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Abstract
The complete sequence of the cDNA for the pro0t2(I) chain of bovine type I procollagen is
presented. The encoded amino acid sequence shows 92.0% identity to the human pro0t2(l)
collagen chain.
Key words: bovine, pro0t2(I) collagen.
Boviae
-110
taagttggaggtactggcca
-g0 cgactgcatgcctgcgccc9ccaggtgatacctccgcc9gtgaccaggggctctgcgcacaaggagtcgcatgtct9agtgtagac
i atgctcagctttgtggatacgcggactttttgtgcttgcagtaacttcgtgcctgaaatgaatccttacaagaggaactgca
I
S C
L
HumAn
Human
P
P
G
T
-L
180
60
181 c t c c t g g c c c c c t g g c c c c t g c c c c c t g g c t g c g a a c t t t c t g c c a g t t t g a t c a a a g a . . . g g t g t
p
264
--
265 g g a c c a t g g g g c t g a g g g a t c c g c c g c t c t 9 a c c t g c c c t c a g g t t c c a g g c t g g g g a g c
8 9 G P M G L M G P R G P P G A S G A P G p Q G F Q G p p
A
88
356
G
]
A
Human
355 ~ g t ~ a a c c ~ g g t c a g a c ~ t c c t g c a g g t g c t c g L g g c c c g c c L g g c c c t c c t g g c a a g g c t g g t g a g ~ a ~ g g t c a c c c t g g a a a a c ~
I I 9 G E P G Q T G P A G A R G P P G P P G K A G E D G H P G K P I 4
A
Bovine
445 g g a g a t g q a g a a g g g t t g t t g 9 a a a g g t t c t g t t t C t g g a a t g g a c t t g g t a a g g a t t a g
Bovine
30
Human
Buaan
61
Bovine
91 aaagcccaatgagataaggaccacgcgaatccaccagccccacaagatgaacgcatcccac
Bovine
Bovine
-1
90
444
534
1 4 9 G R P G E R G V ~ G P Q G A R G F P G T P G L P G F K G I R 1 7 8
Buman
Bovine
535 t c a c a a 9 t c t a t a t t a a c a g c c t g c c c a t t a a t a t t c c t t a a a a c a a c t c c
1
a
G
624
Buman
Bovine
625 c a a a c g a c c c g t g g c t c c g t a g a g a g a c g t g t g t c c c c t c c c a g c g t c c c g t g a a t a t g a a t t
2 0 9 G Q ~ G A R G L P G E R G R V G A P G P A G A R G S
714
D
Human
Bovine
715
ggt~tgtggg~t~tggt~attgg~t~tg~tgg~c~t~cagg~tt~aggtg~t~tgg~aag9gtgaA~t~gga~t~tt
804
2 3 9 G P V G P A G P I G S A G P P G F P G A P G P K G E L G P V 2 6 8
N
Human
Bovine
805 g t a c c t g g t g t g g t g g g g t g t g g g a a g t g g t a g g t t t t g g t g t g a t c t g g a a a
894
Human
269
298
BOVlOl
895 g g a g c c a a t g g g c t t ~ c t ~ t a a 9 g g ~ g ~ t g ~ t ~ g ~ t t ~ g g ~ g ~ g ~ t g g g g c t c ~ g c ~ t ~ t g g a ~ g g g ~ t a ~ t
2
G N ~ G
HULLO
Bovinl
1075
Buman
1165
3
Bulan
Bovine
1255
419
1345
4
1435
4
1525
509
Human
Bovine
Bulaa
Bovine
Buman
Bovi0e
E V G L
G L
V G
T
T
1074
8
ggcgag~tggtg~tgttggg~ag~aggtcctcctggc~cagtggtgaagaaggaaagaqagg~t~a~tggagaaat~a~t
9 G ~ P G A V G Q P G P P G P S G ~ E G K R G B T G ~ I G
$ A
P Q
P N
3
A
1164
T
S
S
A
1344
448
G
L
gg~cagcggga~caa~a9~aga~c~tggcaa~attggatt~cct~ac~aaa~g~c~a~tggtgatc~tgg~aag~tggt~aaaa
9
P A
V
G K
T
a 1524
8
N
~gtcat~ctggt~t~gctg~tgctc~gg~g~t~ag~tcccgat9gcaacaacggt~ctca~gga~t9ga~taca~ggt9tc~a
G
H A
G L
k
G A
R O k
P G
P D G N N
G A
Q G
P
P G
L Q
p
a 1614
538
1704
P
1705 ~ g a g a ~ a g ~ g g t a t c c c t g g t g a ~ t t t g ~ t c ~ c c c t ~ c c c t g c t g g t g ~ a a g a g g g g a g c g g g ~ g c ~ c c c a g g t ~ a a a g t ~ g t ~ c t g c t
5 6 9 G E R G Z P G ~ F G L P G P A G ~ R G E R G p P G ~ S G A ~
L H
P
1794
8
1795 g g g c c t a c t g ~ g c c t a t t ~ g a a ~ c c g a g g ~ c c t t c ~ g ~ a c c c c c ~ g g c c t ~ a t ~ a a a c a a 9 g ~ t 9 ~ c c ~ t g t g g ~ t ~ 9 c ~ t c c
5 9 9 G P T G ~ I G S R G P B G P P G P D G N K G E ~ G V V G A
K
V
a 1884
p
8
V
cactctctccacaccccaaagagtgcggcgcatcagcaagagaaaataaac
1885
2
t
G
19~4
8
p
gg~ctcaga~gtgac~tt9gt~9c~ct~gtagagat~tgct~9t~t9~tcct~gt9ctatt~t~ctcct~t~ctg~ag~aa t
1975
6
Human
Human
ggtt~c~a~ttcc~ctg9aaatatcgg~cc~9ctggtaaagaaggt~tgtgggt~t~t~gtattgacgg~a~ac~tg~g~c~att
1434
Human
Bovine
8
S
ggta9ccgt~tgcaa~tgg~ctgctggtgtg~gagg~c~atgga~a~t~tggt~g~cct~a~agcctg~c~t~at~a~cc~a
1615 g ~ t g ~ a ~ g g t g a a c ~ g ~ t ~ t ~ c t g g t ~ t c c a g ~ c t t c c a g ~ g t ~ t g ~ c t g g c ~ c t ~ c a ~ c a c a g c t g ~ t g a a g c t ~ g ~ a a a c c a
5 3 9 G G K G ~ Q G P A ~ P P O F Q O L P G P A O T A G E ~
S
P
Bovloe
g ~ a g g ~ t ~ c t g g g ~ t g a g g g g a a a t c c t g g c t c c ~ g t g ~ t ~ t a c c t 9 ~ a g c t g a ~ g g ~ a g a g c t g g t g t c a t g g g t ~ c t1254
~t
9 G P P G P P G L R G N P G S R G L P G A D G R A G V M G P A 4 1 8
S
p
Human
Bovine
G N ~
984
I
Bulan
Bovine
Human
Bovine
A G
Human
Bovine
P G
T
Bovine
985 g g ~ t g t ~ g g ~ g ~ t g ~ g t g ~ a ~ g g c g ~ c ~ g ~ g g a c t t g t t ~ g t g a g ~ g g ~ c ~ a g ~ t g g t t c g a a a g g a ~ a 9 a ~ c g g c a a c a a ~
Human
Bovinl
~ G
D
E
P
N
G
H
G P
V
2064
8
T
~ggga~cg~gt~aag~tgg~cccgct~9ccctgct~gccc~9ctggt~tcgtg~ta~t~t~aac~tg~t~a9gtc~tccc~ct 2154
6 B g G D R G E A G P A G P A G P A G P R G S P G E R G E V G P A T I 8
2065
Bovine Proct2(I) c D N A
Bovine
2155 ccccaacgatttcttcctgctgtctctgtcacctgtctaaggggaggaaccaagacccaagggt
7 1 9 G P N G F A G P ~ Q ~ A G Q P G ~ K G ~ R G T K G
87
emaat
7 4
2244
8
Human
Bovine
2245
ggkcct~ttggtcccacaggccccgttgga~c~gccggtccgtct~tccaaat~gcccacctggtcct9~tggaagtcgtggtgatgga
2335
7 7
ggg~tgg~gct~t~t~t~cct~gt~tgctg~c~ga~tggtcccc~t9~ac~tctggt~tct~t~c~t~gcc~ccct
Human
Bovine
Human
Bovine
2424
0
2514
2604
0
~
2605 ggttttctgtctccctctaagtacttctaccaggt9tcgctggatctgtgggtaacctggccccccgcatcgca
6
Bum an
2694
X
2695 ~g~cc~cc~ccc~t~gtccccct~gt~tgtc~cctg9cgtc~at~9t~ctcctggtg~a~ccggtc~tg~cggc~ccct
8
9
9
~
p
p
~
p
p
~
V
~
N
~
V
N
G
~
P
~
E
A
O
H um an
Bovine
2515 g~ctttgtt~tg~g~tccctct~a~gcctg~ac~ctgg~cctc~t~aa~cccaggtccacaaggccttcttggtgctcct
8 3 9 G F V G E K G p S G E p G T k G P P G T P G P Q
Bovine
Human
Bovine
2425 ~gtcctgct~gt~aaga~gggcttcgt9g~cctc~t~gtga~c~ggtc~agt~ggtcga~gtg~agagac~ggtgcctctg~cc~tcct
Human
Bovine
2334
2794
~
~
2705 gg~a~cggtcccccag~cgc~tggtcaacccggacacaag~ggg~gcgtggttaccccggta~c~c~gt~ct~ttggtgctgcc
838 ~ N D m ~
P P ~
)Pt D ~ Q P ( ~ ]HI 14~ 40 ~ ]PL ( ~ Y ~ O LNI ~
~;
~,r ( 3
2874
958
2964
980
101B
3144
1048
3234
1078
Human
Bovine
2875
959
tctcctgccctcagctttcccgttgtaaacgaaaccgtggtaccgtctgcctctgttgtcctgct
~
Human
Hovine
Ip. Q
H
~r
~r
~
I~
G ~ V G
R G
Human
Human
Bovine
Human
Bovine
Human
Bovine
I~
I~
~
T
~,
~
4~ A
P
D
E
3054
3055 ~ctt~aaggg~c~caat~ggttgcaa~tctcccgggtcttgctggtc~tcatggc~tc~gt~ctcccggtgctgtgggtccc~ct
1019 O L K G H N O L
Q G L
P G L
Jk O H H G D Q G ~
P ~ A V G
Human
Bovine
2965 ggtgccttggcccaagagtcccagtggcccacaggtattcgggtgaaagggagcctggtgtaaggtcccaaggtcttcct
989
Bovine
P"
3145 ggtccc~gg9gccct9ct~gtccttctggcccc~ctggc~a~gacggtcgcattggacagcctggtgc~gtcggacctgctggc~ttcgt
1045 ~
p R ~
P 2~ ~
P 8 ~
P 2~ 4~ K b ~ 1~ X ~ Q P G ~
~ ~
P
T
H
T
2~ ~
3235 ~gctctc~g~gtagc~aaggt~ctgctggccctcctg~tccccct~g~c~tcct~gacctcctggcccaagtggtggtg~ttacgagttt
1 0 7 8 G 8 Q G $ Q (~ p A ( ~
P P G P P ~
P P ~
P P (~ P 8 G O O
P
H
V
E
D
3308
3325 ~gttttga~ggag~cttct~cagggc~g~cc~gcctcgctcaccaacttctctcagaccca~ggatt~t9~gttgatgct~ctctgaa~
1109 G F D G D F Y R 2 ~ D
Q P R S P T 8 L R P K D Y E V D2q.
Y
.~ P
3414
1138
3 6 1 5 tctctcacacgttggcccttcttactccgaaggctctgagaacccagcc9cactgcc9agactgagactc9ccc
1 1 3 9 S L M M Q I ~ T L L T P E O S R K N P A R T C R D L R
3324
3504
O
P
3594
8
E
L
3684
8
Human
Bovine
Suman
3505 ccagaatgggcagtggttactactggattaccctaccaaggattctatggatgtatcaaagtatactgtgatttctctactggc
3 1 6 9 p ~ H B G y y W I D p N Q G C T M D A X K V Y C D W
E
Bovine
2595
l
Human
Bovine
Human
Bovine
Human
Bovine
gacctcatccgctcaacctaaactcccagtcagaactggtacaaattccaggccgctgtctg9tagga9aa
9 9 E T C Z ~ Q P E D Z P V K N W Y ~ N S K A K K ~ V ~
N
~
S
D
3685 ~ct~tca~cgg~ggt~ccc~gtttgaatat~tgttga~ggagt~accaccaaggaaatggct~c~caa~ttgcctt~atgcgt~tg~tg
1 2 2 8 T I N G G T Q F Z Y N V E G V T T K E M k T Q L A F M R
~
S
S
3775 gccaaccatgcctctcag~tcacctacc~ttg~a~c~gc~ttgcatacat~gatg~gg~aactggcaacctgaaaaa9gtgtc
| 2 5 9 R N H ~ B Q N I T Y H C K H S X ~ Y M D E E T G N L K K ~
y
3865 ttctgcaagatcctgatgtcacttgttgccgagggcaccagttcacttcactgttcttgtagtggctgctctaaag
1 2 8 9 I ~ G N N D V E L V A E G N H R F T Y T V L V D G
3774
8
3844
V
3954
8
4044
8
Human
Bovine
Human
3955 acaa~tg~atggc~gacaatcattgaat~taaaacaaacaagccatctcgcctgcct~tccttgatattgc~cctttgg~c~tcggt
1 3 1 9 T N E N Q K T X l E Y K T N K P S R L P I L D I k P L
O
T
Bovine
4045 ggcgctg~cc~g~tc~gattgaacattggc~cagtctgtttcaaat~a~c~a~ctca~cctaa~ttaaagaaa~agg~tctga~
4134
F~VD
Human
Bovine
4135
4225
4315
4405
4495
catttct~ttggcc~tt~ctttttcttctttcctaa~tg~aa~ctgaatccttcc~tttcttct~cacatct~cttgctt~ttgtggc
aa~aga~gag~gg~ttg~t~a~agcattgtgc~tacaattta~ttcactccccctcccttttcccctctc~a~a~gatttgg~tttt
~ttttttt~cactctt~c~cctgttgt9g~aaat~t~aacctttgtaa~aa~c~t~a~a~t~aa~ataa~aac~tga~c~
tttgc~cc~ctt~tggcttttg~atatcttccac~ggg~agtttaaaacccaaacttccaaaggtttaaact~cctc~a~ca~tttc
ctgtgagtg~gatccecacctcgt
4224
4314
4404
4494
4518
88
T. Shirai et al.
References
Bateman, J.F., Lamand~, S.R. and Ramshaw, J.A.M.: Collagen
superfamily. In: Extracelhdar Matrix, ed. by Comper, W.D.,