N

CHANGE OF ADDRESS FOR JADA

MANUSCRIPT SUBMISSION, REVIEW

SMOKERS SHOULD QUIT

BEFORE DENTAL
PROCEDURES

SCIENTISTS TISSUE
ENGINEER MANDIBULAR
CONDYLES

cientists have created

mandibular condyles from
rat adult stem cells that are the
precise three-dimensional shape
of the human joint, according to
a study published in the
December issue of the Journal
of Dental Research.
Studies in tissue engineeringusing the bodys own biological materials to repair,
regenerate and replace dam-

ffective Jan. 1, the manuscript review process for The Journal of the
American Dental Association is being handled through JADA Editor
Marjorie K. Jeffcoats office at the University of Pennsylvania School of
Dental Medicine.
All questions about manuscript submission and review should be
directed to this address:
The Journal of the American Dental Association
Editorial Office
University of Pennsylvania
School of Dental Medicine
The Robert Schattner Center
240 S. 40th St., Room E6
Philadelphia, Pa. 19104-6030
Phone: 1-215-746-0224
Fax: 1-215-898-5474
E-mail: jkelley@pobox.upenn.edu
JADAs Guidelines for Authors, including this new address,
are available online at www.ada.org/goto/authorguidelines.

aged organs and tissues, including bone and cartilagehave

focused on the initial step of
repairing a small area of damaged tissue.
Two years ago, Dr. Jeremy
Mao, study co-author and a scientist at the University of
Illinois at Chicago, and colleagues took the next step and
engineered a mandibular
condyle. They isolated adult
mesenchymal stem cells from
rat bone marrow, and then treated the cells in the laboratory to
differentiate them into either
bone-producing or cartilage-producing cells called osteoblasts
and chondrocytes, respectively.
Researchers then seeded the
differentiated cells into a hydrogel polymer solution in stratified layers. The seeded solution
was molded into the shape of a
human mandibular condyle.
Researchers implanted three
small molded structures just
below the skin of immunodeficient mice.
At eight weeks, researchers
harvested the three tissueengineered condyles from the

mice. They found that the

implants had formed on their
own into firm structures that
retained the precise shape and
three-dimensional structure of
the molded human mandibular
condyle.
They also found that the
osteoblasts had produced bone,
and they identified sparse
chondrocyte-like cells within
abundant extracellular matrix
that expressed certain proteins
characteristic of cartilage.
Stressing that their findings
are preliminary, researchers
said they are hopeful because
they produced the structures
from a single population of
stem cells and prompted them
to form two distinct layers of
bone and cartilage. They plan
to attempt to enhance the biological and mechanical properties of the tissue-engineered
condyles. Dr. Mao, however,
said that these results are just
the start of a much bigger scientific challenge.
It is no small task to recapitulate what nature does perfectly during development, he

JADA, Vol. 135, January 2004

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27

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mokers may want to quit

before undergoing oral surgery, say researchers in the
October issue of the Journal of
Periodontology.
Swedish researchers investigated the relationship between
tobacco smoking and the
inflammatory response in
smokers who consumed 10 to 20
cigarettes a day. They studied
15 smokers and 15 nonsmokers
with moderate-to-severe periodontitis who were undergoing
oral surgery. They conducted
clinical examinations and collected gingival crevicular fluid,
or GCF, before the subjects
underwent surgery and at one
and five weeks after treatment.
After analyzing the substances in the GCF, researchers
found that the bodys defense
mechanism was weakened in
smokers, whereas the defense
mechanism in nonsmokers promoted a more favorable healing
response. They interpreted
these findings as smoking possibly interfering with the treatment response. They said that
it also might explain the clinical evidence of inferior treatment outcomes in smokers.

N E W S

said. Although we understand

many of these cues during natural development, we need to
learn how to utilize them to tissue engineer mandibular
condyles.
BACTERIA USE NOVEL
MECHANISM TO EXPRESS
GENES

28

CORRECTION

he last sentence of the first

complete paragraph of the
first column on page 1497 of
November JADA should read,
Thus, a study at the
University of Texas Health
Science Center at Houston
Dental Branch is examining the
population of patents who are
taking aspirin in combination
with clopidogrel bisulfate or
taking clopidogrel bisulfate
alone to establish scientific and
evidence-based guidelines for
perioperative management.

Compiled by Amy E. Lund, editorial

coordinator.

MEETINGS

dThe International Association

for Dental Research will hold its
82nd General Session and
Exhibition March 10-13 in
Honolulu. For more information,
contact Eli Schwarz by phone at
1-703-548-1883, by fax at 1-703548-0066 or by e-mail at
es@iadr.org or visit www.
dentalresearch.org.
dThe American Dental Society
of Europe will hold its 110th
Meeting June 22-25 in Galway,
Ireland. For more information,
contact Dr. Paul ONeilly by
phone at 011-44-1483-72841 or
visit www.adse.co.uk.
APPOINTMENTS/
ELECTIONS/AWARDS

dDr. Nancy S. Arbree,

Boston, was elected president of
the American College of
Prosthodontists. Other officers
are Dr. Patrick M. Lloyd, Iowa
City, Iowa, president-elect; Dr.
Bruce G. Valauri, New York
City, vice president; Dr. Lily T.
Garcia, San Antonio, secretary;
and Dr. David L. Pfeifer,
Moraga, Calif., treasurer. Dr.
Jonathan L. Ferencz, New
York City, is immediate past
president.
dThe University of the Pacific
School of Dentistry has been
named in honor of Dr. Arthur A.
Dugoni, San Francisco. Dr.
Dugoni also received the Dale
Redig Distinguished Service
Award from the California
Dental Association.
dDr. Carmine LoMonaco,
West Caldwell, N.J., was elected
to the Foundation of the
University of Medicine and
Dentistry of New Jersey board.
dDr. Thomas Murnane,
Marblehead, Mass., received the
Presidential Medal from Tufts
University.

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ew research on how bacteria

make compounds critical to
their survival may help scientists create antibiotics for controlling dangerous bacterial
pathogens, say scientists in the
October issue of the
Proceedings of the National
Academy of Sciences.
For decades, scientists
believed that gene regulation in
bacteria depended only on regulatory proteins. New findings,
however, have altered those
beliefs. Researchers found that
bacteria use RNA to directly
measure a signal and to control
the related genes, rather than
using a messenger protein to
send information to the gene.
Researchers at The Ohio
State University, Columbus,
looked at how Bacillus subtilis,
a harmless bacterium, makes
the amino acid lysine. Lysine is
a crucial ingredient in making
protein and in building bacterial cell walls.
Researchers conducted their
experiments on B. subtilis in the
laboratory to look for the mechanism that the bacteria uses to
control the production of lysine.
Cells are really smartthey
only make what they need, said
Tina Henkin, Ph.D., the studys
lead author and a professor of
microbiology. In this case, if
theres enough lysine in the
environment that they can use,
or if theyve already made as
much as they need, the RNA
binds the lysine, and turns off

the lysine synthesis genes so

they wont make more. If they
need lysine, however, the lysinemaking genes are turned on.
This is a way of controlling
gene expression that scientists
didnt know existed, Dr.
Henkin continued. Everybody
assumed that this kind of intracellular communication must
need a regulatory protein in
order to work. The gene that
regulates lysine production in
B. subtilis evolved its own communication system without
needing to talk to a protein.
By studying nonpathogens
with structures and functions
similar to those of pathogenic
bacteria, were learning how
disease-causing bacteria control
their most vital physiological
functions, Dr. Henkin said.
We want to use the information we gain to understand how
these kinds of pathogens
behave and how they control
their own genes, which could
help in developing antibiotics
for some of medicines worst
enemies. We are quickly running out of effective antibiotics,
as the bacteria develop resistance to the ones we have.

N E W S

CALENDAR
OF EVENTS
ADA ANNUAL SESSIONS

2004 Sept. 30-Oct. 3, Orlando,

Fla.
2005 Oct. 6-9, Philadelphia
2006 Oct. 16-19, Las Vegas
2004 CONSTITUENT
DENTAL SOCIETY
ANNUAL MEETINGS

Meeting dates are subject to

change. Dentists interested in
attending any of the listed meetings should contact the sponsoring organization for more
information.
Alabama Dental Association, 836 Washington St.,
Montgomery 36104, 1-334-2651684, June 8-13, Orange
Beach.
Alaska Dental Society,

9170 Jewel Lake Road,

Anchorage 99502-5381, 1-907563-3003, Annual Session,
June 2-5, Fairbanks.
Arizona Dental Association, 4131 North 36th St.,
Phoenix 85018, 1-602-957-4777,
Western Regional Dental
Convention, March 11-13,
Phoenix.
Arkansas State Dental
Association, 2501 Crestwood
Dr., Suite 205, North Little Rock
72116, 1-501-771-7650, April 24, Hot Springs.
California Dental
Association, P.O. Box 13749,
Sacramento 95814, 1-916-4430505, Spring Scientific
Session, April 15-18,
Anaheim; Fall Scientific
Session, Sept. 10-12, San
Francisco.
Colorado Dental Association, 3690 S. Yosemite, Suite
100, Denver 80237-1808, 1-303996-2845, Annual Meeting,
June 11-13, Vail.
Connecticut State Dental
Association, 62 Russ St.,
Hartford 06406, 1-860-278-5550,
Charter Oak Dental Meeting,
May 13-15, Mohegan Sun
Resort.
Delaware State Dental
Society, Christiana Executive
Campus, 200 Continental Dr.,
Suite 111, Newark 19713,
1-302-368-7634, Annual
Meeting, May 14, Dewey
Beach.
District of Columbia
Dental Society, 502 C St.,
NE, Washington 20007, 1-202547-7613, Nations Capital
Dental Meeting, May 13-15,
Washington.
Florida Dental Association,
1111 E. Tennessee St., Suite 102,
Tallahassee 32308-6913, 1-850681-3629, Florida National
Dental Congress, June 17-19,
Orlando.

Georgia Dental Association, Suite 200, Bldg. 17, 7000

Peachtree Dunwoody Road NE,
Atlanta 30328-1655, 1-404-6367553, Annual Meeting, July
22-25, Amelia Island, Fla.
Hawaii Dental Association,
Suite 301, 1345 S. Beretania St.,
Honolulu, 96814-1821, 1-808593-7956, The Hawaii
Meeting, Jan. 15-17,
Honolulu.
Idaho State Dental Association, 1220 W. Hays St., Boise
83702, 1-208-343-7543, June 1619, Boise.
Illinois State Dental
Society, P.O. Box 376,
Springfield 62705, 1-217-5251406, Sept. 10-12, Moline.
Indiana Dental Association,
P.O. Box 2467, Indianapolis
46206, 1-317-634-2610, June
10-12, Indianapolis.
Iowa Dental Association,
505 5th Ave., Suite 333, Des
Moines 50309, 1-515-282-7250,
May 1-3, Des Moines.
Kansas Dental Association,
5200 S.W. Huntoon St., Topeka
66604-2398, 1-785-272-7360,
Midwest Dental Conference,
March 18-21, Kansas City, Mo.
Kentucky Dental Association, 1940 Princeton Dr.,
Louisville 40205, 1-502-4595373, The Kentucky Meeting,
April 1-4, Louisville.
Maine Dental Association,
P.O. Box 215, Manchester 043510215, 1-207-622-7900, MDA
Annual Convention, June 1819, Rockport.
Maryland State Dental
Association, 6410 Dobbin Road,
Suite F, Columbia 21045, 1-410964-2880, Chesapeake Dental
Conference, Sept.
17-19, Ocean City.
Massachusetts Dental
Society, Two Willow St., Suite
200, Southborough 01745,
1-508-480-9797, Yankee Dental

JADA, Vol. 135, January 2004

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29

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dDr. John P. Sullivan,

Naperville, Ill., was appointed
legal counsel of the American
College of Legal Medicine.
dDr. Thomas D. Taylor,
Farmington, Conn., received the
Presidents Award from the
American College of
Prosthodontists. Other recipients
are Dr. Howard M.
Landesman, Denver,
Distinguished Service Award;
Dr. Kenneth Malament,
Boston, the Dan Gordon Award;
Dr. Charles Goodacre, Loma
Linda, Calif., Educator of the
Year Award; and Dr. Robert
Kelly, Farmington, Conn.,
Clinician/Research Award.
dDr. Donald Warren,
Southern Pines, N.C., received
the Honors of the Association
Award from the American
Speech-Language-Hearing
Association.

N E W S

30

87111, 1-505-294-1368, June

9-12, Albuquerque.
New York State Dental
Association, 121 State St., 4th
Floor, Albany 12207, 1-518-4650044, May 13-16, New York City.
North Carolina Dental
Society, P.O. Box 4099, Cary
27519, 1-919-677-1396, May 1316, Myrtle Beach, S.C.
North Dakota Dental
Association, P.O. Box 1332,
Bismarck 58502, 1-701-223-8870,
Midwinter Meeting, Jan. 2324, Fargo; Annual Session,
Sept. 10-12, Bismarck.
Ohio Dental Association,
1370 Dublin Road, Columbus
43215-1009, 1-614-486-2700,
Sept. 16-19, Columbus.
Oklahoma Dental Association, 629 N.W. Grand Blvd.,
Oklahoma City 73118, 1-405848-8873, April 29-May 2,
Tulsa.
Oregon Dental Association,
17898 S.W. McEwan Road,
Portland 97224, 1-503-620-3230,
Oregon Dental Conference,
April 1-3, Portland.
Pennsylvania Dental
Association, P.O. Box 3341,
Harrisburg 17105, 1-717-2345941, April 22-25, Hershey.
Colegio de Cirujanos
Dentistas de Puerto Rico, 200
Domenech Ave., San Juan 00918,
1-787-763-6335,
Feb. 18-21, San Juan.
Rhode Island Dental
Association, 200 Centerville
Road, Suite 7, Warwick 028864339, 1-401-732-6833, May 19,
Providence.
South Carolina Dental
Association, 120 Stonemark
Lane, Columbia 29210, 1-803750-2277, April 29-May 2,
Myrtle Beach.
South Dakota Dental
Association, P.O. Box 1194, 711
E. Wells Ave., Pierre 57501-3335,
1-605-224-9133, Annual

Session, May 13-16, Rapid

City.
Tennessee Dental Association, P.O. Box 120188, Nashville
37212, 1-615-383-8962, Annual
Session, May 13-16, Memphis.
Texas Dental Association,
1946 S. IH35, Suite 400, Austin
78704, 1-512-443-3675, The
Texas Meeting, May 13-16,
San Antonio.
Utah Dental Association,
1151 E. 3900 South, Suite B160,
Salt Lake City 84124, 1-801-2615315, Feb. 26-27, Salt Lake
City.
Vermont State Dental
Society, 100 Dorset St., Suite
18, South Burlington 054036241, 1-802-864-0115, Vermont
Annual Dental Team
Meeting, Sept. 23-24,
Burlington.
Virginia Dental Association, 7525 Staples Mill Road,
Richmond 23228, 1-804-2611610, Sept. 8-12, Norfolk.
Washington State Dental
Association, 2033 Sixth Ave.,
Suite 333, Seattle 98121, 1-206448-1914, Pacific Northwest
Dental Conference, July
22-23, Seattle.
West Virginia Dental
Association, 2003 Quarrier St.,
Charleston 25311-2212,
1-304-344-5246, Annual
Session, July 15-18, White
Sulphur Springs.
Wisconsin Dental Association, Suite 1300, 111 E.
Wisconsin Ave., Milwaukee
53202-4815, 1-414-276-4520,
Jewel of the Great Lakes,
May 1-2, Milwaukee.
Wyoming Dental Association, 502 S. Fourth St., Laramie
82070, 1-307-755-4009, Annual
Session, June 10-13,
Sheridan.
Compiled by Mark Berthold, senior editor,
ADA News.

JADA, Vol. 135, January 2004

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Conference, Jan.
29-Feb. 1, Boston; Annual
Session, May 14, Boston.
Michigan Dental Association, 230 Washington Square, N,
Suite 208, Lansing 48933,
1-517-372-9070, May 19-22,
Detroit.
Minnesota Dental Association, 2236 Marshall Ave., Saint
Paul 55104, 1-651-646-7454,
Star of the North Meeting,
April 23-26, Saint Paul.
Mississippi Dental Association, 2630 Ridgewood Road,
Jackson 39216, 1-601-982-0442,
June 4-9, Destin, Fla.
Missouri Dental Association, 3340 American Ave., P.O.
Box 104900, Jefferson City
65110-4900, 1-573-634-3436,
MDA Winter Session, Jan. 1617, Columbia; Heart of
America Dental Symposium,
July 28-31, Branson.
Montana Dental Association, P.O. Box 1154, Helena
59624-1154, 1-406-443-2061,
Annual Meeting, May 5-7,
Great Falls.
Nebraska Dental Association, 3120 O St., Lincoln
1-402-476-1704, April 23-25,
Lincoln.
Nevada Dental Association, 8863 W. Flamingo Road,
Suite 102, Las Vegas 89147,
1-702-255-4211, Feb. 6-7,
Las Vegas.
New Hampshire Dental
Society, 23 S. State St., Concord
03301, 1-603-225-5961, Annual
Meeting, May 13-15, Mohegan
Sun Casino.
New Jersey Dental
Association, One Dental Plaza,
P.O. Box 6020, North Brunswick
08902-6020, 1-732-821-9400,
Annual Convention, June 911, Atlantic City.
New Mexico Dental
Association, 3736 Eubank
Blvd., Suite D2, Albuquerque