion Date(s) 1-1-71

RESPO:dSIBILITY:

Department(S) Research & Engineering

Division(s) Biological
Project Leader Dr. Stuart A. Bellin

RESOURCES: Project No. .3 7

1969 Operating Cost ^^ / .^
Capital Cost ^
1970 Operating Budget^G-0--p
Capital Cost

Ph. DL-', M.S.

M. 0, yZ ; B. S. 0, S Tech. IJ-Q

(Present or anticipated)

PRIORiTY: A B C D Rank

ACTIC:1:
 PSAJOR TITLE: Fermentation

.,_
.. r ^^? r'I r C11^, :.',^V
P nn ^^^`CC T : : r,^ r,_

PRIHECT ':'L:.: Biochemical Synthesis

7ECr:.;ICr.'_ O13J ECT:% `E: To discover new products for the Company utilizing biological procedures.
The new products may be chemicals, enzymes, flavors, etc. The methods would generally be by
fermentation but not exclusively so.

Vt^LOt: New products from this source would increase Company sales.

Pr2^^,GRESS; S l.;! ::S: Several new enzymes and several new chemicals have been produced from this
research. This phase of the work has been inactive recently because of the big effort on
glucose isomerase. - ,
` ✓
PRO'_^,_`.SILI i Y OF SUCCESS: I ' ' ' '
0 25 50' 75 100%

Rl1:\v'L•

Short ; h;edium ; Long ✓ ; Continuous

. Estimated Cc,;:pletion DGte(s)

6
RESPONSH"ILITY:

Department(s) Research
Division(s) Biological
Project LeGder

RESOURCES: Project No.

1969 Operating Cost

Capi tGl Cost

1970 Operating Budget

Capital Cost

Pn.D. :-.1 ; M.S. B.S. ; Tech.

(PresEn t or an ti ci pated)

PRI C;I TY: A , B C D Rank

kC7I0N:
 PRCJE: ; `J' ^ ; - R,-1'! Et•; S'L"'•. „?Y

PR1Jz:CT iiiH-1: Development of Ariimal Smoke Exposure Machine

TcCf:NICt;L 03J`C`,-:!'S: To develop and evaluate a machine which will expose experimental animals
to cigarette smoke in a manner which simulates human smoking as nearly as possible.

VALUE: Primarily defensive. If a "standard" set of conditions for exposing experimental

animals to smoke can receive general acceptance in the scientific community, there would be
fewer spectacular, anti-cigarette studies reported in which wholly unrealistic smoking
conditions were employed.
PROCPESS; SinMUS: The RJR machine shows signs of being one of the best designs to the present
time. Several improvements are contemplated and will be incorporated as fast as possible.

✓
PROBr"ABIL ITY Or SL°CCESS: L , ' t
0 25 50 75 100%

P.F';N CE'

Short ; Medium ✓ ; Long ; Continuous

Estirated Co.;:pletion Date(s)

R=SPG::SIBILiTY'

Depart^ent(S) Research
Division(s) Biological
Project Leader

RESOURCE:*S• Project No.

i ), j

1909 Opera ti ng Cost I-= s'

Capital Cost
0
1970 OperGti n5 Budget
Capital Cost
r-
Ph.D. M.S. ; B.S. Tech. ^

(Present or an ti ci pated )

- v_
^ -
0
r
PR:(';:-Y: A B C D Rank T
0
A CT IC
 rL'1JOR T]TLE: Foods
Fermentation
1 ,. _ . `• _ orv,^^^ J„ ,•^., ; v
PnO^^::T .`,. , :f^^

Foods by Fermentation Processes

TEC`:NC.''_ To develop new foods, less expensive foods, or higher nutrition

foods by fermentation processes.

VALUE: Foods in one of the above categories could expand our present line of food products.

PROGRESS; STr.-US: Tempeh, an Indonesian food made of fermented soybeans, has shown
consi e-rable progress. Other similar foods are being investigated.

✓
PROB"'BILITY OF SUCCESS:
0 25 50 75 100%

RANGE-

Short ; Medium ✓ ; Long ; Continuous

Estimated Completion Date(s)

RESPONSIEDILIT%'•

Department(s) Research
Division(s) Biological
Project Leader

RESOURCES• Project No.

1969 Operating Cost ' "%''

Capital Cost

1970 Opera ti nc Budget '•`-

Capltal Cost

Ph.D.^^ M.S. B.S. ; Tech. (.,

(Present or anticipated)

PRI ORI i Y: A B C D Rank

ACTION:
 *AJOR TITLE: Fermentation

^.vTI..1
c ^,.,, • ; Y
:'C!
PR^^7_ 1...^ - ^^^^.^

PRC;ECT TITLE: Fermentation Development

TEC;:,'ICr,' CTJSC'r: VC: To learn the factors of a given fermentation which will permit
scaling-up the process to commercial scale.

Vr".LUL: Needed to take any process or product to commercial production.

PROGRESS; STATUS: Significant progress has been made on glucose isomerase. Each
prode
`- c as different problems.

. ✓
PROBABILITY OF SUCCLESS:
0 25 50. 75 100%

RMIC = •

Short ; Medium ✓ ; Long ;.Continuous

Estimated Com:pletion Date(s)

RESPO;;SIBILITI':

Department(s) Research
Division(S) Biological
Project Leader

RESOL' 1 :.7 S: Project No.

1969 0: e:^G t. Cost _

CGpl ta l L.os t'

1970 Operating Budget`

Capital Cost

Ph.D. ; M.S. ; B.S. ^ ' • Tech.-i

^

(Present or anticipa:.ed)

PR I C;.: T Y: A B C . D Rank
f, -.
 MAJOR TITLE: Enzymes

^ 0 v :. C T T
P r, - ^ • ^ -''c^1^k!'. r- t;
T T i hl . ,. . .

P ROJ-E, CT TITLS: Glucose Isomerase

TEC}i1IU.L 03„HT:I'To establish commercially feasible procedures for the production and
use of glucose isomerase enzyme from Arthrobacter.

VAL0E': This project is considered to be most important as a factor in the forthcoming

divestiture of Penick and Ford.

PROaRESS; STATUS: The proced.ure for the production of the enzyme appears to be well established.
A process which involves the adsorption of the enzyme on an inert carrie: and its use in a
continuous column procedure has been established in the laboratory and progress is being made
on making it a commercial reality. ✓
PROBrBILIiY CF SUCC=SS:
0 25 50 75 100/0

RANG E •

Short ✓ ;+,iedi um ; Long ; Conti nuous -

Estir:ated Co pletion Date(s) Late 1970

RESDONSTBILITY:

Department(s) Research
Division(s) Biological
Project Leader

RESOURCE'S: Project No.

1969 Cperati r.e Cos^

Capital Cost '

1970 Operating Budget "

Capital Cost

Ph.D. 3.^ ; M.S. ; B.S. Tech.

(Prese:^ or anticipated)

v
0
0
M
PRIO RT`1': A B C D R4nk

ACTION:
 TLAJOR TITLE: Uevelopment for Uses of Compounds.
D;n^rr - ^ • - - a = ^ r 7 [ 1, 1 C'r .rn^.
_
!
.

°,:D^^0' '' TT:-r' Biological Screening

e

T---CF;\IC;,'_ C30Ei.7i :'E: To identify biological activity of RJR compounds. The activity could be
a commercially useful property of a compound,e.g., insecticide or drug. It could also be a
side effect which could prevent the compound's use,e.g., as a flavorant.

VALUE: If useful activity is found, it could mean millions of dollars for the Company. If
adverse activity is found in an otherwise useful compound, this information needs to be known
to protect the Company's interest against litigation.

PROGRESS; STATUS: Well tested and established procedures are in operation to detect and
measure toxicity insecticide activity, herbicide activity, pharmacologic activity of several
different kinds.

PR0 .S=l3ILITY OF SUCCESS: u I + r I Range of success varies

0 25 50 75 100% with effort.
Probability very high on
RANGE: defensive work.

Short ; P,ediu-n ; Long ✓ ; Continuous

Estimated Co:::pletion Date(s)

R=SPO:iSISILITY:

Department(s) Research
Division(s) Chemistry & Biology
Project Leader

RESOURCES: Proiect No.

1969 Operating Cost

CGDital Cosz

1970 Operating Budget

Capital Cost
^
Ph.D. G5 ; M.S. 1,! C' ; B.S. % ; Tech. ^r^;

(Present or an ti c ipa:.ed )

PR? C;7 T Y: A B C D Rank

ACTION:
 *SA.IOR TITLE: Developm<nt for L'ses of Compounds
c^ .• -, .- ^' . ..
P.,.;^CT
^^, ^ i^:r r^^ ' ?^l•: S^,.•"^-U

iiTLE Toxicity Studies

TFC;\IC.=.L C50ECTI!'=: To determine the toxicity of any chemical or food product developed
at RJR to determine safety of application or obtain data for FDA purposes.

VALUE: A toxicity program is mandatory for research in areas relating to foods and new
potential uses of chemicals or biological preparations.

Pt20:RESS; STATUS: A well-established toxicity program has been in operation for some time.

PRCBfi.STLITY OP SUCCESS: I I I I I
0 25 50 75 100%

RA';CE-

Short Medium ; Long ; Continuous ✓

Estir,ated Co.-mletion Date(S)

RESPONISIBILITY:

Departzent(S) Research
Division(s) BioloQical
Project Leacer

RESOURCES: Project No.

1909 Operating Cost

Capital Cost
^
1970 O;^erG ;.i nC Budget )
Capital Cost

Ph.D. M.S. B.S. Tech. b

(Present or anticipated)

PR=CTY: A B C D Rank
_,,,,,
nCT =U,^.
 MAJOR TITLE: Development for Uses of Compounds

PROJECT INITIATION - REVIEW SU,+MARY

PROJECT TITLE: Evaluation of Compounds

TECHNICAL OBJECTIVE: To identify and characterize any biological activity for compounds
found to be active in the screening program. This work constitutes the major part of the
research work which must be done betkeen the time of discovery of activity, and the time
a compound can be sold for commercial.purposes.
VALUE: The identification and characterization of useful properties of chemical compounds.
could provide new business opportunities for the Company.

PROGRESS; STATUS: Several compounds have been found to possess interesting but not com-
mercially desirable properties. One compound, SRR4A, has been shown to have hypocholesteremic
and estrogenic activity. Evaluations are continuing.

PROBABILITY OF SUCCESS: I I I I I . Variable, depending on

0 25 50 75 100% extent of effort.

RANGE:

Short ; Medium ; Long ✓ ; Continuous ✓

Estimated Completion Date(s)

RESPO.dSIBILITY:

Department(s) Research

Division(s) Biological

Project Leader

RESOURCES: Project No.

19069 Operating Cost`

Capital Cost
\

1970 Operating Budget `

Capital Cost

t . ; B.S. ^- Tech. T
Ph. D. M.S.

(Present or anticipated)

0
0
r
OD
PRIORITY: A B C D Rank

ACTION: 0

♦
 PROJECT INITIATION - REVIEW SUiiNARY

PROJcCT TITLE: Exploratory Biological Research

TECHNICAL ODJECT PJE: To explore new ideas for new products or processes at an early stage,
to determine feasibility of a new concept.

VALUE: Provides a means of establishing new directions for research and new projects.

PROGRESS; STATUS:

✓
PROBABILITY OF SUCCESS: A
0 25 50 75 100%

RANGE:

Short ; Medium ; Long ; Continuous ✓

Estimated Completion Date(s)

RESPONSIBILITY:

Department(s) Research
Division(s) Biological
Project Leader

RESOURCES: Project No.

1969 Operating Cost •

Capital Cost

1970 Operating Budget

Capital Cost

Ph.D. ''.U ; M.S. f.Z^ ; B.S. .ech.

T

(Present or anticipated)

PRIORITY: A B C D Rank

ACTION:
 PROJECT INITIATIO\ - REVIEW SU',',ARY

PROJECT TITLE: Development Sanitary Services

TECF-,N1ICAL OBJECTIVE: To work with Product Development personnel to assure that microbiological
sani
ation standards are given full consideration in the development of any new product. Also,
to assist PD personnel in routine sanitation problems in their regular pilot laboratory operations.

VALUE: It is essential that adequate sanitation consideration be given to every food project.

PROGRESS; STATUS: Dr. Campbell works with PD personnel on new products and regularly surveys
worTc areas for microbiological counts.

✓.
PROBABILITY OF SUCCESS:
0 25 50 75 100%

RANGE:

Short ; Medium ; Long ; Continuous ✓

Estimated Completion Date(s)

RESPONSIBILITY:

Department(s) Research & Development

DiVision(s) Biological
Dr. Michael Campbell
Project Leader.

RESOURCES: Project No. 138

1969 Operating Cost

Capital Cost

1970 Operating Budget

Capital Cost

Ph. D.- .^' ; M.S. ; B. S. ; Tech. 1

(Present or anticipated)

_ - -- - ^,

PRIORiTY: A B C D Rank °
to

ACTION: a
• N
 PROJECT ItJITIATJON' - REVIEt -; S U',•tARY

PROJECT TITLE: Culture Collection Maintenance

TECHNICAL OBJECTIVE: To maintain our collection of various cultures of microorganisms for

research and assay purposes.

VALUE: Our fermentation and sanitary analyses programs require pure cultures of known,
adentified microorganisms. It is an on-going project to maintain the cultures and to
maintain adequate records.

PROGRESS; STATUS:

✓
PROBABILITY OF SUCCESS: ^- ^ ^
^ 0 25 50 75 100%

RANGE:

Short ; Medium ; Long ; Continuous ✓

. Estimated Completion Date(s)

RESPONSIBILITY:

Department(s) Research
Division(s) Microbiological.
Project Leader

RESOURCES: Project No.

1969 Operating Cost

Capital Cost

1970 Operating Budget

Capital Cost

Ph.D. ; M.S. B.S. ; Tech.

(Present or anticipated)

PRIORITY: A B C D Rank

ACTIOPI:
 PROJECT INITIATION - REVIEtN! SU;^',1ARY

PROJECT TITLE: Radiological Services

TECHNICAL OBJECTIVE: To maintain safety program and adequate records for the use of
radioisotopes to satisfy conditions for our AEC license.

VALUE: Required to possess license

PROGRESS; STATUS:

PROBABILITY OF SUCCESS: I I I I I
0 25 50 75 100%

RANGE:

Short ; Medium Long ; Continuous ✓

Estimated Completion Date(s)

RESPONSIBILITY:

Department(s) Research
Division(s) Biological
Project Leader

RESOURCES: Project No..

1969 Operating Cost

Capital Cost

1970 Operating Budget

Capital Cost

Ph.D. ; M.S. ; B.S. ; Tech. ''•^.

(Present or anticipated)

PRIORITY: A B C D Rank

ACTION:
 PROJLCT 71NITIAIIUN - RLVIE:•! SU,"1ARY

PROJECT TITLE: Beetle Control

TECIii^ICAL OBJECTIVE: To devise means of controlling the cigarette beetle in the Company's
premises and products.

VALUE: Cigarette beetle damage has cost the Company much over the years, both'in dollars and
in adverse public relations. Proper control.helps the Company both financially and in public
relations.

PROGRESS; STATUS: This project has resulted in vast improvements in beetle control in the
last few years. The remaining work is primarily of a surveillance and maintenance kind.
Phostoxin for tobacco fumigation was developed under this project.

PROBABILITY OF SUCCESS:
0 25 50 75 100%

RANG E :

Short ; Medium ; Long ; Continuous ✓

Estimated Completion Date(s)

RESPO(dSIBILITY:

Department(s) Research, Green Leaf Storage Engineering

Division(s) BioloQical
Project Leader

RESOURCES: Project No.. 131

1969 Operating Cost

Capital Cost

1970 Operating Budget

Capital Cost

Ph. D. ; M.S. o-F-C ; B. S. 0.25 Tech. r-e25

(Present or anticipated)

PRI ORI TY: A B C D Rank

ACTION:
 PROJECT INITIATION - REVIEW SU"','•'ARY

PROJECT TITLE: Biological Services

TECf!N'ICAL OBJECTIVE: To supply biological research know-how where and whenever it is

needed in the Company. Examples are: flora control in air conditioning water, analysis
of storage effluent, sanitary analysis of foods, insect control, laboratory dish washing
services, etc.
VALUE: Provides in-house consulting service for problems related to biological discipline.

PROGRESS; STATUS:

✓
PROBABILITY OF SUCCESS:
0 25 50 75 100%

P.ANGE:

Short ; Medium ; Long ; Continuous /

Estimated Completion Date(s)

RESPONSIBILITY:

Department(s) Research
Division(s) Biological
Project Leader

RESOURCES: Project No..

1969 Operating Cost

Capital Cost

1970 Operating Budget

Capital Cost

Ph. D. h, ; M.S. O, B. S. ; Tech. I Q/

(Present or anticipated)

PRIORITY: A B C D Rank

ACTION: