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F1
F2
F3
F4
F5
F6
F7
Carvedilol, mg
HPMC (47cps), mg
Eudragit RS100, mg
Glycerin (4 drop), mg
60
500
117.6
60
400
100
117.6
60
250
250
117.6
60
250
250
117.6
60
250
250
117.6
60
250
250
117.6
60
250
250
117.6
Dibutyl phthalate
(1 drop), mg
Ethanol, ml
Acetone, ml
27.4
27.4
27.4
27.4
27.4
27.4
27.4
19
14
5
14
5
14
5
14
5
14
5
14
5
0.25
0.25
0.25
0.25
PEG 400, ml
Tween 80, ml
DMF, ml
DMSO, ml
WU
(mg)
Swelling
% weight
% area
increase
increase
after 30
after 60
min
min
431.31
61.60
F1
0.199
19.63
F2
0.262
21.80
406.11
F3
F4
0.190
0.186
17.40
18.80
F5
F6
0.263
0.177
F7
0.202
TS (kg)
Dummy
Drug
patches
loaded
patches
CU
FE
WVTR
(mg cm2
h-1)
2.333
2.830
88.58
> 300
0.151
59.39
1.793
2.460
84.65
> 300
0.167
291.93
386.07
51.09
35.23
1.233
1.306
1.306
1.816
83.43
93.78
> 300
> 300
0.093
0.104
22.33
14.56
312.667
380.23
52.11
51.09
1.400
1.406
1.856
1.876
89.91
82.10
> 300
> 300
0.136
0.104
20.56
385.09
44.02
1.506
2.076
83.75
> 300
0.109
PC is patch code (F1, F2, F3, F4, F5, F6, and F7 are formulations). TN, WU, TS, CU, FE and WVTR are thickness, weight
uniformity, tensile strength, content uniformity, folding endurance, and water vapour transmission rate, respectively. Each
value is an average of three determinations.
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