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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Digestive Formula
For Healthy Digestion*
Summary
Digestive Formula is a dietary supplement developed
and manufactured by Pharmanex, LLC that has been
formulated to provide all-natural, comprehensive
support for healthy digestion and the prevention of
occasional intestinal discomfort due to overindulgence
in food and drink.* Standardized Artichoke leaf extract,
Ginger root extract, and a proprietary plant-based
blend of enzymes offer a unique three-step approach
to healthy digestion.* Each of these ingredients may
help aid the healthy digestion of food, prevent and
alleviate symptoms of occasional indigestiongas,
bloating, and heartburn, promote food tolerance, and
help relieve the symptoms of overindulgence in food
or drink.* Digestive Formula is recommended to be
taken with meals for the relief or prevention of the
symptoms associated with occasional indigestion.*
Background
The function of the digestive tract is to break
down the foods we eat into simple molecules such as
glucose, amino acids, and fatty acids. Proper digestion
is essential for good health; anything that adversely
affects digestion may not only cause discomfort, but
may lead to more serious conditions. Millions of
people throughout the world suffer from impaired
digestion and digestive complaints. About one third
of the total US population suffers from occasional
digestive complaints.1 Symptoms include early feelings
of satiation and loss of appetite, heartburn, nausea,
vomiting, flatulence, excessive belching, fat intolerance,
irregular bowel movements, etc.2
Many digestive complaints may be due to a poorly
functioning liver-bile system.1 The liver stimulates bile
production, which is then stored in the gall bladder;
bile is secreted from the gall bladder into the small
intestine to help digest fats. Bile is also a primary route
through which toxins are eliminated from the body, so
when bile production is inhibited, this can lead to
increased retention of toxic substances.3 Furthermore,
bile promotes the incorporation of water into stools,
thus softening them.
Decreased bile flow is considered to be the main cause
of non-ulcer digestive complaints.1 Decreased bile flow
is a common cause of digestive disturbances including
Digestive Enzyme(s)
Amylase (Starch)
Glucoamylase (Maltodextrins)
Cellulase (Cellulose)
Lactase (Lactose)
Proteins
Proteases
Bromelain
Fats
Lipase
Health Benefits
Digestive Formulas unique 3-step approach stops
the symptoms of occasional indigestion before they start
by promoting healthy digestion and may help prevent
and alleviate symptoms of occasional indigestiongas,
bloating, and heartburn, and help relieve the symptoms
of overindulgence in food or drink.* 3,611
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Relative change in
biliary volume [%]
160
140
120
100
80
60
40
20
0
-20
-40
Artichoke
Leaf Extract
Placebo
30
60
90
120
150
180
Time [minutes]
GingerClinical Studies
Based on current research, Ginger has been shown
to be effective in reducing nausea of various causes.
In a double blind, placebo-controlled clinical study,
80 naval cadets were given Ginger or a placebo while
at sea. Symptoms of nausea were recorded once an
hour during 4 hours after treatment. Symptoms in the
Ginger group were 38% less than in the placebo group.16
Another clinical study evaluated the efficacy of Ginger
in 36 patients with histories of severe motion sickness.
The Ginger group was able to tolerate mechanically
induced motion sickness better than the dimenhydrinatemedicated group and the placebo group.17
The effectiveness of ginger in post-surgery nausea has
been evaluated in a double-blind, randomized study. Sixty
women who had undergone gynecological surgery were
given ginger, placebo, or the drug metoclopramide.The
incidence of nausea was significantly lower in the ginger
root group as compared to placebo, and was similar to the
metaclopramide group.28
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Proprietary Processing
Side Effects
1.
How Supplied
Digestive Formula is supplied in a bottle of 60
gelatin capsules. Each capsule provides 200 mg Ginger
root extract, 145 mg Pharmanex Proprietary Enzyme
Blend and 135 mg of Artichoke Leaf Extract.
Storage
Store in a cool, dry place. Avoid excessive heat.
Protect from light.
Shelf Life
Expiration date and lot code numbers are stamped
on the bottle.
Warnings
Keep out of reach of children. If you are pregnant
or nursing, or taking a prescription medication, consult
a physician before using this product.
References
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Contraindications/Drug Interactions
If you are pregnant or lactating, taking a prescription medication, or have a medical condition, consult
9.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
10. Lin MY, DiPalma JA, Martini MC, Gross CJ, Harlander SK,
Savaiano DA. Comparative effects of exogenous lactase
(beta-galactosidase) preparations on in vivo lactose digestion.
Dig.Dis.Sci 1993;38:2022 7.
11. Lami F, Callegari C,Tatali M et al. Efficacy of addition of
exogenous lactase to milk in adult lactase deficiency. Am J
Gastroenterol. 1988;83:1145 9.
12. Fintelmann,V. [Artichoke leaf extract]. Z Allg Med
1996;92:3 19,48.
13. Kraft K. Artichoke leaf extractrecent findings reflecting effects
on lipid metabolism, liver and gastrointestinal tracts. Phytomedicine
1997;4:369 78.
14. Lichter Pharma US, Inc. CynaraSL backgroundArtichoke
for the treatment of dyspeptic complaints. 2000:5 9.
15. Artichoke leaf. In: Blumenthal M, Goldberg A, Brinckmann J,
eds. Herbal MedicineExpanded Commission E Monographs.
Newton, MA: Integrative Medicine Communications 2000:10 2.
16. Grontved A, Brask T, Kambskard J, Hentzer E. Ginger root
against seasickness. Acta Oto-Laryngol. 1988;105:45 9.
17. Holtmann S.The Anti-Motion Sickness Mechanisms of Ginger.
Acta Oto 1989;16874.
18. Livesey G.Tolerance of low-digestible carbohydrates: a general
view. Br J Nutr 2001;85 Suppl 1:S716.:S716.
19. Levitt MD, Furne J, Olsson S.The relation of passage of gas an
abdominal bloating to colonic gas production. Ann Intern. Med
1996;124:422 4.
20. Ganiats TG, Norcross WA, Halverson AL, Burford PA, Palinkas
LA. Does Beano prevent gas? A double-blind crossover study of
oral alpha-galactosidase to treat dietary oligosaccharide intolerance. J Fam.Pract 1994;39:4415.
21. Corazza GR, Benati G, Sorge M, Strocchi A, Calza G, Gasbarrini
G. beta-Galactosidase from Aspergillus niger in adult lactose
malabsorption: a double-blind crossover study.Aliment Pharmacol
Ther 1992;6:61 6.
22. Medow MS,Thek KD, Newman LJ, Berezin S, Glassman MS,
Schwarz SM. Beta-galactosidase tablets in the treatment of
lactose intolerance in pediatrics.Am J Dis Child 1990;144:12614.
23. Rode LM,Yang WZ, Beauchemin KA. Fibrolytic enzyme
supplements for dairy cows in early lactation. J Dairy Sci
1999;82:2121 6.
24. Beauchemin KA,Yang WZ, Rode LM. Effects of grain source
and enzyme additive on site and extent of nutrient digestion in
dairy cows. J Dairy Sci 1999;82:378 90.
25. Friesen OD, Guenter W, Rotter BA, Marquardt RR.The effects
of enzyme supplementation on the nutritive value of rye grain
for the young broiler chick. Poult Sci 1991;70:25018.
26. Nahm KH, Carlson CW. Effects of cellulase from Trichoderma
viride on nutrient utilization by broilers. Poult Sci
1985;64:153640.
27. Zempsky WT, Rosenstein BJ, Carroll JA, Oski FA. Effect of
pancreatic enzyme supplements on iron absorption. Am J Dis
Child 1989;143:969 72.
28. Bone ME,Wilkinson DJ,Young JR, McNeil J, Charlton S.
Ginger roota new antiemetic.The effect of ginger root on
postoperative nausea and vomiting after major gynaecological
surgery. Anaesthesia 1990;45:669 71.
29. Bragelmann R, Armbrecht U, Rosemeyer D, Schneider B, Zilly
W, Stockbrugger RW.The effect of pancreatic enzyme supplementation in patients with steatorrhoea after total gastrectomy.
Eur J Gastroenterol Hepatol. 1999;11:2317.
30. Braga M, Cristallo M, De Franchis R et al. Correction of
malnutrition and maldigestion with enzyme supplementation in
patients with surgical suppression of exocrine pancreatic function.
Surg Gynecol Obstet 1988;167:485 92.
31. Ramo OJ, Puolakkainen PA, Seppala K, Schroder TM. Selfadministration of enzyme substitution in the treatment of
exocrine pancreatic insufficiency. Scan J Gastroenterol
1989;24:688 92.
32. Jansen JB, Jebbink MC, Mulders HJ, Lamers CB. Effect of
pancreatic enzyme supplementation on postprandial plasma
cholecystokinin secretion in patients with pancreatic insufficiency. Regul Pept 1989;25:333 42.
33. Andren-Sandberg A.Theory and practice in the individualization
of oral pancreatic enzyme administration for chronic pancreatitis.
Int J Pancreatol. 1989;5 Suppl:51 62.
34. Ansaldi-Balocco N, Santini B, Sarchi C. Efficacy of pancreatic
enzyme supplementation in children with cystic fibrosis:
comparison of two preparations by random crossover study and
a retrospective study of the same patients at two different ages. J
Pediatr Gastroenterol Nutr 1988;7 Suppl 1:S40 5.
35. Petersen W, Heilmann C, Garne S. Pancreatic enzyme supplementation as acid-resistant microspheres versus enteric-coated
granules in cystic fibrosis. A double placebo-controlled crossover study. Acta Paediatr Scan 1987;76:66 9.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Sourcing
Structure
Substantiation