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TECN`,ICr;L OBJECTIVE: To define optimal conditions for the commercial production of mung
bean sprouts.
VALUE: Since mung bean sprouts constitute a major portion of the contents of Chung King
products, and since factory yields of sprouts are erratic, improved yields would mean a
significant savings in factory costs.
PROGRESS; STATUS: Good progress has been made in defining the optimum growth conditions.
Sev^r
- aT-critical factors have been identified and are now under study.
✓ .
PROBABILITY OF SUCCESS: L ^ L
0 25 50 75 100%
MN GE:
RESPO:dSIBILITY:
(Present or anticipated)
PRIORiTY: A B C D Rank
ACTIC:1:
PSAJOR TITLE: Fermentation
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P nn ^^^`CC T : : r,^ r,_
7ECr:.;ICr.'_ O13J ECT:% `E: To discover new products for the Company utilizing biological procedures.
The new products may be chemicals, enzymes, flavors, etc. The methods would generally be by
fermentation but not exclusively so.
Vt^LOt: New products from this source would increase Company sales.
Pr2^^,GRESS; S l.;! ::S: Several new enzymes and several new chemicals have been produced from this
research. This phase of the work has been inactive recently because of the big effort on
glucose isomerase. - ,
` ✓
PRO'_^,_`.SILI i Y OF SUCCESS: I ' ' ' '
0 25 50' 75 100%
Rl1:\v'L•
6
RESPONSH"ILITY:
Department(s) Research
Division(s) Biological
Project LeGder
(PresEn t or an ti ci pated)
kC7I0N:
PRCJE: ; `J' ^ ; - R,-1'! Et•; S'L"'•. „?Y
TcCf:NICt;L 03J`C`,-:!'S: To develop and evaluate a machine which will expose experimental animals
to cigarette smoke in a manner which simulates human smoking as nearly as possible.
✓
PROBr"ABIL ITY Or SL°CCESS: L , ' t
0 25 50 75 100%
P.F';N CE'
R=SPG::SIBILiTY'
Depart^ent(S) Research
Division(s) Biological
Project Leader
(Present or an ti ci pated )
- v_
^ -
0
r
PR:(';:-Y: A B C D Rank T
0
A CT IC
rL'1JOR T]TLE: Foods
Fermentation
1 ,. _ . `• _ orv,^^^ J„ ,•^., ; v
PnO^^::T .`,. , :f^^
VALUE: Foods in one of the above categories could expand our present line of food products.
PROGRESS; STr.-US: Tempeh, an Indonesian food made of fermented soybeans, has shown
consi e-rable progress. Other similar foods are being investigated.
✓
PROB"'BILITY OF SUCCESS:
0 25 50 75 100%
RANGE-
RESPONSIEDILIT%'•
Department(s) Research
Division(s) Biological
Project Leader
(Present or anticipated)
ACTION:
*AJOR TITLE: Fermentation
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c ^,.,, • ; Y
:'C!
PR^^7_ 1...^ - ^^^^.^
TEC;:,'ICr,' CTJSC'r: VC: To learn the factors of a given fermentation which will permit
scaling-up the process to commercial scale.
PROGRESS; STATUS: Significant progress has been made on glucose isomerase. Each
prode
`- c as different problems.
. ✓
PROBABILITY OF SUCCLESS:
0 25 50. 75 100%
RMIC = •
RESPO;;SIBILITI':
Department(s) Research
Division(S) Biological
Project Leader
(Present or anticipa:.ed)
PR I C;.: T Y: A B C . D Rank
f, -.
MAJOR TITLE: Enzymes
^ 0 v :. C T T
P r, - ^ • ^ -''c^1^k!'. r- t;
T T i hl . ,. . .
TEC}i1IU.L 03„HT:I'To establish commercially feasible procedures for the production and
use of glucose isomerase enzyme from Arthrobacter.
PROaRESS; STATUS: The proced.ure for the production of the enzyme appears to be well established.
A process which involves the adsorption of the enzyme on an inert carrie: and its use in a
continuous column procedure has been established in the laboratory and progress is being made
on making it a commercial reality. ✓
PROBrBILIiY CF SUCC=SS:
0 25 50 75 100/0
RANG E •
RESDONSTBILITY:
Department(s) Research
Division(s) Biological
Project Leader
(Prese:^ or anticipated)
v
0
0
M
PRIO RT`1': A B C D R4nk
ACTION:
TLAJOR TITLE: Uevelopment for Uses of Compounds.
D;n^rr - ^ • - - a = ^ r 7 [ 1, 1 C'r .rn^.
_
!
.
T---CF;\IC;,'_ C30Ei.7i :'E: To identify biological activity of RJR compounds. The activity could be
a commercially useful property of a compound,e.g., insecticide or drug. It could also be a
side effect which could prevent the compound's use,e.g., as a flavorant.
VALUE: If useful activity is found, it could mean millions of dollars for the Company. If
adverse activity is found in an otherwise useful compound, this information needs to be known
to protect the Company's interest against litigation.
PROGRESS; STATUS: Well tested and established procedures are in operation to detect and
measure toxicity insecticide activity, herbicide activity, pharmacologic activity of several
different kinds.
R=SPO:iSISILITY:
Department(s) Research
Division(s) Chemistry & Biology
Project Leader
(Present or an ti c ipa:.ed )
ACTION:
*SA.IOR TITLE: Developm<nt for L'ses of Compounds
c^ .• -, .- ^' . ..
P.,.;^CT
^^, ^ i^:r r^^ ' ?^l•: S^,.•"^-U
TFC;\IC.=.L C50ECTI!'=: To determine the toxicity of any chemical or food product developed
at RJR to determine safety of application or obtain data for FDA purposes.
VALUE: A toxicity program is mandatory for research in areas relating to foods and new
potential uses of chemicals or biological preparations.
Pt20:RESS; STATUS: A well-established toxicity program has been in operation for some time.
PRCBfi.STLITY OP SUCCESS: I I I I I
0 25 50 75 100%
RA';CE-
RESPONISIBILITY:
Departzent(S) Research
Division(s) BioloQical
Project Leacer
(Present or anticipated)
PR=CTY: A B C D Rank
_,,,,,
nCT =U,^.
MAJOR TITLE: Development for Uses of Compounds
TECHNICAL OBJECTIVE: To identify and characterize any biological activity for compounds
found to be active in the screening program. This work constitutes the major part of the
research work which must be done betkeen the time of discovery of activity, and the time
a compound can be sold for commercial.purposes.
VALUE: The identification and characterization of useful properties of chemical compounds.
could provide new business opportunities for the Company.
PROGRESS; STATUS: Several compounds have been found to possess interesting but not com-
mercially desirable properties. One compound, SRR4A, has been shown to have hypocholesteremic
and estrogenic activity. Evaluations are continuing.
RANGE:
RESPO.dSIBILITY:
Department(s) Research
Division(s) Biological
Project Leader
t . ; B.S. ^- Tech. T
Ph. D. M.S.
(Present or anticipated)
0
0
r
OD
PRIORITY: A B C D Rank
ACTION: 0
♦
PROJECT INITIATION - REVIEW SUiiNARY
TECHNICAL ODJECT PJE: To explore new ideas for new products or processes at an early stage,
to determine feasibility of a new concept.
VALUE: Provides a means of establishing new directions for research and new projects.
PROGRESS; STATUS:
✓
PROBABILITY OF SUCCESS: A
0 25 50 75 100%
RANGE:
RESPONSIBILITY:
Department(s) Research
Division(s) Biological
Project Leader
(Present or anticipated)
PRIORITY: A B C D Rank
ACTION:
PROJECT INITIATIO\ - REVIEW SU',',ARY
TECF-,N1ICAL OBJECTIVE: To work with Product Development personnel to assure that microbiological
sani
ation standards are given full consideration in the development of any new product. Also,
to assist PD personnel in routine sanitation problems in their regular pilot laboratory operations.
VALUE: It is essential that adequate sanitation consideration be given to every food project.
PROGRESS; STATUS: Dr. Campbell works with PD personnel on new products and regularly surveys
worTc areas for microbiological counts.
✓.
PROBABILITY OF SUCCESS:
0 25 50 75 100%
RANGE:
RESPONSIBILITY:
(Present or anticipated)
_ - -- - ^,
PRIORiTY: A B C D Rank °
to
ACTION: a
• N
PROJECT ItJITIATJON' - REVIEt -; S U',•tARY
VALUE: Our fermentation and sanitary analyses programs require pure cultures of known,
adentified microorganisms. It is an on-going project to maintain the cultures and to
maintain adequate records.
PROGRESS; STATUS:
✓
PROBABILITY OF SUCCESS: ^- ^ ^
^ 0 25 50 75 100%
RANGE:
RESPONSIBILITY:
Department(s) Research
Division(s) Microbiological.
Project Leader
(Present or anticipated)
PRIORITY: A B C D Rank
ACTIOPI:
PROJECT INITIATION - REVIEtN! SU;^',1ARY
TECHNICAL OBJECTIVE: To maintain safety program and adequate records for the use of
radioisotopes to satisfy conditions for our AEC license.
PROGRESS; STATUS:
PROBABILITY OF SUCCESS: I I I I I
0 25 50 75 100%
RANGE:
RESPONSIBILITY:
Department(s) Research
Division(s) Biological
Project Leader
(Present or anticipated)
PRIORITY: A B C D Rank
ACTION:
PROJLCT 71NITIAIIUN - RLVIE:•! SU,"1ARY
TECIii^ICAL OBJECTIVE: To devise means of controlling the cigarette beetle in the Company's
premises and products.
VALUE: Cigarette beetle damage has cost the Company much over the years, both'in dollars and
in adverse public relations. Proper control.helps the Company both financially and in public
relations.
PROGRESS; STATUS: This project has resulted in vast improvements in beetle control in the
last few years. The remaining work is primarily of a surveillance and maintenance kind.
Phostoxin for tobacco fumigation was developed under this project.
PROBABILITY OF SUCCESS:
0 25 50 75 100%
RANG E :
RESPO(dSIBILITY:
(Present or anticipated)
PROGRESS; STATUS:
✓
PROBABILITY OF SUCCESS:
0 25 50 75 100%
P.ANGE:
RESPONSIBILITY:
Department(s) Research
Division(s) Biological
Project Leader
(Present or anticipated)
PRIORITY: A B C D Rank
ACTION: