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Introduction to Genetics
CHAPTER CONCEPTS
Genetics is built on a rich tradition of
discovery and experimentation.
Transmission genetics is the process by which
traits controlled by genes are transmitted
through gametes from generation to
generation.
Mutant strains can be used in genetic crosses
to map the location and distance between
genes.
The Watson-Crick model of DNA structure
explain how genetic information is stored
and expressed. This is the foundation of
molecular genetics.
Recombinant DNA technology
revolutionized genetics, and was the
foundation for the Human Genome Project,
and has generated new fields that combine
genetics with information technology.
Biotechnology provides genetically modified
organisms with uses varying from agriculture
to medicine.
Model organisms used in genetics research
are now utilized in combination with
recombinant DNA technology and genomics
to study human diseases.
Genetic technology is developing faster than
the policies, laws, and conventions that
govern its use.
Introduction to Genetics
I.
History of Genetics
A. Ancient Times
B. Dawn of Modern Biology
C. Charles Darwin and Evolution
II. Advancements in Genetics
A. Mendels Transmission of Traits
B. Chromosome Theory of Inheritance
C. Genetic Variation
D. Chemical Nature of Genes
III. Era of Molecular Genetics
A. Structure of DNA and RNA
B. Gene Expression
C. Proteins and Biological Function
D. Genotype to Phenotype
IV. Recombinant DNA Technology
V. Expansion of Biotechnology
A. Plants, Animals, and the Food Supply
B. Genetics and Medicine
VI. New and Expanding Fields
VII. Model Organisms
A. Modern Set of Genetic Model Organisms
B. Uses on Human Diseases
VIII.
Age of Genetics
A. Nobel Prizes and Genetics
B. Genetics and Society
I. History of Genetics
8000-1000 B.C.
Selective breeding of several species
Cultivation of plants (5000 B.C.)
Golden Age of Greek Culture
Hippocratic School of Medicines On the Seed
argued that humors served as bearers of
hereditary traits (parts in miniature form)
Humors can be altered before passing down
to offspring (inheritance of acquired traits)
Terms
o
Table 1.1. DNA vs RNA
DNA
Double-helix
Deoxyribose sugar
Thymine
Ladder-like
Genotype to Phenotype
Sickle-cell anemia mutant form of
hemoglobin, results from having 1 out of the
146 amino acids in the protein changed
Mutant B-globin cause RBCs to polymerize when the
bloods oxygen concentration is low, forming long
chains of hemoglobin that distort the shape of RBCs
(make it fragile), Sickle-shaped blood cells block blood
flow in cappiliaries and small blood vessels
V. Expansion in Biotechnology
Biotechnology use of recombinant DNA
technology and other molecular techniques to make
products
Plants, Animals, and Food Supply
Transfer of heritable traits across species
using recombinant DNA technology creates
transgenic organisms
Has revolutionized the agriculture industry
Dolly the Sheep (1996), cloned by nuclear
transfer
Genetics and Medicine
Every child bearing couple has an
approximately 3% risk of having a child with
some form of genetic anomaly
Biotechnology has allowed a prenatal
diagnosis of heritable disorders and to test
the parents as carriers