Chapter 6: Verrucal-Papillary Lesions

Test Bank
MULTIPLE CHOICE
1. The pathogenesis of some verrucous carcinomas is believed to be related to which of
the following factors?
a. Treponema pallidum
b. Human papillomavirus subtypes 16 and 18
c. Chronic ethanol ingestion
d. Epstein-Barr virus
e. Chronic irritation
ANS: B
REF: Chap 6 (Squamous papilloma/Oral wart; Table 6-1), pp 149-152
2. A 1 1 cm pedunculated lesion of the soft palate was described microscopically as
being composed of projections of benign epithelium supported by small amounts of
fibrovascular tissue. This describes which of the following?
a. Mixed tumor of salivary gland
b. Keratoacanthoma
c. Squamous papilloma
d. Focal fibrous hyperplasia
e. Mucous extravasation phenomenon
ANS: C

REF: Chap 6 (Squamous papilloma/Oral wart), pp 149-152

3. Significant risk of malignant transformation is associated with which of the

following?
a. Papillary hyperplasia
b. Peripheral ossifying fibroma
c. Squamous papilloma
d. Focal epithelial hyperplasia (Hecks disease)
e. None of the above
ANS: E
REF: Chap 6 (Papillary hyperplasia; Squamous papilloma/Oral wart/Focal epithelial
hyperplasia), pp 149-154 | Chap 7 (Peripheral fibroma), pp 163-164
4. Which of the following verrucal-papillary lesions is associated with the wearing of illfitting dentures and frequently Candida albicans overgrowth?
a. Papillary hyperplasia
b. Verrucous carcinoma
c. Keratoacanthoma
d. Condyloma acuminatum
e. Oral wart
ANS: A

REF: Chap 6 (Papillary hyperplasia/Etiology), p 152

Copyright 2012, 2008, 2003, 1999, 1993, 1989 by Saunders, an imprint of Elsevier Inc.

Test bank

5. A firm asymptomatic submucosal lump, measuring 1 1 cm, appeared in the posterior

hard palate of a 27-year-old man. The duration of the lesion was believed to be
approximately 1 month. Clinical differential diagnosis should include all of the
following except:
a. Lymphoma
b. Mucocele
c. Malignant salivary gland tumor
d. Benign salivary gland tumor
e. Squamous papilloma
ANS: E
REF: Chap 6 (Squamous papilloma/Oral wart/Clinical features), p 150
6. Verrucous carcinoma can be a sequela of which of the following?
a. Secondary syphilis
b. Proliferative verrucous leukoplakia
c. Neurofibromatosis
d. Nevoid basal cell carcinoma syndrome
e. Verruca vulgaris
ANS: B
157

REF: Chap 6 (Verrucous carcinoma/Differential diagnosis), p

7. Which of the following lesions is composed predominantly of benign epithelium?

a. Denture-induced hyperplasia
b. Squamous papilloma
c. Granular cell tumor
d. Mucosal neuroma
e. None of the above
ANS: B
REF: Chap 6 (Squamous papilloma/Oral wart/Histopathology), pp 150-151
8. Oral verrucous carcinoma:
a. Is usually treated with surgery
b. May be related to the use of smokeless tobacco
c. Is microscopically well differentiated
d. Rarely metastasizes to the lung
e. All the above
ANS: E
159

REF: Chap 6 (Verrucous carcinomaentire topic), pp 156-

9. The lesion that may spontaneously involute that mimics squamous cell carcinoma
both clinically and microscopically is known as:
a. Papilloma
b. Keratoacanthoma
c. Peripheral giant cell granuloma
d. Condyloma acuminatum
e. Verruca vulgaris

Copyright 2012, 2008, 2003, 1999, 1993, 1989 by Saunders, an imprint of Elsevier Inc.

Test bank

ANS: B

REF: Chap 6 (Keratoacanthoma/Differential diagnosis), p 155

10. Human papillomaviruses, subtypes 16 and 18, have been implicated in the etiology of
which of the following?
a. Burkitts lymphoma
b. Verrucous carcinoma
c. Carcinoma of the nasopharynx
d. Oral Kaposis sarcoma
e. Salivary gland adenocarcinomas
ANS: B

REF: Chap 6 (Verrucous carcinoma/Etiology), p 156

11. Human papillomavirus has been found in which of the following oral lesions?
a. Verrucous carcinoma
b. Proliferative verrucous leukoplakia
c. Oral warts
d. Squamous papillomas
e. All the above
ANS: E
REF: Chap 6 (Verrucous carcinoma/Squamous papilloma/Oral wart), pp 149-152,
156-159
12. All the following statements relative to oral verrucous carcinoma are correct except:
a. May develop from proliferative verrucous leukoplakia
b. Typically metastasizes early to submandibular lymph nodes
c. Usually treated with surgery
d. Microscopically well differentiated
e. Is both exophytic and endophytic
ANS: B

REF: Chap 6 (Verrucous carcinoma/Clinical features), p 156

13. Which of the following verrucal-papillary lesions is associated with chronic

candidiasis and the wearing of ill-fitting dentures?
a. Verrucous carcinoma
b. Verruca vulgaris (oral wart)
c. Dysplasia
d. Keratoacanthoma
e. None of the above
ANS: E

REF: Chap 6 (Papillary hyperplasia/Etiology), p 152

14. Which of the more than 100 human papillomavirus subtypes have been associated
with the development of human carcinomas?
a. Subtypes 2 and 6
b. Subtypes 11 and 13
c. Subtypes 16 and 18
d. Subtypes 13 and 79a
e. All the above

Copyright 2012, 2008, 2003, 1999, 1993, 1989 by Saunders, an imprint of Elsevier Inc.

Test bank

ANS: C

REF: Chap 6 (Squamous papilloma/Oral wart), pp 149-152

15. Oral squamous papillomas:

a. Are composed of squamous epithelium supported by connective tissue
b. Are rare lesions
c. Are a component of the Peutz-Jeghers syndrome
d. Have moderate malignant potential
e. Are caused by cytomegalovirus (CMV)
ANS: A

REF: Chap 6 (Squamous papilloma/Oral wart), pp 149-152

Copyright 2012, 2008, 2003, 1999, 1993, 1989 by Saunders, an imprint of Elsevier Inc.