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_________________________
. THYROID DISEASES:
___________________
___________________
. P.O.C.
idism
-----* Labs
TSH
* Weight
* Intolerance
* Hair
* Skin
* Mental
* Heart
a & Af
* Muscles
* Reflexes
e
* Fatigue
* Menstrual changes
-----------
Gain
Cold
Coarse
Dry
Depressed
Bradycardia
______________
______________
______________
______________
______________
______________
Loss
Heat
Fine
Moist
Anxious
Tachycardi
___________________ Week
___________________ Diminished
______________ Week
______________ Hyperactiv
___________________ Yes
___________________ Yes
______________ Yes
______________ Yes
. HYPOTHYROIDISM:
_________________
* PRIMARY Hypothyroidism * * Secondary Hypothyroidism *
idism *
________________________
_________________________
______
. -- T3 & T4.
. -- T3 & T4.
. ++ TSH.
. -- or normal TSH.
. Ex: Auto-immune Hashimoto's.
* TERTIARY Hypothyro
___________________
. -- T3 & T4.
. -- or normal TSH.
. HASHIMOTO's THYROIDITIS:
__________________________
. Hypothyroidism symptoms: Slow, tired, fatigued pt with weight gain.
. Anti-TPO Abs (Anti-thyroid peroxidase antibodies).
. -- T4 & ++ TSH.
. Tx -> T4 or thyroxine replacement.
. High risk of developing THYROID LYMPHOMA.
. GENERALIZED RESISTANCE to thyroid hormones:
_____________________________________________
. ++ T3 & T4 levels.
. ++ or Normal TSH level.
. features of HYPO-thyroidism despite having ++ free T3 & T4.
. N.B. HYPOTHYROIDISM & MYOPATHY:
_________________________________
. Un-explained ++ ofe serum CPK creatinine kinase.
. ANA Anti-nuclear antibodies may be +ve in HASHIMOTO's thyroiditis.
. Serum TSH level is the most sensitive test to diagnose hypothyroidism.
. HYPERTHYROIDISM -> "Grave's disease" - "Silent"
adenoma":
- "Subacute" - "Pituitary
________________________________________________________________________________
__________
. Physical findings: . Eye,skin,nails - Not tender - Tender gland - None.
. RAIU scan:
.
(++)
- (--)
(--)
- (++).
. TTT:
. Iodine ablation - None
Aspirin - Surgical r
emoval.
.1. GRAVE's DISEASE:
____________________
. Symptoms of thyrotoxicosis (weight loss - insomnia - hperactivity - tachycard
ia).
. Ophthalmopathy (Exophthalmos & proptosis - Abs against the extra-ocular muscl
es).
. Dermopathy (Thickening & redness of the skin just below the knee).
. Onycolysis (Separation of the nail from the nailbed).
. Peri-orbital lymphocytic infiltration -> Gritty sandy sensation.
. Fibroblast proliferation, hyaluronic acid deposition, edema & fibrosis.
. Throid stimulating immunoglobulins.
. RAIU -> HIGH.
. Tx -> Propylthiouracil (PTU) or methimazole.
. Use radioactive iodine to ablate the gland (May cause permanent HYPO-thyroidi
sm).
. BB (propranolo) to treat sympathetic symptoms, such as tremos & palpitations.
.2. SILENT Thyroiditis:
_______________________
. Auto-immune process.
. Symptoms of thyrotoxicosis (weight loss - insomnia - hperactivity - tachycard
ia).
. NON-tender gland.
. No skin, eye or nail diseases.
. RAIU -> NORMAL.
. Tx -> NONE !
.3. SUB-ACUTE Thyroiditis = De QUERVAIN's THYROIDITIS:
______________________________________________________
. Viral etiology.
. ++ ESR > 50 mm/hr.
. Thyroid TENDRNESS.
. Syms last for < 8 wks due to thyroid depletion.
. RAIU -> LOW.
. Tx -> ASPIRIN to relieve pain.
.4. PITUITARY ADENOMA:
______________________
. THE ONLY CAUSE OF HYPERTHYROIDISM WITH ++ T4 & ++ TSH !
. Dx -> Brain MRI.
. Tx -> Surgical removal.
.N.B. EXOGENOUS THYROID HORMONE ABUSE:
______________________________________
. ++ T4 & -- TSH.
. The galnd will atrophy to the degree of non-palpability on exam.
. N.B. THYROID STORM:
_____________________
. Acute, severe life threatening hyperthyroidism.
. Tx -> IODINE -> Blocks uptake of iodine into the gland.
. Tx -> Propylthiouracil or methimazole -> Blocks the production of thyroxine.
. Tx -> Dexamethazone -> Blocks peripheral conversion of T4 to T3.
_____________________________________________________________________
. HYPOTHYROIDISM:
_________________
. Destruction of thyroid flollicles by radioactive iodine.
. Tx of hypothyroidism is Levo-thyroxine.
. Ophthalmopathy may worsen in 10 % of cases.
. THYROTOXICOSIS:
_________________
. may be a side effect of RADIO-IODINE theray !!
. I - 131 is taken up by thyroid follicles & then destroys them by emitting B-r
ays.
. Dying thyroid cells may release excess thyroid hormone into the circulation.
. Aggravating the hyperthyroid state.
. CONTRA-INDICATIONS to RADIO-ACTIVE IODINE THERAPY:
____________________________________________________
. PREGNANCY.
. VERY SEVERE OPHTHALMOPATHY.
. SIDE EFFECTS of ANTI-THYROID DRUGS (PROPYLTHIOURACIL):
________________________________________________________
. AGRANULOCYTOSIS (fever & sore throat) -> Stop the drug !
. SURGERY SIDE EFFECTS:
_______________________
. Permanent hypothyroidism.
. Risk of recurrent laryngeal nerve damage.
. COMPLICATIONS of UN-TREATED HYPER-THYROID PATIENTS:
_____________________________________________________
-> RAPID BONE LOSS -> due to ++ osteoclastic activity .
-> CARDIAC TACHYARRHYTMIA (Af).
. N.B. HYPERTENSION in pts with THYROTOXICOSIS:
_______________________________________________
. is predominantly SYSTOLIC.
. caused by HYPERDYNAMIC CIRCULATION.
. N.B. INDICATIONS OF THYROID FUNCTION TESTS:
_____________________________________________
-> HYPERLIPIDEMIA.
-> Un-explained hyponatremia.
-> Un-exlained ++ CPK.
# THYROID MALIGNANCIES:
_______________________
1 * PAPILLARY CARCINOMA:
________________________
-> MOST COMMON TYPE & BEST PROGNOSIS.
-> Slow infiltrative local spread.
-> Presence of PSAMMOMA bodies.
2 * MEDULLARY CARCINOMA:
________________________
-> CALCITONIN secretion.
3 * FOLLICULAR CARCINOMA:
_________________________
-> Invasion of the tumor capsule & blood vessels.
-> Early metastasis to distant organs.
.
.
.
.
.
____________________
____________________
____________________
____________________
____________________
.
.
.
.
.
> 600
> 18
NORMAL.
NEGATIVE.
> 320.
. DIABETIC NEPHROPATHY:
_______________________
. Begins with HYPERFILTRATION (++GFR) & MICROALBUMINURIA.
. If not ttt well .. Micro becomes Macroalbumiuria > 300 mg/dl.
. INTENSIVE BLOOD PRESSURE CONTROL to prevent worsenening of the condition.
. Use ACE Is with blood pressure goal 130/80 mmHg.
. Most sensitive screening test is -> RANDOM URINE MICRO-ALBUMIN/CREATININE RAT
IO.
. DIABETIC NEUROPATHY:
______________________
. DISTAL SYMMETRIC SENSORIMOTOR PLOYNEUROPATHY.
. STOCKING GLOVE pattern.
. It is the most common risk factor of foot ulcerations in diabetics.
. Tx -> TCAs (Amitriptyline - Gabapentin).
. DIABETIC GASTROPATHY:
_______________________
. Autonomic neuropathy of the GIT.
. Symptoms of delayed gastric emptying & gastroparesis.
. -- Esophageal dysmotility -> Dysphagia.
. -- Gastric emptying -------> Gastroparesis.
. Gastroparesis (Nausea - vomiting - early satiety - postprandial fullness).
. -- intestinal function ----> diarrhea - constipation - incontinence.
. Tx -> DN control - SMALL FREQUENT MEALS - METOCLOPROMIDE (prokinetic & Antiem
itic).
. SEs of Metoclopromide -> Extrapyramidal syms -> Tardive dyskinesia (Give Eryt
hromycin).
. ERECTILE DYSFUNCTION in D.M.:
_______________________________
. Due to vascular complications & neuropathy.
. 1st line of ttt is phosphodiesterase inhibitor (Sildenafil).
. Contr'd in pts being ttt with NITRATES.
. Sildenafil may predispose to PRIAPISM.
. When combined with an Alpha blocker (Prazosin), it is imp. to give them 4 hrs
apart,,
. to avoid SEVERE HYPOTENSION.
. DIABETIC FOOT management -> DEBRIDEMENT & proper wound care.
______________________________________________________________
. CAUSES OF HYPOGLYCEMIA in NON-DIABETIC pts:
_____________________________________________
1 - INSULINOMA (BETA cell tumor).
2 - SURREPTITIOUS use of insulin or sulfonylurea.
. INSULINOMA:
_____________
. BETA CELL TUMOR.
. Normally, blood glucose < 60 mg/dl result in complete suppression of insulin
secretion.
. Hypoglycemia in the presence of inappropriately ++ serum insulin levels = ins
ulinoma.
. ++ C-peptide level.
. ++ Pro-insulin.
. DIABETES INSIPIDUS:
_____________________
. Due to ADH defeciency or resistance.
. Urine osmolality is < serum osmolality.
. Polyurea & polydipsia.
. H/O of tendency to COLD BEVERAGES to QUENCH THIRST.
. Exclude psychogenic polydipsia using water deprivation test.
. Differentiate bet. central & nephrogenic DI using ARGININE VASOPRESSIN.
. Tx -> NORMAL SALINE.
. Tx -> CENTRAL -> INTRANASAL SPRAY DDAVP.
. Tx -> NEPHROGENIC -> NSAIDs & HCZ.
. HOW CAN U DIFFERENTIATE BET. DI & PSYCHOGENIC POLYDIPSIA:
___________________________________________________________
. WATER DEPRIVATION TEST:
__________________________
. Failure to concentrate urine after deprivation -> DI.
. Production of concentrated urine ---------------> Psychogenic polydipsia.
. HOW CAN U DIFFERENTIATE BET. CENTRAL & NEPHROGENIC DI:
________________________________________________________
. ARGININE VASOPRESSIN (AVP) or DESMOPRESSIN adminstration:
____________________________________________________________
. CENTRAL DI -----> ++ in urine osmolality.
. NEPHROGENIC DI -> No significant ++ !
. SYNDROME OF INAPPROPRIATE ADH SECRETION (SIADH):
__________________________________________________
. ++ ADH levels without stimuli of its release.
. NORMAL SERUM osmolality -> 275 - 295 mOsm.
. NORMAL URINE osmolality -> 50 - 1400 mOsm.
. Dx -> Simultaneous measurment of urine & plasma osmolality.
. The normal response to hypotonicity (low plasma osmolality) is ,
. the production of maximally diluted urine (low urine osmolality -> < 100 mOsm
.)
. LOW plasma osmolal. (<280 mOsm.) & HIGH urine osmolality (>100-150mOsm) is di
agnostic.
. Tx of SIADH:
-> Mild symptoms (forgetfulness & unstable gait) -> Fluid restriction.
-> Moderate symptoms (Confusion & lethargy) -> HYPERTONIC SALINE (3%).
-> Severe symptoms (seizures & coma) -> Hypertonic saline + Conivaptan.
. BOTTOM LINE:
______________
* Diabetes insipidus:
______________________
. Polyurea - polydipsia - excretion of diluted urine with ++ serum osmolality.
* 1ry (Psychogenic) polydipsia:
________________________________
. Excessive water drinking -> BOTH plasma & urine are diluted.
* SIADH:
_________
. Hyponatremia - LOW serum osmolality & inappropriately high urine osmolality.
. P.O.C.------- # DIABETES INSIPIDUS -------- # PSYCHOGENIC POLYDIPSIA ---------
# SIADH
_____
__________________
_____
-> SERUM osm. --->
(+)
(-)
-> URINE osm. --->
(-)
(+)
______________________
(-)
(-)
. HYPER-VITAMINOSIS "D":
________________________
. H/O of trials of weight loss with vitamin supplementations.
. Vit. D ++ Ca absorption -> Hypercalcemia.
. Constipation - Abd. pain - Polyurea - Polydipsia.
. METABOLIC $YNDROME:
_____________________
1- ABDOMINAL OBESITY ->
2- DIABETIS MELLITIS ->
3- HYPERTENSION ------>
4- HYPERLIPIDEMIA ---->
mg/dl).
.
.
.
ed
.
.
.
.
.
Pts with hypo-albuminemia can have a low level of total plasma ca,
However ,, They may NOT present with clinical hypocalcemia,
Because their level of ionized calcium (physilologically active form) remain
normal.
So .. it is imp. to calculate the CORRECTED SERUM CALCIUM LEVEL.
CORRECTED SERUM CALCIUM LEVEL = TOTAL Ca + 0.8 (4 - Serum Albumin).
Another rough method,
With every 1 g/dl change in serum albumin level from 4 g/dl,
there is a change in total plasma Ca level by 0.8 mg/dl.
.|
.|
.|
.+1,25(OH)D
.+25(OH)D
.|
.|
.|
.________________
.+PTHrP
AL LABs
.|
.|
.|
.|
.> 250
.< 100
.TUMOR
THYROIDISM
.|
.|
P. MYELOMA
1ry or 3ry
.Familial
al tumor
Hyperpara.Hypercalcemic
egaly
thyroidism
.Hypocalciuria
toxicity
.NORM
ilization
. IMPORTANT CASE SCENARIO:
__________________________
. Rapid ascent to a height of 10000 feet -> HYPO-calcemia ! HOW ?? (++ Albumin
bound Ca).
________________________________________________________________________________
__________
. Respiratory alkalosis = ++ pH level -> ++ the affinity of serum albumin to ca
lcium.
. ++ the levels of ALBUMIN-bound Ca -> -- the level of IONIZED Ca (Active form)
.
. -- Ionized Ca (Active form) -> Hypocalcemia manifestations.
. PAN-HYPO-PITUITARISM:
_______________________
* Pituitary tumors are the most common cause by exerting pressure on pituitary
cells.
* ACTH defeciency (2ry adrenal insuffeciency): "-- Glucocorticoids":
____________________________________________________________________
-> Postural hypotension & tachycardia.
-> Fatigue & weight loss.
-> -- libido, hypoglycemia & eosinophilia.
* HYPOTHYROIDISM (Central):
___________________________
-> Fatigue, cold intolerance, -- appetite, constipation & dry skin.
-> Bradycardia, delayed relaxation phase of DTRs & anemia.
* -- GONADOTROPINS:
___________________
-> Women -> Amenorrhea, infertility & hot flashes.
-> Men -> -- energy & libido.
. OSTEOPOROSIS:
_______________
. Postmenopausal woman.
. presenting with multiple bony #s.
. NORMAL serum Ca - PO4 & PTH.
. OSTEOMALACIA:
_______________
. Vit. D defeciency in ADULTS.
. Bony pain & tendrness.
. -- serum Ca & PO4.
. -- urinary Ca.
. ++ ALP & ++ PTH.
. -- 25 OH-D.
. X-ray -> BILATERAL SYMMETRIC PSEUDO-FRACTURES (LOOSER ZONES).
. PAGET's DISEASE:
__________________
. NORMAL serum Ca - PO4 & PTH.
. INCREASED ++ ALKALINE PHOSPHATASE.
. Tx -> BIPHOSPHONATES -> inhibit OsteoCLASTs asctivity.
. CAUSES of HYPOKALEMIA & --BICARBONATE HCO3 {Metabolic Alkalosis} -> (Check REN
IN):
________________________________________________________________________________
____
.. CAUSES of HYPOKALEMIA & ++ ALDOSTERONE & -- RENIN -> PRIMARY HYPER-ALDOSTERON
ISM.
_____________________________________________________
.. CAUSES of HYPOKALEMIA & ++ BOTH ALDOSTERONE & RENIN -> (Check Cl):
_____________________________________________________________________
(A) WITH ++ CHLORIDE (Check Na):
_________________________________
1- -- Na -----> (Diuretic use).
2- Normal Na -> (Bartter's $).
3- ++ Na -----> (Renin secreting tumor).
. SURREPTITIOUS VOMITING:
_________________________
. Scars & calluses on the dorsum of the hands & dental erosions.
. Result from chemical & mechanical injury as the pt uses his hands to induce v
omiting.
. Dental erosions result due to ++ exposure to gastric acid..
. May lead to hypovolemia & hypochloremia -> Low urine Cl level.
. CAUSES OF HYPERTENSION & HYPOKALEMIA:
_______________________________________
. Primary hyperaldosteronism & Reno-vascular hypertension.
. Check the PLASMA RENIN ACTIVITY (PRA).
. Primary hyperaldosteronism -> LOW PRA.
. Reno-vascular hypertension -> HIGH PRA.
# ADRENAL DISORDERS:
____________________
____________________
.1. CUSHING $YNDROME = HYPER-Corticolism:
_________________________________________
. ++ Cortisol.
. Fat redistribution -> Truncal obesity - moon face - buffalo hump - thin arms
& legs.
. Easy bruising & striae -> Cortisol leads to loss of collagen.
. Hypertension -> From salt & water retention.
. Ms wasting.
. Hirsutism -> due to ++ adrenal androgen levels.
. Hyperglycemia - Hyperlipidemia - Leukocytosis - Metabolic alkalosis.
. Dx -> 1 mg over-night dexamethasone suppression test:
_______________________________________________________
. Give dexamethasone at 11 a.m. the night before.
. A normal person will will suppress the 8 a.m. level.
. A NORMAL 1 mg overnight dexamethasone suppression test EXCLUDES hypercorticol
ism.
. Abnormal test may be false elevated due to stress or alcoholism.
. Dx -> 24 hour urine cortisol:
_______________________________
. Done to confirm that an overnight dexamethasone suppression test is not false
ly ++.
_______________________________________________________________________________
_
. Sources of Cushing $ ------> Pituitary tumor - Ectopic - ACTH Adrenal adenoma
:
_______________________________________________________________________________
_
.
.
.
.
ACTH ---------------------->
High dose dexamethazone --->
Specific tests ------------>
Tx ------------------------>
HIGH
Suppression
MRI
Removal
- HIGH
No
CT
- Removal
LOW.
No.
CT adrenals.
Removal.
. ACTH LOW
.________________
____
.|
. PRIMARY AI
RY AI
.3. PRIMARY HYPER-ALDOSTERONISM:
.|
. SECONDARY or TERTIA
________________________________
. Hypokalemia + Hypertension + Proximal muscle weakness & numbness.
. Hypernatremia + metbaolic alkalosis.
. Dx -> Measure (PA:PRA) -> Plasma Aldosterone : Plasma Renin Activity ratio.
. Result -> ++ Plasma Aldosterone & -- Plasma Renin Activity i.e. Ratio > 30 !
. (PA:PRA) -> is the most specific test.
. Confirm the diagnosis -> Aldosterone suppression test.
. Give oral or IV NaCl then measure 24 hs urinary or plasma aldosterone level.
. If Aldosterone level > 14 mg/24 hs despite Na loading -> So Dx is confirmed.
. Once u confirm the diagnosis -> Detect the cause,
. CT scan of the adrenals -> Adrenal mass -> Adrenal vein sampling.
. EVALUATION OF SUSPECTED HYPERALDOSTERONISM:
_____________________________________________
. HYPERTENSION & HYPOKALEMIA
_____________________________
|
. Measure PLASMA RENIN ACTIVITY (PRA)
______________________________________
.& PLASMA ALDOSTERONE CONCENTRATION (PAC)
_________________________________________
|
______________________________________________________
|
|
|
. + PRA & + PAC
. - PRA & + PAC
. - PRA & - PAC
________________
________________
________________
|
|
|
SECONDARY HYPERALDOSTERONISM PRIMARY HYPERALDOSTERONISM Other causes of ++ A
ldosterone
____________________________ __________________________ ____________________
__________
* Diuretic use.
* Do a CT ADRENAL to
*Congenital adrenal h
yperplasia
* Liver cirrhosis.
* detect the etiology ! * Glucocorticoid resi
stance.
* Congestive heart failure.
* Exogenous mineraloc
orticoid.
* Reno-vascular hypertension.
* Cushing's $yndrome.
* Renin secreting tumor.
* Malignant hypertension.
* Coarctation of the aorta.
.4. PHEOCHROMOCYTOMA:
_____________________
. Headache, palpitations, tremors, anxiety & flushing.
. Episodic elevations of blood pressue.
. Dx -> BEST INITIAL -> ++ catecholamines level in plasma & urine.
. Dx -> BEST INITIAL -> ++ metanephrines & VMA levels.
. Dx -> MOST ACCURATE -> CT or MRI or MIBG of the adrenal glands.
. Tx -> PHENOXYBENZAMINE (Alpha blocker) "FIRST" to control blood pressure.
. e'out Alpha blockage, BB may lead to CATASTROPHIC ++ in BP due to unopposed A
lpha stim.
. Tx -> Propranolol is used "AFTER" an alpha blocker .
. Tx -> Surgical resection.
. N.B. It is a part of MEN type 2 A & B (DNA testing is imp. RET PROTO-ONCOGENE
).
____________________
- * 17 hydroxylase de
____________________
- * -- Adrenal androg
- * NO hirsutism
- * NO
- * HYPERTENSION
. ++ PRL.
. Hypogoandism & galactorrhea.