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DOSAGE FORMS
I. Introduction
Drug
Any article or agent that is used for the diagnosis, mitigation, treatment, prevention & cure of disea
ses in man
and animals
Agents used to affect the structure & any function of the body of man & other animals
Excipients
Agents that are used to solubilize, suspend, thicken, dilute, emulsify, stabilize, preserve, c
olor, &
flavor medicinal agents into appealing & efficacious dosage forms
Cosmetics
Any substance or preparation intended to be placed in contact with the external parts of the human
body
(epidermis, hair system, nails, lips, & external genitals) or with the teeth & the mucous membrane
of the oral
cavity with a view exclusively or mainly to clean, perfume, changing their appearance, correcting b
ody odors
&/or protecting them or keeping them in good condition
Stability
Improved solubility
Improved appearance
Ease of administration
Palatability
A.
Powders
Intimate mixture of finely divided drugs or chemicals, which are intended for external & inter
nal use
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Advantages
flexibility in compounding
devoid of mixture
relatively stable
Disadvantages
Inaccuracy of dose
Not easily wetted (low absorption)
Not suitable for dispensing
Some powders are hygroscopic and deliquescent
Obtain quantitative data for size, shape, & distribution of drug particles & other components
to be
used in the formulation
1. Dissolution
Particle size
Rate of dissolution
ex. Micronization
1. Suspendability
2. Uniformity
Content uniformity
Weight variation
3. Penetrability
4. Feel
Prevent grittiness
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3 types
5. Wedgewood crystals
a. Levigation
Forming a paste by the addition of a nonsolvent (levigating paste)
Lowers the particle size but does not dissolve the powder
Ex. Mineral oil & glycerins
a. Pulverization by Intervention
Addition of a nonvolatile substance
Ex. Camphor + Mineral Oil
Iodine crystals + Ether
Types of Powders
13. Bulk powders large quantities of oral powders
a. Dentrifices mild abrasive, anticariogenic
b. Dusting powders locally applied, nontoxic
c. Douche powders starting material for vaginal douche
d. Insufflations blown into body cavity by the use of insufflator (ex. for ears, nose)
e. Triturations 10% of active ingredient
Types of paper
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sub
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D.
Granules
B.
Effervescent Granules
Releases CO2 to mask the disagreeable taste of drug
Components:
NAHCO3
Citric acid (C6H8O7) if alone, it yields a sticky mixture
Tartaric acid (C4H4O6) if alone, it easily crumbles
** Should have both citric & tartaric
C.
Tablets
Solid dosage forms that are prepared by molding or compression.
TYPES OF TABLETS:
1.
2.
B.
Disadvantages:
Adds bulk to the formulation (>50%)
Time consuming
Requires expertise
D.
Film Coated Tablets Involves the application of a thin plastic like material on the tablet
.
Advantages:
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gastric
mucosa.
Reasons:
To increase absorption of a drug
To prevent gastric irritation
To offer protection for drugs destroyed by acid.
F.
Chewable Tablets
For those who have difficulty in swallowing
Does not need disintegrants
Usual diluents are Mannitol and Xylitol (SugarFree preparations)
G.
Effervescent Tablets
When in contact with water, It will release CO2
H.
Buccal Tablets
Tablets placed in the buccal cavity (Between the cheeks & gums)
Disintegration time: 4 hours
I.
Sublingual Tablets
Tablets placed under the tongue
Fast disintegration time
Used for emergency drugs : Clonidine (Catapress)
ISMN (Imdur)
ISDN (Isordil)
J.
K.
L.
Wet Granulation
Dry Granulation
3. Direct Compression From Powder to Tablet
For materials with excellent flow property and cohesive proper
1.
2.
ty
EX: NaCl, KCl
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