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La respuesta inmune
La respuesta a un
Immunidad Adptativa
varios receptores
TCR, Ig
recombinacin gentica
distribuda ampliamente
distribucin limitada
Clulas B y T
no-clonal
clonal
memoria inmunolgica
Glicoconjugados
B
Glicoprotena
OH CH OH
2
HO
H
OH
Glicolpido
CH2OH O
H H
O
O
H
HN
NH H
H
CH2OH
OH H
H
H
O
C CH3 H
HO
O CH2
H H
H
O
O
H OH
O
O
O
NH4
OH
C
CH2OH
H
H
H
+ - O
H
O
H
H
H
H
HO
OH
H2C H OH
NH H
OH
C CH3
O
O
H H
OH
A
A: Porcin glicano
B: Porcin aglicona
HO
HO
HO
HO O
N-glicosilacin
HO
HO
HO
OO
OH
HO O
HO
HO
HO
HO O
O
O
O
O
HO
HO
HO
OH
O
O
HO
HO
OH
HO
HO
NH
HO
O
HO
O
NH
H
N
O
O
O
HO
HO
O
O
O
HO
HO
O
HO
NH
OH
OH
O
O
OH
OH
OH
HO
CH2OH
OH
OH
H H
OH
NHAc
OH
OH
HO
H H
OH
NH
C O
OH
CH2
CH2
NH CH CO NH CH2 CO NH CH CO
Esquema de la O-glicosilacin
ST6GalNAc-III
ST6GalNAc-IV
(ST6GalNAc-I)
(ST6GalNAC-II)
Ser/Thr
Ser/Thr
Antgeno disialyl Tn
ST3Gal-I
(ST3Gal-II)
(ST3Gal-IV)
Core 1 GalT
Core 2 GalNAcT
GalNAc
cido Silico
(n)
Gal
Ser/Thr
antgeno Tn
Ser/Thr
antgeno T
ST6GalNAc-I
Ser/Thr
Antgeno sialyl Tn
ST6GalNAc-II
(ST6GalNAc-I)
Ser/Thr
Ser/Thr
GlcNAc
Fuc
Ser/Thr
HO
HO
HO
HO O
HO
HO
HO
OO
OH
HO O
HO
HO
HO
HO O
O
O
HO
HO
HO
OH
O
O
HO
HO
OH
HO
HO
NH
HO
O
HO
O
NH
H
N
O
O
O
HO
HO
O
O
O
HO
HO
O
HO
OH
OH
O
OH
O
OH
HO
O
OH
O
O
OH
OH
HO
O
OH
OH
OH
NH
Recognition (self/non-self)
Soluble
Lectins, LBP, PGBP
Membrane-associated receptors
NK cell, homing, scavenger, complement, TLRs, etc
Intracellular
NODs
Signaling
TLRs
NODs
Effector functions
Soluble
Complement, lysozyme, antimicrobial peptides
Membrane-associated
Nramp
Intracellular
Soluble
Receptors
Lectins
(MBL, ficolins
lung surfactant)
C1q
Pentraxins
(CRP, SAP)
Soluble
Receptors
C-type Lectin
Membrane Receptors
Lectins
(MBL, ficolins
lung surfactant)
C1q
PM
Pentraxins
(CRP, SAP)
DC-SIGN
C
C
C
C
C
Selectin
MF-MR
Soluble
Receptors
C-type Lectin
Membrane Receptors
Lectins
(MBL, ficolins
lung surfactant)
C1q
PM
Pentraxins
(CRP, SAP)
DC-SIGN
C
C
C
C
C
MF-MR
NK Cell
Receptors
Selectin
CL
C2
J
C2
V/C2
ITIM
ITIM
ITIM
ITIM
ITIM
ITIM
Soluble
Receptors
C-type Lectin
Membrane Receptors
Lectins
(MBL, ficolins
lung surfactant)
C1q
PM
Pentraxins
(CRP, SAP)
DC-SIGN
C
C
C
C
C
MF-MR
NK Cell
Receptors
Selectin
CL
C2
Scavenger
Receptors
J
C2
V/C2
ITIM
ITIM
ITIM
ITIM
ITIM
ITIM
CD68 CD-36
SR-A
Soluble
Receptors
C-type Lectin
Membrane Receptors
Lectins
(MBL, ficolins
lung surfactant)
C1q
PM
Pentraxins
(CRP, SAP)
DC-SIGN
C
C
C
C
C
MF-MR
NK Cell
Receptors
Selectin
CL
C2
Scavenger Complement
Receptors Receptors
J
C2
V/C2
ITIM
ITIM
ITIM
ITIM
ITIM
ITIM
CD68 CD-36
SR-A
Soluble
Receptors
C-type Lectin
Membrane Receptors
Lectins
(MBL, ficolins
lung surfactant)
C1q
DC-SIGN
Pentraxins
(CRP, SAP)
C
C
C
C
C
MF-MR
NK Cell
Receptors
Selectin
Scavenger Complement
Receptors Receptors
Toll-like
Receptors
LBP
CD14
CL
C2
J
C2
PM
LRR
V/C2
ITIM
ITIM
ITIM
ITIM
ITIM
ITIM
CD68 CD-36
SR-A
TIR
MyD
88
NBS
NBS
CARD
CARD
NOD-1
CARD
NOD-2
TIRAP
Intracellular
Receptors
NF-kB
MD-2
Immune response
genes
dsRNA
LP
PG
LP
TIR
TIR
TIR
(?)
CpG
Flagellin
Zym
LP
TIR
TIR
TIR
TIR
TIR
TIR
TIR
10
LPS
CpG (?)
PM
Transmembrane
Domain
Cys-rich
Complementbinding
Domain
(var. number)
Collagen-like
EGF-like
Domain
(var. number)
C RD
C RD
MBL
macrophage
macrophage
macrophage
FMR
macrophage
FMR
bacterium
macrophage
Alternative Pathway
C3-H2O
Ab-antigen
Factor D
C1qrs
Factor B
C2
C4
Lytic pathway
C3
C3 convertase
Phagocytosis
Complement Pathways
Lectin Pathway
Alternative Pathway
Ab-antigen
MBL
MASP
C2
C1qrs
C4
C2
C4
Lytic pathway
C3
C3-H2O
Factor D
Factor B
C3 convertase
Phagocytosis
C3b, C5b
PMN
C3b, C5b
MF-MR
TLRs
PMN
C3b, C5b
MF-MR
Macrophage
TLRs
PMN
C3b, C5b
Target
cell
NCR-L
MHC
Ly49H
CD94
NCR
+ x
NK
MF-MR
Pathogen
destruction
Effector
function
Macrophage
TLRs
PMN
C3b, C5b
Target
cell
NCR-L
Pathogen
destruction
MHC
Ly49H
CD94
NCR
+ x
Effector
function
NK
MF-MR
Pathogen
destruction
Effector
function
Macrophage
TLRs
PMN
IFN-
IFN-
Dendritic
Cell
C3a, C5a
+
Target
cell
NCR-L
MHC
Ly49H
CD94
NCR
Pathogen
destruction
TLRs
Effector
function
+ x
NK
+
IFN-g
MF-MR
Pathogen
destruction
Effector
function
Macrophage
TLRs
PMN
IFN-
IFN-
Dendritic
Cell
C3b, C5b
+
Target
cell
NCR-L
MHC
Ly49H
CD94
NCR
Pathogen
destruction
TLRs
Effector
function
+ x
NK
+
IFN-g
MF-MR
Pathogen
destruction
Effector
function
Macrophage
TLRs
CD40
PMN
IFN-
IFN-
Dendritic
Cell
C3b, C5b
MHC
+
Target
cell
NCR-L
MHC
Ly49H
CD94
NCR
Pathogen
destruction
TLRs
Effector
function
+ x
NK
CD86
+
IFN-g
CD80
MF-MR
Pathogen
destruction
Effector
function
Macrophage
TLRs
CD40
PMN
IFN-
IFN-
Dendritic
Cell
C3a, C5a
MHC
+
Target
cell
NCR-L
MHC
Ly49H
CD94
NCR
Pathogen
destruction
TLRs
Effector
function
+ x
NK
CD86
+
IFN-g
CD80
MF-MR
Destruccin
patgeno
Funcin
efectora
Macrophage
CD40
TLRs
PMN
IFN-
IFN-
CD40L
Dendritic
Cell
C3b, C5b
CD40L
MHC
+
Target
cell
NCR-L
Funcin
efectora
+ x
NK
TCR
TLRs
T Cell
MHC
Ly49H
CD94
NCR
Destruccin
patgeno
B Cell
CD40
CD86
+
IFN-g
CD80
CD28
MF-MR
Destruccin
patgenos
Funcin
efectora
Macrophage
CD40
TLRs
PMN
IFN-
IFN-
CD40L
Dendritic
Cell
C3a, C5a
+
Target
cell
NCR-L
NCR
Funcin
efectora
+ x
NK
TCR
TLRs
T Cell
MHC
Ly49H
CD94
Funcin
Efectora
CD40L
MHC
Destruccin
patgenos
B Cell
CD40
CD86
+
IFN-g
CD80
CD28
Inmunidad
Memoria
Destruccin
patgenos
Tight adhesion
(integrin activation)
Extravasation
leukocytes
epithelial
cells
L-selectin
selectin
adhesion
molecule
integrin
adhesion
molecule
integrin
Sialectinas
La familia de SIGLECS
Colectinas
Receptores de colectinas
Gal-4 and Gal-8 are expressed by the intestinal epithelium and each have
CRDs (left). Galectins can tightly bind blood group B carbohydrates, which
some bacteria express on the side chains of surface lipopolysaccharides.
Upon binding of either of these lectins (middle), bacteria rapidly lose
viability. Surface blebs appear as the bacteria are killed. Nat Med. 16 (2010)
263-4.
Mecanismos de patogenia
Enfermedad
Alteracin en la glicosilacin
Manifestacin clnica
Fibrosis qustica
Sndrome de
Wiskott Aldrich
Inmunodeficiencia severa
otitis media, eccema,
petequias, linfadenopata,
esplenomegalia, anemia.
Nada es verdad.