Spanish White Biotech Pipeline 2014

An overview of industrial biotechnology projects currently developed by the Spanish biotech industry

Spanish White Biotech Pipeline*

B I O P R O D UC T S

Ready for
exploitation
15%

Applied R&D
15%

BIOPRODUCTS
Company

Name

Indication

ABENGOA BIOENERGA
ABENGOA BIOENERGA
ABENGOA BIOENERGA
ALGAENERGY
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Bioibrica
Biomedal
Biomedal
Biomedal
Biomedal
Biomedal
Biomedal
Biomedal
GAIKER - IK4
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
NANOIMMUNOTECH
PROTEOS BIOTECH
PROTEOS BIOTECH
PROTEOS BIOTECH
ABENGOA BIOENERGA
INKEMIA IUCT GROUP
SYGNIS BIOTECH S.L
ABENGOA BIOENERGA
Biomedal
Biomedal
NEOL BIOSOLUTIONS
NEOL BIOSOLUTIONS
Phyture Biotech
Fundacin MEDINA
Fundacin MEDINA
SYGNIS BIOTECH S.L
SYGNIS BIOTECH S.L
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
NEOL BIOSOLUTIONS
INKEMIA IUCT GROUP
ABENGOA BIOENERGA
LEITAT
REPSOL
REPSOL
INKEMIA IUCT GROUP
CIBER-BBN
CIBER-BBN
CIBER-BBN
CIBER-BBN
LEITAT

DDGS (Dried Distillers Grains with Solubles)

Sugars
Microalgae collection
Microalgae products with excellent properties for several applications and sectors
Terra-Sorb
Biostimulant
Inicium
Biostimulant
StressSal
Biostimulant
Terramin
Biostimulant
Terra Humic
Biostimulant
AminoQuelant
Bioavailable Nutrition
Optimus
Plant protection (resistance to biotic stress)
Armurox
Plant protection (endogenous defense mechanisms)
Cera Trap
Biological Attractants
Dacus Trap
Biological Attractants
Mosca Trap
Biological Attractants
Suzukii Trap
Biological Attractants
Flyral
Biological Attractants
Biocebo
Biological Attractants
rProtein A (4xZ)
Synthetic derivative produced by recombinant expression. Antibody purification
rProtein G (3xC)
Synthetic derivative produced by recombinant expression. Antibody purification
ProPure rProtein A FastCAp
Immunoglobulin capture and purification cartridges
ProPure rProtein G FastCAp
Immunoglobulin capture and purification cartridges
ProPure rProtein A Rapid Flow
Immunoglobulin capture and purification affinity medium
ProPure rProtein G Rapid Flow
Immunoglobulin capture and purification affinity medium
ProPure rProtein A LCL Agarose Immunoglobulin capture and purification affinity medium
Antibacterial polymers and coatings and evaluation of biocide properties
GC-S51
New solvent from renewable materials for synthesis of APIs
CAT-Apudp / Bcpym / Hmudp
New catalyst pyrimidine phosphorilase nucleoside
CAT-Bcun - Gbspum - Ssdeod
New catalyst Purine Phosphorilase Nucleoside
GC-BIO-DF / GC-BIO-F
2-deoxy-5-fluorouridine. 5-fluorouridine. Anticancer / Colon & Pancreas / Colon & Breast
BIO-TFT
Trifluorothymidine / Antiviral (Ophthalmic) / Herpes Cornea
GC-BIO-DAP / BIO-AP
2,6-diaminopurine deoxiriboside. Anticancer / 2,6-diaminopurine riboside. Antiviral. Anticancer
GC-S79
Solvents from renewable materials for the biodiesel sector
SOL-LAOC4 / GC-S77 / GC-DMA New solvent from renewable materials for metal degreasing and for Paint and varnishes from DMA
NITZIPPER
Family of products ready to be easily, quickly and efficiently bioconjugated (antibodies, dyes, enzymes, micro / nanoestructures, peptides, molecules, linkers, etc)
PROTEOS-RPROT
Recombinant proteins and growth factors
PROTEOS-PCAI
Personal care active ingredients and products
PBSerum
Enzymatic cosmoceutics
Cellulolytic and Hemicellulolytic enzymes
GC-S78
New solvent from renewable materials for Crop protection
Sygnis Biotech
QualiPhi (next-gen version of Phi 29 DNA polymerase)
Microalgae collection
rProtein A Resins
Immunoglobulin capture and purification
nLZ4-Cys
Cost effective ligand for antibody purification
Yeast biomass for different end markets. High protein content and vitamins
9000 microorganism collection for different bio industrial processes
Plant cell cultures for dermatological applications
MEDiversity
Microbial Collections
MEDgene
Microbial Genetic Bank
Sygnis Biotech
New Primase / Polymerase
Sygnis Biotech
New polymerases for Next Generation Sequencing
Bio-EPS
New exopolysaccharides use as nutraceutical and cosmetics (8 compounds)
CAT-Halo1 / Halo2
Enzymatic mixture with hydrolytic activity / with lipase and protease activity
CAT-Halolip / Haloprot
New halolipase / New haloprotease
Microbial triglycerides obtained from fermentation
BIO-K3
Menadione (vitamin K3)
n-butanol
Protein hydrolysates
New microalgae strain with high oil production
Microorganisms for biofuel production
BIO-CEM
New microorganisms for self healing concrete
BBN-F1 a F4. Rare Diseases
Biomaterial with metallic coating. Polymeric material. Bone regeneration
Lipophilic derivatives siRNA. Modified siRNA. Gene therapy
Targeted delivery carrier. Oncology
Protein hydrolysates

Basic R&D

Ready for
exploitation

Applied R&D

Industrial
scale up

Available

<<< <<<<<<< < < < <<

<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <<
<<< <<<<<<< < < < <
<<< <<<<<<< < < < <
<<< <<<<<<< < < < <
<<< <<<<<<< < < <
<<< <<<<<<< < < <
<<< <<<<<<< < < <
<<< <<<<<<< < < <
<<< <<<<<<< < < <
<<< <<<<<<< < < <
<<< <<<<<<< < <
<<< <<<<<<< < <
<<< <<<<<<< < <
<<< <<<<<<< < <
<<< <<<<<<< <
<<< <<<<<<< <
<<< <<<<<<< <
<<< <<<<<<< <
<<< <<<<<<<
<<<<<<
<<<<<<
<<<<<<
<<<<
<<<
<<
<<
<<
<<
<<

Technology
transfer in process

Patent

4
4
4
4
4
4
4

4
4
4
4
4
4
4

4
4
4

4
4
4
4
4
4
4
4
4

4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4

4
4
4

4
4

4
4
4
4
4
4
4

4
4
4

4
4
4
4
4

TECHNOLOGIES
Basic R&D 8%

Industrial scale up 62%

TECHNOLOGIES

Applied R&D 13%

Ready for
exploitation
88%

Company

Name

www.asebio.com

Spanish Bioindustry Association

ASEBIO, the Spanish Bioindustry Association, encompasses over 270 firms, associations, foundations, universities, technology and
research centers which carry out activities directly or indirectly related to biotechnology.

The wide number of associates makes ASEBIO the most appropriate meeting platform to face up the challenges of developing the
biotechnology sector in Spain.

Around 620 companies research and develop products in the Spanish biotechnology sector.

ALGAENERGY
ALGAENERGY
BIOCHEMIZE
BIOCHEMIZE
BIOCHEMIZE
BIOCHEMIZE
Biomedal
BIOMOL-INFORMATICS
Bionanoplus
Bionanoplus
Bionanoplus
Bionaturis
Bionaturis
BIONET
BIONET
BIONET
BIONET
BIONET
BIONET
BIONET
BIOPOLIS
BIOPOLIS
BIOSEARCH
BIOSEARCH
BIOSEARCH
Curaxys
Fundacin MEDINA
Fundacin MEDINA
Fundacin MEDINA
Fundacin MEDINA
Fundacin MEDINA
FUNDACION PROGRESO Y SALUD (SAS)
GADEA BIOPHARMA
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
FUNDACION PROGRESO Y SALUD (GENYO)
INGENIATRICS
INGENIATRICS
INGENIATRICS
INGENIATRICS
INGENIATRICS
INGENIATRICS
INGENIATRICS
INGENIATRICS

Indication

Basic R&D

Microalgae Production Technology for several applications

Microalgae production facilities, technologies, control and harvesting systems
PB
Screening for microbial and enzymatic biocatalysis
SC-enz
Enzymatic screening for modification of chemical structures
Enzymatic technological platform for advanced esterification reactions
Enzymatic technological platform for advanced aldolic reactions
CASCADE
Bacterial expression system
BIOMOL - HTCM
In silico drug discovery through combinatorial quimioinformatics
NANO-GES
Topical (skin and mucus) drug delivery technology using polymeric nanoparticles
TUG
Transungual drug delivery technology using polymeric nanoparticles
NANO-GES
Topical Ophthalmic drug delivery technology using polymeric nanoparticles
FLYLIFE
Baculovirus expression system. MVB, WSVB, upstream development, downstream development, analytical development, scale-up
FLYPIDS
Recombinant expression of second generation vaccines (VLPs, chimeric, subunits)
BIONET
Serial 35 L. Bioreactor
BIONET
Serial Membrane filtration units
BIONET
Fermentation technologies
BIONET
Membrane filtration technologies
BIONET
Serial 5 L. Bioreactor
BIONET
Serial 350-1000 L. Bioreactor
BIONET
Serial CIP units
Bio-Cpe
High added value compounds extraction
Bio-Cl
Recombinant protein expression for therapeutic and diagnostic application
Screenings for antimicrobial, antiobesity, inhibitory of cholesterol absorption activity
Pilot plant in main food applications. Preparation of dairy prototypes and other food matrices
Testing and Calibration laboratory accredited by ENAC according to ISO17025
Biosimilars monoclonal antibodies Platform
MEDiscovery
Bioactive Molecule Discovery Platform
MEDmicro
Microbial Fermentation & Scale Up Platform
MEDchemistry
LCMS & NMR Analytical Platform
MEDScreen
High Throughput Screening of Biotechnological Products
Bioanalysis mass spectrometry platform
IMABIS-105
Microplate Vacuum Washer
Sterile final pharmaceutical forms
Active packaging
Microencapsulation of biosubstances, active ingredients, and essential oils
Incorporation of active substances in textile fibers
CO2 Supercritical
Spray-drying
Pyrolysis
Photobioreactor
BACM-15
Lentiviral System for the generation of High Producing Clones (Protein Production)
FLOW FOCUSING
One step microencapsulation producing small & homogeneous spheres, core-shell, double-shell particles
FLOW BLURRING
Highly efficient spray of extremely fine droplets production
MICROPARTICLES MANUFACTURING Tailored in-plant scaled-up manufacturing
ONENEB
Improved sensitivity and robustness analytic nebulizer and micronebulizer for spectrometry systems
NE-4
High throughput nebulizer for material process: drying, pulverisation, etc. Able to operate with highly viscous materials
CELLENA
User-friendly bioencapsulation portable platform to encapsulate high molecular weight compounds, microorganisms and cells
FLOW SPRAY-DRYER
Brand-new spray-drying and spray-chilling equipment integrating proprietary technology emitters for highly accurate and efficient microparticles production
MICROPARTICLES DEVELOPMENT
Customised CRO microencapsulation services for cosmetics, chemicals, consumer goods, Including SPHERES, CORE-SHELL and DOUBLE SHELL structure
ATOMISATION EQUIPMENT /
INGENIATRICS
Development and manufacturing of proprietary technology nebulizers, atomisers, and equipment or devices including it / coating systems
COATING SYSTEMS
INKEMIA IUCT GROUP
GC-SOLV
Substitution for green safer solvent from renewable resources in different industrial applications
INKEMIA IUCT GROUP
CG-Bio-GMO
Molecular biology: genetically modified microorganism
INKEMIA IUCT GROUP
Bio-HTB
High throughput biotechnological synthesis of small molecules
Laboratorios LETI
Protein Purification
Life Length
TAT
Telomere measurement
Lonza Biologics Porrio
Stirred bioreactors 5.000 & 10.000 L. scale & single-use bioreactors
Lonza Biologics Porrio
Custom manufacturing of monoclonal antibodies and recombinant proteins using mammalian cell culture
Lonza Biologics Porrio
Analytical Services for the Biotechnology Industry
NANOIMMUNOTECH
NITBIOSENSING
Colorimetric biosensor
NANOIMMUNOTECH
NITBIOSENSING
Thermal biosensor based on visual detection by colour change in a support where an analyte is present, produced by heat when irradiated with external light source
NEIKER
Protein purification
NEIKER
Development of microalgae culture strategies to obtain high lipid biomass content
Phyture Biotech
Plant cell cultures technology for the development of dermocosmetic product
PROTEOS BIOTECH
PROTEOS-PPS
Protein Purification System
PROTEOS BIOTECH
PROTEOS-MENC
Microencapsulation of active ingredients and enzymes
PROTEOS BIOTECH
PROTEOS-MEM
Microemulsification of active ingredients and enzymes
PROTEOS BIOTECH
PROTEOS-BESE
Bacterial expression system in E. coli
FUNDACION PROGRESO Y SALUD (GENYO) GENYO-13002
Insulator for improve gene expression
NEIKER
Soil microorganism detection
Plebiotic
PleMD
Molecular Dynamics solution
NEOL BIOSOLUTIONS
TRIBIOPLAST
Production of biopolymers
BIOMOL-INFORMATICS
Generating 3D computer models for bacterial protein polymers as scaffolds for nanowires
LEITAT
Antimicrobial / antifungal /antibiofouling and quorum sensing inhibitors screening
LEITAT
Biosurfactant production
PROTEOS BIOTECH
PROTEOS-BESB
Bacterial expression system in Bacillus megaterium
LEITAT
Protein purification
LEITAT
Enzyme immobilisation
LEITAT
Anaerobic digestion and partial anaerobic digestion
LEITAT
Microbial Fuel Cells
Phyture Biotech
Plant cell cultures technology for recombinant proteins production

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

*Based on data provided by ASEBIO associated companies. APRIL 2014.

www.asebio.com

Ready for
exploitation

Applied R&D

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<
<

Available

Technology
transfer in process

Patent

4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4

4
4
4
4
4
4
4

4
4
4
4

4
4
4
4

4
4
4
4
4

4
4
4
4

4
4

4
4
4
4
4
4
4
4
4

Only special preparations

4
4
4
4
4
4

4
4
4
4
4
4
4

4
4

Spanish White Biotech Pipeline*

Spanish White Biotech Pipeline 2014

An overview of industrial biotechnology projects currently developed by the Spanish biotech industry

BIOPROCESSES

BIOPROCESSES

Basic R&D 3%
Applied R&D 24%
Industrial
scale up 40%

Ready for
exploitation 33%

Ready for Industrial

exploitation scale up

Company

Name

Indication

Basic R&D

3P BIOPHARMACEUTICALS
3P BIOPHARMACEUTICALS
3P BIOPHARMACEUTICALS
3P BIOPHARMACEUTICALS
BIOCHEMIZE
BIOCHEMIZE
BIOCHEMIZE
BIOCHEMIZE
BIOCHEMIZE
BIOCHEMIZE
Biomedal
Biomedal
Bionaturis
BIONET
BIONET
BIOPOLIS
BIOPOLIS
BIOPOLIS
BIOPOLIS
BIOSEARCH
Camelina Company Espaa
Curaxys
GADEA BIOPHARMA
GADEA BIOPHARMA
GADEA BIOPHARMA
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
Laboratorios LETI
Lonza Biologics Porrio
PLASMIA BIOTECH
PRAXIS
ALGAENERGY
Bionaturis
BIOPOLIS
BIOPOLIS
BIOPOLIS
Fundacin MEDINA
Fundacin MEDINA
GADEA BIOPHARMA
GADEA BIOPHARMA
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
GAIKER - IK4
INKEMIA IUCT GROUP
INKEMIA IUCT GROUP
NEIKER
NEIKER
NEOL BIOSOLUTIONS
PROTEOS BIOTECH
PROTEOS BIOTECH
PROTEOS BIOTECH
ABENGOA BIOENERGA
nanoMyP
NEIKER
Phyture Biotech
PROTEOS BIOTECH
PROTEOS BIOTECH
Bioibrica
Curaxys
Curaxys
LEITAT
LEITAT
LEITAT
LEITAT
NEOL BIOSOLUTIONS
ABENGOA BIOENERGA
Neuron Bio
Phyture Biotech
LEITAT
LEITAT
LEITAT
LEITAT
PROTEOS BIOTECH
PROTEOS BIOTECH
PROTEOS BIOTECH
PROTEOS BIOTECH
LEITAT
GAIKER - IK4
Phyture Biotech

CMO GMP certified

CMO GMP certified
CMO GMP certified
CMO GMP certified
PB-est
PB-red
PB-oxi
PB-met
PB-rac
PB-ald
LYTAG-2nd-PHASE
HISTAG-2nd-PHASE
FLYLIFE

Freedom-to-operate platform in Bacteria, yeast and mammalian

Bioprocess Development/Optimisation Platform (USP/DSP)
Analytics development and validation platform (API, IMP, IPC) for New biological entities
Analytics development and validation platform (API, IMP, IPC) for Biosimilars
Enzymatic and microbial platform for esterification of organic compounds
Enzymatic and microbial platform for reduction of oxygen functional groups
Enzymatic and microbial platform for oxidation of aromatic methylenes
Enzymatic and microbial platform for methylation of aromatic compounds
Enzymatic and microbial platform for separation of racemic compounds
Enzymatic and microbial platform for aldolic condensations
Protein separation and purification
Protein separation and purification of his-tagged proteins in aqueous two phase systems
Baculovirus-based expression system at industrial scale (MVB, WVS, upstream, downstream)
Process Development/Optimisation (USP and DSP)
Scale up and GMP facilities design
Custom cloning and expression of recombinant protein
Biosynthesis of chemical compounds
Process development for biopolymers production
Bioprocesses / biocatalysis
Manufacture and Purification of plant extracts
Camelina oil: Feedstock for Bio products (bioplastics, biolubricants, biopolymers, gondoic acid)
Upstream & Downstream process
Biotechnological production of steroids
Biotechnological production of APIs
Scale up and production
Contaminated soils bioremediation
Biological treatments for water purification
Biopolymers development
Production in bioreactor of micro-algae (biodiesel and functional ingredients) and fermentation
Production of protein extracts / allergens
Analytical services and stability studies of DS and DP
Biocatalytic synthesis of nucleoside analogues
Micro-nano-formulation, aseptic filling and freeze-drying
Biomass integral valorisation process
Recombinant expression of second generation vaccines (VLPs, chimeric, subunits)
Process Development for PHA production
Production and purification of recombinant proteins
Production of biopharmaceuticals, key organic compounds and green chemicals
Fermentation of new fungal and bacterial strains with biotechnological applications
Isolation of new natural products from microbial fermentations
Bacterial and fungal fermentation and DSP
Aseptic lyophilisation and filling of APIs
Biodetergency
Bioremediation
Biofunctional nanoparticles synthesis
Fermentation. Production of microorganisms and recombinant proteins
Prospection, isolation, characterisation and performance of new microorganisms in industrial biotechnology
Substitution of chemical processes for bioprocesses
Production of Recombinant Proteins
Production of Omega-3-Rich Oil from microalgae
Production of single cell oils
Bacterial fermentation
Protein expression systems
Production of Recombinant Proteins
Biochemical production of monomers from sugars
Synthesis of nanostructured tissues for biocatalytic processes
Production of carotenoids from microalgae
Development of plant cell cultures as new cosmetic actives ingredients
Proteolytic processes - meat waste
Proteolytic processes - dairy applications
Biogas production plan project from fat
Manufacture and Purification of Recombinant Proteins (GMP)
Production of Monoclonal Antibodies (GMP)
Enzymatic protein hydrolisation processes
Biogas production from waste and effluents
Biosurfactant production processes from commercial and renewable feedstock
Biotechnological cotton process
Omega 3 bioprocess
Catalytic synthesis of n-butanol from ethanol
Biosynthesis of new polyketides derivatives
Development of plant cell cultures for dermatologic pathologies
Bioprocess for textile processing
Substitution of chemical processes by bioprocesses
Enzymatic improvement of fats and fat valorisation
Obteining of protein hydrolysates
Proteolytic processes - detergents applications
Biocatalysis processes - Essential fatty acids
Microbial biogas production
Production of Biosimilars
Enzymatic synthesis of prebiotic ingredients
Development of soil remediation process based on nanoparticles
Recombinant proteins production through plant cell cultures platform

<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<<
<<<<<<<<<<
<<<<<<<<<<
<<<<<<<<<<
<<<<<<<<<<
<<<<<<<<<<
<<<<<<<<<<
<<<<<<<<<
<<<<<<<<<
<<<<<<<<<
<<<<<<<<<
<<<<<<<<<
<<<<<<<<<
<<<<<<<<<
<<<<<<<<<
<<<<<<<<
<<<<<<<
<<<<<<<
<<<<<<
<<<<<<
<<<<<<
<<<<<<
<<<<<
<<<<<
<<<<<
<<<<<
<<<
<<
<

Bio-Cl
Bio-Snt
Bio-BPL
Bio-Ctl
Liquid biofuel

Proteins & Peptides

FLYPIDS
Bio-PHA
Bio-Rp
Bio-Bph

Bio-SRC
Bio-PROC

MICROBIOL
PROTEOS - BFERM
PROTEOS - PEX
PROTEOS - PRP
Tiss Series

PROTEOS-PPMW
PROTEOS-PPDA

NST-Pkt

PROTEOS-PPDET
PROTEOS-BPEFA
PROTEOS-MBP
PROTEOS-BS

Applied R&D

Technology
transfer in process

Patent

Available
4
4
4
4

4
4
4
4
4
4
4
4
4

4
4
4
4
4
4

4
4

4
4
4
4
4

4
4
4
4
4

4
4
4
4

4
4
4
4
4

4
4

4
4
4

BIOFUELS
First (1st), second
(2nd) or third (3rd) Activity
generation

www.asebio.com

Spanish Bioindustry Association

ASEBIO, the Spanish Bioindustry Association, encompasses over 270 firms, associations, foundations, universities, technology and
research centers which carry out activities directly or indirectly related to biotechnology.

Around 620 companies research and develop products in the Spanish biotechnology sector.

The wide number of associates makes ASEBIO the most appropriate meeting platform to face up the challenges of developing the
biotechnology sector in Spain.

Company

Types of Biofuels

Raw material

ABENGOA BIOENERGA
ABENGOA BIOENERGA
ABENGOA BIOENERGA
ALGAENERGY

Bioethanol
Bioethanol
Biodiesel
Biomass, biodiesel, bioethanol, biogas

BANCO ESPAOL DE ALGAS

Biomass, biodiesel, bioethanol, biogas

Cereal, sugarcane
Lignocellulosic material, MSW
Oils
Microalgae & cyanobacteria
Microalgae, cyanobacteria (marine, freshwater,
brackish and hypersaline environments)

BIONET

Biodiesel, bioethanol, biogas, H2

Fermentative biomass microorganisms

2nd 3rd

BIOPOLIS

Biodiesel, bioethanol, biogas

Fermentative biomass microorganisms

Camelina Company Espaa

Liquid biofuel

Camelina Company Espaa

Added value

1st
2nd
1st
2nd

Industrial production
Development of technologies for industrial production
Industrial production
Laboratory production & genetic engineering

Improvement of yields over initial sugars together with high process profitability
Flagship facility for commercial exploitation of 2G Bioethanol under construction
Production process optimised for Biodiesel production
Higher yield than 1st generation: No conflict with human food. Use of non agricultural land. Grow on either wastewater, brackish water or seawater. Daily harvesting

3rd

Fast growing strains, isolation of new species, selection of strains

New biodiversity & cultivation systems, extremophiles, new techniques, connection with pilot plant units at real conditions, and R&D groups

Equipment supply

Engineering services, equipment supply and turn key project

2nd

Development of optimised microorganisms for biofuels

Process optimisation

Camelina oil

2nd

Sustainable feedstock

Sustainable feedstock for 2nd generation liquid biofuel. Development for aviation liquid biofuel: biojetfuel

Liquid biofuel

Camelina oil

2nd

Sustainable feedstock

Sustainable feedstock for 2nd generation liquid biofuel. Biodiesel

EntreChem

Biogas

Organic waste

1st

Microbial population analysis

Identification of key microorganisms in anaerobic digesters to drive performance optimisation

GAIKER - IK4

Biodiesel

Oils

Process improvement, development and testing of new reactions

Versatile pilot plant facility

GAIKER - IK4

Biodiesel

Animal processing fats

2nd

Process improvement

Versatile pilot plant facility

GAIKER - IK4

Biodiesel

Microseaweeds

2nd

Development of the complete process: from microseaweed selection to biodiesel production

Pilot plant facilities for the microseaweed culture, filtration, extraction and production of biodiesel

GAIKER - IK4

All

All

Life Cycle Analysis and Life Cycle Costing

New tool for the environmental and social evaluation of biofuels

INGENIATRICS

All

Fuel Delivery

Optimised fuel atomization

Diminishes emissions - gas and solid particles, makes combustion more efficiently. Capacity to make viscous materials burn, e.g. glycerine

INGENIATRICS

All

Emissions

Treatment of NOx Emissions

Diminshes NOx emissions utilising urea with improved efficiency

INKEMIA IUCT group

Biofuels for S-50 diesel engines

Glycerol

2nd

Development of new biofuels and other biotech products

100% of biomass (oil) use, as it converts glycerine into a biofuel with improved properties compared to famers

INKEMIA IUCT group

Heating

Glycerol and other

2nd

New biofuel for heating in industrial furnaces

100% biomass use. Substitutes fuel oils. Economically viable. Does not need preheating of the fuel oils for ignition

INKEMIA IUCT group

Synthesis and purification of biofuels either

All
by chemical or biotechnological routes

1st and 2nd

Process optimisation of biofuel production

One stop shop for biofuel process optimization

LEITAT

All

All

1st and 2nd

LCA

Quantification of the environmental improvements and sustainability of different processes of energy production and biofuels

LEITAT

Biogas

Organic waste

2nd

Process development

Process optimisation

LEITAT

Cogeneration/Heating

Biomass

2nd

Energy studies

Study the technical feasibility of the power source

LEITAT

Bioethanol

Biomass

2nd

Pretreatment of raw material

Improvement of the saccharification efficiency by chemical or enzymatic pathways

LEITAT

Electricity

Organic effluents

2nd

Microbial Fuel Cells development

Obtaining energy from organic waste effluents

LEITAT

Biodiesel

Oils

Transesterification process development

Recovery of oily waste. More sustainable process

NEIKER

Diesel

Microalgae

2nd

Genetic transformation

Process profitability increase: mixed use algae

NEIKER

Diesel

Microalgae

2nd

Strains selection

Improving farm profitability

NEIKER

Diesel

Microalgae

2nd

Biomass production

Significant yield increase in the production of biomass

NEIKER

Diesel

Crops

1st

Crop agronomy

Improvement of farm profitability

NEIKER

Diesel

Crops

1st

Exploitation and valorisation of by-products

Integrated utilisation of biomass: energy and animal feed

NEIKER

Biogas

Organic waste

2nd

Biomethanisation process improvement

Recycling organic wastes to generate methane processes

NEIKER

Biogas

Microalgae

2nd

Biomass production

Technical feasibility study of the power source

NEIKER

Cogeneration

Organic waste

2nd

Digestate Treatment

Technical feasibility study of digestate in agriculture

NEIKER

Cogeneration

Organic waste

2nd

Nutrients removal

Increased profitability of processes through a combination of different organic sources

NEIKER

Gas heating

Biomass

2nd

Improvement of biomass production systems

Reduced costs of intensive agricultural production systems: energy efficiency of production processes

Neol BioSolutions

Biofuels, oils, biomass, biogas

Raw glycerine; lignocellulose biomass

2nd

MicroBiOil (Production of renewable biofuels)

Valorisation of by-products. High yield production of single cell oils

PIONEER HI-BRED

Biodiesel

Oil Crops (Sunflower and Rape)

1st

Development of improved varieties

Sunflower and rapeseed hybrids with higher levels of fatty acids and yield per unit area, adapted to specific agricultural conditions in Spain

PIONEER HI-BRED

Bioethanol

Crops (Corn and Sorghum)

1st

Development of improved varieties

Corn hybrids with higher starch content and extractable per unit area production adapted to specific agricultural conditions in Spain

PIONEER HI-BRED

Biomass

Crops (Corn and Sorghum)

1st

Development of improved varieties

Hybrids of maize and sorghum forage with high production capacity of dry matter per unit surface area adapted to specific agricultural conditions in Spain

PIONEER HI-BRED

Biogas

Crops (Corn and Sorghum)

1st

Development of improved varieties

Hybrids of maize and sorghum forage with high production capacity of dry matter per unit surface area adapted to specific agricultural conditions in Spain

PIONEER HI-BRED

Biogas

Fermentative biomass bacteria

2nd

Development of specific strains

Strains of Bacillus spp. With a high generation capacity of lactic acid for the preservation of forage and cell lysis capacity for a more effective capacity in anaerobic digestion

REPSOL

Biofuels

Microalgae

3rd

Development of technologies for industrial production

Improvement of the culture and downstream processes. Viability of the production.

REPSOL

Biofuels

Lignocellulosic material

2nd

Development of microorganisms and optimisation of biofuel production

Synthetic biology approach for new biofuel precursor molecules production

1st and 2nd

1st and 2nd

1st and 2nd

*Based on data provided by ASEBIO associated companies. APRIL 2014.

www.asebio.com